|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 6 1755-1768, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
KA Barth and SW Wilson
Developmental Biology Research Centre, Randall Institute, King's College London, UK.
We have isolated zebrafish nk2.2, a member of the Nk-2 family of homeobox genes. nk2.2 is expressed in a continuous narrow band of cells along a boundary zone demarcating the location at which two of the earliest nuclei in the brain differentiate. This band of cells is located within a few cell diameters of cells expressing the signalling molecule sonic hedgehog/vertebrate hedgehog-1 (shh/vhh-1). Injection of shh/vhh-1 RNA results in ectopic expression of nk2.2 and concomitant abnormalities in the forebrain and eyes. Moreover, cyclops mutant embryos, which initially lack neurectodermal expression of shh/vhh-1, show a concomitant lack of nk2.2 expression. Together, these results suggest a requirement of shh/vhh-1 protein for the spatial regulation of nk2.2 expression.
This article has been cited by other articles:
|
|
 |
|
  S. Scholpp, I. Foucher, N. Staudt, D. Peukert, A. Lumsden, and C. Houart Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon Development, September 1, 2007; 134(17): 3167 - 3176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Nakada, S. Satoh, Y. Tabata, K.-i. Arai, and S. Watanabe Transcriptional Repressor foxl1 Regulates Central Nervous System Development by Suppressing shh Expression in Zebra Fish. Mol. Cell. Biol., October 1, 2006; 26(19): 7246 - 7257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu, B. P. Srinivas, S. Y. Tay, A. Mak, X. Yu, S. G. P. Lee, H. Yang, K. R. Govindarajan, B. Leong, G. Bourque, et al. Genomewide Expression Profiling in the Zebrafish Embryo Identifies Target Genes Regulated by Hedgehog Signaling During Vertebrate Development Genetics, October 1, 2006; 174(2): 735 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gutin, M. Fernandes, L. Palazzolo, H. Paek, K. Yu, D. M. Ornitz, S. K. McConnell, and J. M. Hebert FGF signalling generates ventral telencephalic cells independently of SHH Development, August 1, 2006; 133(15): 2937 - 2946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Koppen, B. G. Fernandez, L. Carvalho, A. Jacinto, and C.-P. Heisenberg Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila. Development, July 1, 2006; 133(14): 2671 - 2681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Link, L. Carvalho, I. Castanon, P. Stockinger, A. Shevchenko, and C.-P. Heisenberg Identification of regulators of germ layer morphogenesis using proteomics in zebrafish J. Cell Sci., May 15, 2006; 119(10): 2073 - 2083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Scholpp, O. Wolf, M. Brand, and A. Lumsden Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon Development, March 1, 2006; 133(5): 855 - 864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Seth, J. Culverwell, M. Walkowicz, S. Toro, J. M. Rick, S. C. F. Neuhauss, Z. M. Varga, and R. O. Karlstrom belladonna/(lhx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain Development, February 15, 2006; 133(4): 725 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ohyama, P. Ellis, S. Kimura, and M. Placzek Directed differentiation of neural cells to hypothalamic dopaminergic neurons Development, December 1, 2005; 132(23): 5185 - 5197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Zeltser Shh-dependent formation of the ZLI is opposed by signals from the dorsal diencephalon Development, May 1, 2005; 132(9): 2023 - 2033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dutta, J.-E. Dietrich, G. Aspock, R. D. Burdine, A. Schier, M. Westerfield, and Z. M. Varga pitx3 defines an equivalence domain for lens and anterior pituitary placode Development, April 1, 2005; 132(7): 1579 - 1590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-A. Montero, L. Carvalho, M. Wilsch-Brauninger, B. Kilian, C. Mustafa, and C.