spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Grindley, J. C.
Right arrow Articles by Hill, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grindley, J. C.
Right arrow Articles by Hill, R. E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 121, Issue 5 1433-1442, Copyright © 1995 by Company of Biologists

JOURNAL ARTICLES

The role of Pax-6 in eye and nasal development

JC Grindley, DR Davidson and RE Hill
Developmental Genetics Section, Western General Hospital, Edinburgh, UK.

Small eye (Sey) mice homozygous for mutations in the Pax-6 gene have no lenses and no nasal cavities. We have examined the ontogeny of eye and nasal defects in Sey/Sey embryos and have related the defects seen to the pattern of Pax-6 mRNA expression in the mouse during normal eye and nasal development. There are two principal components of the early eye, the neural ectoderm of the optic vesicle, which forms the retina, and the overlying surface ectoderm, which forms the lens and cornea. By studying these interacting tissues in normal and Sey/Sey embryos, we have identified processes for which Pax-6 is important and can thus suggest possible roles for the Pax-6 gene. Pax-6 is essential for the formation of lens placodes from surface ectoderm. In normal development, early Pax-6 mRNA expression in a broad domain of surface ectoderm is downregulated, but expression is specifically maintained in the developing lens placode. Moreover, other Pax-6-expressing tissues are frequently those that have can transdifferentiate into lens. Thus, phenotype and expression together suggest a role for Pax-6 in lens determination. At least some functions of Pax-6 can be separated from the influence of other tissues. Early Sey/Sey optic vesicles are abnormally broad and fail to constrict proximally. These defects occur prior to the time of lens placode formation and probably reflect a requirement for Pax-6 in neural ectoderm. In surface ectoderm domains, where Pax-6 expression is known to be independent of the presence of an optic vesicle, Pax-6 function is required for the maintenance of its own transcription. The mutual dependency of lens and optic vesicle development can also be studied using the Small eye mutation. Using region-specific markers we find that, in the morphologically abnormal Sey/Sey optic vesicles, aspects of normal proximo-distal specification nevertheless persist, despite the complete absence of lens. Like the lens, the nasal cavities develop from ectodermal placodes that normally express Pax-6 mRNA, fail to form in Sey/Sey mice and show Pax-6-dependent Pax-6 mRNA regulation. Analysis of patterns of programmed cell death and absence of nasal region expression from an Msx-1 transgene in Sey/Sey embryos suggest a requirement for Pax-6 in the transition from presumptive nasal ectoderm to placode, and that Msx-1, or genes regulating it, are possible targets for Pax-6.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
S. Yun, Y. Saijoh, K. E. Hirokawa, D. Kopinke, L. C. Murtaugh, E. S. Monuki, and E. M. Levine
Lhx2 links the intrinsic and extrinsic factors that control optic cup formation
Development, December 1, 2009; 136(23): 3895 - 3906.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. K. Chauhan, A. Disanza, S.-Y. Choi, S. C. Faber, M. Lou, H. E. Beggs, G. Scita, Y. Zheng, and R. A. Lang
Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination
Development, November 1, 2009; 136(21): 3657 - 3667.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
P. Vopalensky and Z. Kozmik
Eye evolution: common use and independent recruitment of genetic components
Phil Trans R Soc B, October 12, 2009; 364(1531): 2819 - 2832.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. A. Chanas, J. M. Collinson, T. Ramaesh, N. Dora, D. A. Kleinjan, R. E. Hill, and J. D. West
Effects of Elevated Pax6 Expression and Genetic Background on Mouse Eye Development
Invest. Ophthalmol. Vis. Sci., September 1, 2009; 50(9): 4045 - 4059.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. N. Smith, L.-A. Miller, G. Radice, R. Ashery-Padan, and R. A. Lang
Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis
Development, September 1, 2009; 136(17): 2977 - 2985.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
O. Shaham, A. N. Smith, M. L. Robinson, M. M. Taketo, R. A. Lang, and R. Ashery-Padan
Pax6 is essential for lens fiber cell differentiation
Development, August 1, 2009; 136(15): 2567 - 2578.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
K. S Alatzoglou, D. Kelberman, and M. T Dattani
The role of SOX proteins in normal pituitary development
J. Endocrinol., March 1, 2009; 200(3): 245 - 258.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
L. J. Leiper, J. Ou, P. Walczysko, R. Kucerova, D. N. Lavery, J. D. West, and J. M. Collinson
Control of Patterns of Corneal Innervation by Pax6
Invest. Ophthalmol. Vis. Sci., March 1, 2009; 50(3): 1122 - 1128.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Bhattacharyya and M. Bronner-Fraser
Competence, specification and commitment to an olfactory placode fate
Development, December 15, 2008; 135(24): 4165 - 4177.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
V. Oron-Karni, C. Farhy, M. Elgart, T. Marquardt, L. Remizova, O. Yaron, Q. Xie, A. Cvekl, and R. Ashery-Padan
Dual requirement for Pax6 in retinal progenitor cells
