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Development, Vol 121, Issue 5 1533-1545, Copyright © 1995 by Company of Biologists

JOURNAL ARTICLES

Notch1 is required for the coordinate segmentation of somites

RA Conlon, AG Reaume and J Rossant
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

Members of the Notch family of transmembrane receptors mediate a number of developmental decisions in invertebrates. In order to study Notch function in a vertebrate organism, we have mutated the Notch1 gene of the mouse. Notch1 gene function is required for embryonic survival in the second half of gestation. In the first half of gestation, we have found no effect of the mutation on the normal programs of neurogenesis, myogenesis or apoptosis. We conclude that Notch1 function is not essential for these processes, at least in early postimplantation development. However, we have found that somitogenesis is delayed and disorganized in Notch1 mutant embryos. We propose that Notch1 normally coordinates the process of somitogenesis, and we provide a model of how this might occur.
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 Proc. Natl. Acad. Sci. USAHome page
S. Shi and P. Stanley
Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways
PNAS, April 29, 2003; 100(9): 5234 - 5239.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
D. Small, D. Kovalenko, R. Soldi, A. Mandinova, V. Kolev, R. Trifonova, C. Bagala, D. Kacer, C. Battelli, L. Liaw, et al.
Notch Activation Suppresses Fibroblast Growth Factor-dependent Cellular Transformation
J. Biol. Chem., April 25, 2003; 278(18): 16405 - 16413.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
T. Li, G. Ma, H. Cai, D. L. Price, and P. C. Wong
Nicastrin Is Required for Assembly of Presenilin/gamma -Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of beta -Amyloid Precursor Protein in Mammals
J. Neurosci., April 15, 2003; 23(8): 3272 - 3277.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
K. Serth, K. Schuster-Gossler, R. Cordes, and A. Gossler
Transcriptional oscillation of Lunatic fringe is essential for somitogenesis
Genes & Dev., April 1, 2003; 17(7): 912 - 925.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
T. Schroeder, S. T. Fraser, M. Ogawa, S. Nishikawa, C. Oka, G. W. Bornkamm, S.-I. Nishikawa, T. Honjo, and U. Just
Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesis
PNAS, April 1, 2003; 100(7): 4018 - 4023.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
N. S. Hamblet, N. Lijam, P. Ruiz-Lozano, J. Wang, Y. Yang, Z. Luo, L. Mei, K. R. Chien, D. J. Sussman, and A. Wynshaw-Boris
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure
Development, March 14, 2003; 129(24): 5827 - 5838.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
S. Hans and J. A. Campos-Ortega
On the organisation of the regulatory region of the zebrafish deltaD gene
Development, March 12, 2003; 129(20): 4773 - 4784.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
A. C. Oates and R. K. Ho
Hairy/E(spl)-related (Her) genes are central components of the segmentation oscillator and display redundancy with the Delta/Notch signaling pathway in the formation of anterior segmental boundaries in the zebrafish
Development, March 8, 2003; 129(12): 2929 - 2946.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
S. Lutolf, F. Radtke, M. Aguet, U. Suter, and V. Taylor
Notch1 is required for neuronal and glial differentiation in the cerebellum
Development, March 3, 2003; 129(2): 373 - 385.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
H. Karlstrom, P. Beatus, K. Dannaeus, G. Chapman, U. Lendahl, and J. Lundkvist
A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling
PNAS, December 24, 2002; 99(26): 17119 - 17124.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
S.-E. Lin, T. Oyama, T. Nagase, K. Harigaya, and M. Kitagawa
Identification of New Human Mastermind Proteins Defines a Family That Consists of Positive Regulators for Notch Signaling
J. Biol. Chem., December 20, 2002; 277(52): 50612 - 50620.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
A. H. Campos, W. Wang, M. J. Pollman, and G. H. Gibbons
Determinants of Notch-3 Receptor Expression and Signaling in Vascular Smooth Muscle Cells: Implications in Cell-Cycle Regulation
Circ. Res., November 29, 2002; 91(11): 999 - 1006.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
R. Rozmahel, H. T. J. Mount, F. Chen, V. Nguyen, J. Huang, S. Erdebil, J. Liauw, G. Yu, H. Hasegawa, Y. Gu, et al.
Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype
PNAS, October 29, 2002; 99(22): 14452 - 14457.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
L. A. Hanna, R. K. Foreman, I. A. Tarasenko, D. S. Kessler, and P. A. Labosky
Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo
Genes & Dev., October 15, 2002; 16(20): 2650 - 2661.
[Abstract] [Full Text] [PDF]