-P. Heisenberg Shield formation at the onset of zebrafish gastrulation Development, March 15, 2005; 132(6): 1187 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Stamataki, F. Ulloa, S. V. Tsoni, A. Mynett, and J. Briscoe A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube Genes & Dev., March 1, 2005; 19(5): 626 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Norton, M. Mangoli, Z. Lele, H.-M. Pogoda, B. Diamond, S. Mercurio, C. Russell, H. Teraoka, H. L. Stickney, G.-J. Rauch, et al. Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones Development, February 15, 2005; 132(4): 645 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Wilbanks, G. B. Fralish, M. L. Kirby, L. S. Barak, Y.-X. Li, and M. G. Caron {beta}-Arrestin 2 Regulates Zebrafish Development Through the Hedgehog Signaling Pathway Science, December 24, 2004; 306(5705): 2264 - 2267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kapsimali, L. Caneparo, C. Houart, and S. W. Wilson Inhibition of Wnt/Axin/{beta}-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity Development, December 1, 2004; 131(23): 5923 - 5933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Park, J. Shin, and B. Appel Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling Development, December 1, 2004; 131(23): 5959 - 5969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Cheesman, M. J. Layden, T. Von Ohlen, C. Q. Doe, and J. S. Eisen Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation Development, November 1, 2004; 131(21): 5221 - 5232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Feng, B. White, O. V. Tyurina, B. Guner, T. Larson, H. Y. Lee, R. O. Karlstrom, and J. D. Kohtz Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids Development, September 1, 2004; 131(17): 4357 - 4370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sekimizu, N. Nishioka, H. Sasaki, H. Takeda, R. O. Karlstrom, and A. Kawakami The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling Development, June 1, 2004; 131(11): 2521 - 2532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Ulrich, M. L. Concha, P. J. Heid, E. Voss, S. Witzel, H. Roehl, M. Tada, S. W. Wilson, R. J. Adams, D. R. Soll, et al. Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation Development, November 15, 2003; 130(22): 5375 - 5384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Carreira-Barbosa, M. L. Concha, M. Takeuchi, N. Ueno, S. W. Wilson, and M. Tada Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish Development, September 1, 2003; 130(17): 4037 - 4046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. O. Karlstrom, O. V. Tyurina, A. Kawakami, N. Nishioka, W. S. Talbot, H. Sasaki, and A. F. Schier Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development Development, April 15, 2003; 130(8): 1549 - 1564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kang, F. Huang, D. Li, M. Shankland, W. Gaffield, and D. A. Weisblat A hedgehog homolog regulates gut formation in leech (Helobdella) Development, April 15, 2003; 130(8): 1645 - 1657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Pabst, J. Rummelies, B. Winter, and H.-H. Arnold Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerve Development, March 15, 2003; 130(6): 1193 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Take-uchi, J. D. W. Clarke, and S. W. Wilson Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity Development, March 1, 2003; 130(5): 955 - 968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Dong, H. Teraoka, K. Yamazaki, S. Tsukiyama, S. Imani, T. Imagawa, J. J. Stegeman, R. E. Peterson, and T. Hiraga 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Zebrafish Embryo: Local Circulation Failure in the Dorsal Midbrain Is Associated with Increased Apoptosis Toxicol. Sci., September 1, 2002; 69(1): 191 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Teraoka, W. Dong, S. Ogawa, S. Tsukiyama, Y. Okuhara, M. Niiyama, N. Ueno, R. E. Peterson, and