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Development, Vol 121, Issue 5 1283-1299, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
CB Ware, MC Horowitz, BR Renshaw, JS Hunt, D Liggitt, SA Koblar, BC Gliniak, HJ McKenna, T Papayannopoulou, B Thoma and al. et
Immunex, Seattle, WA 98101, USA.
The low-affinity receptor for leukemia inhibitory factor (LIFR) interacts with gp130 to induce an intracellular signal cascade. The LIFR-gp130 heterodimer is implicated in the function of diverse systems. Normal placentation is disrupted in LIFR mutant animals, which leads to poor intrauterine nutrition but allows fetuses to continue to term. Fetal bone volume is reduced greater than three-fold and the number of osteoclasts is increased six-fold, resulting in severe osteopenia of perinatal bone. Astrocyte numbers are reduced in the spinal cord and brain stem. Late gestation fetal livers contain relatively high stores of glycogen, indicating a metabolic disorder. Hematologic and primordial germ cell compartments appear normal. Pleiotropic defects in the mutant animals preclude survival beyond the day of birth.
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Z. Wang and S. Melmed Functional Map of a Placenta-specific Enhancer of the Human Leukemia Inhibitory Factor Receptor Gene J. Biol. Chem., October 2, 1998; 273(40): 26069 - 26077. [Abstract] [Full Text] [PDF]
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T. Bellido, C. A. O'Brien, P. K. Roberson, and S. C. Manolagas Transcriptional Activation of the p21WAF1,CIP1,SDI1 Gene by Interleukin-6 Type Cytokines. A PREREQUISITE FOR THEIR PRO-DIFFERENTIATING AND ANTI-APOPTOTIC EFFECTS ON HUMAN OSTEOBLASTIC CELLS J. Biol. Chem., August 14, 1998; 273(33): 21137 - 21144. [Abstract] [Full Text] [PDF]
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M. G. Hinds, T. Maurer, J.-G. Zhang, N. A. Nicola, and R. S. Norton Solution Structure of Leukemia Inhibitory Factor J. Biol. Chem., May 29, 1998; 273(22): 13738 - 13745. [Abstract] [Full Text] [PDF]
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P. Rajan and R. D. G. McKay Multiple Routes to Astrocytic Differentiation in the CNS J. Neurosci., May 15, 1998; 18(10): 3620 - 3629. [Abstract] [Full Text] [PDF]
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S. A. Koblar, A. M. Turnley, B. J. Classon, K. L. Reid, C. B. Ware, S. S. Cheema, M. Murphy, and P. F. Bartlett Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor PNAS, March 17, 1998; 95(6): 3178 - 3181. [Abstract] [Full Text] [PDF]
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M Geissen, S Heller, D Pennica, U Ernsberger, and H Rohrer The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling Development, January 12, 1998; 125(23): 4791 - 4801. [Abstract] [PDF]
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B. A. Habecker, A. J. Symes, N. Stahl, N. J. Francis, A. Economides, J. S. Fink, G. D. Yancopoulos, and S. C. Landis A Sweat Gland-derived Differentiation Activity Acts through Known Cytokine Signaling Pathways J. Biol. Chem., November 28, 1997; 272(48): 30421 - 30428. [Abstract] [Full Text] [PDF]
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K. Kawasaki, Y.-H. Gao, S. Yokose, Y. Kaji, T. Nakamura, T. Suda, K. Yoshida, T. Taga, T. Kishimoto, H. Kataoka, et al. Osteoclasts Are Present in gp130-Deficient Mice Endocrinology, November 1, 1997; 138(11): 4959 - 4965. [Abstract] [Full Text] [PDF]
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Z. Wang and S. Melmed Identification of an Upstream Enhancer within a Functional Promoter of the Human Leukemia Inhibitory Factor Receptor Gene and Its Alternative Promoter Usage J. Biol. Chem., October 31, 1997; 272(44): 27957 - 27965. [Abstract] [Full Text] [PDF]
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A. B. Vernallis, K. R. Hudson, and J. K. Heath An Antagonist for the Leukemia Inhibitory Factor Receptor Inhibits Leukemia Inhibitory Factor, Cardiotrophin-1, Ciliary Neurotrophic Factor, and Oncostatin M J. Biol. Chem., October 24, 1997; 272(43): 26947 - 26952. [Abstract] [Full Text] [PDF]
