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Development, Vol 121, Issue 5 1533-1545, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
RA Conlon, AG Reaume and J Rossant
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Members of the Notch family of transmembrane receptors mediate a number of developmental decisions in invertebrates. In order to study Notch function in a vertebrate organism, we have mutated the Notch1 gene of the mouse. Notch1 gene function is required for embryonic survival in the second half of gestation. In the first half of gestation, we have found no effect of the mutation on the normal programs of neurogenesis, myogenesis or apoptosis. We conclude that Notch1 function is not essential for these processes, at least in early postimplantation development. However, we have found that somitogenesis is delayed and disorganized in Notch1 mutant embryos. We propose that Notch1 normally coordinates the process of somitogenesis, and we provide a model of how this might occur.
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A. Louvi, S. S. Sisodia, and E. A. Grove Presenilin 1 in migration and morphogenesis in the central nervous system Development, July 1, 2004; 131(13): 3093 - 3105. [Abstract] [Full Text] [PDF] |
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R. Cordes, K. Schuster-Gossler, K. Serth, and A. Gossler Specification of vertebral identity is coupled to Notch signalling and the segmentation clock Development, March 15, 2004; 131(6): 1221 - 1233. [Abstract] [Full Text] [PDF] |
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P. Wang, F. A. Pereira, D. Beasley, and H. Zheng Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis Development, October 15, 2003; 130(20): 5019 - 5029. [Abstract] [Full Text] [PDF] |
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S. Shi and P. Stanley Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways PNAS, April 29, 2003; 100(9): 5234 - 5239. [Abstract] [Full Text] [PDF] |
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T. Li, G. Ma, H. Cai, D. L. Price, and P. C. Wong Nicastrin Is Required for Assembly of Presenilin/gamma -Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of beta -Amyloid Precursor Protein in Mammals J. Neurosci., April 15, 2003; 23(8): 3272 - 3277. [Abstract] [Full Text] [PDF] |
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K. Serth, K. Schuster-Gossler, R. Cordes, and A. Gossler Transcriptional oscillation of Lunatic fringe is essential for somitogenesis Genes & Dev., April 1, 2003; 17(7): 912 - 925. [Abstract] [Full Text] [PDF] |
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T. Schroeder, S. T. Fraser, M. Ogawa, S. Nishikawa, C. Oka, G. W. Bornkamm, S.-I. Nishikawa, T. Honjo, and U. Just Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesis PNAS, April 1, 2003; 100(7): 4018 - 4023. [Abstract] [Full Text] [PDF] |
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N. S. Hamblet, N. Lijam, P. Ruiz-Lozano, J. Wang, Y. Yang, Z. Luo, L. Mei, K. R. Chien, D. J. Sussman, and A. Wynshaw-Boris Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure Development, March 14, 2003; 129(24): 5827 - 5838. [Abstract] [Full Text] [PDF] |
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A. C. Oates and R. K. Ho Hairy/E(spl)-related (Her) genes are central components of the segmentation oscillator and display redundancy with the Delta/Notch signaling pathway in the formation of anterior segmental boundaries in the zebrafish Development, March 8, 2003; 129(12): 2929 - 2946. [Abstract] [Full Text] [PDF] |
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S. Lutolf, F. Radtke, M. Aguet, U. Suter, and V. Taylor Notch1 is required for neuronal and glial differentiation in the cerebellum Development, March 3, 2003; 129(2): 373 - 385. [Abstract] [Full Text] [PDF] |
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H. Karlstrom, P. Beatus, K. Dannaeus, G. Chapman, U. Lendahl, and J. Lundkvist A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling PNAS, December 24, 2002; 99(26): 17119 - 17124. [Abstract] [Full Text] [PDF] |
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S.-E. Lin, T. Oyama, T. Nagase, K. Harigaya, and M. Kitagawa Identification of New Human Mastermind Proteins Defines a Family That Consists of Positive Regulators for Notch Signaling J. Biol. Chem., December 20, 2002; 277(52): 50612 - 50620. [Abstract] [Full Text] [PDF] |
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A. H. Campos, W. Wang, M. J. Pollman, and G. H. Gibbons Determinants of Notch-3 Receptor Expression and Signaling in Vascular Smooth Muscle Cells: Implications in Cell-Cycle Regulation Circ. Res., November 29, 2002; 91(11): 999 - 1006. [Abstract] [Full Text] [PDF] |
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R. Rozmahel, H. T. J. Mount, F. Chen, V. Nguyen, J. Huang, S. Erdebil, J. Liauw, G. Yu, H. Hasegawa, Y. Gu, et al. Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype PNAS, October 29, 2002; 99(22): 14452 - 14457. [Abstract] [Full Text] [PDF] |
