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Development, Vol 122, Issue 1 359-369, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
JF de Celis, A Garcia-Bellido and SJ Bray
Department of Genetics, University of Cambridge, UK.
The cells along the dorsoventral boundary of the Drosophila wing imaginal disc have distinctive properties and their specification requires Notch activity. Later in development, these cells will form the wing margin, where sensory organs and specialised trichomes appear in a characteristic pattern. We find that Notch is locally activated in these cells, as demonstrated by the restricted expression of the Enhancer of split proteins in dorsal and ventral cells abutting the D/V boundary throughout the third larval instar. Furthermore other genes identified by their involvement in Notch signaling during neurogenesis, such as Delta and Suppressor of Hairless, also participate in Notch function at the dorsoventral boundary. In addition, Serrate, a similar transmembrane protein to Delta, behaves as a ligand required in dorsal cells to activate Notch at the boundary. Notch gain-of-function alleles in which Notch activity is not restricted to the dorsoventral boundary cause miss-expression of cut and wingless and overgrowth of the disc, illustrating the importance of localised Notch activation for wing development.
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C Rodriguez-Esteban, J. Schwabe, J. Pena, D. Rincon-Limas, J Magallon, J Botas, and J. Belmonte Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth Development, January 10, 1998; 125(20): 3925 - 3934. [Abstract] [PDF]
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A Majumdar, R Nagaraj, and U Banerjee strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila. Genes & Dev., May 15, 1997; 11(10): 1341 - 1353. [Abstract] [PDF]
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S Sotillos, F Roch, and S Campuzano The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs Development, January 12, 1997; 124(23): 4769 - 4779. [Abstract] [PDF]
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J. de Celis and S Bray Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing Development, January 9, 1997; 124(17): 3241 - 3251. [Abstract] [PDF]
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D. Sherwood and D. McClay Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation Development, January 9, 1997; 124(17): 3363 - 3374. [Abstract] [PDF]
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N. Hukriede, Y Gu, and R. Fleming A dominant-negative form of Serrate acts as a general antagonist of Notch activation Development, January 9, 1997; 124(17): 3427 - 3437. [Abstract] [PDF]
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X Sun and S Artavanis-Tsakonas Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila Development, January 9, 1997; 124(17): 3439 - 3448. [Abstract] [PDF]
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S. Jackson and K Blochlinger cut interacts with Notch and protein kinase A to regulate egg chamber formation and to maintain germline cyst integrity during Drosophila oogenesis Development, January 9, 1997; 124(18): 3663 - 3672. [Abstract] [PDF]
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R. Fleming, Y Gu, and N. Hukriede Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc Development, January 8, 1997; 124(15): 2973 - 2981. [Abstract] [PDF]
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S. Johnston, C Rauskolb, R Wilson, B Prabhakaran, K. Irvine, and T. Vogt A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway Development, January 6, 1997; 124(11): 2245 - 2254. [Abstract] [PDF]
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J. de Celis, S Bray, and A Garcia-Bellido Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing Development, January 5, 1997; 124(10): 1919 - 1928. [Abstract] [PDF]
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C. Micchelli, E. Rulifson, and S. Blair The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate Development, January 4, 1997; 124(8): 1485 - 1495. [Abstract] [PDF]
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W. Jen, D Wettstein, D Turner, A Chitnis, and C Kintner The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos Development, January 3, 1997; 124(6): 1169 - 1178. [Abstract] [PDF]
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J L Gomez-Skarmeta and J Modolell araucan and caupolican provide a link between compartment subdivisions and patterning of sensory organs and veins in the Drosophila wing. Genes & Dev., November 15, 1996; 10(22): 2935 - 2945. [Abstract] [PDF]
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C. Neumann and S. Cohen A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing Development, January 11, 1996; 122(11): 3477 - 3485. [Abstract] [PDF]
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