spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ang, S. L.
Right arrow Articles by Rossant, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ang, S. L.
Right arrow Articles by Rossant, J.

Development, Vol 122, Issue 1 243-252, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain

SL Ang, O Jin, M Rhinn, N Daigle, L Stevenson and J Rossant
Institute de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/Universite Louis Pasteur, Illkirch, C.U. de Strasbourg, France.

Mouse Otx2 is a bicoid-class homeobox gene, related to the Drosophila orthodenticle (otd) gene. Expression of this gene is initially widespread in the epiblast at embryonic day 5.5 but becomes progressively restricted to the anterior end of the embryo at the headfold stage. In flies, loss of function mutations in otd result in deletion of pre-antennal and antennal segments; which leads to the absence of head structures derived from these segments. To study the function of Otx2 in mice, we have generated a homeobox deletion mutation in this gene. Mice homozygous for this mutation show severe defects in gastrulation and in formation of axial mesoderm and loss of anterior neural tissues. These results demonstrate that Otx2 is required for proper development of the epiblast and patterning of the anterior brain in mice, and supports the idea of evolutionary conservation of the function of Otd/Otx genes in head development in flies and mice.


This article has been cited by other articles:


Home page
 DevelopmentHome page
S. L. Lewis, P.-L. Khoo, R. A. De Young, K. Steiner, C. Wilcock, M. Mukhopadhyay, H. Westphal, R. V. Jamieson, L. Robb, and P. P. L. Tam
Dkk1 and Wnt3 interact to control head morphogenesis in the mouse
Development, May 15, 2008; 135(10): 1791 - 1801.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
N. Parashurama, Y. Nahmias, C. H. Cho, D. van Poll, A. W. Tilles, F. Berthiaume, and M. L. Yarmush
Activin Alters the Kinetics of Endoderm Induction in Embryonic Stem Cells Cultured on Collagen Gels
Stem Cells, February 1, 2008; 26(2): 474 - 484.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Koike, A. Nishida, S. Ueno, H. Saito, R. Sanuki, S. Sato, A. Furukawa, S. Aizawa, I. Matsuo, N. Suzuki, et al.
Functional Roles of Otx2 Transcription Factor in Postnatal Mouse Retinal Development
Mol. Cell. Biol., December 1, 2007; 27(23): 8318 - 8329.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. Zhou, H. Chipperfield, D. A. Melton, and W. H. Wong
A gene regulatory network in mouse embryonic stem cells
PNAS, October 16, 2007; 104(42): 16438 - 16443.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H. H. Kim, A. Wolfe, R. N. Cohen, S. C. Eames, A. L. Johnson, C. N. Wieland, and S. Radovick
In Vivo Identification of a 107-Base Pair Promoter Element Mediating Neuron-Specific Expression of Mouse Gonadotropin-Releasing Hormone
Mol. Endocrinol., February 1, 2007; 21(2): 457 - 471.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Kurokawa, Y. Sakurai, A. Inoue, R. Nakayama, N. Takasaki, Y. Suda, T. Miyake, C. T. Amemiya, and S. Aizawa
Evolutionary constraint on Otx2 neuroectoderm enhancers-deep conservation from skate to mouse and unique divergence in teleost
PNAS, December 19, 2006; 103(51): 19350 - 19355.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Enkhmandakh, A. V. Makeyev, and D. Bayarsaihan
The role of the proline-rich domain of Ssdp1 in the modular architecture of the vertebrate head organizer
PNAS, August 1, 2006; 103(31): 11631 - 11636.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Z. Lin, R. Cantos, M. Patente, and D. K. Wu
Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling
Development, May 15, 2005; 132(10): 2309 - 2318.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. Vernay, M. Koch, F. Vaccarino, J. Briscoe, A. Simeone, R. Kageyama, and S.-L. Ang
Otx2 Regulates Subtype Specification and Neurogenesis in the Midbrain
J. Neurosci., May 11, 2005; 25(19): 4856 - 4867.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
I. Oda-Ishii, V. Bertrand, I. Matsuo, P. Lemaire, and H. Saiga
Making very similar embryos with divergent genomes: conservation of regulatory mechanisms of Otx between the ascidians Halocynthia roretzi and Ciona intestinalis
Development, April 1, 2005; 132(7): 1663 - 1674.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
T. Akagi, M. Mandai, S. Ooto, Y. Hirami, F. Osakada, R. Kageyama, N. Yoshimura, and M. Takahashi
Otx2 Homeobox Gene Induces Photoreceptor-Specific Phenotypes in Cells Derived from Adult Iris and Ciliary Tissue
Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4570 - 4575.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Ohtoshi and R. R. Behringer
Neonatal Lethality, Dwarfism, and Abnormal Brain Development in Dmbx1 Mutant Mice
