spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gorman, M.
Right arrow Articles by Baker, B. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gorman, M.
Right arrow Articles by Baker, B. S.

Development, Vol 121, Issue 2 463-475, Copyright © 1995 by Company of Biologists

JOURNAL ARTICLES

Molecular characterization of the male-specific lethal-3 gene and investigations of the regulation of dosage compensation in Drosophila

M Gorman, A Franke and BS Baker
Department of Biological Sciences, Stanford University, CA 94305, USA.

In Drosophila, dosage compensation occurs by transcribing the single male X chromosome at twice the rate of each of the two female X chromosomes. This hypertranscription requires four autosomal male-specific lethal (msl) genes and is negatively regulated by the Sxl gene in females. Two of the msls, the mle and msl-1 genes, encode proteins that are associated with hundreds of specific sites along the length of the male X chromosome. MLE and MSL-1 X chromosome binding are negatively regulated by Sxl in females and require the functions of the other msls in males. To investigate further the regulation of dosage compensation and the role of the msls in this process, we have cloned and molecularly characterized another msl, the msl-3 gene. We have found that MSL-3 is also associated with the male X chromosome. We have further investigated whether Sxl negatively regulates MSL-3 X-chromosome binding in females and whether MSL-3 X-chromosome binding requires the other msls. Our results suggest that the MLE, MSL-1 and MSL-3 proteins may associate with one another in a male-specific heteromeric complex on the X chromosome to achieve its hypertranscription.


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
P. Zhang, J. Du, B. Sun, X. Dong, G. Xu, J. Zhou, Q. Huang, Q. Liu, Q. Hao, and J. Ding
Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3
Nucleic Acids Res., December 2, 2006; 34(22): 6621 - 6628.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
X. Deng and V. H. Meller
roX RNAs Are Required for Increased Expression of X-Linked Genes in Drosophila melanogaster Males
Genetics, December 1, 2006; 174(4): 1859 - 1866.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Furuhashi, M. Nakajima, and S. Hirose
DNA supercoiling factor contributes to dosage compensation in Drosophila
Development, November 15, 2006; 133(22): 4475 - 4483.
[Abstract] [Full Text] [PDF]

Home page
 Protein Sci.Home page
P. Zhang, J. Zhao, B. Wang, J. Du, Y. Lu, J. Chen, and J. Ding
The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14.
Protein Sci., October 1, 2006; 15(10): 2423 - 2434.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. A. Alekseyenko, E. Larschan, W. R. Lai, P. J. Park, and M. I. Kuroda
High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome
Genes & Dev., April 1, 2006; 20(7): 848 - 857.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
I. V. Kotlikova, O. V. Demakova, V. F. Semeshin, V. V. Shloma, L. V. Boldyreva, M. I. Kuroda, and I. F. Zhimulev
The Drosophila Dosage Compensation Complex Binds to Polytene Chromosomes Independently of Developmental Changes in Transcription
Genetics, February 1, 2006; 172(2): 963 - 974.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
T. Straub, G. D. Gilfillan, V. K. Maier, and P. B. Becker
The Drosophila MSL complex activates the transcription of target genes
Genes & Dev., October 1, 2005; 19(19): 2284 - 2288.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
F. N. Hamada, P. J. Park, P. R. Gordadze, and M. I. Kuroda
Global regulation of X chromosomal genes by the MSL complex in Drosophila melanogaster
Genes & Dev., October 1, 2005; 19(19): 2289 - 2294.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
V. Morales, C. Regnard, A. Izzo, I. Vetter, and P. B. Becker
The MRG Domain Mediates the Functional Integration of MSL3 into the Dosage Compensation Complex
Mol. Cell. Biol., July 15, 2005; 25(14): 5947 - 5954.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C.-G. Lee, T. W. Reichman, T. Baik, and M. B. Mathews
MLE Functions as a Transcriptional Regulator of the roX2 Gene
J. Biol. Chem., November 12, 2004; 279(46): 47740 - 47745.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. J. Greenberg, J. L. Yanowitz, and P. Schedl
The Drosophila GAGA Factor Is Required for Dosage Compensation in Males and for the Formation of the Male-Specific-Lethal Complex Chromatin Entry Site at 12DE
Genetics, January 1, 2004; 166(1): 279 - 289.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. L. Sass, A. Pannuti, and J. C. Lucchesi
Male-specific lethal complex of Drosophila targets activated regions of the X chromosome for chromatin remodeling
PNAS, July 8, 2003; 100(14): 8287 - 8291.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
K. Tajul-Arifin, R. Teasdale, T. Ravasi, D. A. Hume, RIKEN GER Group, GSL Members, and J. S. Mattick
Identification and Analysis of Chromodomain-Containing Proteins Encoded in the Mouse Transcriptome
Genome Res., June 1, 2003; 13(6): 1416 - 1429.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. S. Pardo, J. K. Leung, J. C. Lucchesi, and O. M. Pereira-Smith
MRG15, a Novel Chromodomain Protein, Is Present in Two Distinct Multiprotein Complexes Involved in Transcriptional Activation
J. Biol. Chem., December 20, 2002; 277(52): 50860 - 50866.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
P. Badenhorst, M. Voas, I. Rebay, and C. Wu
Biological functions of the ISWI chromatin remodeling complex NURF
Genes & Dev., December 15, 2002; 16(24): 3186 - 3198.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Gonzalez, J. M. Ranz, and A. Ruiz
Chromosomal Elements Evolve at Different Rates in the Drosophila Genome
Genetics, July 1, 2002; 161(3): 1137 - 1154.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. M. Volpe, H. Horowitz, C. M. Grafer, S. M. Jackson, and C. A. Berg
Drosophila rhino Encodes a Female-Specific Chromo-domain Protein That Affects Chromosome Structure and Egg Polarity
Genetics, November 1, 2001; 159(3): 1117 - 1134.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. D. Lieb, C. O. de Solorzano, E. G. Rodriguez, A. Jones, M. Angelo, S. Lockett, and B. J. Meyer
The Caenorhabditis elegans Dosage Compensation Machinery Is Recruited to X Chromosome DNA Attached to an Autosome
Genetics, December 1, 2000; 156(4): 1603 - 1621.
[Abstract] [Full Text]

