|
|
|
|||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 5 1283-1299, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
CB Ware, MC Horowitz, BR Renshaw, JS Hunt, D Liggitt, SA Koblar, BC Gliniak, HJ McKenna, T Papayannopoulou, B Thoma and al. et
Immunex, Seattle, WA 98101, USA.
The low-affinity receptor for leukemia inhibitory factor (LIFR) interacts with gp130 to induce an intracellular signal cascade. The LIFR-gp130 heterodimer is implicated in the function of diverse systems. Normal placentation is disrupted in LIFR mutant animals, which leads to poor intrauterine nutrition but allows fetuses to continue to term. Fetal bone volume is reduced greater than three-fold and the number of osteoclasts is increased six-fold, resulting in severe osteopenia of perinatal bone. Astrocyte numbers are reduced in the spinal cord and brain stem. Late gestation fetal livers contain relatively high stores of glycogen, indicating a metabolic disorder. Hematologic and primordial germ cell compartments appear normal. Pleiotropic defects in the mutant animals preclude survival beyond the day of birth.
This article has been cited by other articles:
![]() |
Y. Takahashi, M. Takahashi, N. Carpino, S.-T. Jou, J.-R. Chao, S. Tanaka, Y. Shigeyoshi, E. Parganas, and J. N. Ihle Leukemia Inhibitory Factor Regulates Trophoblast Giant Cell Differentiation via Janus Kinase 1-Signal Transducer and Activator of Transcription 3-Suppressor of Cytokine Signaling 3 Pathway Mol. Endocrinol., July 1, 2008; 22(7): 1673 - 1681. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Lorenzo, M. Horowitz, and Y. Choi Osteoimmunology: Interactions of the Bone and Immune System Endocr. Rev., June 1, 2008; 29(4): 403 - 440. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. S. Fitzgerald, T. G. Poehlmann, E. Schleussner, and U. R. Markert Trophoblast invasion: the role of intracellular cytokine signalling via signal transducer and activator of transcription 3 (STAT3) Hum. Reprod. Update, April 17, 2008; (2008) dmn010v1. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. V. Ingman and R. L. Jones Cytokine knockouts in reproduction: the use of gene ablation to dissect roles of cytokines in reproductive biology Hum. Reprod. Update, March 1, 2008; 14(2): 179 - 192. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. de la Iglesia, G. Konopka, S. V. Puram, J. A. Chan, R. M. Bachoo, M. J. You, D. E. Levy, R. A. DePinho, and A. Bonni Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway Genes & Dev., February 15, 2008; 22(4): 449 - 462. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Seita, M. Asakawa, J. Ooehara, S.-i. Takayanagi, Y. Morita, N. Watanabe, K. Fujita, M. Kudo, J. Mizuguchi, H. Ema, et al. Interleukin-27 directly induces differentiation in hematopoietic stem cells Blood, February 15, 2008; 111(4): 1903 - 1912. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Ding, H. Song, X. Wang, A. Khatua, and B. C Paria Leukemia inhibitory factor ligand-receptor signaling is important for uterine receptivity and implantation in golden hamsters (Mesocricetus auratus) Reproduction, January 1, 2008; 135(1): 41 - 53. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Wang, H. Xie, X. Sun, S. Tranguch, H. Zhang, X. Jia, D. Wang, S. K. Das, B. Desvergne, W. Wahli, et al. Stage-specific Integration of Maternal and Embryonic Peroxisome Proliferator-activated Receptor {delta} Signaling Is Critical to Pregnancy Success J. Biol. Chem., December 28, 2007; 282(52): 37770 - 37782. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. A. White, J.-G. Zhang, L. A. Salamonsen, M. Baca, W. D. Fairlie, D. Metcalf, N. A. Nicola, L. Robb, and E. Dimitriadis From the Cover: Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy PNAS, December 4, 2007; 104(49): 19357 - 19362. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Huyton, J.-G. Zhang, C. S. Luo, M.-Z. Lou, D. J. Hilton, N. A. Nicola, and T. P. J. Garrett An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor PNAS, July 31, 2007; 104(31): 12737 - 12742. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Kuure, A. Popsueva, M. Jakobson, K. Sainio, and H. Sariola Glycogen Synthase Kinase-3 Inactivation and Stabilization of beta-Catenin Induce Nephron Differentiation in Isolated Mouse and Rat Kidney Mesenchymes J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1130 - 1139. