Development, Vol 122, Issue 1 151-160, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion

PJ Gage, ML Roller, TL Saunders, LM Scarlett and SA Camper
Department of Human Genetics, University of Michigan Medical School, Medical Science II M3816, Ann Arbor 48109-0618, USA.

The Ames dwarf mouse transmits a recessive mutation (df) resulting in a profound anterior pituitary hypocellularity due to a general lack of thyrotropes, somatotropes and lactotropes. These cell types are also dependent on the pituitary-specific transcription factor, Pit-1. We present evidence that expression of Pit-1 and limited commitment to these cells lineages occurs in df/df pituitaries. Thus, the crucial role of df may be in lineage-specific proliferation, rather than cytodifferentiation. The presence of all three Pit-1-dependent cell types in clonally derived clusters provides compelling evidence that these three lineages share a common, pluripotent precursor cell. Clusters containing different combinations of Pit-1-dependent cell types suggests that the Pit-1+ precursor cells choose from multiple developmental options during ontogeny. Characterization of df/df<-->+/+ chimeric mice demonstrated that df functions by a cell-autonomous mechanism. Therefore, df and Pit-1 are both cell-autonomous factors required for thyrotrope, somatotrope and lactotrope ontogeny, but their relative roles are different.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				D. Kelberman and M. T. Dattani Hypothalamic and pituitary development: novel insights into the aetiology Eur. J. Endocrinol., August 1, 2007; 157(suppl_1): S3 - S14. [Abstract] [Full Text] [PDF]

				L. T. Raetzman, B. S. Wheeler, S. A. Ross, P. Q. Thomas, and S. A. Camper Persistent Expression of Notch2 Delays Gonadotrope Differentiation Mol. Endocrinol., November 1, 2006; 20(11): 2898 - 2908. [Abstract] [Full Text] [PDF]

				R. D. Ward, B. M. Stone, L. T. Raetzman, and S. A. Camper Cell Proliferation and Vascularization in Mouse Models of Pituitary Hormone Deficiency Mol. Endocrinol., June 1, 2006; 20(6): 1378 - 1390. [Abstract] [Full Text] [PDF]

				C. J. Phelps Postnatal Regression of Hypothalamic Dopaminergic Neurons in Prolactin-Deficient Snell Dwarf Mice Endocrinology, December 1, 2004; 145(12): 5656 - 5664. [Abstract] [Full Text] [PDF]

				M. L. Brinkmeier, M. A. Potok, K. B. Cha, T. Gridley, S. Stifani, J. Meeldijk, H. Clevers, and S. A. Camper TCF and Groucho-Related Genes Influence Pituitary Growth and Development Mol. Endocrinol., November 1, 2003; 17(11): 2152 - 2161. [Abstract] [Full Text] [PDF]

				H. Suh, P. J. Gage, J. Drouin, and S. A. Camper Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification Development, March 3, 2003; 129(2): 329 - 337. [Abstract] [Full Text] [PDF]

				T. C. Vieira, M. R. Dias da Silva, J. M. Cerutti, E. Brunner, M. Borges, L. T. Arnaldi, P. Kopp, and J. Abucham Familial Combined Pituitary Hormone Deficiency due to a Novel Mutation R99Q in the Hot Spot Region of Prophet of Pit-1 Presenting as Constitutional Growth Delay J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 38 - 44. [Abstract] [Full Text] [PDF]

				L. E. Olson, J. S. Dasen, B. Gun Ju, J. Tollkuhn, and M. G. Rosenfeld Paired-like Repression/Activation in Pituitary Development Recent Prog. Horm. Res., January 1, 2003; 58(1): 249 - 261. [Abstract] [Full Text] [PDF]

				L. E. Olson and M. G. Rosenfeld Perspective: Genetic and Genomic Approaches in Elucidating Mechanisms of Pituitary Development Endocrinology, June 1, 2002; 143(6): 2007 - 2011. [Abstract] [Full Text] [PDF]

				L. J. Cushman, D. E. Watkins-Chow, M. L. Brinkmeier, L. T. Raetzman, A. L. Radak, R. V. Lloyd, and S. A. Camper Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility Hum. Mol. Genet., May 1, 2001; 10(11): 1141 - 1153. [Abstract] [Full Text] [PDF]

				Heritable Disorders of Pituitary Development J. Clin. Endocrinol. Metab., December 1, 1999; 84(12): 4362 - 4370. [Abstract] [Full Text]

				C. J. Phelps and D. L. Hurley Pituitary Hormones as Neurotrophic Signals: Update on Hypothalamic Differentiation in Genetic Models of Altered Feedback Experimental Biology and Medicine, October 2, 1999; 222(1): 39 - 58. [Abstract] [Full Text]

				C. Flück, J. Deladoey, K. Rutishauser, A. Eblé, U. Marti, W. Wu, and P. E. Mullis Phenotypic Variability in Familial Combined Pituitary Hormone Deficiency Caused by a PROP1 Gene Mutation Resulting in the Substitution of Arg->Cys at Codon 120 (R120C) J. Clin. Endocrinol. Metab., October 1, 1998; 83(10): 3727 - 3734. [Abstract] [Full Text]

				M. Treier, A. S. Gleiberman, S. M. O'Connell, D. P. Szeto, J. A. McMahon, A. P. McMahon, and M. G. Rosenfeld Multistep signaling requirements for pituitary organogenesis in vivo Genes & Dev., June 1, 1998; 12(11): 1691 - 1704. [Abstract] [Full Text]

				J. J. Tremblay, C. Lanctôt, and J. Drouin The pan-Pituitary Activator of Transcription, Ptx1 (Pituitary Homeobox 1), Acts in Synergy with SF-1 and Pit1 and Is an Upstream Regulator of the Lim-Homeodomain Gene Lim3/Lhx3 Mol. Endocrinol., March 1, 1998; 12(3): 428 - 441. [Abstract] [Full Text]

				A K Ryan and M G Rosenfeld POU domain family values: flexibility, partnerships, and developmental codes. Genes & Dev., May 15, 1997; 11(10): 1207 - 1225. [PDF]