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Development, Vol 121, Issue 5 1263-1272, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
L Maves and G Schubiger
Department of Zoology NJ-15, University of Washington, Seattle 98195, USA.
Drosophila imaginal discs, the precursors of the adult fly appendages, have been the subject of intensive developmental studies, particularly on cell determination. Cultured disc fragments are recognized not only for the ability to maintain their determined state through extra cell divisions but also for the ability to transdetermine, or switch to the determined state of a different disc. An understanding of transdetermination at a molecular level will provide further insight into the requirements for maintaining cell determination. We find that ectopic expression of the Drosophila gene wingless induces transdetermination of foreleg imaginal disc cells to wing cells. This transdetermination occurs in foreleg discs of developing larvae without disc fragmentation. The in situ-transdetermining cells localize to the dorsal region of the foreleg disc. This wingless-induced transdetermination event is remarkably similar to the leg-to-wing switch that occurs after leg disc culture. Thus we have identified a new approach to a molecular dissection of transdetermination.
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S Goto and S Hayashi Specification of the embryonic limb primordium by graded activity of Decapentaplegic Development, January 1, 1997; 124(1): 125 - 132. [Abstract] [PDF]
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L. Johnston and G Schubiger Ectopic expression of wingless in imaginal discs interferes with decapentaplegic expression and alters cell determination Development, January 11, 1996; 122(11): 3519 - 3529. [Abstract] [PDF]
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F. Diaz-Benjumea and S. Cohen Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing Development, January 12, 1995; 121(12): 4215 - 4225. [Abstract] [PDF]
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