Mol. Cell. Biol., September 1, 2004; 24(17): 7548 - 7558.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Kurokawa, N. Takasaki, H. Kiyonari, R. Nakayama, C. Kimura-Yoshida, I. Matsuo, and S. Aizawa
Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm
Development, July 15, 2004; 131(14): 3307 - 3317.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. Gao, H. Y. Shi, C. Daughty, N. Cella, and M. Zhang
Maspin plays an essential role in early embryonic development
Development, April 1, 2004; 131(7): 1479 - 1489.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Kimura-Yoshida, K. Kitajima, I. Oda-Ishii, E Tian, M. Suzuki, M. Yamamoto, T. Suzuki, M. Kobayashi, S. Aizawa, and I. Matsuo
Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification
Development, January 1, 2004; 131(1): 57 - 71.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. Hirth, L. Kammermeier, E. Frei, U. Walldorf, M. Noll, and H. Reichert
An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila
Development, June 1, 2003; 130(11): 2365 - 2373.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. Chen, Y. Liang, W. Deng, K. Shimizu, A. M. Ashique, E. Li, and Y.-P. Li
The zinc-finger protein CNBP is required for forebrain formation in the mouse
Development, April 1, 2003; 130(7): 1367 - 1379.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Hide, J. Hatakeyama, C. Kimura-Yoshida, E Tian, N. Takeda, Y. Ushio, T. Shiroishi, S. Aizawa, and I. Matsuo
Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice
Development, March 11, 2003; 129(18): 4347 - 4357.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Mukhopadhyay, A. Teufel, T. Yamashita, A. D. Agulnick, L. Chen, K. M. Downs, A. Schindler, A. Grinberg, S.-P. Huang, D. Dorward, et al.
Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation
Development, February 1, 2003; 130(3): 495 - 505.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. G. Kelley, M. L. Givens, N. Rave-Harel, S. B. Nelson, S. Anderson, and P. L. Mellon
Neuron-Restricted Expression of the Rat Gonadotropin-Releasing Hormone Gene Is Conferred by a Cell-Specific Protein Complex that Binds Repeated CAATT Elements
Mol. Endocrinol., November 1, 2002; 16(11): 2413 - 2425.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
A. Dohmoto, K. Shimizu, Y. Asada, and T. Maeda
Quantitative Trait Loci on Chromosomes 10 and 11 Influencing Mandible Size of SMXA RI Mouse Strains
J. Dent. Res., July 1, 2002; 81(7): 501 - 504.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Roberts, H. F. Sutherland, H. Farmer, W. Kimber, S. Halford, A. Carey, J. M. Brickman, A. Wynshaw-Boris, and P. J. Scambler
Targeted Mutagenesis of the Hira Gene Results in Gastrulation Defects and Patterning Abnormalities of Mesoendodermal Derivatives Prior to Early Embryonic Lethality
Mol. Cell. Biol., April 1, 2002; 22(7): 2318 - 2328.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. C. Wardle, D. H. Wainstock, and H. L. Sive
Cement gland-specific activation of the Xag1 promoter is regulated by co-operation of putative Ets and ATF/CREB transcription factors
Development, January 10, 2002; 129(19): 4387 - 4397.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Y. H. Li and A. L. Joyner
Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression
Development, December 15, 2001; 128(24): 4979 - 4991.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Acampora, P. P. Boyl, M. Signore, J. P. Martinez-Barbera, C. Ilengo, E. Puelles, A. Annino, H. Reichert, G. Corte, and A. Simeone
OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation
Development, December 1, 2001; 128(23): 4801 - 4813.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. D. Tremblay, N. R. Dunn, and E. J. Robertson
Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation
Development, September 15, 2001; 128(18): 3609 - 3621.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
P. P. Boyl, M. Signore, D. Acampora, J. P. Martinez-Barbera, C. Ilengo, A. Annino, G. Corte, and A. Simeone
Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR
Development, August 1, 2001; 128(15): 2989 - 3000.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. Yamamoto, C. Meno, Y. Sakai, H. Shiratori, K. Mochida, Y. Ikawa, Y. Saijoh, and H. Hamada
The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse
Genes & Dev., May 15, 2001; 15(10): 1242 - 1256.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
P. A. Hoodless, M. Pye, C. Chazaud, E. Labbé, L. Attisano, J. Rossant, and J. L. Wrana
FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse
Genes & Dev., May 15, 2001; 15(10): 1257 - 1271.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
A Perea-Gomez, K. Lawson, M Rhinn, L Zakin, P Brulet, S Mazan, and S. Ang
Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo
Development, January 3, 2001; 128(5): 753 - 765.
[Abstract] [PDF]

