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Development, Vol 121, Issue 2 439-451, Copyright © 1995 by Company of Biologists

JOURNAL ARTICLES

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

PH Crossley and GR Martin
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco 94143-0452, USA.

Evidence is accumulating that members of the FGF gene family provide signals that act locally to regulate growth and patterning in vertebrate embryos. In this report, we provide a detailed analysis of the mouse Fgf8 gene. We have mapped the Fgf8 locus to the distal region of mouse chromosome 19, and sequenced the 5' coding region of the gene. Our data identify a new coding exon, and locate multiple splice donor and splice acceptor sites that can be used to produce at least seven transcripts encoding a family of secreted FGF8 proteins with different N termini. From these results, it appears that Fgf8 is structurally the most complex member of the FGF family described to date. In the embryo, many of the regions in which Fgf8 RNA is localized are known to direct outgrowth and patterning, including the apical ectodermal ridge of the limb bud, the primitive streak and tail bud, the surface ectoderm overlying the facial primorida and the midbrain-hindbrain junction, suggesting that FGF8 may be a component of the regulatory signals that emanate from these regions.
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Feedback interactions between MKP3 and ERK MAP kinase control scleraxis expression and the specification of rib progenitors in the developing chick somite
Development, March 15, 2005; 132(6): 1305 - 1314.
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 DevelopmentHome page
E. S. Ng, L. Azzola, K. Sourris, L. Robb, E. G. Stanley, and A. G. Elefanty
The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells
Development, March 1, 2005; 132(5): 873 - 884.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
A. E. Brent, T. Braun, and C. J. Tabin
Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development
Development, February 1, 2005; 132(3): 515 - 528.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
A. Suzuki-Hirano, T. Sato, and H. Nakamura
Regulation of isthmic Fgf8 signal by sprouty2
Development, January 15, 2005; 132(2): 257 - 265.
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 Hum Mol GenetHome page
C. E. Keegan, J. E. Hutz, T. Else, M. Adamska, S. P. Shah, A. E. Kent, J. M. Howes, W. G. Beamer, and G. D. Hammer
Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator
Hum. Mol. Genet., January 1, 2005; 14(1): 113 - 123.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
A. E. Serls, S. Doherty, P. Parvatiyar, J. M. Wells, and G. H. Deutsch
Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung
Development, January 1, 2005; 132(1): 35 - 47.
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 DevelopmentHome page
T. Hu, H. Yamagishi, J. Maeda, J. McAnally, C. Yamagishi, and D. Srivastava
Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors
Development, November 1, 2004; 131(21): 5491 - 5502.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
A. A. Rana, J. P. M. Barbera, T. A. Rodriguez, D. Lynch, E. Hirst, J. C. Smith, and R. S. P. Beddington
Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates
Development, October 15, 2004; 131(20): 4999 - 5007.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
T. Sato and H. Nakamura
The Fgf8 signal causes cerebellar differentiation by activating the Ras-ERK signaling pathway
Development, September 1, 2004; 131(17): 4275 - 4285.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
L. Chi, S. Zhang, Y. Lin, R. Prunskaite-Hyyrylainen, R. Vuolteenaho, P. Itaranta, and S. Vainio
Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development
Development, July 15, 2004; 131(14): 3345 - 3356.
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 DevelopmentHome page
D. Kurokawa, N. Takasaki, H. Kiyonari, R. Nakayama, C. Kimura-Yoshida, I. Matsuo, and S. Aizawa
Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm
Development, July 15, 2004; 131(14): 3307 - 3317.
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 DevelopmentHome page
D. Kurokawa, H. Kiyonari, R. Nakayama, C. Kimura-Yoshida, I. Matsuo, and S. Aizawa
Regulation of Otx2 expression and its functions in mouse forebrain and midbrain
Development, July 15, 2004; 131(14): 3319 - 3331.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
Y. Ohkubo, A. O. Uchida, D. Shin, J. Partanen, and F. M. Vaccarino
Fibroblast Growth Factor Receptor 1 Is Required for the Proliferation of Hippocampal Progenitor Cells and for Hippocampal Growth in Mouse
J. Neurosci., July 7, 2004; 24(27): 6057 - 6069.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
O. G. Kelly, K. I. Pinson, and W. C. Skarnes
The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
Development, June 15, 2004; 131(12): 2803 - 2815.
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 Proc. Natl. Acad. Sci. USAHome page
K. Chawengsaksophak, W. de Graaff, J. Rossant, J. Deschamps, and F. Beck
Cdx2 is essential for axial elongation in mouse development
PNAS, May 18, 2004; 101(20): 7641 - 7645.
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 J. Biol. Chem.Home page
K. Nogami, H. Suzuki, H. Habuchi, N. Ishiguro, H. Iwata, and K. Kimata
Distinctive Expression Patterns of Heparan Sulfate O-Sulfotransferases and Regional Differences in Heparan Sulfate Structure in Chick Limb Buds
J. Biol. Chem., February 27, 2004; 279(9): 8219 - 8229.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
L. Zakin and E. M. De Robertis
Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development
Development, January 15, 2004; 131(2): 413 - 424.
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 DevelopmentHome page
J. S. Zoltewicz, N. J. Stewart, R. Leung, and A. S. Peterson
Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis
Development, January 1, 2004; 131(1): 3 - 14.
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 DevelopmentHome page
K. M. Downs, E. R. Hellman, J. McHugh, K. Barrickman, and K. E. Inman
Investigation into a role for the primitive streak in development of the murine allantois
Development, January 1, 2004; 131(1): 37 - 55.
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 DevelopmentHome page
Y. Alvarez, M. T. Alonso, V. Vendrell, L. C. Zelarayan, P. Chamero, T. Theil, M. R. Bosl, S. Kato, M. Maconochie, D. Riethmacher, et al.
Requirements for FGF3 and FGF10 during inner ear formation
Development, December 22, 2003; 130(25): 6329 - 6338.
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 DevelopmentHome page
T. L. Macatee, B. P. Hammond, B. R. Arenkiel, L. Francis, D. U. Frank, and A. M. Moon
Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development
Development, December 22, 2003; 130(25): 6361 - 6374.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
R. A. DeYoung, J. C. Baker, D. Cado, and A. Winoto
The Orphan Steroid Receptor Nur77 Family Member Nor-1 Is Essential for Early Mouse Embryogenesis
J. Biol. Chem., November 21, 2003; 278(47): 47104 - 47109.
[Abstract] [Full Text] [PDF]

