|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 9 3099-3110, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
P Ataliotis, K Symes, MM Chou, L Ho and M Mercola
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
During Xenopus gastrulation, platelet-derived growth factor (PDGF) receptor-alpha is expressed in involuting marginal zone cells which migrate over ectodermal cells expressing PDGF-A. To investigate the role of PDGF signalling during this process, we have generated a novel point mutant of PDGF receptor-alpha analogous to the W37 mutation of c-kit. This molecule is a specific, potent, dominant inhibitor of PDGF signalling in vivo. Injection of RNA encoding this protein into Xenopus embryos prevents closure of the blastopore, leads to abnormal gastrulation and a loss of anterior structures. Convergent extension is not inhibited in these embryos, but rather, involuting mesodermal cells fail to adhere to the overlying ectoderm. PDGF may therefore be required for mesodermal cell-substratum interaction.
This article has been cited by other articles:
|
|
 |
|
  J. Andrae, R. Gallini, and C. Betsholtz Role of platelet-derived growth factors in physiology and medicine Genes & Dev., May 15, 2008; 22(10): 1276 - 1312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Liu, A. Sato, D. Khadka, R. Bharti, H. Diaz, L. W. Runnels, and R. Habas Mechanism of activation of the Formin protein Daam1 PNAS, January 8, 2008; 105(1): 210 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Van Stry, A. Kazlauskas, S. L. Schreiber, and K. Symes Distinct effectors of platelet-derived growth factor receptor-{alpha} signaling are required for cell survival during embryogenesis PNAS, June 7, 2005; 102(23): 8233 - 8238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-A. Montero, L. Carvalho, M. Wilsch-Brauninger, B. Kilian, C. Mustafa, and C.-P. Heisenberg Shield formation at the onset of zebrafish gastrulation Development, March 15, 2005; 132(6): 1187 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nagel, E. Tahinci, K. Symes, and R. Winklbauer Guidance of mesoderm cell migration in the Xenopus gastrula requires PDGF signaling Development, June 1, 2004; 131(11): 2727 - 2736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. V. Hoch and P. Soriano Roles of PDGF in animal development Development, October 15, 2003; 130(20): 4769 - 4784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Meyer, V. Dayanir, F. Majnoun, and N. Rahimi The Presence of a Single Tyrosine Residue at the Carboxyl Domain of Vascular Endothelial Growth Factor Receptor-2/FLK-1 Regulates Its Autophosphorylation and Activation of Signaling Molecules J. Biol. Chem., July 19, 2002; 277(30): 27081 - 27087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Park, N. Warner, K. Mood, T. Pawson, and I. O. Daar Low-Molecular-Weight Protein Tyrosine Phosphatase Is a Positive Component of the Fibroblast Growth Factor Receptor Signaling Pathway Mol. Cell. Biol., May 15, 2002; 22(10): 3404 - 3414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schohl and F. Fagotto {beta}-catenin, MAPK and Smad signaling during early Xenopus development Development, January 1, 2002; 129(1): 37 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Carballada, H Yasuo, and P Lemaire Phosphatidylinositol-3 kinase acts in parallel to the ERK MAP kinase in the FGF pathway during Xenopus mesoderm induction Development, January 1, 2001; 128(1): 35 - 44. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Ikuno, F.-L. Leong, and A. Kazlauskas Attenuation of Experimental Proliferative Vitreoretinopathy by Inhibiting the Platelet-Derived Growth Factor Receptor Invest. Ophthalmol. Vis. Sci., September 1, 2000; 41(10): 3107 - 3116. [Abstract] [Full Text]
|
|
|
|
|
|
L. D. Chong, E. K. Park, E. Latimer, R. Friesel, and I. O. Daar Fibroblast Growth Factor Receptor-Mediated Rescue of x-Ephrin B1-Induced Cell Dissociation in Xenopus Embryos Mol. Cell. Biol., January 15, 2000; 20(2): 724 - 734. [Abstract] [Full Text]
|
|
|
|
 |
|
 C.-H. Heldin and B. Westermark Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor Physiol Rev, October 1, 1999; 79(4): 1283 - 1316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Hirschi, S. A. Rohovsky, L. H. Beck, S. R. Smith, and P. A. D'Amore Endothelial Cells Modulate the Proliferation of Mural Cell Precursors via Platelet-Derived Growth Factor-BB and Heterotypic Cell Contact Circ. Res., February 19, 1999; 84(3): 298 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Wunnenberg-Stapleton, I. Blitz, C Hashimoto, and K. Cho Involvement of the small GTPases XRhoA and XRnd1 in cell adhesion and head formation in early Xenopus development Development, January 12, 1999; 126(23): 5339 - 5351. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Damjanovski, X. Karp, S. Funk, E. H. Sage, and M. J. Ringuette Ectopic Expression of SPARC in Xenopus Embryos Interferes with Tissue Morphogenesis: Identification of a Bioactive Sequence in the C-terminal EF Hand J. Histochem. Cytochem., May 1, 1997; 45(5): 643 - 656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tanaka, W. Lu, R. Gupta, and B. J. Mayer Expression of mutated Nck SH2/SH3 adaptor respecifies mesodermal cell fate in Xenopus laevis development PNAS, April 29, 1997; 94(9): 4493 - 4498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P Lindahl, L Karlsson, M Hellstrom, S Gebre-Medhin, K Willetts, J. Heath, and C Betsholtz Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development Development, January 10, 1997; 124(20): 3943 - 3953. [Abstract] [PDF]
|
|
|
|
|
|
P Soriano The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites Development, January 7, 1997; 124(14): 2691 - 2700. [Abstract] [PDF]
|
|
|
|
|
|
C. E. Adler, T. Miyoshi-Akiyama, L. M. Aleman, M. Tanaka, J. M. Smith, and B. J. Mayer Abl Family Kinases and Cbl Cooperate with the Nck Adaptor to Modulate Xenopus Development J. Biol. Chem., November 10, 2000; 275(46): 36472 - 36478. [Abstract] [Full Text] [PDF]
|
|