Development, December 15, 2008; 135(24): 4037 - 4047.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Chen, Y.-q. Doughman, S. Gu, A. Jarrell, S.-i. Aota, A. Cvekl, M. Watanabe, S. L. Dunwoodie, R. S. Johnson, V. van Heyningen, et al.
Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis
Development, September 1, 2008; 135(17): 2939 - 2948.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Favor, C. J. Gloeckner, A. Neuhauser-Klaus, W. Pretsch, R. Sandulache, S. Saule, and I. Zaus
Relationship of Pax6 Activity Levels to the Extent of Eye Development in the Mouse, Mus musculus
Genetics, July 1, 2008; 179(3): 1345 - 1355.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
P. P. Gopal and J. A. Golden
Pax6-/- Mice Have a Cell Nonautonomous Defect in Nonradial Interneuron Migration
Cereb Cortex, April 1, 2008; 18(4): 752 - 762.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
P. Heine, E. Dohle, K. Bumsted-O'Brien, D. Engelkamp, and D. Schulte
Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development
Development, March 1, 2008; 135(5): 805 - 811.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. Li, D. Goldowitz, and D. J. Swanson
The Requirement of Pax6 for Postnatal Eye Development: Evidence from Experimental Mouse Chimeras
Invest. Ophthalmol. Vis. Sci., July 1, 2007; 48(7): 3292 - 3300.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Song, K. R. Schwab, L. T. Patterson, T. Yamaguchi, X. Lin, S. S. Potter, and R. A. Lang
pygopus 2 has a crucial, Wnt pathway-independent function in lens induction
Development, May 15, 2007; 134(10): 1873 - 1885.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Q. Yan, W.-B. Liu, J. Qin, J. Liu, H.-G. Chen, X. Huang, L. Chen, S. Sun, M. Deng, L. Gong, et al.
Protein Phosphatase-1 Modulates the Function of Pax-6, a Transcription Factor Controlling Brain and Eye Development
J. Biol. Chem., May 11, 2007; 282(19): 13954 - 13965.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Berger, S. Berger, T. C. Tuoc, M. D'Amelio, F. Cecconi, J. A. Gorski, K. R. Jones, P. Gruss, and A. Stoykova
Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosis
Development, April 1, 2007; 134(7): 1311 - 1322.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
T. Grocott, V. Frost, M. Maillard, T. Johansen, G. N. Wheeler, L. J. Dawes, I. M. Wormstone, and A. Chantry
The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter
Nucleic Acids Res., February 16, 2007; 35(3): 890 - 901.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Manuel, P. A. Georgala, C. B. Carr, S. Chanas, D. A. Kleinjan, B. Martynoga, J. O. Mason, M. Molinek, J. Pinson, T. Pratt, et al.
Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization
Development, February 1, 2007; 134(3): 545 - 555.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
E. Prabagaran, A.H. Bandivdekar, V. Dighe, and V.P. Raghavan
HOXBES2: A Novel Epididymal HOXB2 Homeoprotein and Its Domain-Specific Association with Spermatozoa
Biol Reprod, February 1, 2007; 76(2): 314 - 326.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
E. Diamond, M. Amen, Q. Hu, H. M. Espinoza, and B. A. Amendt
Functional interactions between Dlx2 and lymphoid enhancer factor regulate Msx2
Nucleic Acids Res., November 6, 2006; 34(20): 5951 - 5965.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
S. Kanakubo, T. Nomura, K.-i. Yamamura, J.-i. Miyazaki, M. Tamai, and N. Osumi
Abnormal migration and distribution of neural crest cells in Pax6 heterozygous mutant eye, a model for human eye diseases.
Genes Cells, August 1, 2006; 11(8): 919 - 933.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
T. Ramaesh, K. Ramaesh, R. Leask, A. Springbett, S. C. Riley, B. Dhillon, and J. D. West
Increased Apoptosis and Abnormal Wound-Healing Responses in the Heterozygous Pax6+/- Mouse Cornea
Invest. Ophthalmol. Vis. Sci., May 1, 2006; 47(5): 1911 - 1917.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. Martin and A. K. Groves
Competence of cranial ectoderm to respond to Fgf signaling suggests a two-step model of otic placode induction
Development, March 1, 2006; 133(5): 877 - 887.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Takaki, M. Fujimoto, K. Sugahara, T. Nakahari, S. Yonemura, Y. Tanaka, N. Hayashida, S. Inouye, T. Takemoto, H. Yamashita, et al.
Maintenance of Olfactory Neurogenesis Requires HSF1, a Major Heat Shock Transcription Factor in Mice
J. Biol. Chem., February 24, 2006; 281(8): 4931 - 4937.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J. Graw, J. Loster, O. Puk, D. Munster, N. Haubst, D. Soewarto, H. Fuchs, B. Meyer, P. Nurnberg, W. Pretsch, et al.
Three Novel Pax6 Alleles in the Mouse Leading to the Same Small-Eye Phenotype Caused by Different Consequences at Target Promoters
Invest. Ophthalmol. Vis. Sci., December 1, 2005; 46(12): 4671 - 4683.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Kawauchi, J. Shou, R. Santos, J. M. Hebert, S. K. McConnell, I. Mason, and A. L. Calof
Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse
Development, December 1, 2005; 132(23): 5211 - 5223.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
A. L. Evans and P. J. Gage
Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development
Hum. Mol. Genet., November 15, 2005; 14(22): 3347 - 3359.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
N. Davis-Silberman, T. Kalich, V. Oron-Karni, T. Marquardt, M. Kroeber, E. R. Tamm, and R. Ashery-Padan
Genetic dissection of Pax6 dosage requirements in the developing mouse eye