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L. A. Hanna, R. K. Foreman, I. A. Tarasenko, D. S. Kessler, and P. A. Labosky Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo Genes & Dev., October 15, 2002; 16(20): 2650 - 2661. [Abstract] [Full Text] [PDF] |
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S. Genoud, C. Lappe-Siefke, S. Goebbels, F. Radtke, M. Aguet, S. S. Scherer, U. Suter, K.-A. Nave, and N. Mantei Notch1 control of oligodendrocyte differentiation in the spinal cord J. Cell Biol., August 19, 2002; 158(4): 709 - 718. [Abstract] [Full Text] [PDF] |
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Y. Sato, K. Yasuda, and Y. Takahashi Morphological boundary forms by a novel inductive event mediated by Lunatic fringe and Notch during somitic segmentation Development, August 1, 2002; 129(15): 3633 - 3644. [Abstract] [Full Text] [PDF] |
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C. A. Henry, M. K. Urban, K. K. Dill, J. P. Merlie, M. F. Page, C. B. Kimmel, and S. L. Amacher Two linked hairy/Enhancer of split-related zebrafish genes, her1 and her7, function together to refine alternating somite boundaries Development, August 1, 2002; 129(15): 3693 - 3704. [Abstract] [Full Text] [PDF] |
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W. Wang, A. H. Campos, C. Z. Prince, Y. Mou, and M. J. Pollman Coordinate Notch3-Hairy-related Transcription Factor Pathway Regulation in Response to Arterial Injury. MEDIATOR ROLE OF PLATELET-DERIVED GROWTH FACTOR AND ERK J. Biol. Chem., June 21, 2002; 277(26): 23165 - 23171. [Abstract] [Full Text] [PDF] |
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W. Wang, C. Z. Prince, Y. Mou, and M. J. Pollman Notch3 Signaling in Vascular Smooth Muscle Cells Induces c-FLIP Expression via ERK/MAPK Activation. RESISTANCE TO Fas LIGAND-INDUCED APOPTOSIS J. Biol. Chem., June 7, 2002; 277(24): 21723 - 21729. [Abstract] [Full Text] [PDF] |
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H. Han, K. Tanigaki, N. Yamamoto, K. Kuroda, M. Yoshimoto, T. Nakahata, K. Ikuta, and T. Honjo Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision Int. Immunol., June 1, 2002; 14(6): 637 - 645. [Abstract] [Full Text] [PDF] |
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J. Bose, L. Grotewold, and U. Ruther Pallister-Hall syndrome phenotype in mice mutant for Gli3 Hum. Mol. Genet., May 1, 2002; 11(9): 1129 - 1135. [Abstract] [Full Text] [PDF] |
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S. Hitoshi, T. Alexson, V. Tropepe, D. Donoviel, A. J. Elia, J. S. Nye, R. A. Conlon, T. W. Mak, A. Bernstein, and D. van der Kooy Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells Genes & Dev., April 1, 2002; 16(7): 846 - 858. [Abstract] [Full Text] [PDF] |
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B. E. Berechid, M. Kitzmann, D. R. Foltz, A. H. Roach, D. Seiffert, L. A. Thompson, R. E. Olson, A. Bernstein, D. B. Donoviel, and J. S. Nye Identification and Characterization of Presenilin-independent Notch Signaling J. Biol. Chem., March 1, 2002; 277(10): 8154 - 8165. [Abstract] [Full Text] [PDF] |
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S Lovestone and D M McLoughlin Protein aggregates and dementia: is there a common toxicity? J. Neurol. Neurosurg. Psychiatry, February 1, 2002; 72(2): 152 - 161. [Abstract] [Full Text] [PDF] |
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J.L. Stanton and D.P.L. Green A set of 1542 mouse blastocyst and pre-blastocyst genes with well-matched human homologues Mol. Hum. Reprod., February 1, 2002; 8(2): 149 - 166. [Abstract] [Full Text] [PDF] |
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R. M. Anderson, A. R. Lawrence, R. W. Stottmann, D. Bachiller, and J. Klingensmith Chordin and noggin promote organizing centers of forebrain development in the mouse Development, January 11, 2002; 129(21): 4975 - 4987. [Abstract] [Full Text] [PDF] |
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S. L. Dunwoodie, M. Clements, D. B. Sparrow, X. Sa, R. A. Conlon, and R. S. P. Beddington Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm Development, January 4, 2002; 129(7): 1795 - 1806. [Abstract] [Full Text] [PDF] |
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S. A. Holley, D. Julich, G.-J. Rauch, R. Geisler, and C. Nusslein-Volhard her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis Development, January 3, 2002; 129(5): 1175 - 1183. [Abstract] [Full Text] [PDF] |
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O. Voiculescu, E. Taillebourg, C. Pujades, C. Kress, S. Buart, P. Charnay, and S. Schneider-Maunoury Hindbrain patterning: Krox20 couples segmentation and specification of regional identity Development, December 15, 2001; 128(24): 4967 - 4978. [Abstract] [Full Text] [PDF] |
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