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Development, Vol 121, Issue 6 1845-1854, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
MC Dickson, JS Martin, FM Cousins, AB Kulkarni, S Karlsson and RJ Akhurst
Department of Medical Genetics, University of Glasgow, Duncan Guthrie Institute, Yorkhill, UK.
Transforming growth factor beta 1 (TGF beta 1) is shown here to be required for yolk sac haematopoiesis and endothelial differentiation. Mice with a targeted mutation in the TGF beta 1 gene were examined to determine the cause of prenatal lethality, which occurs in 50% of homozygous TGF beta 1 null (TGF beta 1-/-) conceptions. 50% of TGF beta 1-/- and 25% of TGF beta 1-+-) conceptions. 50% of TGF beta 1-/- and 25% of TGF beta 1+/- conceptuses were found to die at around 10.5 dpc. The primary defects were restricted to extraembryonic tissues, namely the yolk sac vasculature and haematopoietic system. The embryos per se showed developmental retardation, oedema and necrosis, which were probably secondary to the extraembryonic lesions. The defect in vasculogenesis appeared to affect endothelial differentiation, rather than the initial appearance and outgrowth of endothelial cells. Initial differentiation of yolk sac mesoderm to endothelial cells occurred, but defective differentiation resulted in inadequate capillary tube formation, and weak vessels with reduced cellular adhesiveness. Defective haematopoiesis resulted in a reduced erythroid cell number within the yolk sac. Defective yolk sac vasculogenesis and haematopoiesis were present either together, or in isolation of each other. The phenotypes are consistent with the observation of abundant TGF beta 1 gene expression in both endothelial and haematopoietic precursors. The data indicate that the primary effect of loss of TGF beta 1 function in vivo is not increased haematopoietic or endothelial cell proliferation, which might have been expected by deletion of a negative growth regulator, but defective haematopoiesis and endothelial differentiation.
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Y. Chai, Y. Ito, and J. Han TGF-{beta} SIGNALING AND ITS FUNCTIONAL SIGNIFICANCE IN REGULATING THE FATE OF CRANIAL NEURAL CREST CELLS Critical Reviews in Oral Biology & Medicine, March 1, 2003; 14(2): 78 - 88. [Abstract] [Full Text] [PDF] |
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C. Bondjers, M. Kalen, M. Hellstrom, S. J. Scheidl, A. Abramsson, O. Renner, P. Lindahl, H. Cho, J. Kehrl, and C. Betsholtz Transcription Profiling of Platelet-Derived Growth Factor-B-Deficient Mouse Embryos Identifies RGS5 as a Novel Marker for Pericytes and Vascular Smooth Muscle Cells Am. J. Pathol., March 1, 2003; 162(3): 721 - 729. [Abstract] [Full Text] [PDF] |
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K. C. Flanders and J. K. Burmester Medical Applications of Transforming Growth Factor-{beta} Clin. Med. Res., January 1, 2003; 1(1): 13 - 20. [Abstract] [Full Text] [PDF] |
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B. Liu, Y. Sun, F. Jiang, S. Zhang, Y. Wu, Y. Lan, X. Yang, and N. Mao Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis Blood, January 1, 2003; 101(1): 124 - 133. [Abstract] [Full Text] [PDF] |
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H. Chang, C. W. Brown, and M. M. Matzuk Genetic Analysis of the Mammalian Transforming Growth Factor-{beta} Superfamily Endocr. Rev., December 1, 2002; 23(6): 787 - 823. [Abstract] [Full Text] [PDF] |
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A. Rodriguez-Pena, N. Eleno, A. Duwell, M. Arevalo, F. Perez-Barriocanal, O. Flores, N. Docherty, C. Bernabeu, M. Letarte, and J. M. Lopez-Novoa Endoglin Upregulation During Experimental Renal Interstitial Fibrosis in Mice Hypertension, November 1, 2002; 40(5): 713 - 720. [Abstract] [Full Text] [PDF] |