Hum. Mol. Genet., August 1, 2005; 14(15): 2265 - 2276.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Kimura, Y. Suda, D. Kurokawa, Z. M. Hossain, M. Nakamura, M. Takahashi, A. Hara, and S. Aizawa
Emx2 and Pax6 Function in Cooperation with Otx2 and Otx1 to Develop Caudal Forebrain Primordium That Includes Future Archipallium
J. Neurosci., May 25, 2005; 25(21): 5097 - 5108.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Gotoh, M. Ito, S. Yamamoto, I. Yoshino, N. Song, Y. Wang, I. Lax, J. Schlessinger, M. Shibuya, and R. A. Lang
Tyrosine phosphorylation sites on FRS2{alpha} responsible for Shp2 recruitment are critical for induction of lens and retina
PNAS, December 7, 2004; 101(49): 17144 - 17149.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. Nakamura, F. Chiambaretta, J. Sugar, V. Sapin, and B. Y. J. T. Yue
Developmentally Regulated Expression of KLF6 in the Mouse Cornea and Lens
Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4327 - 4332.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Leconte, L. Lecoin, P. Martin, and S. Saule
Pax6 Interacts with cVax and Tbx5 to Establish the Dorsoventral Boundary of the Developing Eye
J. Biol. Chem., November 5, 2004; 279(45): 47272 - 47277.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. K. Duncan, L. Xie, L. L. David, M. L. Robinson, J. R. Taube, W. Cui, and L. W. Reneker
Ectopic Pax6 Expression Disturbs Lens Fiber Cell Differentiation
Invest. Ophthalmol. Vis. Sci., October 1, 2004; 45(10): 3589 - 3598.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. E. Treisman
How to make an eye
Development, August 15, 2004; 131(16): 3823 - 3827.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
F. J. Lovicu, P. Steven, S. Saika, and J. W. McAvoy
Aberrant Lens Fiber Differentiation in Anterior Subcapsular Cataract Formation: A Process Dependent on Reduced Levels of Pax6
Invest. Ophthalmol. Vis. Sci., June 1, 2004; 45(6): 1946 - 1953.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Hirose, Z. M. Varga, H. Kondoh, and M. Furutani-Seiki
Single cell lineage and regionalization of cell populations during Medaka neurulation
Development, June 1, 2004; 131(11): 2553 - 2563.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J. M. Collinson, S. A. Chanas, R. E. Hill, and J. D. West
Corneal Development, Limbal Stem Cell Function, and Corneal Epithelial Cell Migration in the Pax6+/- Mouse
Invest. Ophthalmol. Vis. Sci., April 1, 2004; 45(4): 1101 - 1108.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Cui, S. I. Tomarev, J. Piatigorsky, A. B. Chepelinsky, and M. K. Duncan
Mafs, Prox1, and Pax6 Can Regulate Chicken {beta}B1-Crystallin Gene Expression
J. Biol. Chem., March 19, 2004; 279(12): 11088 - 11095.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Nomura and N. Osumi
Misrouting of mitral cell progenitors in the Pax6/small eyerat telencephalon
Development, February 15, 2004; 131(4): 787 - 796.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. E. Zuber, G. Gestri, A. S. Viczian, G. Barsacchi, and W. A. Harris
Specification of the vertebrate eye by a network of eye field transcription factors
Development, November 1, 2003; 130(21): 5155 - 5167.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. G. Corbin, M. Rutlin, N. Gaiano, and G. Fishell
Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning
Development, October 15, 2003; 130(20): 4895 - 4906.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Baumer, T. Marquardt, A. Stoykova, D. Spieler, D. Treichel, R. Ashery-Padan, and P. Gruss
Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6
Development, July 1, 2003; 130(13): 2903 - 2915.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. D. Dakubo, Y. P. Wang, C. Mazerolle, K. Campsall, A. P. McMahon, and V. A. Wallace
Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development
Development, July 1, 2003; 130(13): 2967 - 2980.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
D. A. Tyas, H. Pearson, P. Rashbass, and D. J. Price
Pax6 Regulates Cell Adhesion during Cortical Development
Cereb Cortex, June 1, 2003; 13(6): 612 - 619.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. Davis, M. K. Duncan, W. G. Robison Jr, and J. Piatigorsky
Requirement for Pax6 in corneal morphogenesis: a role in adhesion
J. Cell Sci., June 1, 2003; 116(11): 2157 - 2167.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
T. Ramaesh, J. M. Collinson, K. Ramaesh, M. H. Kaufman, J. D. West, and B. Dhillon
Corneal Abnormalities in Pax6+/- Small Eye Mice Mimic Human Aniridia-Related Keratopathy
Invest. Ophthalmol. Vis. Sci., May 1, 2003; 44(5): 1871 - 1878.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. Yamada, Y. Mizutani-Koseki, T. Hasegawa, N. Osumi, H. Koseki, and N. Takahashi
Cell-autonomous involvement of Mab21l1 is essential for lens placode development
Development, May 1, 2003; 130(9): 1759 - 1770.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Estivill-Torrus, H. Pearson, V. van Heyningen, D. J. Price, and P. Rashbass
Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors
Development, March 3, 2003; 129(2): 455 - 466.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Benassayag, S. Plaza, P. Callaerts, J. Clements, Y. Romeo, W. J. Gehring, and D. L. Cribbs
Evidence for a direct functional antagonism of the selector genes proboscipedia and eyeless in Drosophila head development
Development, February 1, 2003; 130(3): 575 - 586.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
