|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 8 2681-2693, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
S Heller, TP Finn, J Huber, R Nishi, M Geissen, AW Puschel and H Rohrer
Max-Planck-Institut fur Hirnforschung, Abt. Neurochemie, Frankfurt/M., Germany.
Growth promoting activity (GPA) is a chick growth factor with low homology to mammalian ciliary neurotrophic factor (CNTF) (47% sequence identity with rat CNTF) but displays similar biological effects on neuronal development. We have isolated a chick cDNA coding for GPA receptor (GPAR alpha), a GPI-anchored protein that is 70% identical to hCNTFR alpha. Functional analysis revealed that GPAR alpha mediates several biological effects of both GPA and CNTF. Soluble GPAR alpha supports GPA- and CNTF-dependent survival of human TF-1 cells. In sympathetic neurons, GPAR alpha mediates effects of both GPA and CNTF on the expression of vasoactive intestinal peptide (VIP) as shown by the inhibition of GPA- and CNTF-mediated VIP induction upon GPAR alpha antisense RNA expression. These results demonstrate that GPAR alpha is able to mediate effects of two neurokines that are only distantly related. GPAR alpha mRNA expression is largely restricted to the nervous system and was detected in all neurons that have been shown to respond to GPA or CNTF by increased survival or differentiation, i.e. ciliary, sympathetic, sensory dorsal root, motoneurons, retinal ganglion cells and amacrine cells. Interestingly, GPAR alpha mRNA was additionally found in neuronal populations and at developmental periods not known to be influenced by GPA or CNTF, suggesting novel functions for GPAR alpha and its ligands during neurogenesis and neuron differentiation.
This article has been cited by other articles:
|
|
 |
|
  T. W. Gould and R. W. Oppenheim The Function of Neurotrophic Factor Receptors Expressed by the Developing Adductor Motor Pool In Vivo J. Neurosci., May 12, 2004; 24(19): 4668 - 4682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Schulz-Key, H.-D. Hofmann, C. Beisenherz-Huss, C. Barbisch, and M. Kirsch Ciliary Neurotrophic Factor as a Transient Negative Regulator of Rod Development in Rat Retina Invest. Ophthalmol. Vis. Sci., September 1, 2002; 43(9): 3099 - 3108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Stanke, D Junghans, M Geissen, C Goridis, U Ernsberger, and H Rohrer The Phox2 homeodomain proteins are sufficient to promote the development of sympathetic neurons Development, January 9, 1999; 126(18): 4087 - 4094. [Abstract] [PDF]
|
|
|
|
|
|
K. Krieglstein, P. Henheik, L. Farkas, J. Jaszai, D. Galter, K. Krohn, and K. Unsicker Glial Cell Line-Derived Neurotrophic Factor Requires Transforming Growth Factor-beta for Exerting Its Full Neurotrophic Potential on Peripheral and CNS Neurons J. Neurosci., December 1, 1998; 18(23): 9822 - 9834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang and S. W. Halvorsen Reciprocal Regulation of Ciliary Neurotrophic Factor Receptors and Acetylcholine Receptors during Synaptogenesis in Embryonic Chick Atria J. Neurosci., September 15, 1998; 18(18): 7372 - 7380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Geissen, S Heller, D Pennica, U Ernsberger, and H Rohrer The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling Development, January 12, 1998; 125(23): 4791 - 4801. [Abstract] [PDF]
|
|
|
|
 |
|
 M. A. Wishingrad, S. Koshlukova, and S. W. Halvorsen Ciliary Neurotrophic Factor Stimulates the Phosphorylation of Two Forms of STAT3 in Chick Ciliary Ganglion Neurons J. Biol. Chem., August 8, 1997; 272(32): 19752 - 19757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B Pain, M. Clark, M Shen, H Nakazawa, M Sakurai, J Samarut, and R. Etches Long-term in vitro culture and characterisation of avian embryonic stem cells with multiple morphogenetic potentialities Development, January 8, 1996; 122(8): 2339 - 2348. [Abstract] [PDF]
|
|