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Falconi, K. Oizumi, and J. E. Aubin Leukemia Inhibitory Factor Influences the Fate Choice of Mesenchymal Progenitor Cells Stem Cells, February 1, 2007; 25(2): 305 - 312. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. E. Davey and P. W. Zandstra Spatial Organization of Embryonic Stem Cell Responsiveness to Autocrine Gp130 Ligands Reveals an Autoregulatory Stem Cell Niche Stem Cells, November 1, 2006; 24(11): 2538 - 2548. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Mohri, Y. Fujio, M. Maeda, T. Ito, T. Iwakura, Y. Oshima, Y. Uozumi, M. Segawa, H. Yamamoto, T. Kishimoto, et al. Leukemia Inhibitory Factor Induces Endothelial Differentiation in Cardiac Stem Cells J. Biol. Chem., March 10, 2006; 281(10): 6442 - 6447. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Forrai, K. Boyle, A. H. Hart, L. Hartley, S. Rakar, T. A. Willson, K. M. Simpson, A. W. Roberts, W. S. Alexander, A. K. Voss, et al. Absence of Suppressor of Cytokine Signalling 3 Reduces Self-Renewal and Promotes Differentiation in Murine Embryonic Stem Cells Stem Cells, March 1, 2006; 24(3): 604 - 614. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Oberle, A. Schober, V. Meyer, B. Holtmann, C. Henderson, M. Sendtner, and K. Unsicker Loss of Leukemia Inhibitory Factor Receptor beta or Cardiotrophin-1 Causes Similar Deficits in Preganglionic Sympathetic Neurons and Adrenal Medulla J. Neurosci., February 8, 2006; 26(6): 1823 - 1832. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Dimitriadis, C.A. White, R.L. Jones, and L.A. Salamonsen Cytokines, chemokines and growth factors in endometrium related to implantation Hum. Reprod. Update, November 1, 2005; 11(6): 613 - 630. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J Kimber Leukaemia inhibitory factor in implantation and uterine biology Reproduction, August 1, 2005; 130(2): 131 - 145. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. D. Watson and J. C. Cross Development of Structures and Transport Functions in the Mouse Placenta Physiology, June 1, 2005; 20(3): 180 - 193. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. J. Jenkins, A. W. Roberts, M. Najdovska, D. Grail, and M. Ernst The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis Blood, May 1, 2005; 105(9): 3512 - 3520. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Kuroda, M. Tada, H. Kubota, H. Kimura, S.-y. Hatano, H. Suemori, N. Nakatsuji, and T. Tada Octamer and Sox Elements Are Required for Transcriptional cis Regulation of Nanog Gene Expression Mol. Cell. Biol., March 15, 2005; 25(6): 2475 - 2485. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Dorval-Coiffec, J.-G. Delcros, H. Hakovirta, J. Toppari, B. Jegou, and C. Piquet-Pellorce Identification of the Leukemia Inhibitory Factor Cell Targets Within the Rat Testis Biol Reprod, March 1, 2005; 72(3): 602 - 611. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. AGHAJANOVA Leukemia Inhibitory Factor and Human Embryo Implantation Ann. N.Y. Acad. Sci., December 1, 2004; 1034(1): 176 - 183. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. L Lopes, J. A Desmarais, and B. D Murphy Embryonic diapause and its regulation Reproduction, December 1, 2004; 128(6): 669 - 678. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. C. Horowitz, Y. Xi, D. L. Pflugh, D. G. T. Hesslein, D. G. Schatz, J. A. Lorenzo, and A. L. M. Bothwell Pax5-Deficient Mice Exhibit Early Onset Osteopenia with Increased Osteoclast Progenitors J. Immunol., December 1, 2004; 173(11): 6583 - 6591. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Sumi, Y. Fujimoto, N. Nakatsuji, and H. Suemori STAT3 Is Dispensable for Maintenance of Self-Renewal in Nonhuman Primate Embryonic Stem Cells Stem Cells, September 1, 2004; 22(5): 861 - 872. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. P. Eswarakumar, M. C. Horowitz, R. Locklin, G. M. Morriss-Kay, and P. Lonai A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis PNAS, August 24, 2004; 101(34): 12555 - 12560. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. R. Gonzalez, B. R. Rueda, M. P. Ramos, R. D. Littell, S. Glasser, and P. C. Leavis Leptin-Induced Increase in Leukemia Inhibitory Factor and Its Receptor by Human Endometrium Is Partially Mediated by Interleukin 1 Receptor Signaling Endocrinology, August 1, 2004; 145(8): 3850 - 3857. