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Development, Vol 122, Issue 10 2977-2986, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

H Zhang and A Bradley
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

To address the function of bone morphogenetic protein-2 (BMP2) in mammalian development, mice with a targeted deletion of the Bmp2 mature region were generated using embryonic stem cell technology. This mutation caused embryonic lethality when homozygous. Mutant embryos failed to close the proamniotic canal, which caused the malformation of the amnion/chorion. BMP2-deficient embryos also exhibited a defect in cardiac development, manifested by the abnormal development of the heart in the exocoelomic cavity. These defects are consistent with the expression of Bmp2 in the extraembryonic mesoderm cells and promyocardium. Thus BMP2 is a critical factor for both extraembryonic and embryonic development.
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T. Ueyama, H. Kasahara, T. Ishiwata, Q. Nie, and S. Izumo
Myocardin Expression Is Regulated by Nkx2.5, and Its Function Is Required for Cardiomyogenesis
Mol. Cell. Biol., December 15, 2003; 23(24): 9222 - 9232.
[Abstract] [Full Text] [PDF]

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 Endocr. Rev.Home page
B. C. J. van der Eerden, M. Karperien, and J. M. Wit
Systemic and Local Regulation of the Growth Plate
Endocr. Rev., December 1, 2003; 24(6): 782 - 801.
[Abstract] [Full Text] [PDF]

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 Physiol. Rev.Home page
A. F. M. MOORMAN and V. M. CHRISTOFFELS
Cardiac Chamber Formation: Development, Genes, and Evolution
Physiol Rev, October 1, 2003; 83(4): 1223 - 1267.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
M. Moser, O. Binder, Y. Wu, J. Aitsebaomo, R. Ren, C. Bode, V. L. Bautch, F. L. Conlon, and C. Patterson
BMPER, a Novel Endothelial Cell Precursor-Derived Protein, Antagonizes Bone Morphogenetic Protein Signaling and Endothelial Cell Differentiation
Mol. Cell. Biol., August 15, 2003; 23(16): 5664 - 5679.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
D. Bachiller, J. Klingensmith, N. Shneyder, U. Tran, R. Anderson, J. Rossant, and E. M. De Robertis
The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome
Development, August 1, 2003; 130(15): 3567 - 3578.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
M. C. Hu, T. D. Piscione, and N. D. Rosenblum
Elevated SMAD1/{beta}-catenin molecular complexes and renal medullary cystic dysplasia in ALK3 transgenic mice
Development, June 15, 2003; 130(12): 2753 - 2766.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
N. Ghosh-Choudhury, S. L. Abboud, L. Mahimainathan, B. Chandrasekar, and G. G. Choudhury
Phosphatidylinositol 3-Kinase Regulates Bone Morphogenetic Protein-2 (BMP-2)-induced Myocyte Enhancer Factor 2A-dependent Transcription of BMP-2 Gene in Cardiomyocyte Precursor Cells
J. Biol. Chem., June 6, 2003; 278(24): 21998 - 22005.
[Abstract] [Full Text] [PDF]

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 Cardiovasc ResHome page
M. J. Solloway and R. P. Harvey
Molecular pathways in myocardial development: a stem cell perspective
Cardiovasc Res, May 1, 2003; 58(2): 264 - 277.
[Abstract] [Full Text] [PDF]

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 Endocr. Rev.Home page
E. Canalis, A. N. Economides, and E. Gazzerro
Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton
Endocr. Rev., April 1, 2003; 24(2): 218 - 235.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
A. Vogel-Hopker and H. Rohrer
The specification of noradrenergic locus coeruleus (LC) neurones depends on bone morphogenetic proteins (BMPs)
Development, March 4, 2003; 129(4): 983 - 991.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
C. A. Adelman, S. Chattopadhyay, and J. J. Bieker
The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription factors during embryoid body differentiation in serum-free media
Development, March 3, 2003; 129(2): 539 - 549.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
E. C. Delot, M. E. Bahamonde, M. Zhao, and K. M. Lyons
BMP signaling is required for septation of the outflow tract of the mammalian heart
Development, January 1, 2003; 130(1): 209 - 220.
[Abstract] [Full Text] [PDF]

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 Endocr. Rev.Home page
H. Chang, C. W. Brown, and M. M. Matzuk
Genetic Analysis of the Mammalian Transforming Growth Factor-{beta} Superfamily
Endocr. Rev., December 1, 2002; 23(6): 787 - 823.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
A. L. Hager-Theodorides, S. V. Outram, D. K. Shah, R. Sacedon, R. E. Shrimpton, A. Vicente, A. Varas, and T. Crompton
Bone Morphogenetic Protein 2/4 Signaling Regulates Early Thymocyte Differentiation
J. Immunol., November 15, 2002; 169(10): 5496 - 5504.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
Z. Zhang, Y. Song, X. Zhao, X. Zhang, C. Fermin, and Y. Chen
Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis
Development, September 1, 2002; 129(17): 4135 - 4146.
[Abstract] [Full Text] [PDF]