B. K. Chauhan, W. Zhang, K. Cveklova, M. Kantorow, and A. Cvekl
Identification of Differentially Expressed Genes in Mouse Pax6 Heterozygous Lenses
Invest. Ophthalmol. Vis. Sci., June 1, 2002; 43(6): 1884 - 1890.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Singh, R. Mishra, N. A. Arango, J. M. Deng, R. R. Behringer, and G. F. Saunders
Iris hypoplasia in mice that lack the alternatively spliced Pax6(5a) isoform
PNAS, May 14, 2002; 99(10): 6812 - 6815.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. Ormestad, A. Blixt, A. Churchill, T. Martinsson, S. Enerback, and P. Carlsson
Foxe3 Haploinsufficiency in Mice: A Model for Peters' Anomaly
Invest. Ophthalmol. Vis. Sci., May 1, 2002; 43(5): 1350 - 1357.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. W. Clark, B. E. Fee, and J. L. Cleveland
Misexpression of the Eyes Absent Family Triggers the Apoptotic Program
J. Biol. Chem., January 25, 2002; 277(5): 3560 - 3567.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Baumer, T. Marquardt, A. Stoykova, R. Ashery-Padan, K. Chowdhury, and P. Gruss
Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle
Development, January 10, 2002; 129(19): 4535 - 4545.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Arendt, K. Tessmar, M.-I. M. de Campos-Baptista, A. Dorresteijn, and J. Wittbrodt
Development of pigment-cup eyes in the polychaete Platynereis dumerilii and evolutionary conservation of larval eyes in Bilateria
Development, January 3, 2002; 129(5): 1143 - 1154.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Punzo, M. Seimiya, S. Flister, W. J. Gehring, and S. Plaza
Differential interactions of eyeless and twin of eyeless with the sine oculis enhancer
Development, January 2, 2002; 129(3): 625 - 634.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
R. V. Jamieson, R. Perveen, B. Kerr, M. Carette, J. Yardley, E. Heon, M. G. Wirth, V. van Heyningen, D. Donnai, F. Munier, et al.
Domain disruption and mutation of the bZIP transcription factor, MAF,associated with cataract, ocular anterior segment dysgenesis and coloboma
Hum. Mol. Genet., January 1, 2002; 11(1): 33 - 42.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Zhao, F.-C. Hung, J. S. Colvin, A. White, W. Dai, F. J. Lovicu, D. M. Ornitz, and P. A. Overbeek
Patterning the optic neuroepithelium by FGF signaling and Ras activation
Development, December 15, 2001; 128(24): 5051 - 5060.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Favor, H. Peters, T. Hermann, W. Schmahl, B. Chatterjee, A. Neuhauser-Klaus, and R. Sandulache
Molecular Characterization of Pax62Neu Through Pax610Neu: An Extension of the Pax6 Allelic Series and the Identification of Two Possible Hypomorph Alleles in the Mouse Mus musculus
Genetics, December 1, 2001; 159(4): 1689 - 1700.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
P. V. Dimanlig, S. C. Faber, W. Auerbach, H. P. Makarenkova, and R. A. Lang
The upstream ectoderm enhancer in Pax6 has an important role in lens induction
Development, November 15, 2001; 128(22): 4415 - 4424.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. C. Faber, P. Dimanlig, H. P. Makarenkova, S. Shirke, K. Ko, and R. A. Lang
Fgf receptor signaling plays a role in lens induction
Development, November 15, 2001; 128(22): 4425 - 4438.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Bernier, W. Vukovich, L. Neidhardt, B. G. Herrmann, and P. Gruss
Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium
Development, October 15, 2001; 128(20): 3987 - 3994.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
D. Smith, E. Wagner, O. Koul, P. McCaffery, and U. C. Drager
Retinoic Acid Synthesis for the Developing Telencephalon
Cereb Cortex, October 1, 2001; 11(10): 894 - 905.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Murakami, M. Ogasawara, F. Sugahara, S. Hirano, N. Satoh, and S. Kuratani
Identification and expression of the lamprey Pax6 gene: evolutionary origin of the segmented brain of vertebrates
Development, September 15, 2001; 128(18): 3521 - 3531.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. M. Collinson, J. C. Quinn, M. A. Buchanan, M. H. Kaufman, S. E. Wedden, J. D. West, and R. E. Hill
Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye
PNAS, July 24, 2001; (2001) 161144098.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
C. Punzo, S. Kurata, and W. J. Gehring
The eyeless homeodomain is dispensable for eye development in Drosophila
Genes & Dev., July 1, 2001; 15(13): 1716 - 1723.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
Y. Kamachi, M. Uchikawa, A. Tanouchi, R. Sekido, and H. Kondoh
Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development
Genes & Dev., May 15, 2001; 15(10): 1272 - 1286.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
R. J. Davis, W. Shen, Y. I. Sandler, M. Amoui, P. Purcell, R. Maas, C.-N. Ou, H. Vogel, A. L. Beaudet, and G. Mardon
Dach1 Mutant Mice Bear No Gross Abnormalities in Eye, Limb, and Brain Development and Exhibit Postnatal Lethality
Mol. Cell. Biol., March 1, 2001; 21(5): 1484 - 1490.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
R. Ashery-Padan, T. Marquardt, X. Zhou, and P. Gruss
Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
Genes & Dev., November 1, 2000; 14(21): 2701 - 2711.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
V. Vendrell, E. Carnicero, F. Giraldez, M. T. Alonso, and T. Schimmang
Induction of inner ear fate by FGF3
Development, May 15, 2000; 127(10): 2011 - 2019.
[Abstract] [PDF]