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. K. Humphrey, G. M. Beattie, A. D. Lopez, N. Bucay, C. C. King, M. T. Firpo, S. Rose-John, and A. Hayek Maintenance of Pluripotency in Human Embryonic Stem Cells Is STAT3 Independent Stem Cells, July 1, 2004; 22(4): 522 - 530. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Classen-Linke, G. Muller-Newen, P.C. Heinrich, H.M. Beier, and U. von Rango The cytokine receptor gp130 and its soluble form are under hormonal control in human endometrium and decidua Mol. Hum. Reprod., July 1, 2004; 10(7): 495 - 504. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. K. Dey, H. Lim, S. K. Das, J. Reese, B. C. Paria, T. Daikoku, and H. Wang Molecular Cues to Implantation Endocr. Rev., June 1, 2004; 25(3): 341 - 373. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Mackman Role of Tissue Factor in Hemostasis, Thrombosis, and Vascular Development Arterioscler. Thromb. Vasc. Biol., June 1, 2004; 24(6): 1015 - 1022. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. De Felici, M.L. Scaldaferri, M. Lobascio, S. Iona, V. Nazzicone, F.G. Klinger, and D. Farini Experimental approaches to the study of primordial germ cell lineage and proliferation Hum. Reprod. Update, May 1, 2004; 10(3): 197 - 206. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Abir, B. Fisch, S. Jin, M. Barnnet, S. Freimann, R. Van den Hurk, D. Feldberg, S. Nitke, H. Krissi, and A. Ao Immunocytochemical detection and RT-PCR expression of leukaemia inhibitory factor and its receptor in human fetal and adult ovaries Mol. Hum. Reprod., May 1, 2004; 10(5): 313 - 319. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. A. Rodriguez, D. B. Sparrow, A. N. Scott, S. L. Withington, J. I. Preis, J. Michalicek, M. Clements, T. E. Tsang, T. Shioda, R. S. P. Beddington, et al. Cited1 Is Required in Trophoblasts for Placental Development and for Embryo Growth and Survival Mol. Cell. Biol., January 1, 2004; 24(1): 228 - 244. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Fedorcsak and R. Storeng Effects of Leptin and Leukemia Inhibitory Factor on Preimplantation Development and STAT3 Signaling of Mouse Embryos In Vitro Biol Reprod, November 1, 2003; 69(5): 1531 - 1538. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Tanaka, Y. Hirabayashi, T. Sekiguchi, T. Inoue, M. Katsuki, and A. Miyajima Targeted disruption of oncostatin M receptor results in altered hematopoiesis Blood, November 1, 2003; 102(9): 3154 - 3162. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. P. Ng, W. He, and N. Y. Ip Leukemia Inhibitory Factor Receptor Signaling Negatively Modulates Nerve Growth Factor-induced Neurite Outgrowth in PC12 Cells and Sympathetic Neurons J. Biol. Chem., October 3, 2003; 278(40): 38731 - 38739. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. A. Molyneaux, K. Schaible, and C. Wylie GP130, the shared receptor for the LIF/IL6 cytokine family in the mouse, is not required for early germ cell differentiation, but is required cell-autonomously in oocytes for ovulation Development, September 15, 2003; 130(18): 4287 - 4294. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Wang, Q. Chen, J. Corne, Z. Zhu, C. G. Lee, V. Bhandari, R. J. Homer, and J. A. Elias Pulmonary Expression of Leukemia Inhibitory Factor Induces B Cell Hyperplasia and Confers Protection in Hyperoxia J. Biol. Chem., August 15, 2003; 278(33): 31226 - 31232. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Stankoff, M.-S. Aigrot, F. Noel, A. Wattilliaux, B. Zalc, and C. Lubetzki Ciliary Neurotrophic Factor (CNTF) Enhances Myelin Formation: A Novel Role for CNTF and CNTF-Related Molecules J. Neurosci., November 1, 2002; 22(21): 9221 - 9227. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Palmqvist, E. Persson, H. H. Conaway, and U. H. Lerner IL-6, Leukemia Inhibitory Factor, and Oncostatin M Stimulate Bone Resorption and Regulate the Expression of Receptor Activator of NF-{kappa}B Ligand, Osteoprotegerin, and Receptor Activator of NF-{kappa}B in Mouse Calvariae J. Immunol., September 15, 2002; 169(6): 3353 - 3362. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Ozaki and W. J. Leonard Cytokine and Cytokine Receptor Pleiotropy and Redundancy J. Biol. Chem., August 9, 2002; 277(33): 29355 - 29358. [Full Text] [PDF] |
||||
![]() |
