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Development, Vol 121, Issue 2 489-503, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
L Kwee, HS Baldwin, HM Shen, CL Stewart, C Buck, CA Buck and MA Labow
Department of Biotechnology, Roche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110-1199, USA.
VCAM-1 is a cytokine-inducible cell surface protein capable of mediating adhesion to leukocytes expressing alpha 4 integrins. Mice deficient in VCAM-1 expression were produced by targeted homologous recombination in ES cells. VCAM-1-deficient embryos were not viable and exhibited either of two distinct phenotypes. Approximately half of the embryos died before embryonic day 11.5 and exhibited a severe defect in placental development in which the allantois failed to fuse with the chorion. The remaining VCAM-1-deficient embryos survived to embryonic day 11.5-12.5 and displayed several abnormalities in their developing hearts including a reduction of the compact layer of the ventricular myocardium and intraventricular septum. The hearts also contained significant amounts of blood in the pericardial space and lacked an epicardium. alpha 4 and VCAM-1 were found to be expressed in wild-type embryos in a reciprocal fashion in the chorion and allantois and in the epicardium and the underlying myocardium, although VCAM-1 was expressed in the intraventricular septum in the absence of adjacent alpha 4-expressing cells. These data suggest important roles for VCAM-1 and alpha 4 in the development of the placenta and the heart.
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J. Lavie, F. Dandre, H. Louis, J.-M. D. Lamaziere, and J. Bonnet Vascular Cell Adhesion Molecule-1 Gene Expression during Human Smooth Muscle Cell Differentiation Is Independent of NF-kappa B Activation J. Biol. Chem., January 22, 1999; 274(4): 2308 - 2314. [Abstract] [Full Text] [PDF]
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O. Wendling, P. Chambon, and M. Mark Retinoid X receptors are essential for early mouse development and placentogenesis PNAS, January 19, 1999; 96(2): 547 - 551. [Abstract] [Full Text] [PDF]
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H Wu, S. Lee, J Gao, X Liu, and M. Iruela-Arispe Inactivation of erythropoietin leads to defects in cardiac morphogenesis Development, January 8, 1999; 126(16): 3597 - 3605. [Abstract] [PDF]
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A. Moore, L McInnes, J Kreidberg, N. Hastie, and A Schedl YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis Development, January 5, 1999; 126(9): 1845 - 1857. [Abstract] [PDF]
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T. Landerholm, X. Dong, J Lu, N. Belaguli, R. Schwartz, and M. Majesky A role for serum response factor in coronary smooth muscle differentiation from proepicardial cells Development, January 5, 1999; 126(10): 2053 - 2062. [Abstract] [PDF]
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M. Solloway and E. Robertson Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup Development, January 4, 1999; 126(8): 1753 - 1768. [Abstract] [PDF]
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P. Hunter, B. Swanson, M. Haendel, G. Lyons, and J. Cross Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development Development, January 3, 1999; 126(6): 1247 - 1258. [Abstract] [PDF]
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D. T. Loo, S. B. Kanner, and A. Aruffo Filamin Binds to the Cytoplasmic Domain of the beta 1-Integrin. IDENTIFICATION OF AMINO ACIDS RESPONSIBLE FOR THIS INTERACTION J. Biol. Chem., September 4, 1998; 273(36): 23304 - 23312. [Abstract] [Full Text] [PDF]
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A. C. Gittenberger-de Groot, M.-P. F.M. Vrancken Peeters, M. M.T. Mentink, R. G. Gourdie, and R. E. Poelmann Epicardium-Derived Cells Contribute a Novel Population to the Myocardial Wall and the Atrioventricular Cushions Circ. Res., June 1, 1998; 82(10): 1043 - 1052. [Abstract] [Full Text] [PDF]