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 Am. J. Respir. Cell Mol. Bio.Home page
A. Rosendahl, E. Pardali, M. Speletas, P. ten Dijke, C.-H. Heldin, and P. Sideras
Activation of Bone Morphogenetic Protein/Smad Signaling in Bronchial Epithelial Cells during Airway Inflammation
Am. J. Respir. Cell Mol. Biol., August 1, 2002; 27(2): 160 - 169.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
P. S. Amieux, D. G. Howe, H. Knickerbocker, D. C. Lee, T. Su, G. S. Laszlo, R. L. Idzerda, and G. S. McKnight
Increased Basal cAMP-dependent Protein Kinase Activity Inhibits the Formation of Mesoderm-derived Structures in the Developing Mouse Embryo
J. Biol. Chem., July 19, 2002; 277(30): 27294 - 27304.
[Abstract] [Full Text] [PDF]

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 JCBHome page
M. Zhao, S. E. Harris, D. Horn, Z. Geng, R. Nishimura, G. R. Mundy, and Di Chen
Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation
J. Cell Biol., June 10, 2002; 157(6): 1049 - 1060.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
V. Gaussin, T. Van de Putte, Y. Mishina, M. C. Hanks, A. Zwijsen, D. Huylebroeck, R. R. Behringer, and M. D. Schneider
Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3
PNAS, February 14, 2002; (2002) 42390499.
[Abstract] [Full Text] [PDF]

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 ScienceHome page
C. Thisse and L. I. Zon
Organogenesis--Heart and Blood Formation from the Zebrafish Point of View
Science, January 18, 2002; 295(5554): 457 - 462.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
R. M. Anderson, A. R. Lawrence, R. W. Stottmann, D. Bachiller, and J. Klingensmith
Chordin and noggin promote organizing centers of forebrain development in the mouse
Development, January 11, 2002; 129(21): 4975 - 4987.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
E. Minina, H. M. Wenzel, C. Kreschel, S. Karp, W. Gaffield, A. P. McMahon, and A. Vortkamp
BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
Development, November 15, 2001; 128(22): 4523 - 4534.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
K. D. Tremblay, N. R. Dunn, and E. J. Robertson
Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation
Development, September 15, 2001; 128(18): 3609 - 3621.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
J. M. Rossi, N. R. Dunn, B. L.M. Hogan, and K. S. Zaret
Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm
Genes & Dev., August 1, 2001; 15(15): 1998 - 2009.
[Abstract] [Full Text] [PDF]

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 JCBHome page
K. Monzen, Y. Hiroi, S. Kudoh, H. Akazawa, T. Oka, E. Takimoto, D. Hayashi, T. Hosoda, M. Kawabata, K. Miyazono, et al.
Smads, Tak1, and Their Common Target Atf-2 Play a Critical Role in Cardiomyocyte Differentiation
J. Cell Biol., May 14, 2001; 153(4): 687 - 698.
[Abstract] [Full Text] [PDF]

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 JBJSHome page
A. H. Reddi
Bone Morphogenetic Proteins: From Basic Science to Clinical Applications
J. Bone Joint Surg. Am., April 1, 2001; 83(90010): S1 - 6.
[Full Text] [PDF]

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 JBJSHome page
A. H. Reddi
Bone Morphogenetic Proteins: From Basic Science to Clinical Applications
J. Bone Joint Surg. Am., March 1, 2001; 83(1_suppl_1): S1 - S6.
[Full Text] [PDF]

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 DevelopmentHome page
K. Mintzer, M. Lee, G Runke, J Trout, M Whitman, and M. Mullins
Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation
Development, January 3, 2001; 128(6): 859 - 869.
[Abstract] [PDF]

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 EndocrinologyHome page
F. De Luca, K. M. Barnes, J. A. Uyeda, S. De-Levi, V. Abad, T. Palese, V. Mericq, and J. Baron
Regulation of Growth Plate Chondrogenesis by Bone Morphogenetic Protein-2
Endocrinology, January 1, 2001; 142(1): 430 - 436.
[Abstract] [Full Text] [PDF]

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 Biol. Reprod.Home page
Y. Ying and G.-Q. Zhao
Detection of Multiple Bone Morphogenetic Protein Messenger Ribonucleic Acids and Their Signal Transducer, Smad1, During Mouse Decidualization
Biol Reprod, December 1, 2000; 63(6): 1781 - 1786.
[Abstract] [Full Text]


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