|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 9 2767-2777, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
JL Villano and FN Katz
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235-9038, USA.
Genes capable of translating positional information into regulated growth lie at the heart of morphogenesis, yet few genes with this function have been identified. Mutants in the Drosophila four-jointed (fj) gene show reduced growth and altered differentiation only within restricted sectors of the proximal-distal (PD) axis in the leg and wing, thus fj is a candidate for a gene with this coordination function. Consistent with a position-sensitive role, we show that fj is expressed in a regional pattern in the developing leg, wing, eye and optic lobe. The fj gene encodes a novel type II membrane glycoprotein. When the cDNA is translated in an in vitro translation system in the presence of exogenous microsomal membranes, the intralumenal portion of some of the molecules is cleaved, yielding a secreted C-terminal fragment. We propose that fj encodes a secreted signal that functions as a positive regulator of regional growth and differentiation along the PD axis of the imaginal discs.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Strutt Gradients and the Specification of Planar Polarity in the Insect Cuticle Cold Spring Harb Perspect Biol, November 1, 2009; 1(5): a000489 - a000489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Mao, B. Kucuk, and K. D. Irvine Drosophila lowfat, a novel modulator of Fat signaling Development, October 1, 2009; 136(19): 3223 - 3233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Willecke, F. Hamaratoglu, L. Sansores-Garcia, C. Tao, and G. Halder From the Cover: Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation PNAS, September 30, 2008; 105(39): 14897 - 14902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. V. V. G. Reddy and K. D. Irvine The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation Development, September 1, 2008; 135(17): 2827 - 2838. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. O. Ishikawa, H. Takeuchi, R. S. Haltiwanger, and K. D. Irvine Four-jointed Is a Golgi Kinase That Phosphorylates a Subset of Cadherin Domains Science, July 18, 2008; 321(5887): 401 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Mao, C. Rauskolb, E. Cho, W.-L. Hu, H. Hayter, G. Minihan, F. N. Katz, and K. D. Irvine Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila Development, July 1, 2006; 133(13): 2539 - 2551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matakatsu and S. S. Blair Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins Development, June 15, 2006; 133(12): 2315 - 2324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tanoue and M. Takeichi New insights into Fat cadherins J. Cell Sci., June 1, 2005; 118(11): 2347 - 2353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cho and K. D. Irvine Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling Development, September 15, 2004; 131(18): 4489 - 4500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matakatsu and S. S. Blair Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing Development, August 1, 2004; 131(15): 3785 - 3794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Rodriguez The dachsous gene, a member of the cadherin family, is required for Wg-dependent pattern formation in the Drosophila wing disc Development, July 1, 2004; 131(13): 3195 - 3206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Strutt, J. Mundy, K. Hofstra, and D. Strutt Cleavage and secretion is not required for Four-jointed function in Drosophila patterning Development, February 15, 2004; 131(4): 881 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Strutt Frizzled signalling and cell polarisation in Drosophila and vertebrates Development, October 1, 2003; 130(19): 4501 - 4513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kolzer, B. Fuss, M. Hoch, and T. Klein defective proventriculus is required for pattern formation along the proximodistal axis, cell proliferation and formation of veins in the Drosophila wing Development, September 1, 2003; 130(17): 4135 - 4147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fanto, L. Clayton, J. Meredith, K. Hardiman, B. Charroux, S. Kerridge, and H. McNeill The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor Development, February 15, 2003; 130(4): 763 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. R. Buckles, C. Rauskolb, J. L. Villano, and F. N. Katz four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg Development, September 15, 2001; 128(18): 3533 - 3542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Casares and R. S. Mann The Ground State of the Ventral Appendage in Drosophila Science, August 24, 2001; 293(5534): 1477 - 1480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Casares and R. Mann A dual role for homothorax in inhibiting wing blade development and specifying proximal wing identities in Drosophila Development, January 4, 2000; 127(7): 1499 - 1508. [Abstract] [PDF]
|
|
|
|
|
|
S. Bishop, T Klein, A. Arias, and J. Couso Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch Development, January 7, 1999; 126(13): 2993 - 3003. [Abstract] [PDF]
|
|
|
|
|
|
V. Papayannopoulos, A. Tomlinson, V. M. Panin, C. Rauskolb, and K. D. Irvine Dorsal-Ventral Signaling in the Drosophila Eye Science, September 25, 1998; 281(5385): 2031 - 2034. [Abstract] [Full Text]
|
|
|
|
 |
|
 O. Saget, F. Forquignon, P. Santamaria, and N. B. Randsholt Needs and Targets for the multi sex combs Gene Product in Drosophila melanogaster Genetics, August 1, 1998; 149(4): 1823 - 1838. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H McNeill, C H Yang, M Brodsky, J Ungos, and M A Simon mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye. Genes & Dev., April 15, 1997; 11(8): 1073 - 1082. [Abstract] [PDF]
|
|