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Y. Nakashima, E. W. Raines, A. S. Plump, J. L. Breslow, and R. Ross Upregulation of VCAM-1 and ICAM-1 at Atherosclerosis-Prone Sites on the Endothelium in the ApoE-Deficient Mouse Arterioscler Thromb Vasc Biol, May 1, 1998; 18(5): 842 - 851. [Abstract] [Full Text] [PDF]
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T. L. Jesse, R. LaChance, M. F. Iademarco, and D. C. Dean Interferon Regulatory Factor-2 Is a Transcriptional Activator in Muscle Where It Regulates Expression of Vascular Cell Adhesion Molecule-1 J. Cell Biol., March 9, 1998; 140(5): 1265 - 1276. [Abstract] [Full Text] [PDF]
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A. Roebroek, L Umans, I. Pauli, E. Robertson, F van Leuven, W. Van de Ven, and D. Constam Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin Development, January 12, 1998; 125(24): 4863 - 4876. [Abstract] [PDF]
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K. Downs, S Gifford, M Blahnik, and R. Gardner Vascularization in the murine allantois occurs by vasculogenesis without accompanying erythropoiesis Development, January 11, 1998; 125(22): 4507 - 4520. [Abstract] [PDF]
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X Xu, M Weinstein, C Li, M Naski, R. Cohen, D. Ornitz, P Leder, and C Deng Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction Development, January 2, 1998; 125(4): 753 - 765. [Abstract] [PDF]
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C. Duplaa, T. Couffinhal, P. Dufourcq, B. Llanas, C. Moreau, and J. Bonnet The Integrin Very Late Antigen-4 Is Expressed in Human Smooth Muscle Cell: Involvement of {alpha}4 and Vascular Cell Adhesion Molecule-1 During Smooth Muscle Cell Differentiation Circ. Res., February 1, 1997; 80(2): 159 - 169. [Abstract] [Full Text]
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X Warot, C Fromental-Ramain, V Fraulob, P Chambon, and P Dolle Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts Development, January 12, 1997; 124(23): 4781 - 4791. [Abstract] [PDF]
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M. Fishman and K. Chien Fashioning the vertebrate heart: earliest embryonic decisions Development, January 6, 1997; 124(11): 2099 - 2117. [Abstract] [PDF]
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H Weiler-Guettler, W. Aird, H Rayburn, M Husain, and R. Rosenberg Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos Development, July 1, 1996; 122(7): 2271 - 2281. [Abstract] [PDF]
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J. Rossant Mouse Mutants and Cardiac Development : New Molecular Insights Into Cardiogenesis Circ. Res., March 1, 1996; 78(3): 349 - 353. [Abstract] [Full Text]
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G.T. Wong, L. Ruiz-Avila, D. Ming, K.S. Gannon, and R.F. Margolskee Biochemical and Transgenic Analysis of Gustducin's Role in Bitter and Sweet Transduction Cold Spring Harb Symp Quant Biol, January 1, 1996; 61(0): 173 - 184. [Abstract] [PDF]
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R Fassler and M Meyer Consequences of lack of beta 1 integrin gene expression in mice. Genes & Dev., August 1, 1995; 9(15): 1896 - 1908. [Abstract] [PDF]
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C Oka, T Nakano, A Wakeham, J. de la Pompa, C Mori, T Sakai, S Okazaki, M Kawaichi, K Shiota, T. Mak, et al. Disruption of the mouse RBP-J kappa gene results in early embryonic death Development, January 10, 1995; 121(10): 3291 - 3301. [Abstract] [PDF]
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T. Fujiwara, N. R. Dunn, and B. L. M. Hogan Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse PNAS, November 20, 2001; 98(24): 13739 - 13744. [Abstract] [Full Text] [PDF]
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P. D. Calvert, N. V. Krasnoperova, A. L. Lyubarsky, T. Isayama, M. Nicolo, B. Kosaras, G. Wong, K. S. Gannon, R. F. Margolskee, R. L. Sidman, et al. Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit PNAS, December 5, 2000; 97(25): 13913 - 13918. [Abstract] [Full Text] [PDF]
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