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Development, Vol 122, Issue 1 161-171, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
P Heitzler, M Bourouis, L Ruel, C Carteret and P Simpson
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/ULP, ILLKIRCH, Strasbourg, France.
Like the neuroblasts of the central nervous system, sensory organ precursors of the peripheral nervous system of the Drosophila thorax arise as single spaced cells. However, groups of cells initially have neural potential as visualized by the expression of the proneural genes achaete and scute. A class of genes, known as the 'neurogenic genes', function to restrict the proportion of cells that differentiate as sensory organ precursors. They mediate cell communication between the competent cells by means of an inhibitory signal, Delta, that is transduced through the Notch receptor and results in a cessation of achaete-scute activity. Here we show that mutation of either the bHLH-encoding genes of the Enhancer of split complex (E(spl)-C) or groucho, like Notch or Delta mutants, cause an overproduction of sensory organ precursors at the expense of epidermis. The mutant cells behave antonomously suggesting that the corresponding gene products are required for reception of the inhibitory signal. Epistasis experiments place both E(spl)-C bHLH-encoding genes and groucho downstream of Notch and upstream of achaete and scute, consistent with the idea that they are part of the Notch signalling cascade. Since all competent cells produce both the receptor and its ligand, it was postulated that Notch and Delta are linked within each cell by a feedback loop. We show, that, like mutant Notch cells, cells mutant for E(spl)-C bHLH-encoding genes or groucho inhibit neighbouring wild-type cells causing them to adopt the epidermal fate. This inhibition requires the genes of the achaete-scute complex (AS-C) which must therefore regulate the signal Delta. Thus there is a regulatory loop between Notch and Delta that is under the transcriptional control of the E(spl)-C and AS-C genes.
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A Majumdar, R Nagaraj, and U Banerjee strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila. Genes & Dev., May 15, 1997; 11(10): 1341 - 1353. [Abstract] [PDF]
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D Doherty, L. Jan, and Y. Jan The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta Development, January 10, 1997; 124(19): 3881 - 3893. [Abstract] [PDF]
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J. de Celis and S Bray Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing Development, January 9, 1997; 124(17): 3241 - 3251. [Abstract] [PDF]
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A Pflugrad, J. Meir, T. Barnes, and D. Miller The Groucho-like transcription factor UNC-37 functions with the neural specificity gene unc-4 to govern motor neuron identity in C. elegans Development, January 5, 1997; 124(9): 1699 - 1709. [Abstract] [PDF]
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L Seugnet, P Simpson, and M Haenlin Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila Development, January 5, 1997; 124(10): 2015 - 2025. [Abstract] [PDF]
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B Grant and I Greenwald Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans Development, January 2, 1997; 124(3): 637 - 644. [Abstract] [PDF]
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D. Wettstein, D. Turner, and C Kintner The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis Development, January 2, 1997; 124(3): 693 - 702. [Abstract] [PDF]
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C Shawber, D Nofziger, J. Hsieh, C Lindsell, O Bogler, D Hayward, and G Weinmaster Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway Development, January 12, 1996; 122(12): 3765 - 3773. [Abstract] [PDF]
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J. de Celis, J de Celis, P Ligoxygakis, A Preiss, C Delidakis, and S Bray Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development Development, January 9, 1996; 122(9): 2719 - 2728. [Abstract] [PDF]
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K. W. McLarren, F. M. Theriault, and S. Stifani Association with the Nuclear Matrix and Interaction with Groucho and RUNX Proteins Regulate the Transcription Repression Activity of the Basic Helix Loop Helix Factor Hes1 J. Biol. Chem., January 5, 2001; 276(2): 1578 - 1584. [Abstract] [Full Text] [PDF]
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