T. Hiraga 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Zebrafish Embryo: Altered Regional Blood Flow and Impaired Lower Jaw Development Toxicol. Sci., February 1, 2002; 65(2): 192 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rallu, R. Machold, N. Gaiano, J. G. Corbin, A. P. McMahon, and G. Fishell Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling Development, January 11, 2002; 129(21): 4963 - 4974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mathieu, A. Barth, F. M. Rosa, S. W. Wilson, and N. Peyrieras Distinct and cooperative roles for Nodal and Hedgehog signals during hypothalamic development Development, January 7, 2002; 129(13): 3055 - 3065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. M. Varga, A. Amores, K. E. Lewis, Y.-L. Yan, J. H. Postlethwait, J. S. Eisen, and M. Westerfield Zebrafish smoothened functions in ventral neural tube specification and axon tract formation Development, September 15, 2001; 128(18): 3497 - 3509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-P. Heisenberg, C. Houart, M. Take-uchi, G.-J. Rauch, N. Young, P. Coutinho, I. Masai, L. Caneparo, M. L. Concha, R. Geisler, et al. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon Genes & Dev., June 1, 2001; 15(11): 1427 - 1434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Corbin, N Gaiano, R. Machold, A Langston, and G Fishell The Gsh2 homeodomain gene controls multiple aspects of telencephalic development Development, January 12, 2000; 127(23): 5007 - 5020. [Abstract] [PDF]
|
|
|
|
|
|
T Pratt, T Vitalis, N Warren, J. Edgar, J. Mason, and D. Price A role for Pax6 in the normal development of dorsal thalamus and its cortical connections Development, January 12, 2000; 127(23): 5167 - 5178. [Abstract] [PDF]
|
|
|
|
|
|
C. Fode, Q. Ma, S. Casarosa, S.-L. Ang, D. J. Anderson, and F. Guillemot A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons Genes & Dev., January 1, 2000; 14(1): 67 - 80. [Abstract] [Full Text]
|
|
|
|
|
|
R. O. Karlstrom, W. S. Talbot, and A. F. Schier Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning Genes & Dev., February 15, 1999; 13(4): 388 - 393. [Abstract] [Full Text]
|
|
|
|
|
|
K. Barth, Y Kishimoto, K. Rohr, C Seydler, S Schulte-Merker, and S. Wilson Bmp activity establishes a gradient of positional information throughout the entire neural plate Development, January 11, 1999; 126(22): 4977 - 4987. [Abstract] [PDF]
|
|
|
|
|
|
L Sussel, O Marin, S Kimura, and J. Rubenstein Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum Development, January 8, 1999; 126(15): 3359 - 3370. [Abstract] [PDF]
|
|
|
|
|
|
D Arendt and K Nubler-Jung Comparison of early nerve cord development in insects and vertebrates Development, January 6, 1999; 126(11): 2309 - 2325. [Abstract] [PDF]
|
|
|
|
|
|
F Muller, B Chang, S Albert, N Fischer, L Tora, and U Strahle Intronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notochord Development, January 5, 1999; 126(10): 2103 - 2116. [Abstract] [PDF]
|
|
|
|
|
|
L. Roth, P Bormann, A Bonnet, and E Reinhard beta-thymosin is required for axonal tract formation in developing zebrafish brain Development, January 4, 1999; 126(7): 1365 - 1374. [Abstract] [PDF]
|
|
|
|
 |
|
 D. W. Sretavan and K. Kruger Randomized Retinal Ganglion Cell Axon Routing at the Optic Chiasm of GAP-43-Deficient Mice: Association with Midline Recrossing and Lack of Normal Ipsilateral Axon Turning J. Neurosci., December 15, 1998; 18(24): 10502 - 10513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Weiss, T. Von Ohlen, D. M. Mellerick, G. Dressler, C. Q. Doe, and M. P. Scott Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity Genes & Dev., November 15, 1998; 12(22): 3591 - 3602. [Abstract] [Full Text]
|
|
|
|
|
|
L. E. Hake, R. Mendez, and J. D. Richter Specificity of RNA Binding by CPEB: Requirement for RNA Recognition Motifs and a Novel Zinc Finger Mol. Cell. Biol., February 1, 1998; 18(2): 685 - 693. [Abstract] [Full Text]