Home page
 IOVSHome page
M. K. Duncan, A. Cvekl, X. Li, and J. Piatigorsky
Truncated Forms of Pax-6 Disrupt Lens Morphology in Transgenic Mice
Invest. Ophthalmol. Vis. Sci., February 1, 2000; 41(2): 464 - 473.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
C. van Raamsdonk and S. Tilghman
Dosage requirement and allelic expression of PAX6 during lens placode formation
Development, January 12, 2000; 127(24): 5439 - 5448.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M Schwarz, F Cecconi, G Bernier, N Andrejewski, B Kammandel, M Wagner, and P Gruss
Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6
Development, January 10, 2000; 127(20): 4325 - 4334.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
M. Duncan, Z Kozmik, K Cveklova, J Piatigorsky, and A Cvekl
Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression
J. Cell Sci., January 9, 2000; 113(18): 3173 - 3185.
[Abstract] [PDF]

Home page
 DevelopmentHome page
H. Makarenkova, M Ito, V Govindarajan, S. Faber, L Sun, G McMahon, P. Overbeek, and R. Lang
FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development
Development, January 6, 2000; 127(12): 2563 - 2572.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J. Collinson, R. Hill, and J. West
Different roles for Pax6 in the optic vesicle and facial epithelium mediate early morphogenesis of the murine eye
Development, January 3, 2000; 127(5): 945 - 956.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
M. Hallonet, T. Hollemann, T. Pieler, and P. Gruss
Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system
Genes & Dev., December 1, 1999; 13(23): 3106 - 3114.
[Abstract] [Full Text]

