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Development, Vol 122, Issue 1 243-252, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
SL Ang, O Jin, M Rhinn, N Daigle, L Stevenson and J Rossant
Institute de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/Universite Louis Pasteur, Illkirch, C.U. de Strasbourg, France.
Mouse Otx2 is a bicoid-class homeobox gene, related to the Drosophila orthodenticle (otd) gene. Expression of this gene is initially widespread in the epiblast at embryonic day 5.5 but becomes progressively restricted to the anterior end of the embryo at the headfold stage. In flies, loss of function mutations in otd result in deletion of pre-antennal and antennal segments; which leads to the absence of head structures derived from these segments. To study the function of Otx2 in mice, we have generated a homeobox deletion mutation in this gene. Mice homozygous for this mutation show severe defects in gastrulation and in formation of axial mesoderm and loss of anterior neural tissues. These results demonstrate that Otx2 is required for proper development of the epiblast and patterning of the anterior brain in mice, and supports the idea of evolutionary conservation of the function of Otd/Otx genes in head development in flies and mice.
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D Acampora, V Avantaggiato, F Tuorto, and A Simeone Genetic control of brain morphogenesis through Otx gene dosage requirement Development, January 9, 1997; 124(18): 3639 - 3650. [Abstract] [PDF]
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M. Fan and S. Sokol A role for Siamois in Spemann organizer formation Development, January 7, 1997; 124(13): 2581 - 2589. [Abstract] [PDF]
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C Lanctot, B Lamolet, and J Drouin The bicoid-related homeoprotein Ptx1 defines the most anterior domain of the embryo and differentiates posterior from anterior lateral mesoderm Development, January 7, 1997; 124(14): 2807 - 2817. [Abstract] [PDF]
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S Filosa, J. Rivera-Perez, A. Gomez, A Gansmuller, H Sasaki, R. Behringer, and S. Ang Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis Development, January 7, 1997; 124(14): 2843 - 2854. [Abstract] [PDF]
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M Andreazzoli, M Pannese, and E Boncinelli Activating and repressing signals in head development: the role of Xotx1 and Xotx2 Development, January 5, 1997; 124(9): 1733 - 1743. [Abstract] [PDF]
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P. Labosky, G. Winnier, T. Jetton, L Hargett, A. Ryan, M. Rosenfeld, A. Parlow, and B. Hogan The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex Development, January 4, 1997; 124(7): 1263 - 1274. [Abstract] [PDF]
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L Lemaire, T Roeser, J. Izpisua-Belmonte, and M Kessel Segregating expression domains of two goosecoid genes during the transition from gastrulation to neurulation in chick embryos Development, January 4, 1997; 124(8): 1443 - 1452. [Abstract] [PDF]
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I Varlet, J Collignon, and E. Robertson nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation Development, January 3, 1997; 124(5): 1033 - 1044. [Abstract] [PDF]
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 P. Thomas, J.M. Brickman, H. Poopperl, R. Krumlauf, and R.S.P. Beddington Axis Duplication and Anterior Identity in the Mouse Embryo Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 115 - 125. [Abstract] [PDF]
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M. Wakamiya, J.A. Rivera-Perez, A. Baldini, and R.R. Behringer Goosecoid and Goosecoid-related Genes in Mouse Embryogenesis Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 145 - 149. [Abstract] [PDF]
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D.H. Rowitch, P.S. Danielian, S.M.K. Lee, Y. Echelard, and A.P. McMahon Cell Interactions in Patterning the Mammalian Midbrain Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 535 - 544. [Abstract] [PDF]
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I. Matsuo, Y. Suda, M. Yoshida, T. Ueki, C. Kimura, S. Kuratani, and S. Aizawa Otx and Emx Functions in Patterning of the Vertebrate Rostral Head Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 545 - 553. [Abstract] [PDF]
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M Yoshida, Y Suda, I Matsuo, N Miyamoto, N Takeda, S Kuratani, and S Aizawa Emx1 and Emx2 functions in development of dorsal telencephalon Development, January 1, 1997; 124(1): 101 - 111. [Abstract] [PDF]
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A. Schier, S. Neuhauss, K. Helde, W. Talbot, and W Driever The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail Development, January 1, 1997; 124(2): 327 - 342. [Abstract] [PDF]
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L. Gammill and H Sive Identification of otx2 target genes and restrictions in ectodermal competence during Xenopus cement gland formation Development, January 1, 1997; 124(2): 471 - 481. [Abstract] [PDF]
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S Millet, E Bloch-Gallego, A Simeone, and R. Alvarado-Mallart The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic grafts Development, January 12, 1996; 122(12): 3785 - 3797. [Abstract] [PDF]
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