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 JCBHome page
S. Genoud, C. Lappe-Siefke, S. Goebbels, F. Radtke, M. Aguet, S. S. Scherer, U. Suter, K.-A. Nave, and N. Mantei
Notch1 control of oligodendrocyte differentiation in the spinal cord
J. Cell Biol., August 19, 2002; 158(4): 709 - 718.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
Y. Sato, K. Yasuda, and Y. Takahashi
Morphological boundary forms by a novel inductive event mediated by Lunatic fringe and Notch during somitic segmentation
Development, August 1, 2002; 129(15): 3633 - 3644.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
C. A. Henry, M. K. Urban, K. K. Dill, J. P. Merlie, M. F. Page, C. B. Kimmel, and S. L. Amacher
Two linked hairy/Enhancer of split-related zebrafish genes, her1 and her7, function together to refine alternating somite boundaries
Development, August 1, 2002; 129(15): 3693 - 3704.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
W. Wang, A. H. Campos, C. Z. Prince, Y. Mou, and M. J. Pollman
Coordinate Notch3-Hairy-related Transcription Factor Pathway Regulation in Response to Arterial Injury. MEDIATOR ROLE OF PLATELET-DERIVED GROWTH FACTOR AND ERK
J. Biol. Chem., June 21, 2002; 277(26): 23165 - 23171.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
W. Wang, C. Z. Prince, Y. Mou, and M. J. Pollman
Notch3 Signaling in Vascular Smooth Muscle Cells Induces c-FLIP Expression via ERK/MAPK Activation. RESISTANCE TO Fas LIGAND-INDUCED APOPTOSIS
J. Biol. Chem., June 7, 2002; 277(24): 21723 - 21729.
[Abstract] [Full Text] [PDF]

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 Int ImmunolHome page
H. Han, K. Tanigaki, N. Yamamoto, K. Kuroda, M. Yoshimoto, T. Nakahata, K. Ikuta, and T. Honjo
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
Int. Immunol., June 1, 2002; 14(6): 637 - 645.
[Abstract] [Full Text] [PDF]

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 Hum Mol GenetHome page
J. Bose, L. Grotewold, and U. Ruther
Pallister-Hall syndrome phenotype in mice mutant for Gli3
Hum. Mol. Genet., May 1, 2002; 11(9): 1129 - 1135.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
S. Hitoshi, T. Alexson, V. Tropepe, D. Donoviel, A. J. Elia, J. S. Nye, R. A. Conlon, T. W. Mak, A. Bernstein, and D. van der Kooy
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells
Genes & Dev., April 1, 2002; 16(7): 846 - 858.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
B. E. Berechid, M. Kitzmann, D. R. Foltz, A. H. Roach, D. Seiffert, L. A. Thompson, R. E. Olson, A. Bernstein, D. B. Donoviel, and J. S. Nye
Identification and Characterization of Presenilin-independent Notch Signaling
J. Biol. Chem., March 1, 2002; 277(10): 8154 - 8165.
[Abstract] [Full Text] [PDF]

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 J. Neurol. Neurosurg. PsychiatryHome page
S Lovestone and D M McLoughlin
Protein aggregates and dementia: is there a common toxicity?
J. Neurol. Neurosurg. Psychiatry, February 1, 2002; 72(2): 152 - 161.
[Abstract] [Full Text] [PDF]

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 Mol Hum ReprodHome page
J.L. Stanton and D.P.L. Green
A set of 1542 mouse blastocyst and pre-blastocyst genes with well-matched human homologues
Mol. Hum. Reprod., February 1, 2002; 8(2): 149 - 166.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
R. M. Anderson, A. R. Lawrence, R. W. Stottmann, D. Bachiller, and J. Klingensmith
Chordin and noggin promote organizing centers of forebrain development in the mouse
Development, January 11, 2002; 129(21): 4975 - 4987.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
S. L. Dunwoodie, M. Clements, D. B. Sparrow, X. Sa, R. A. Conlon, and R. S. P. Beddington
Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm
Development, January 4, 2002; 129(7): 1795 - 1806.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
S. A. Holley, D. Julich, G.-J. Rauch, R. Geisler, and C. Nusslein-Volhard
her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis
Development, January 3, 2002; 129(5): 1175 - 1183.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
O. Voiculescu, E. Taillebourg, C. Pujades, C. Kress, S. Buart, P. Charnay, and S. Schneider-Maunoury
Hindbrain patterning: Krox20 couples segmentation and specification of regional identity
Development, December 15, 2001; 128(24): 4967 - 4978.
[Abstract] [Full Text] [PDF]


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