T. Hatta, K. Moriyama, K. Nakashima, T. Taga, and H. Otani The Role of gp130 in Cerebral Cortical Development: In Vivo Functional Analysis in a Mouse Exo Utero System J. Neurosci., July 1, 2002; 22(13): 5516 - 5524. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Tsuruda, M. Jougasaki, G. Boerrigter, B. K. Huntley, H. H. Chen, A. B. D'Assoro, S. C. Lee, A. M. Larsen, A. Cataliotti, and J. C. Burnett Jr Cardiotrophin-1 Stimulation of Cardiac Fibroblast Growth: Roles for Glycoprotein 130/Leukemia Inhibitory Factor Receptor and the Endothelin Type A Receptor Circ. Res., February 8, 2002; 90(2): 128 - 134. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Rossant Stem Cells from the Mammalian Blastocyst Stem Cells, November 1, 2001; 19(6): 477 - 482. [Abstract] [Full Text] |
||||
![]() |
T. Shimazaki, T. Shingo, and S. Weiss The Ciliary Neurotrophic Factor/Leukemia Inhibitory Factor/gp130 Receptor Complex Operates in the Maintenance of Mammalian Forebrain Neural Stem Cells J. Neurosci., October 1, 2001; 21(19): 7642 - 7653. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. W. Roberts, L. Robb, S. Rakar, L. Hartley, L. Cluse, N. A. Nicola, D. Metcalf, D. J. Hilton, and W. S. Alexander Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3 PNAS, July 31, 2001; 98(16): 9324 - 9329. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Ernst, M. Inglese, P. Waring, I. K. Campbell, S. Bao, F. J. Clay, W. S. Alexander, I. P. Wicks, D. M. Tarlinton, U. Novak, et al. Defective gp130-mediated Signal Transducer and Activator of Transcription (STAT) Signaling Results in Degenerative Joint Disease, Gastrointestinal Ulceration, and Failure of Uterine Implantation J. Exp. Med., July 16, 2001; 194(2): 189 - 204. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Nichols, I. Chambers, T. Taga, and A. Smith Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines Development, June 15, 2001; 128(12): 2333 - 2339. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Mi, H. Haeberle, and B. A. Barres Induction of Astrocyte Differentiation by Endothelial Cells J. Neurosci., March 1, 2001; 21(5): 1538 - 1547. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. R. Chen, J.-G. Cheng, T. Shatzer, L. Sewell, L. Hernandez, and C. L. Stewart Leukemia Inhibitory Factor Can Substitute for Nidatory Estrogen and Is Essential to Inducing a Receptive Uterus for Implantation But Is Not Essential for Subsequent Embryogenesis Endocrinology, December 1, 2000; 141(12): 4365 - 4372. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. DUVAL, B. REINHARDT, C. KEDINGER, and H. BOEUF Role of suppressors of cytokine signaling (Socs) in leukemia inhibitory factor (LIF) -dependent embryonic stem cell survival FASEB J, August 1, 2000; 14(11): 1577 - 1584. [Abstract] [Full Text] |
||||
![]() |
B. NaitOumesmar, A. B. Copperman, and R. A. Lazzarini Placental Expression and Chromosomal Localization of the Human Gcm 1 Gene J. Histochem. Cytochem., July 1, 2000; 48(7): 915 - 922. [Abstract] [Full Text] |
||||
![]() |
C. Passavant, X. Zhao, S.K. Das, S.K. Dey, and R.A. Mead Changes in Uterine Expression of Leukemia Inhibitory Factor Receptor Gene During Pregnancy and Its Up-Regulation by Prolactin in the Western Spotted Skunk Biol Reprod, July 1, 2000; 63(1): 301 - 307. [Abstract] [Full Text] |
||||
![]() |
M. Itoh, Y. Yoshida, K. Nishida, M. Narimatsu, M. Hibi, and T. Hirano Role of Gab1 in Heart, Placenta, and Skin Development and Growth Factor- and Cytokine-Induced Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Activation Mol. Cell. Biol., May 15, 2000; 20(10): 3695 - 3704. [Abstract] [Full Text] |
||||
![]() |
A. Bader, H. Al-Dubai, and G. Weitzer Leukemia Inhibitory Factor Modulates Cardiogenesis in Embryoid Bodies in Opposite Fashions Circ. Res., April 14, 2000; 86(7): 787 - 794. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. C. Manolagas Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis Endocr. Rev., April 1, 2000; 21(2): 115 - 137. [Abstract] [Full Text] |
||||
![]() |
J. A. Bowen and J. S. Hunt The Role of Integrins in Reproduction Experimental Biology and Medicine, April 1, 2000; 223(4): 331 - 343. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. P. Haines, R. B. Voyle, and P. D. Rathjen Intracellular and Extracellular Leukemia Inhibitory Factor Proteins Have Different Cellular Activities That Are Mediated by Distinct Protein Motifs Mol. Biol. Cell, April 1, 2000; 11(4): 1369 - 1383. [Abstract] [Full Text] |
||||
![]() |
C. Piquet-Pellorce, I. Dorval-Coiffec, M.-D. Pham, and B. Jegou Leukemia Inhibitory Factor Expression and Regulation within the Testis Endocrinology, March 1, 2000; 141(3): 1136 - 1141. [Abstract] [Full Text] [PDF] |
||||