Home page
 DevelopmentHome page
B. Lake, R Ford, and K. Kao
Xrel3 is required for head development in Xenopus laevis
Development, January 1, 2001; 128(2): 263 - 273.
[Abstract] [PDF]

Home page
 J. Orthod.Home page
M. T. Cobourne
Construction for the Modern Head: current concepts in craniofacial development
J. Orthod., December 1, 2000; 27(4): 307 - 314.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Cantos, L. K. Cole, D. Acampora, A. Simeone, and D. K. Wu
Patterning of the mammalian cochlea
PNAS, October 24, 2000; 97(22): 11707 - 11713.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. B. Nelson, M. A. Lawson, C. G. Kelley, and P. L. Mellon
Neuron-Specific Expression of the Rat Gonadotropin-Releasing Hormone Gene Is Conferred by Interactions of a Defined Promoter Element with the Enhancer in GT1-7 Cells
Mol. Endocrinol., September 1, 2000; 14(9): 1509 - 1522.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
A. Foley, I Skromne, and C. Stern
Reconciling different models of forebrain induction and patterning: a dual role for the hypoblast
Development, January 9, 2000; 127(17): 3839 - 3854.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A Camus, B. Davidson, S Billiards, P Khoo, J. Rivera-Perez, M Wakamiya, R. Behringer, and P. Tam
The morphogenetic role of midline mesendoderm and ectoderm in the development of the forebrain and the midbrain of the mouse embryo
Development, January 5, 2000; 127(9): 1799 - 1813.
[Abstract] [PDF]

Home page
 DevelopmentHome page
K. Adams, J. Maida, J. Golden, and R. Riddle
The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer
Development, January 5, 2000; 127(9): 1857 - 1867.
[Abstract] [PDF]

Home page
 DevelopmentHome page
Y Watanabe and H Nakamura
Control of chick tectum territory along dorsoventral axis by Sonic hedgehog
Development, January 3, 2000; 127(5): 1131 - 1140.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
M. Hallonet, T. Hollemann, T. Pieler, and P. Gruss
Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system
Genes & Dev., December 1, 1999; 13(23): 3106 - 3114.
[Abstract] [Full Text]

Home page
 Cereb CortexHome page
Y. Hatanaka and E. G. Jones
Novel Genes Expressed in the Developing Medial Cortex
Cereb Cortex, September 1, 1999; 9(6): 577 - 585.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
E. Boncinelli
Review : Otx and Emx Homeobox Genes in Brain Development
Neuroscientist, May 1, 1999; 5(3): 164 - 172.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
F. Loosli, S. Winkler, and J. Wittbrodt
Six3 overexpression initiates the formation of ectopic retina
Genes & Dev., March 15, 1999; 13(6): 649 - 654.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
D. P. Szeto, C. Rodriguez-Esteban, A. K. Ryan, S. M. O'Connell, F. Liu, C. Kioussi, A. S. Gleiberman, J. C. Izpisúa-Belmonte, and M. G. Rosenfeld
Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development
Genes & Dev., February 15, 1999; 13(4): 484 - 494.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
A Liu, K Losos, and A. Joyner
FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate
Development, January 11, 1999; 126(21): 4827 - 4838.
[Abstract] [PDF]

Home page
 DevelopmentHome page
P. Tam and K. Steiner
Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo
Development, January 11, 1999; 126(22): 5171 - 5179.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M Rhinn, A Dierich, M Le Meur, and S Ang
Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain
Development, January 10, 1999; 126(19): 4295 - 4304.
[Abstract] [PDF]

