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Development, Vol 122, Issue 1 243-252, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
SL Ang, O Jin, M Rhinn, N Daigle, L Stevenson and J Rossant
Institute de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/Universite Louis Pasteur, Illkirch, C.U. de Strasbourg, France.
Mouse Otx2 is a bicoid-class homeobox gene, related to the Drosophila orthodenticle (otd) gene. Expression of this gene is initially widespread in the epiblast at embryonic day 5.5 but becomes progressively restricted to the anterior end of the embryo at the headfold stage. In flies, loss of function mutations in otd result in deletion of pre-antennal and antennal segments; which leads to the absence of head structures derived from these segments. To study the function of Otx2 in mice, we have generated a homeobox deletion mutation in this gene. Mice homozygous for this mutation show severe defects in gastrulation and in formation of axial mesoderm and loss of anterior neural tissues. These results demonstrate that Otx2 is required for proper development of the epiblast and patterning of the anterior brain in mice, and supports the idea of evolutionary conservation of the function of Otd/Otx genes in head development in flies and mice.
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F Ristoratore, M Carl, K Deschet, L Richard-Parpaillon, D Boujard, J Wittbrodt, D Chourrout, F Bourrat, and J. Joly The midbrain-hindbrain boundary genetic cascade is activated ectopically in the diencephalon in response to the widespread expression of one of its components, the medaka gene Ol-eng2 Development, January 9, 1999; 126(17): 3769 - 3779. [Abstract] [PDF] |
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D Arendt and K Nubler-Jung Comparison of early nerve cord development in insects and vertebrates Development, January 6, 1999; 126(11): 2309 - 2325. [Abstract] [PDF] |
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H Morsli, F Tuorto, D Choo, M. Postiglione, A Simeone, and D. Wu Otx1 and Otx2 activities are required for the normal development of the mouse inner ear Development, January 6, 1999; 126(11): 2335 - 2343. [Abstract] [PDF] |
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M Epstein, G Pillemer, R Yelin, J. Yisraeli, and A Fainsod Patterning of the embryo along the anterior-posterior axis: the role of the caudal genes Development, January 10, 1997; 124(19): 3805 - 3814. [Abstract] [PDF] |
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C Kimura, N Takeda, M Suzuki, M Oshimura, S Aizawa, and I Matsuo Cis-acting elements conserved between mouse and pufferfish Otx2 genes govern the expression in mesencephalic neural crest cells Development, January 10, 1997; 124(20): 3929 - 3941. [Abstract] [PDF] |
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P. Thomas, J.M. Brickman, H. Poopperl, R. Krumlauf, and R.S.P. Beddington Axis Duplication and Anterior Identity in the Mouse Embryo Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 115 - 125. [Abstract] [PDF] |
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M. Wakamiya, J.A. Rivera-Perez, A. Baldini, and R.R. Behringer Goosecoid and Goosecoid-related Genes in Mouse Embryogenesis Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 145 - 149. [Abstract] [PDF] |
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D.H. Rowitch, P.S. Danielian, S.M.K. Lee, Y. Echelard, and A.P. McMahon Cell Interactions in Patterning the Mammalian Midbrain Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 535 - 544. [Abstract] [PDF] |
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I. Matsuo, Y. Suda, M. Yoshida, T. Ueki, C. Kimura, S. Kuratani, and S. Aizawa Otx and Emx Functions in Patterning of the Vertebrate Rostral Head Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 545 - 553. [Abstract] [PDF] |
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M Yoshida, Y Suda, I Matsuo, N Miyamoto, N Takeda, S Kuratani, and S Aizawa Emx1 and Emx2 functions in development of dorsal telencephalon Development, January 1, 1997; 124(1): 101 - 111. [Abstract] [PDF] |
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A. Schier, S. Neuhauss, K. Helde, W. Talbot, and W Driever The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail Development, January 1, 1997; 124(2): 327 - 342. [Abstract] [PDF] |
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L. Gammill and H Sive Identification of otx2 target genes and restrictions in ectodermal competence during Xenopus cement gland formation Development, January 1, 1997; 124(2): 471 - 481. [Abstract] [PDF] |
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S Millet, E Bloch-Gallego, A Simeone, and R. Alvarado-Mallart The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic grafts Development, January 12, 1996; 122(12): 3785 - 3797. [Abstract] [PDF] |
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