Home page
 J. Cell Biol.Home page
Y. Jin, Y. Wang, J. Johansen, and K. M. Johansen
JIL-1, a Chromosomal Kinase Implicated in Regulation of Chromatin Structure, Associates with the Male Specific Lethal (MSL) Dosage Compensation Complex
J. Cell Biol., May 29, 2000; 149(5): 1005 - 1010.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. F. Partridge, B. Borgstrøm, and R. C. Allshire
Distinct protein interaction domains and protein spreading in a complex centromere
Genes & Dev., April 1, 2000; 14(7): 783 - 791.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
M. J. Bertram, N. G. Berube, X. Hang-Swanson, Q. Ran, J. K. Leung, S. Bryce, K. Spurgers, R. J. Bick, A. Baldini, Y. Ning, et al.
Identification of a Gene That Reverses the Immortal Phenotype of a Subset of Cells and Is a Member of a Novel Family of Transcription Factor-Like Genes
Mol. Cell. Biol., February 1, 1999; 19(2): 1479 - 1485.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C.-G. Lee, V. d. C. Soares, C. Newberger, K. Manova, E. Lacy, and J. Hurwitz
RNA helicase A is essential for normal gastrulation
PNAS, November 10, 1998; 95(23): 13709 - 13713.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
K. A. Chang and M. I. Kuroda
Modulation of MSL1 Abundance in Female Drosophila Contributes to the Sex Specificity of Dosage Compensation
Genetics, October 1, 1998; 150(2): 699 - 709.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
A Franke, A Dernburg, G. Bashaw, and B. Baker
Evidence that MSL-mediated dosage compensation in Drosophila begins at blastoderm
Development, January 9, 1996; 122(9): 2751 - 2760.
[Abstract] [PDF]

Home page
 ScienceHome page
R. L. Kelley and M. I. Kuroda
Equality for X Chromosomes
Science, December 8, 1995; 270(5242): 1607 - 1610.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A Hilfiker, H Amrein, A Dubendorfer, R Schneiter, and R Nothiger
The gene virilizer is required for female-specific splicing controlled by Sxl, the master gene for sexual development in Drosophila
Development, January 12, 1995; 121(12): 4017 - 4026.
[Abstract] [PDF]

Home page
 DevelopmentHome page
R. Roseman, J. Swan, and P. Geyer
A Drosophila insulator protein facilitates dosage compensation of the X chromosome min-white gene located at autosomal insertion sites
Development, January 11, 1995; 121(11): 3573 - 3582.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D. Hsu, P. Chuang, and B. Meyer
DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation
Development, January 10, 1995; 121(10): 3323 - 3334.
[Abstract] [PDF]


© The Company of Biologists Ltd 1995