|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 3 887-901, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
AK Groves, KM George, JP Tissier-Seta, JD Engel, JF Brunet and DJ Anderson
Division of Biology 216-76, California Institute of Technology, Pasadena 91125.
We have examined the regulation of transcription factor gene expression and phenotypic markers in developing chick sympathetic neurons. Sympathetic progenitor cells first express the bHLH transcriptional regulator Cash-1 (a chicken achaete-scute homologue), followed by coordinate expression of Phox2, a paired homeodomain protein, and GATA-2, a zinc finger protein. SCG10, a pan-neuronal membrane protein, is first detected one stage later, followed by the catecholaminergic neurotransmitter enzyme tyrosine hydroxylase (TH). We have used these markers to ask two questions: (1) is their expression dependent upon inductive signals derived from the notochord or floor plate?; (2) does their sequential expression reflect a single linear pathway or multiple parallel pathways? Notochord ablation experiments indicate that the floor plate is essential for induction of GATA-2, Phox2 and TH, but not for that of Cash-1 and SCG10. Taken together these data suggest that the development of sympathetic neurons involves multiple transcriptional regulatory cascades: one, dependent upon notochord or floor plate-derived signals and involving Phox2 and GATA-2, is assigned to the expression of the neurotransmitter phenotype; the other, independent of such signals and involving Cash-1, is assigned to the expression of pan-neuronal properties. The parallel specification of different components of the terminal neuronal phenotype is likely to be a general feature of neuronal development.
This article has been cited by other articles:
|
|
 |
|
  T. Van de Putte, A. Francis, L. Nelles, L. A. van Grunsven, and D. Huylebroeck Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome Hum. Mol. Genet., June 15, 2007; 16(12): 1423 - 1436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. El Wakil, C. Francius, A. Wolff, J. Pleau-Varet, and J. Nardelli The GATA2 transcription factor negatively regulates the proliferation of neuronal progenitors Development, June 1, 2006; 133(11): 2155 - 2165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Benjanirut, M. Paris, W.-H. Wang, S. J. Hong, K. S. Kim, R. L. Hullinger, and O. M. Andrisani The cAMP Pathway in Combination with BMP2 Regulates Phox2a Transcription via cAMP Response Element Binding Sites J. Biol. Chem., February 3, 2006; 281(5): 2969 - 2981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chen, M. Ji, M. Paris, R. L. Hullinger, and O. M. Andrisani The cAMP Pathway Regulates Both Transcription and Activity of the Paired Homeobox Transcription Factor Phox2a Required for Development of Neural Crest-derived and Central Nervous System-derived Catecholaminergic Neurons J. Biol. Chem., December 9, 2005; 280(49): 41025 - 41036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Oren, I. Torregroza, and T. Evans An Oct-1 binding site mediates activation of the gata2 promoter by BMP signaling Nucleic Acids Res., August 1, 2005; 33(13): 4357 - 4367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. R. Schubert and A. Lumsden Transcriptional control of early tract formation in the embryonic chick midbrain Development, April 15, 2005; 132(8): 1785 - 1793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tsarovina, A. Pattyn, J. Stubbusch, F. Muller, J. van der Wees, C. Schneider, J.-F. Brunet, and H. Rohrer Essential role of Gata transcription factors in sympathetic neuron development Development, October 1, 2004; 131(19): 4775 - 4786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Grundschober, M. L. Malosio, L. Astolfi, T. Giordano, P. Nef, and J. Meldolesi Neurosecretion Competence. A COMPREHENSIVE GENE EXPRESSION PROGRAM IDENTIFIED IN PC12 CELLS J. Biol. Chem., September 20, 2002; 277(39): 36715 - 36724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Enomoto, P. A. Crawford, A. Gorodinsky, R. O. Heuckeroth, E. M. Johnson Jr., and J. Milbrandt RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons Development, October 15, 2001; 128(20): 3963 - 3974. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Bilodeau, T. Boulineau, R. L. Hullinger, and O. M. Andrisani Cyclic AMP Signaling Functions as a Bimodal Switch in Sympathoadrenal Cell Development in Cultured Primary Neural Crest Cells Mol. Cell. Biol., May 1, 2000; 20(9): 3004 - 3014. [Abstract] [Full Text]
|
|
|
|
|
|
D. J. Swanson, M. Adachi, and E. J. Lewis The Homeodomain Protein Arix Promotes Protein Kinase A-dependent Activation of the Dopamine beta -Hydroxylase Promoter through Multiple Elements and Interaction with the Coactivator cAMP-response Element-binding Protein-binding Protein J. Biol. Chem., January 28, 2000; 275(4): 2911 - 2923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Howard, M Stanke, C Schneider, X Wu, and H Rohrer The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification Development, January 9, 2000; 127(18): 4073 - 4081. [Abstract] [PDF]
