|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 7 2019-2030, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
AP Jarman, Y Sun, LY Jan and YN Jan
Howard Hughes Medical Institute, University of California, San Francisco 94143-0724, USA.
The Drosophila gene atonal encodes a basic helix-loop-helix protein similar to those encoded by the proneural genes of the achaete-scute complex (AS-C). The AS-C are required in the Drosophila PNS for the selection of neural precursors of external sense organs. We have isolated mutants of atonal, which reveal that this gene encodes the proneural gene for chordotonal organs and photoreceptors. In atonal mutants, all observable adult chordotonal organs, and almost all embryonic chordotonal organs fail to form; all adult photoreceptors are missing. For both types of sense organ, this defect is already apparent at the level of precursor formation. Therefore it is a failure in the epidermal-neural decision process i.e. a proneural defect. The failure to form photoreceptors results in atrophy of the atonal mutant imaginal disc, due to apoptosis and lack of stimulation of division. Lack of photoreceptors should also eliminate signalling that arises from differentiating photoreceptors and is required for morphogenetic furrow movement in the wild-type eye disc. Nevertheless, a remnant morphogenetic furrow is still observed in the atonal mutant disc. This presumably reflects the process of furrow initiation, which would not depend on signals from developing photoreceptors.
This article has been cited by other articles:
|
|
 |
|
  G. I. Miura, J.-Y. Roignant, M. Wassef, and J. E. Treisman Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor Development, June 1, 2008; 135(11): 1913 - 1922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Matsuno, H. Kose, M. Okabe, and Y. Hiromi TFIIH controls developmentally-regulated cell cycle progression as a holocomplex. Genes Cells, November 1, 2007; 12(11): 1289 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Sukhanova, D. K. Deb, G. M. Gordon, M. T. Matakatsu, and W. Du Proneural Basic Helix-Loop-Helix Proteins and Epidermal Growth Factor Receptor Signaling Coordinately Regulate Cell Type Specification and cdk Inhibitor Expression during Development Mol. Cell. Biol., April 15, 2007; 27(8): 2987 - 2996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. Millimaki, E. M. Sweet, M. S. Dhason, and B. B. Riley Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch Development, January 15, 2007; 134(2): 295 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Zhang, S. Ranade, C. Q. Cai, C. Clouser, and F. Pignoni Direct control of neurogenesis by selector factors in the fly eye: regulation of atonal by Ey and So Development, December 15, 2006; 133(24): 4881 - 4889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-Y. Roignant, S. Hamel, F. Janody, and J. E. Treisman The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway. Genes & Dev., April 1, 2006; 20(7): 795 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Anderson, R. Bhandari, and J. P. Kumar A Genetic Screen Identifies Putative Targets and Binding Partners of CREB-Binding Protein in the Developing Drosophila Eye Genetics, December 1, 2005; 171(4): 1655 - 1672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Rodrigues, E. Werner, and K. Moses Genetic and biochemical analysis of the role of Egfr in the morphogenetic furrow of the developing Drosophila eye Development, November 1, 2005; 132(21): 4697 - 4707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Kay, B. A. Link, and H. Baier Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina Development, June 1, 2005; 132(11): 2573 - 2585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Escudero, E. Caminero, K. L. Schulze, H. J. Bellen, and J. Modolell Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila Development, March 15, 2005; 132(6): 1211 - 1222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lim and K.-W. Choi Induction and autoregulation of the anti-proneural gene Bar during retinal neurogenesis in Drosophila Development, November 15, 2004; 131(22): 5573 - 5580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Caldwell, M. M. Miller, S. Wing, D. R. Soll, and D. F. Eberl Dynamic analysis of larval locomotion in Drosophila chordotonal organ mutants PNAS, December 23, 2003; 100(26): 16053 - 16058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lim and K.