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P. I. Teng, M. R. Dichiara, L. G. Komuves, K. Abe, T. Quertermous, and J. N. Topper Inducible and selective transgene expression in murine vascular endothelium Physiol Genomics, October 29, 2002; 11(2): 99 - 107. [Abstract] [Full Text] [PDF] |
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A. H. Shah, W. B. Tabayoyong, S. Y. Kimm, S.-J. Kim, L. van Parijs, and C. Lee Reconstitution of Lethally Irradiated Adult Mice with Dominant Negative TGF-{beta} Type II Receptor-Transduced Bone Marrow Leads to Myeloid Expansion and Inflammatory Disease J. Immunol., October 1, 2002; 169(7): 3485 - 3491. [Abstract] [Full Text] [PDF] |
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A. Nishihara, T. Watabe, T. Imamura, and K. Miyazono Functional Heterogeneity of Bone Morphogenetic Protein Receptor-II Mutants Found in Patients with Primary Pulmonary Hypertension Mol. Biol. Cell, September 1, 2002; 13(9): 3055 - 3063. [Abstract] [Full Text] [PDF] |
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W. Schacke, K.-F. Beck, J. Pfeilschifter, F. Koch, and L.-O. Hattenbach Modulation of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 by Transforming Growth Factor-{beta} in Human Retinal Glial Cells Invest. Ophthalmol. Vis. Sci., August 1, 2002; 43(8): 2799 - 2805. [Abstract] [Full Text] [PDF] |
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H. Miyashita, T. Yamazaki, T. Akada, O. Niizeki, M. Ogawa, S.-i. Nishikawa, and Y. Sato A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis Blood, May 1, 2002; 99(9): 3241 - 3249. [Abstract] [Full Text] [PDF] |
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H. Sasaki, Y. Kobayashi, Y. Nakashima, S. Moriyama, H. Yukiue, M. Kaji, M. Kiriyama, I. Fukai, Y. Yamakawa, and Y. Fujii {beta}IGH3, a TGF-{beta} Inducible Gene, is Overexpressed in Lung Cancer Jpn. J. Clin. Oncol., March 1, 2002; 32(3): 85 - 89. [Abstract] [Full Text] [PDF] |
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J. P. Grande, G. M. Warner, H. J. Walker, A. N. K. Yusufi, J. Cheng, C. E. Gray, J. B. Kopp, and K. A. Nath TGF-{beta}1 Is an Autocrine Mediator of Renal Tubular Epithelial Cell Growth and Collagen IV Production Experimental Biology and Medicine, March 1, 2002; 227(3): 171 - 181. [Abstract] [Full Text] [PDF] |
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K. K. Hirschi, L. Lai, N. S. Belaguli, D. A. Dean, R. J. Schwartz, and W. E. Zimmer Transforming Growth Factor-beta Induction of Smooth Muscle Cell Phenotpye Requires Transcriptional and Post-transcriptional Control of Serum Response Factor J. Biol. Chem., February 15, 2002; 277(8): 6287 - 6295. [Abstract] [Full Text] [PDF] |
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R.O. HYNES, J.C. LIVELY, J.H. MCCARTY, D. TAVERNA, S.E. FRANCIS, K. HODIVALA-DILKE, and Q. XIAO The Diverse Roles of Integrins and Their Ligands in Angiogenesis Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 143 - 154. [Abstract] [PDF] |
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S. K. Cho, A. Bourdeau, M. Letarte, and J. C. Zuniga-Pflucker Expression and function of CD105 during the onset of hematopoiesis from Flk1+ precursors Blood, December 15, 2001; 98(13): 3635 - 3642. [Abstract] [Full Text] [PDF] |
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H. O. Akman, H. Zhang, M. A. Q. Siddiqui, W. Solomon, E. L. P. Smith, and O. A. Batuman Response to hypoxia involves transforming growth factor-beta 2 and Smad proteins in human endothelial cells Blood, December 1, 2001; 98(12): 3324 - 3331. [Abstract] [Full Text] [PDF] |
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