Home page
 Cereb CortexHome page
N. Warren, D. Caric, T. Pratt, J. A. Clausen, P. Asavaritikrai, J. O. Mason, R. E. Hill, and D. J. Price
The Transcription Factor, Pax6, is Required for Cell Proliferation and Differentiation in the Developing Cerebral Cortex
Cereb Cortex, September 1, 1999; 9(6): 627 - 635.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
H. E. Xu, M. A. Rould, W. Xu, J. A. Epstein, R. L. Maas, and C. O. Pabo
Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding
Genes & Dev., May 15, 1999; 13(10): 1263 - 1275.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
K. Kenyon, S. Moody, and M Jamrich
A novel fork head gene mediates early steps during Xenopus lens formation
Development, January 11, 1999; 126(22): 5107 - 5116.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D Engelkamp, P Rashbass, A Seawright, and V van Heyningen
Role of Pax6 in development of the cerebellar system
Development, January 8, 1999; 126(16): 3585 - 3596.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A. Borycki, J Li, F Jin, C. Emerson, and J. Epstein
Pax3 functions in cell survival and in pax7 regulation
Development, January 4, 1999; 126(8): 1665 - 1674.
[Abstract] [PDF]

Home page
 DevelopmentHome page
P. Xu, X Zhang, S Heaney, A Yoon, A. Michelson, and R. Maas
Regulation of Pax6 expression is conserved between mice and flies
Development, January 1, 1999; 126(2): 383 - 395.
[Abstract] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. K. Duncan, J. I. Haynes II, A. Cvekl, and J. Piatigorsky
Dual Roles for Pax-6: a Transcriptional Repressor of Lens Fiber Cell-Specific beta -Crystallin Genes
Mol. Cell. Biol., September 1, 1998; 18(9): 5579 - 5586.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Ma, D. Papermaster, and C. L. Cepko
A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice
PNAS, August 18, 1998; 95(17): 9938 - 9943.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. A. McMahon, S. Takada, L. B. Zimmerman, C.-M. Fan, R. M. Harland, and A. P. McMahon
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
Genes & Dev., May 15, 1998; 12(10): 1438 - 1452.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
N. Brown, S Kanekar, M. Vetter, P. Tucker, D. Gemza, and T Glaser
Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis
Development, January 12, 1998; 125(23): 4821 - 4833.
[Abstract] [PDF]