-W. Choi Bar homeodomain proteins are anti-proneural in the Drosophila eye: transcriptional repression of atonal by Bar prevents ectopic retinal neurogenesis Development, December 15, 2003; 130(24): 5965 - 5974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. S. Dong, S. V. Todi, D. F. Eberl, and G. Boekhoff-Falk Drosophila spalt/spalt-related mutants exhibit Townes-Brocks' syndrome phenotypes PNAS, September 2, 2003; 100(18): 10293 - 10298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Kumar, F. Hsiung, M. A. Powers, and K. Moses Nuclear translocation of activated MAP kinase is developmentally regulated in the developing Drosophila eye Development, August 15, 2003; 130(16): 3703 - 3714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Rawlins, N. M. White, and A. P. Jarman Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups Development, August 15, 2003; 130(16): 3715 - 3724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, L. Li, K. D. Irvine, and N. E. Baker Notch activity in neural cells triggered by a mutant allele with altered glycosylation Development, July 1, 2003; 130(13): 2829 - 2840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Michaut, S. Flister, M. Neeb, K. P. White, U. Certa, and W. J. Gehring Analysis of the eye developmental pathway in Drosophila using DNA microarrays PNAS, April 1, 2003; 100(7): 4024 - 4029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Lee, K. Amanai, A. Shearn, and J. E. Treisman The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms Development, March 14, 2003; 129(24): 5697 - 5706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Cadigan, A. D. Jou, and R. Nusse Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless Development, March 9, 2003; 129(14): 3393 - 3402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Brodu, P. R. Elstob, and A. P. Gould abdominal A specifies one cell type in Drosophila by regulating one principal target gene Development, March 8, 2003; 129(12): 2957 - 2963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cau, S. Casarosa, and F. Guillemot Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage Development, March 6, 2003; 129(8): 1871 - 1880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. S. Dong, J. S. Dicks, and G. Panganiban Distal-less and homothorax regulate multiple targets to pattern the Drosophila antenna Development, March 6, 2003; 129(8): 1967 - 1974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Frankfort and G. Mardon R8 development in the Drosophila eye: a paradigm for neural selection and differentiation Development, March 5, 2003; 129(6): 1295 - 1306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Hsiung and K. Moses Retinal development in Drosophila: specifying the first neuron Hum. Mol. Genet., May 15, 2002; 11(10): 1207 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lo, E. Dormand, A. Greenwood, and D. J. Anderson Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells Development, January 4, 2002; 129(7): 1553 - 1567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Baonza and M. Freeman Notch signalling and the initiation of neural development in the Drosophila eye Development, October 15, 2001; 128(20): 3889 - 3898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Jiao, M. Daube, H. Duan, Y. Zou, E. Frei, and M. Noll Headless flies generated by developmental pathway interference Development, September 1, 2001; 128(17): 3307 - 3319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Brown, S. Patel, J. Brzezinski, and T. Glaser Math5 is required for retinal ganglion cell and optic nerve formation Development, July 1, 2001; 128(13): 2497 - 2508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Yang and N. Baker Role of the EGFR/Ras/Raf pathway in specification of photoreceptor cells in the Drosophila retina Development, January 4, 2001; 128(7): 1183 - 1191. [Abstract] [PDF]
|
|
|
|
|
|
P. Elstob, V Brodu, and A. Gould spalt-dependent switching between two cell fates that are induced by the Drosophila EGF receptor Development, January 3, 2001; 128(5): 723 - 732. [Abstract] [PDF]
|
|
|
|
|
|
J Treisman Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development Development, January 2, 2001; 128(4): 603 - 615. [Abstract] [PDF]
|
|
|
|
|
|
S. W. Wang, B. S. Kim, K. Ding, H. Wang, D. Sun, R. L. Johnson, W. H. Klein, and L. Gan Requirement for math5 in the development of retinal ganglion cells Genes & Dev., January 1, 2001; 15(1): 24 - 29. [Abstract] [Full Text]
|
|
|
|
|
|
F. Chanut, A. Luk, and U. Heberlein A Screen for Dominant Modifiers of roDom, a Mutation That Disrupts Morphogenetic Furrow Progression in Drosophila, Identifies Groucho and Hairless as Regulators of atonal Expression Genetics, November 1, 2000; 156(3): 1203 - 1217. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. F. Eberl, R. W. Hardy, and M. J. Kernan Genetically Similar Transduction Mechanisms for Touch and Hearing in Drosophila J. Neurosci., August 15, 2000; 20(16): 5981 - 5988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Hassan and H. J. Bellen Doing the MATH: is the mouse a good model for fly development? Genes & Dev., August 1, 2000; 14(15): 1852 - 1865. [Full Text]
|
|
|
|
|
|
J. D. Wasserman, S. Urban, and M. Freeman A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling Genes & Dev., July 1, 2000; 14(13): 1651 - 1663. [Abstract] [Full Text]
|
|
|
|
|
|