|
|
|
|
|
|
A. Groves and M Bronner-Fraser Competence, specification and commitment in otic placode induction Development, January 8, 2000; 127(16): 3489 - 3499. [Abstract] [PDF]
|
|
|
|
|
|
Y Wakamatsu, T. Maynard, and J. Weston Fate determination of neural crest cells by NOTCH-mediated lateral inhibition and asymmetrical cell division during gangliogenesis Development, January 7, 2000; 127(13): 2811 - 2821. [Abstract] [PDF]
|
|
|
|
|
|
C. Baker and M Bronner-Fraser Establishing neuronal identity in vertebrate neurogenic placodes Development, January 7, 2000; 127(14): 3045 - 3056. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Eastman, H. R. Horvitz, and Y. Jin Coordinated Transcriptional Regulation of the unc-25 Glutamic Acid Decarboxylase and the unc-47 GABA Vesicular Transporter by the Caenorhabditis elegans UNC-30 Homeodomain Protein J. Neurosci., August 1, 1999; 19(15): 6225 - 6234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M A Leibl, T Ota, M N Woodward, S E Kenny, D A Lloyd, C R Vaillant, and D H Edgar Expression of endothelin 3 by mesenchymal cells of embryonic mouse caecum Gut, February 1, 1999; 44(2): 246 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Lints and S. Emmons Patterning of dopaminergic neurotransmitter identity among Caenorhabditis elegans ray sensory neurons by a TGFbeta family signaling pathway and a Hox gene Development, January 12, 1999; 126(24): 5819 - 5831. [Abstract] [PDF]
|
|
|
|
|
|
P. White and D. Anderson In vivo transplantation of mammalian neural crest cells into chick hosts reveals a new autonomic sublineage restriction Development, January 10, 1999; 126(19): 4351 - 4363. [Abstract] [PDF]
|
|
|
|
|
|
M Stanke, D Junghans, M Geissen, C Goridis, U Ernsberger, and H Rohrer The Phox2 homeodomain proteins are sufficient to promote the development of sympathetic neurons Development, January 9, 1999; 126(18): 4087 - 4094. [Abstract] [PDF]
|
|
|
|
|
|
J. Pisano and S. Birren Restriction of developmental potential during divergence of the enteric and sympathetic neuronal lineages Development, January 7, 1999; 126(13): 2855 - 2868. [Abstract] [PDF]
|
|
|
|
|
|
S Finotto, K Krieglstein, A Schober, F Deimling, K Lindner, B Bruhl, K Beier, J Metz, J. Garcia-Arraras, J. Roig-Lopez, et al. Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells Development, January 7, 1999; 126(13): 2935 - 2944. [Abstract] [PDF]
|
|
|
|
|
|
S. Perez, S Rebelo, and D. Anderson Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo Development, January 4, 1999; 126(8): 1715 - 1728. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Britsch, L. Li, S. Kirchhoff, F. Theuring, V. Brinkmann, C. Birchmeier, and D. Riethmacher The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system Genes & Dev., June 15, 1998; 12(12): 1825 - 1836. [Abstract] [Full Text]
|
|
|
|
|
|
M. Hirsch, M. Tiveron, F Guillemot, J. Brunet, and C Goridis Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system Development, January 2, 1998; 125(4): 599 - 608. [Abstract] [PDF]
|
|
|
|
|
|
L Lo, M. Tiveron, and D. Anderson MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity Development, January 2, 1998; 125(4): 609 - 620. [Abstract] [PDF]
|
|
|
|
|
|
D. J. Swanson, E. Zellmer, and E. J. Lewis The Homeodomain Protein Arix Interacts Synergistically with Cyclic AMP to Regulate Expression of Neurotransmitter Biosynthetic Genes J. Biol. Chem., October 24, 1997; 272(43): 27382 - 27392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Meng, H. Tang, B. A. Ong, M. J. Farrell, and S. Lin Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2 PNAS, June 10, 1997; 94(12): 6267 - 6272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Ma, L. Sommer, P. Cserjesi, and D. J. Anderson Mash1 and neurogenin1 Expression Patterns Define Complementary Domains of Neuroepithelium in the Developing CNS and Are Correlated with Regions Expressing Notch Ligands J. Neurosci., May 15, 1997; 17(10): 3644 - 3652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Mathis, C Bonnerot, L Puelles, and J. Nicolas Retrospective clonal analysis of the cerebellum using genetic laacZ/lacZ mouse mosaics Development, January 10, 1997; 124(20): 4089 - 4104. [Abstract] [PDF]
|
|
|
|
|
|
M.-C. Tiveron, M.-R. Hirsch, and J.-F. Brunet The Expression Pattern of the Transcription Factor Phox2 Delineates Synaptic Pathways of the Autonomic Nervous System J. Neurosci., December 1, 1996; 16(23): 7649 - 7660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E Reissmann, U Ernsberger, P. Francis-West, D Rueger, P. Brickell, and H Rohrer Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons Development, January 7, 1996; 122(7): 2079 - 2088. [Abstract] [PDF]
|
|
|
|
|
|
C. Brodski, H. Schnurch, and G. Dechant Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons PNAS, August 15, 2000; 97(17): 9683 - 9688. [Abstract] [Full Text] [PDF]
|
|