Home page
 DevelopmentHome page
T Hollemann, E Bellefroid, and T Pieler
The Xenopus homologue of the Drosophila gene tailless has a function in early eye development
Development, January 7, 1998; 125(13): 2425 - 2432.
[Abstract] [PDF]

Home page
 DevelopmentHome page
Y Kamachi, M Uchikawa, J Collignon, R Lovell-Badge, and H Kondoh
Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction
Development, January 7, 1998; 125(13): 2521 - 2532.
[Abstract] [PDF]

Home page
 DevelopmentHome page
S Glardon, L. Holland, W. Gehring, and N. Holland
Isolation and developmental expression of the amphioxus Pax-6 gene (AmphiPax-6): insights into eye and photoreceptor evolution
Development, January 7, 1998; 125(14): 2701 - 2710.
[Abstract] [PDF]

Home page
 DevelopmentHome page
G Halder, P Callaerts, S Flister, U Walldorf, U Kloter, and W. Gehring
Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development
Development, January 6, 1998; 125(12): 2181 - 2191.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J Hyer, T Mima, and T Mikawa
FGF1 patterns the optic vesicle by directing the placement of the neural retina domain
Development, January 3, 1998; 125(5): 869 - 877.
[Abstract] [PDF]

Home page
 CROBMHome page
K.M. Weiss, D.W. Stock, and Z. Zhao
Dynamic Interactions and the Evolutionary Genetics of Dental Patterning
Critical Reviews in Oral Biology & Medicine, January 1, 1998; 9(4): 369 - 398.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. S. Wang, R. Y. L. Tsai, and R. R. Reed
The Characterization of the Olf-1/EBF-Like HLH Transcription Factor Family: Implications in Olfactory Gene Regulation and Neuronal Development
J. Neurosci., June 1, 1997; 17(11): 4149 - 4158.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Bovolenta, A. Mallamaci, P. Briata, G. Corte, and E. Boncinelli
Implication of OTX2 in Pigment Epithelium Determination and Neural Retina Differentiation
J. Neurosci., June 1, 1997; 17(11): 4243 - 4252.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1995