Development, Vol 121, Issue 8 2407-2418, Copyright © 1995 by Company of Biologists

JOURNAL ARTICLES

Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta

B Bettenhausen, M Hrabe de Angelis, D Simon, JL Guenet and A Gossler
Max-Delbruck-Laboratorium in der MPG, Koln, Germany.

The Drosophila Delta (Dl) gene is essential for cell-cell communication regulating the determination of various cell fates during development. Dl encodes a transmembrane protein, which contains tandem arrays of epidermal-growth-factor-like repeats in the extracellular domain and directly interacts with Notch, another transmembrane protein with similar structural features, in a ligand-receptor-like manner. Similarly, cell-cell interactions involving Delta-like and Notch-like proteins are required for cell fate determinations in C. elegans. Notch homologues were also isolated from several vertebrate species, suggesting that cell-to-cell signaling mediated by Delta- and Notch-like proteins could also underlie cell fate determination during vertebrate development. However, in vertebrates, no Delta homologues have yet been described. We have isolated a novel mouse gene, Dll1 (delta-like gene 1), which maps to the mouse t-complex and whose deduced amino acid sequence strongly suggests that Dll1 represents a mammalian gene closely related to Drosophila Delta. Dll1 is transiently expressed during gastrulation and early organogenesis, and in a tissue-restricted manner in adult animals. Between day 7 and 12.5 of development, expression was detected in the paraxial mesoderm, closely correlated with somitogenesis, and in subsets of cells in the nervous system. In adult animals, transcripts were detected in lung and heart. Dll1 expression in the paraxial mesoderm and nervous system is strikingly similar to the expression of mouse Notch1 during gastrulation and early organogenesis. The overlapping expression patterns of the Dll1 and Notch1 genes suggest that cells in these tissues can communicate by interaction of the Dll1 and Notch1 proteins. Our results support the idea that Delta- and Notch-like proteins are involved in cell-to-cell communication in mammalian embryos and suggest a role for these proteins in cellular interactions underlying somitogenesis and development of the nervous system.
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				Q. Ma, L. Sommer, P. Cserjesi, and D. J. Anderson Mash1 and neurogenin1 Expression Patterns Define Complementary Domains of Neuroepithelium in the Developing CNS and Are Correlated with Regions Expressing Notch Ligands J. Neurosci., May 15, 1997; 17(10): 3644 - 3652. [Abstract] [Full Text] [PDF]

				M.-C. Hernandez, P. J. Andres-Barquin, S. Martinez, A. Bulfone, J. L.R. Rubenstein, and M. A. Israel ENC-1: A Novel Mammalian Kelch-Related Gene Specifically Expressed in the Nervous System Encodes an Actin-Binding Protein J. Neurosci., May 1, 1997; 17(9): 3038 - 3051. [Abstract] [Full Text] [PDF]

				K. A. Moore, B. Pytowski, L. Witte, D. Hicklin, and I. R. Lemischka Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs PNAS, April 15, 1997; 94(8): 4011 - 4016. [Abstract] [Full Text] [PDF]

				Z.-Z. Bao and C. L. Cepko The Expression and Function of Notch Pathway Genes in the Developing Rat Eye J. Neurosci., February 15, 1997; 17(4): 1425 - 1434. [Abstract] [Full Text] [PDF]

				J. de Celis and S Bray Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing Development, January 9, 1997; 124(17): 3241 - 3251. [Abstract] [PDF]

				S. Dunwoodie, D Henrique, S. Harrison, and R. Beddington Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo Development, January 8, 1997; 124(16): 3065 - 3076. [Abstract] [PDF]

				S. Johnston, C Rauskolb, R Wilson, B Prabhakaran, K. Irvine, and T. Vogt A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway Development, January 6, 1997; 124(11): 2245 - 2254. [Abstract] [PDF]

				T. Mitsiadis, D Henrique, I Thesleff, and U Lendahl Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4 Development, January 4, 1997; 124(8): 1473 - 1483. [Abstract] [PDF]

				J. de la Pompa, A Wakeham, K. Correia, E Samper, S Brown, R. Aguilera, T Nakano, T Honjo, T. Mak, J Rossant, et al. Conservation of the Notch signalling pathway in mammalian neurogenesis Development, January 3, 1997; 124(6): 1139 - 1148. [Abstract] [PDF]

				W. Jen, D Wettstein, D Turner, A Chitnis, and C Kintner The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos Development, January 3, 1997; 124(6): 1169 - 1178. [Abstract] [PDF]

				Y. Jiang, M Brand, C. Heisenberg, D Beuchle, M Furutani-Seiki, R. Kelsh, R. Warga, M Granato, P Haffter, M Hammerschmidt, et al. Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 205 - 216. [Abstract] [PDF]

				K. Shimizu, S. Chiba, T. Saito, K. Kumano, T. Takahashi, and H. Hirai Manic Fringe and Lunatic Fringe Modify Different Sites of the Notch2 Extracellular Region, Resulting in Different Signaling Modulation J. Biol. Chem., July 6, 2001; 276(28): 25753 - 25758. [Abstract] [Full Text] [PDF]