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C. M. Owczarek, Y. Zhang, M. J. Layton, D. Metcalf, B. Roberts, and N. A. Nicola The Unusual Species Cross-reactivity of the Leukemia Inhibitory Factor Receptor alpha -Chain Is Determined Primarily by the Immunoglobulin-like Domain J. Biol. Chem., September 19, 1997; 272(38): 23976 - 23985. [Abstract] [Full Text] [PDF]
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T. Bellido, V. Z. C. Borba, P. Roberson, and S. C. Manolagas Activation of the Janus Kinase/STAT (Signal Transducer and Activator of Transcription) Signal Transduction Pathway by Interleukin-6-Type Cytokines Promotes Osteoblast Differentiation Endocrinology, September 1, 1997; 138(9): 3666 - 3676. [Abstract] [Full Text] [PDF]
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I. Gloaguen, P. Costa, A. Demartis, D. Lazzaro, A. Di Marco, R. Graziani, G. Paonessa, F. Chen, C. I. Rosenblum, L. H. T. Van der Ploeg, et al. Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance PNAS, June 10, 1997; 94(12): 6456 - 6461. [Abstract] [Full Text] [PDF]
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K. Takeda, K. Noguchi, W. Shi, T. Tanaka, M. Matsumoto, N. Yoshida, T. Kishimoto, and S. Akira Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality PNAS, April 15, 1997; 94(8): 3801 - 3804. [Abstract] [Full Text] [PDF]
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M. Peters, P. Schirmacher, J. Goldschmitt, M. Odenthal, C. Peschel, E. Fattori, G. Ciliberto, H.-P. Dienes, K.-H. M. z. Buschenfelde, and S. Rose-John Extramedullary Expansion of Hematopoietic Progenitor Cells in Interleukin (IL)-6-sIL-6R Double Transgenic Mice J. Exp. Med., February 17, 1997; 185(4): 755 - 766. [Abstract] [Full Text] [PDF]
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C Neophytou, A. Vernallis, A Smith, and M. Raff Muller-cell-derived leukaemia inhibitory factor arrests rod photoreceptor differentiation at a postmitotic pre-rod stage of development Development, January 6, 1997; 124(12): 2345 - 2354. [Abstract] [PDF]
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Z. Ezzeddine, X Yang, T DeChiara, G Yancopoulos, and C. Cepko Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina Development, January 3, 1997; 124(5): 1055 - 1067. [Abstract] [PDF]
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K K Johe, T G Hazel, T Muller, M M Dugich-Djordjevic, and R D McKay Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes & Dev., December 15, 1996; 10(24): 3129 - 3140. [Abstract] [PDF]
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M. Ernst, A. Oates, and A. R. Dunn gp130-mediated Signal Transduction in Embryonic Stem Cells Involves Activation of Jak and Ras/Mitogen-activated Protein Kinase Pathways J. Biol. Chem., November 22, 1996; 271(47): 30136 - 30143. [Abstract] [Full Text] [PDF]
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B A Edgar and S A Datar Zygotic degradation of two maternal Cdc25 mRNAs terminates Drosophila's early cell cycle program. Genes & Dev., August 1, 1996; 10(15): 1966 - 1977. [Abstract] [PDF]
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K. R. Hudson, A. B. Vernallis, and J. K. Heath Characterization of the Receptor Binding Sites of Human Leukemia Inhibitory Factor and Creation of Antagonists J. Biol. Chem., May 17, 1996; 271(20): 11971 - 11978. [Abstract] [Full Text] [PDF]
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C. M. Owczarek, M. J. Layton, L. G. Robb, N. A. Nicola, and C. G. Begley Molecular Basis of the Soluble and Membrane-bound Forms of the Murine Leukemia Inhibitory Factor Receptor alpha-Chain J. Biol. Chem., March 8, 1996; 271(10): 5495 - 5504. [Abstract] [Full Text] [PDF]
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