|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 5 1361-1372, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
S Kramer, SR West and Y Hiromi
Department of Molecular Biology, Princeton University, NJ 08544-1014, USA.
Drosophila seven-up is an orphan receptor of the steroid receptor family that is required to specify photoreceptor neuron subtypes in the developing compound eye. Expression of seven-up is confined to four of the eight photoreceptor precursors, R3/R4/R1/R6. We show that misexpression of seven-up in any of the other cell types within the developing ommatidium interferes with their differentiation. Each cell type responds differently to seven-up misexpression. For example, ectopic expression in the non-neuronal cone cells using the sevenless promoter/enhancer (sev-svp) causes the cone cells to take on a neuronal identity. Ectopic expression of seven-up in R2/R5 using the rough enhancer (ro-svp) causes these neurons to lose aspects of their photoreceptor subtype identity while remaining neuronal. Each cell type appears to have a different developmental time window that is sensitive to misexpressed seven-up. The temporal order of responsiveness of each cell type to misexpressed seven-up is similar but not identical to the order of neuronal differentiation. This suggests that there are processes of specification that are distinct from the specification to become a photoreceptor neuron. We have identified members of the ras signaling pathway as suppressors of the cone cell to R7 neuron transformation caused by sev-svp. Suppression of the sev-svp phenotype can be achieved by decreasing the gene-dosage of any of the members of the ras-pathway. This suggests that the function of seven-up in the cone cells requires ras signaling. However, a decrease in ras signaling results in enhancement of the phenotype caused by the ro-svp transgene. We discuss the relationship between decisions controlled by seven-up and those controlled by ras signaling.
This article has been cited by other articles:
|
|
 |
|
  A. Faedo, G. S. Tomassy, Y. Ruan, H. Teichmann, S. Krauss, S. J. Pleasure, S. Y. Tsai, M.-J. Tsai, M. Studer, and J. L. R. Rubenstein COUP-TFI Coordinates Cortical Patterning, Neurogenesis, and Laminar Fate and Modulates MAPK/ERK, AKT, and {beta}-Catenin Signaling Cereb Cortex, December 28, 2007; (2007) bhm238v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Sprecher, F. Pichaud, and C. Desplan Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates Genes & Dev., September 1, 2007; 21(17): 2182 - 2195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Pearn, J. Fisher, A. K. Burnett, and R. L. Darley The role of PKC and PDK1 in monocyte lineage specification by Ras Blood, May 15, 2007; 109(10): 4461 - 4469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Iwanami, Y. Hiromi, and M. Okabe Cell-type specific utilization of multiple negative feedback loops generates developmental constancy Genes Cells, July 1, 2005; 10(7): 743 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Otsuki, Y. Hayashi, M. Kato, H. Yoshida, and M. Yamaguchi Characterization of dRFX2, a novel RFX family protein in Drosophila Nucleic Acids Res., October 19, 2004; 32(18): 5636 - 5648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Sullivan and C. S. Thummel Temporal Profiles of Nuclear Receptor Gene Expression Reveal Coordinate Transcriptional Responses during Drosophila Development Mol. Endocrinol., November 1, 2003; 17(11): 2125 - 2137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yuasa, M. Okabe, S. Yoshikawa, K. Tabuchi, W.-C. Xiong, Y. Hiromi, and H. Okano Drosophila homeodomain protein REPO controls glial differentiation by cooperating with ETS and BTB transcription factors Development, June 1, 2003; 130(11): 2419 - 2428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Adam, T. Sourisseau, R. Métivier, Y. Le Page, C. Desbois, D. Michel, and G. Salbert COUP-TFI (Chicken Ovalbumin Upstream Promoter-Transcription Factor I) Regulates Cell Migration and Axogenesis in Differentiating P19 Embryonal Carcinoma Cells Mol. Endocrinol., December 1, 2000; 14(12): 1918 - 1933. [Abstract] [Full Text]
|
|
|
|
|
|
C Pazman, C. Mayes, M Fanto, S. Haynes, and M Mlodzik Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and Rho-mediated signaling Development, January 4, 2000; 127(8): 1715 - 1725. [Abstract] [PDF]
|
|
|
|
|
|
S Kramer, M Okabe, N Hacohen, M. Krasnow, and Y Hiromi Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila Development, January 6, 1999; 126(11): 2515 - 2525. [Abstract] [PDF]
|
|
|
|
|
|
W. Chou, A Huber, J Bentrop, S Schulz, K Schwab, L. Chadwell, R Paulsen, and S. Britt Patterning of the R7 and R8 photoreceptor cells of Drosophila: evidence for induced and default cell-fate specification Development, January 2, 1999; 126(4): 607 - 616. [Abstract] [PDF]
|
|
|
|
|
|
B. Kerber, S. Fellert, and M. Hoch Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney Genes & Dev., June 15, 1998; 12(12): 1781 - 1786. [Abstract] [Full Text]
|
|
|
|
|
|
J. Kumar, M Tio, F Hsiung, S Akopyan, L Gabay, R Seger, B. Shilo, and K Moses Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation Development, January 10, 1998; 125(19): 3875 - 3885. [Abstract] [PDF]
|
|
|
|
 |
|
 Q. Li, I. K. Hariharan, F. Chen, Y. Huang, and J. A. Fischer Genetic interactions with Rap1 and Ras1 reveal a second function for the Fat facets deubiquitinating enzyme in Drosophila eye development PNAS, November 11, 1997; 94(23): 12515 - 12520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Y. Tsai and M.-J. Tsai Chick Ovalbumin Upstream Promoter-Transcription Factors (COUP-TFs): Coming of Age Endocr. Rev., April 1, 1997; 18(2): 229 - 240. [Abstract] [Full Text]
|
|
|
|
|
|
G Begemann, N Paricio, R Artero, I Kiss, M Perez-Alonso, and M Mlodzik muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins Development, January 11, 1997; 124(21): 4321 - 4331. [Abstract] [PDF]
|
|
|
|
|
|
T Matsuo, K Takahashi, S Kondo, K Kaibuchi, and D Yamamoto Regulation of cone cell formation by Canoe and Ras in the developing Drosophila eye Development, January 7, 1997; 124(14): 2671 - 2680. [Abstract] [PDF]
|
|
|
|
|
|
M Freeman Cell determination strategies in the Drosophila eye Development, January 1, 1997; 124(2): 261 - 270. [Abstract] [PDF]
|
|
|
|
 |
|
 S. L. Marcus, C. J. Winrow, J. P. Capone, and R. A. Rachubinski A p56lck Ligand Serves as a Coactivator of an Orphan Nuclear Hormone Receptor J. Biol. Chem., November 1, 1996; 271(44): 27197 - 27200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Daga, C A Karlovich, K Dumstrei, and U Banerjee Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1. Genes & Dev., May 15, 1996; 10(10): 1194 - 1205. [Abstract] [PDF]
|
|
|
|
|
|
Y Huang and J. Fischer-Vize Undifferentiated cells in the developing Drosophila eye influence facet assembly and require the Fat facets ubiquitin-specific protease Development, January 10, 1996; 122(10): 3207 - 3216. [Abstract] [PDF]
|
|