D. Portman and S. Emmons The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage Development, January 12, 2000; 127(24): 5415 - 5426. [Abstract] [PDF]
|
|
|
|
|
|
B Kuang, S. Wu, Y Shin, L Luo, and P Kolodziej split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo Development, January 4, 2000; 127(7): 1517 - 1529. [Abstract] [PDF]
|
|
|
|
|
|
N. White and A. Jarman Drosophila atonal controls photoreceptor R8-specific properties and modulates both receptor tyrosine kinase and Hedgehog signalling Development, January 4, 2000; 127(8): 1681 - 1689. [Abstract] [PDF]
|
|
|
|
|
|
A. Helms, A. Abney, N Ben-Arie, H. Zoghbi, and J. Johnson Autoregulation and multiple enhancers control Math1 expression in the developing nervous system Development, January 3, 2000; 127(6): 1185 - 1196. [Abstract] [PDF]
|
|
|
|
|
|
C.-K. Chen and C.-T. Chien Negative regulation of atonal in proneural cluster formation of Drosophila R8 photoreceptors PNAS, April 27, 1999; 96(9): 5055 - 5060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Daniel, K Dumstrei, J. Lengyel, and V Hartenstein The control of cell fate in the embryonic visual system by atonal, tailless and EGFR signaling Development, January 7, 1999; 126(13): 2945 - 2954. [Abstract] [PDF]
|
|
|
|
|
|
M Dominguez Dual role for Hedgehog in the regulation of the proneural gene atonal during ommatidia development Development, January 6, 1999; 126(11): 2345 - 2353. [Abstract] [PDF]
|
|
|
|
|
|
P zur Lage and A. Jarman Antagonism of EGFR and notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors Development, January 6, 1999; 126(14): 3149 - 3157. [Abstract] [PDF]
|
|
|
|
|
|
S. Spencer, P. Powell, D. Miller, and R. Cagan Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina Development, January 12, 1998; 125(23): 4777 - 4790. [Abstract] [PDF]
|
|
|
|
|
|
N. Brown, S Kanekar, M. Vetter, P. Tucker, D. Gemza, and T Glaser Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis Development, January 12, 1998; 125(23): 4821 - 4833. [Abstract] [PDF]
|
|
|
|
|
|
J. Kumar, M Tio, F Hsiung, S Akopyan, L Gabay, R Seger, B. Shilo, and K Moses Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation Development, January 10, 1998; 125(19): 3875 - 3885. [Abstract] [PDF]
|
|
|
|
|
|
G. Flores, A Daga, H. Kalhor, and U Banerjee Lozenge is expressed in pluripotent precursor cells and patterns multiple cell types in the Drosophila eye through the control of cell-specific transcription factors Development, January 9, 1998; 125(18): 3681 - 3687. [Abstract] [PDF]
|
|
|
|
|
|
Y Sun, L. Jan, and Y. Jan Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system Development, January 9, 1998; 125(18): 3731 - 3740. [Abstract] [PDF]
|
|
|
|
|
|
D. Hazelett, M Bourouis, U Walldorf, and J. Treisman decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc Development, January 9, 1998; 125(18): 3741 - 3751. [Abstract] [PDF]
|
|
|
|
|
|
C. Brennan, M Ashburner, and K Moses Ecdysone pathway is required for furrow progression in the developing Drosophila eye Development, January 7, 1998; 125(14): 2653 - 2664. [Abstract] [PDF]
|
|
|
|
|
|
A. Helms and J. Johnson Progenitors of dorsal commissural interneurons are defined by MATH1 expression Development, January 3, 1998; 125(5): 919 - 928. [Abstract] [PDF]
|
|
|
|
|
|
M. Hirsch, M. Tiveron, F Guillemot, J. Brunet, and C Goridis Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system Development, January 2, 1998; 125(4): 599 - 608. [Abstract] [PDF]
|
|
|
|
|
|
J. Kumar and K. Moses Transcription factors in eye development: a gorgeous mosaic? Genes & Dev., August 15, 1997; 11(16): 2023 - 2028. [Full Text] [PDF]
|
|
|
|
|
|
D. Strutt and M Mlodzik Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc Development, January 9, 1997; 124(17): 3233 - 3240. [Abstract] [PDF]
|
|
|
|
|
|
M Okabe and H Okano Two-step induction of chordotonal organ precursors in Drosophila embryogenesis Development, January 3, 1997; 124(5): 1045 - 1053. [Abstract] [PDF]
|
|
|
|
|
|
G. Reddy, B Gupta, K Ray, and V Rodrigues Development of the Drosophila olfactory sense organs utilizes cell-cell interactions as well as lineage Development, January 2, 1997; 124(3): 703 - 712. [Abstract] [PDF]
|
|
|
|
|
|
M Freeman Cell determination strategies in the Drosophila eye Development, January 1, 1997; 124(2): 261 - 270. [Abstract] [PDF]
|
|
|
|
|
|
C.-t. Chien, C.-D. Hsiao, L. Y. Jan, and Y. N. Jan Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes PNAS, November 12, 1996; 93(23): 13239 - 13244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Dokucu, S. Zipursky, and R. Cagan Atonal, rough and the resolution of proneural clusters in the developing Drosophila retina Development, January 12, 1996; 122(12): 4139 - 4147. [Abstract] [PDF]
|
|
|
|
|
|
Y. Sun, L. Y. Jan, and Y. N. Jan Ectopic scute induces Drosophila ommatidia development without R8 founder photoreceptors PNAS, June 6, 2000; 97(12): 6815 - 6819. [Abstract] [Full Text] [PDF]
|
|
