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Development, Vol 121, Issue 3 855-865, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
Y Gu, NA Hukriede and RJ Fleming
Department of Biology, University of Rochester, NY 14627.
Serrate and Delta encode structurally related proteins in D. melanogaster that bind within a common extracellular region on the NOTCH receptor molecule. We used ectopic expression to determine if SERRATE could mediate in vivo functions parallel or antagonistic to those proposed for the putative NOTCH ligand DELTA. Our results demonstrate that Serrate can replace Delta gene function during embryonic neuroblast segregation and that expression of Serrate leads to a NOTCH-dependent suppression of achaete expression in proneural clusters. Our findings strongly suggest that SERRATE functions as an alternative ligand capable of NOTCH activation.
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