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 JCBHome page
B. L. Allen and A. C. Rapraeger
Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assembly
J. Cell Biol., November 10, 2003; 163(3): 637 - 648.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
T. Shimokawa, Y. Furukawa, M. Sakai, M. Li, N. Miwa, Y.-M. Lin, and Y. Nakamura
Involvement of the FGF18 Gene in Colorectal Carcinogenesis, as a Novel Downstream Target of the {beta}-Catenin/T-Cell Factor Complex
Cancer Res., October 1, 2003; 63(19): 6116 - 6120.
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 DevelopmentHome page
A. Abzhanov, E. Tzahor, A. B. Lassar, and C. J. Tabin
Dissimilar regulation of cell differentiation in mesencephalic (cranial) and sacral (trunk) neural crest cells in vitro
Development, October 1, 2003; 130(19): 4567 - 4579.
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 DevelopmentHome page
B. W. Draper, D. W. Stock, and C. B. Kimmel
Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development
Development, October 1, 2003; 130(19): 4639 - 4654.
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 DevelopmentHome page
J. Walshe and I. Mason
Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development
Development, September 15, 2003; 130(18): 4337 - 4349.
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 Genes Dev.Home page
I. del Barco Barrantes, G. Davidson, H.-J. Grone, H. Westphal, and C. Niehrs
Dkk1 and noggin cooperate in mammalian head induction
Genes & Dev., September 15, 2003; 17(18): 2239 - 2244.
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 Genes Dev.Home page
N. Soshnikova, D. Zechner, J. Huelsken, Y. Mishina, R. R. Behringer, M. M. Taketo, E. B. Crenshaw III, and W. Birchmeier
Genetic interaction between Wnt/{beta}-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb
Genes & Dev., August 15, 2003; 17(16): 1963 - 1968.
[Abstract] [Full Text] [PDF]


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