Home page
 DevelopmentHome page
F Ristoratore, M Carl, K Deschet, L Richard-Parpaillon, D Boujard, J Wittbrodt, D Chourrout, F Bourrat, and J. Joly
The midbrain-hindbrain boundary genetic cascade is activated ectopically in the diencephalon in response to the widespread expression of one of its components, the medaka gene Ol-eng2
Development, January 9, 1999; 126(17): 3769 - 3779.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D Arendt and K Nubler-Jung
Comparison of early nerve cord development in insects and vertebrates
Development, January 6, 1999; 126(11): 2309 - 2325.
[Abstract] [PDF]

Home page
 DevelopmentHome page
H Morsli, F Tuorto, D Choo, M. Postiglione, A Simeone, and D. Wu
Otx1 and Otx2 activities are required for the normal development of the mouse inner ear
Development, January 6, 1999; 126(11): 2335 - 2343.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D Acampora, V Avantaggiato, F Tuorto, P Barone, M Perera, D Choo, D Wu, G Corte, and A Simeone
Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes
Development, January 4, 1999; 126(7): 1417 - 1426.
[Abstract] [PDF]

Home page
 DevelopmentHome page
K Fekany, Y Yamanaka, T Leung, H. Sirotkin, J Topczewski, M. Gates, M Hibi, A Renucci, D Stemple, A Radbill, et al.
The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures
Development, January 4, 1999; 126(7): 1427 - 1438.
[Abstract] [PDF]

Home page
 DevelopmentHome page
K Hentges, K Thompson, and A Peterson
The flat-top gene is required for the expansion and regionalization of the telencephalic primordium
Development, January 4, 1999; 126(8): 1601 - 1609.
[Abstract] [PDF]

Home page
 DevelopmentHome page
Y Suda, J Nakabayashi, I Matsuo, and S Aizawa
Functional equivalency between Otx2 and Otx1 in development of the rostral head
Development, January 2, 1999; 126(4): 743 - 757.
[Abstract] [PDF]

Home page
 DevelopmentHome page
H Knoetgen, C Viebahn, and M Kessel
Head induction in the chick by primitive endoderm of mammalian, but not avian origin
Development, January 2, 1999; 126(4): 815 - 825.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. E. Mead, Y. Zhou, K. D. Lustig, T. L. Huber, M. W. Kirschner, and L. I. Zon
Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins
PNAS, September 15, 1998; 95(19): 11251 - 11256.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. Shawlot, J. M. Deng, and R. R. Behringer
Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis
PNAS, May 26, 1998; 95(11): 6198 - 6203.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Guazzi, M. L. Pintonello, A. Vigano, and E. Boncinelli
Regulatory Interactions between the Human HOXB1, HOXB2, and HOXB3 Proteins and the Upstream Sequence of the Otx2 Gene in Embryonal Carcinoma Cells
J. Biol. Chem., May 1, 1998; 273(18): 11092 - 11099.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Nagao, S. Leuzinger, D. Acampora, A. Simeone, R. Finkelstein, H. Reichert, and K. Furukubo-Tokunaga
Developmental rescue of Drosophila cephalic defects by the human Otx genes
PNAS, March 31, 1998; 95(7): 3737 - 3742.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D Acampora, V Avantaggiato, F Tuorto, P Briata, G Corte, and A Simeone
Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation
Development, January 12, 1998; 125(24): 5091 - 5104.
[Abstract] [PDF]

Home page
 DevelopmentHome page
K. Ba-Charvet, Y von Boxberg, S Guazzi, E Boncinelli, and P Godement
A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain
Development, January 11, 1998; 125(21): 4273 - 4282.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D Dufort, L Schwartz, K Harpal, and J Rossant
The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis
Development, January 8, 1998; 125(16): 3015 - 3025.
[Abstract] [PDF]

Home page
 DevelopmentHome page
K Lun and M Brand
A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary
Development, January 8, 1998; 125(16): 3049 - 3062.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M Hallonet, T Hollemann, R Wehr, N. Jenkins, N. Copeland, T Pieler, and P Gruss
Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain
Development, January 7, 1998; 125(14): 2599 - 2610.
[Abstract] [PDF]