spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Donjacour, A. A.
Right arrow Articles by Cunha, G. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Donjacour, A. A.
Right arrow Articles by Cunha, G. R.

Development, Vol 121, Issue 7 2199-2207, Copyright © 1995 by Company of Biologists

JOURNAL ARTICLES

Induction of prostatic morphology and secretion in urothelium by seminal vesicle mesenchyme

AA Donjacour and GR Cunha
Department of Anatomy, University of California at San Francisco 94143-0452, USA.

Mesenchymal-epithelial interactions are essential for the development of the male reproductive tract. Tissue recombination experiments have been used to define the characteristics of these interactions. When mesenchyme, embryonic connective tissue, is recombined with epithelium from another organ an instructive induction may occur in which the developmental fate of the epithelium is altered. Instructive inductions are most common when the epithelium that is removed from the mesenchyme and the epithelium that is recombined with the mesenchyme are from the same germ layer. All of the mesenchyme of the male reproductive tract is of mesodermal origin. The epithelia of these organs are derived from either the mesodermal Wolffian duct epithelium or the endodermal urogenital sinus epithelium. Urogenital sinus mesenchyme can instructively induce bladder and urethral epithelium to form prostate (Donjacour, A. A. and Cunha, G. R. (1993) Endocrinol. 132, 2342-2350) and seminal vesicle mesenchyme can instructively induce epithelium from the ductus deferens and ureter (Cunha, G. R., Young, P., Higgins, S. J. and Cooke, P. S. (1991) Development 111, 145-158) to form seminal vesicle. To see whether inductive interactions could occur across germ layers in this system, seminal vesicle mesenchyme, normally associated with a mesodermal epithelium, was recombined with epithelium from neonatal or adult bladder or urethra, which are of endodermal origin. The resulting tissue recombinants were analyzed histologically and by immunocytochemistry and western blotting with antibodies to prostatic and seminal vesicle secretory proteins. Full prostatic differentiation was observed in tissue recombinants made with seminal vesicle mesenchyme plus either adult or neonatal bladder or urethral epithelium.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
R. Heer, A. T. Collins, C. N. Robson, B. K. Shenton, and H. Y. Leung
KGF suppresses {alpha}2{beta}1 integrin function and promotes differentiation of the transient amplifying population in human prostatic epithelium.
J. Cell Sci., April 1, 2006; 119(Pt 7): 1416 - 1424.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Barrow, H. Stadler, and M. Capecchi
Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse
Development, January 3, 2000; 127(5): 933 - 944.
[Abstract] [PDF]


© The Company of Biologists Ltd 1995