|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 2 407-416, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
KM Downs and RL Gardner
Imperial Cancer Research Fund, Department of Zoology, University of Oxford, UK.
Culture of postimplantation conceptuses was used in conjunction with microsurgery to investigate the timing, the mechanism and the developmental regulation of chorioallantoic fusion in the mouse. The timing of fusion was determined in both freshly recovered conceptuses and in those that had been cultured from as early as the mid-streak stage. Attachment of the allantois to the chorion was found to have occurred in most conceptuses by the 6-somite stage, irrespective of whether they had been cultured. In investigating the mechanism of fusion, we wished to determine whether it depended on directed growth of the allantoic bud or on its differential adhesion to the chorion. Microsurgery was used to transplant allantoic tissue into the exocoelomic cavity of conceptuses from which the resident allantois had been removed. In synchronous grafting experiments, transplanted allantoises typically attached to the chorion despite loss of their connection with the hindgut region of the fetus. Hence selective attachment of the allantois to the chorion clearly cannot depend simply on its directed growth. While the transplanted allantoic tissue attached to the chorion selectively, it did not attach to it precociously, despite being favourably positioned to do so. These findings argue that the initial attachment of the allantois to the chorion depends on a selective adhesive mechanism that is developmentally regulated. Further grafting experiments in which donor conceptuses were either more or less advanced than hosts revealed that attachment of the allantois to the chorion depends primarily on the stage of the allantois rather than on the stage of the chorion. Collectively, these findings support the hypothesis that the initial stage of chorioallantoic fusion depends on selective adhesion between regionally differentiated mesodermal surfaces which is governed principally by the stage of development of the allantois.
This article has been cited by other articles:
|
|
 |
|
  B. M. Zeigler, D. Sugiyama, M. Chen, Y. Guo, K. M. Downs, and N. A. Speck The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential Development, November 1, 2006; 133(21): 4183 - 4192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Inman and K. M. Downs Brachyury is required for elongation and vasculogenesis in the murine allantois Development, August 1, 2006; 133(15): 2947 - 2959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. van Nes, W. de Graaff, F. Lebrin, M. Gerhard, F. Beck, and J. Deschamps The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice Development, February 1, 2006; 133(3): 419 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Downs, E. R. Hellman, J. McHugh, K. Barrickman, and K. E. Inman Investigation into a role for the primitive streak in development of the murine allantois Development, January 1, 2004; 131(1): 37 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Uy, K. M. Downs, and R. L. Gardner Inhibition of trophoblast stem cell potential in chorionic ectoderm coincides with occlusion of the ectoplacental cavity in the mouse Development, March 10, 2003; 129(16): 3913 - 3924. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hagel, E. L. George, A. Kim, R. Tamimi, S. L. Opitz, C. E. Turner, A. Imamoto, and S. M. Thomas The Adaptor Protein Paxillin Is Essential for Normal Development in the Mouse and Is a Critical Transducer of Fibronectin Signaling Mol. Cell. Biol., February 1, 2002; 22(3): 901 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Rider, S. R. Jones, R. T. Foster, and K. Imakawa Changes in the Temporal and Spatial Expression of H{beta}58 During Formation and Maturation of the Chorioallantoic Placenta in the Rat Biol Reprod, December 1, 2000; 63(6): 1735 - 1746. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. C. Forsberg, K. M. Downs, and E. H. Bresnick Direct interaction of NF-E2 with hypersensitive site 2 of the beta -globin locus control region in living cells Blood, July 1, 2000; 96(1): 334 - 339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kinder, T. Tsang, G. Quinlan, A. Hadjantonakis, A Nagy, and P. Tam The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo Development, January 11, 1999; 126(21): 4691 - 4701. [Abstract] [PDF]
|
|
|
|
|
|
P. Hunter, B. Swanson, M. Haendel, G. Lyons, and J. Cross Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development Development, January 3, 1999; 126(6): 1247 - 1258. [Abstract] [PDF]
|
|
|
|
|
|
K. Downs, S Gifford, M Blahnik, and R. Gardner Vascularization in the murine allantois occurs by vasculogenesis without accompanying erythropoiesis Development, January 11, 1998; 125(22): 4507 - 4520. [Abstract] [PDF]
|
|
|
|
|
|
K. Downs and C Harmann Developmental potency of the murine allantois Development, January 7, 1997; 124(14): 2769 - 2780. [Abstract] [PDF]
|
|