|
|
|
|
|
|
C Bourguignon, J Li, and N Papalopulu XBF-1, a winged helix transcription factor with dual activity, has a role in positioning neurogenesis in Xenopus competent ectoderm Development, January 12, 1998; 125(24): 4889 - 4900. [Abstract] [PDF]
|
|
|
|
|
|
J. Kohtz, D. Baker, G Corte, and G Fishell Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog Development, January 12, 1998; 125(24): 5079 - 5089. [Abstract] [PDF]
|
|
|
|
|
|
K. Ba-Charvet, Y von Boxberg, S Guazzi, E Boncinelli, and P Godement A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain Development, January 11, 1998; 125(21): 4273 - 4282. [Abstract] [PDF]
|
|
|
|
|
|
J. Incardona, W Gaffield, R. Kapur, and H Roelink The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction Development, January 9, 1998; 125(18): 3553 - 3562. [Abstract] [PDF]
|
|
|
|
|
|
R Tuttle, J. Braisted, L. Richards, and D. O'Leary Retinal axon guidance by region-specific cues in diencephalon Development, January 3, 1998; 125(5): 791 - 801. [Abstract] [PDF]
|
|
|
|
|
|
S. Kim, M Hebrok, and D. Melton Notochord to endoderm signaling is required for pancreas development Development, January 11, 1997; 124(21): 4243 - 4252. [Abstract] [PDF]
|
|
|
|
|
|
E. Pera and M Kessel Patterning of the chick forebrain anlage by the prechordal plate Development, January 10, 1997; 124(20): 4153 - 4162. [Abstract] [PDF]
|
|
|
|
|
|
R Koster, R Stick, F Loosli, and J Wittbrodt Medaka spalt acts as a target gene of hedgehog signaling Development, January 8, 1997; 124(16): 3147 - 3156. [Abstract] [PDF]
|
|
|
|
|
|
J Lee, K. Platt, P Censullo, and A Ruiz i Altaba Gli1 is a target of Sonic hedgehog that induces ventral neural tube development Development, January 7, 1997; 124(13): 2537 - 2552. [Abstract] [PDF]
|
|
|
|
|
|
R Macdonald, J Scholes, U Strahle, C Brennan, N Holder, M Brand, and S. Wilson The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain Development, January 6, 1997; 124(12): 2397 - 2408. [Abstract] [PDF]
|
|
|
|
|
|
A. Schier, S. Neuhauss, K. Helde, W. Talbot, and W Driever The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail Development, January 1, 1997; 124(2): 327 - 342. [Abstract] [PDF]
|
|
|
|
|
|
C. Heisenberg, M Brand, Y. Jiang, R. Warga, D Beuchle, F. van Eeden, M Furutani-Seiki, M Granato, P Haffter, M Hammerschmidt, et al. Genes involved in forebrain development in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 191 - 203. [Abstract] [PDF]
|
|
|
|
|
|
R. Karlstrom, T Trowe, S Klostermann, H Baier, M Brand, A. Crawford, B Grunewald, P Haffter, H Hoffmann, S. Meyer, et al. Zebrafish mutations affecting retinotectal axon pathfinding Development, January 12, 1996; 123(1): 427 - 438. [Abstract] [PDF]
|
|
|
|
|
|
J. Concordet, K. Lewis, J. Moore, L. Goodrich, R. Johnson, M. Scott, and P. Ingham Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning Development, January 9, 1996; 122(9): 2835 - 2846. [Abstract] [PDF]
|
|
|
|
|
|
Y Nakagawa, T Kaneko, T Ogura, T Suzuki, M Torii, K Kaibuchi, K Arai, S Nakamura, and M Nakafuku Roles of cell-autonomous mechanisms for differential expression of region-specific transcription factors in neuroepithelial cells Development, January 8, 1996; 122(8): 2449 - 2464. [Abstract] [PDF]
|
|
|
|
|
|
G Hauptmann and T Gerster Complex expression of the zp-50 pou gene in the embryonic zebrafish brain is altered by overexpression of sonic hedgehog Development, January 6, 1996; 122(6): 1769 - 1780. [Abstract] [PDF]
|
|
|
|
|
|
K Shimamura, D. Hartigan, S Martinez, L Puelles, and J. Rubenstein Longitudinal organization of the anterior neural plate and neural tube Development, January 12, 1995; 121(12): 3923 - 3933. [Abstract] [PDF]
|
|
|
|
|
|
R Macdonald, K. Barth, Q Xu, N Holder, I Mikkola, and S. Wilson Midline signalling is required for Pax gene regulation and patterning of the eyes Development, January 10, 1995; 121(10): 3267 - 3278. [Abstract] [PDF]
|
|
