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Development, Vol 122, Issue 11 3381-3391, Copyright © 1996 by Company of Biologists


JOURNAL ARTICLES

Pax2 contributes to inner ear patterning and optic nerve trajectory

M Torres, E Gomez-Pardo and P Gruss
Abteilung Molekulare Zellbiologie, Max-Planck-Institut fur Biophysikalische Chemie, Gottingen, Germany.

During gestation, the paired box-containing gene Pax2 is expressed in the mid-hindbrain area, developing eye and inner ear. We generated Pax2 null mutant mice, which show the requirement of Pax2 for the establishment of axonal pathways along the optic stalks and ventral diencephalon. In mutant brains, the optic tracts remain totally ipsilateral due to agenesis of the optic chiasma. Furthermore, Pax2 mutants show extension of the pigmented retina into the optic stalks and failure of the optic fissure to close resulting in coloboma. In the inner ear, Pax2 mutants show agenesis of the cochlea and the spiral ganglion, i.e., the parts of the organ responsible for auditory function and in whose primordium Pax2 is expressed. Our results identify Pax2 as a major regulator of patterning during organogenesis of the eye and inner ear and indicate its function in morphogenetic events required for closure of the optic fissure and neural tube.
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[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
C. K. Stayner, H. E. Cunliffe, T. A. Ward, and M. R. Eccles
Cloning and Characterization of the Human PAX2 Promoter
J. Biol. Chem., September 25, 1998; 273(39): 25472 - 25479.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
J Adam, A Myat, I Le Roux, M Eddison, D Henrique, D Ish-Horowicz, and J Lewis
Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: parallels with Drosophila sense-organ development
Development, January 12, 1998; 125(23): 4645 - 4654.
[Abstract] [PDF]


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DevelopmentHome page
K. Ba-Charvet, Y von Boxberg, S Guazzi, E Boncinelli, and P Godement
A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain
Development, January 11, 1998; 125(21): 4273 - 4282.
[Abstract] [PDF]


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DevelopmentHome page
M Xiang, W. Gao, T Hasson, and J. Shin
Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells
Development, January 10, 1998; 125(20): 3935 - 3946.
[Abstract] [PDF]


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DevelopmentHome page
W Fu, H Duan, E Frei, and M Noll
shaven and sparkling are mutations in separate enhancers of the Drosophila Pax2 homolog
Development, January 8, 1998; 125(15): 2943 - 2950.
[Abstract] [PDF]


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DevelopmentHome page
M Kobayashi, R Toyama, H Takeda, I. Dawid, and K Kawakami
Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish
Development, January 8, 1998; 125(15): 2973 - 2982.
[Abstract] [PDF]


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DevelopmentHome page
P. Pfeffer, T Gerster, K Lun, M Brand, and M Busslinger
Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function
Development, January 8, 1998; 125(16): 3063 - 3074.
[Abstract] [PDF]


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DevelopmentHome page
D. Rowitch, Y Echelard, P. Danielian, K Gellner, S Brenner, and A. McMahon
Identification of an evolutionarily conserved 110 base-pair cis-acting regulatory sequence that governs Wnt-1 expression in the murine neural plate
Development, January 7, 1998; 125(14): 2735 - 2746.
[Abstract] [PDF]


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DevelopmentHome page
H Wada, H Saiga, N Satoh, and P. Holland
Tripartite organization of the ancestral chordate brain and the antiquity of placodes: insights from ascidian Pax-2/5/8, Hox and Otx genes
Development, January 3, 1998; 125(6): 1113 - 1122.
[Abstract] [PDF]


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DevelopmentHome page
H Herbrand, S Guthrie, T Hadrys, S Hoffmann, H. Arnold, S Rinkwitz-Brandt, and E Bober
Two regulatory genes, cNkx5-1 and cPax2, show different responses to local signals during otic placode and vesicle formation in the chick embryo
Development, January 2, 1998; 125(4): 645 - 654.
[Abstract] [PDF]


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CROBMHome page
K.M. Weiss, D.W. Stock, and Z. Zhao
Dynamic Interactions and the Evolutionary Genetics of Dental Patterning
Critical Reviews in Oral Biology & Medicine, January 1, 1998; 9(4): 369 - 398.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
D. Wu, F. Nunes, and D Choo
Axial specification for sensory organs versus non-sensory structures of the chicken inner ear
Development, January 1, 1998; 125(1): 11 - 20.
[Abstract] [PDF]


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DevelopmentHome page
T Hadrys, T Braun, S Rinkwitz-Brandt, H. Arnold, and E Bober
Nkx5-1 controls semicircular canal formation in the mouse inner ear
Development, January 1, 1998; 125(1): 33 - 39.
[Abstract] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
M. Schwarz, G. Alvarez-Bolado, P. Urbanek, M. Busslinger, and P. Gruss
Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: Evidence from targeted mutations
PNAS, December 23, 1997; 94(26): 14518 - 14523.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
J. Kumar and K. Moses
Transcription factors in eye development: a gorgeous mosaic?
Genes & Dev., August 15, 1997; 11(16): 2023 - 2028.
[Full Text] [PDF]


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Genes Dev.Home page
W. Fu and M. Noll
The Pax2 homolog sparkling is required for development of cone and pigment cells in the Drosophila eye
Genes & Dev., August 15, 1997; 11(16): 2066 - 2078.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
P. Urbanek, I. Fetka, M. H. Meisler, and M. Busslinger
Cooperation of Pax2 and Pax5 in midbrain and cerebellum development
PNAS, May 27, 1997; 94(11): 5703 - 5708.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
H. Chamberlin, R. Palmer, A. Newman, P. Sternberg, D. Baillie, and J. Thomas
The PAX gene egl-38 mediates developmental patterning in Caenorhabditis elegans
Development, January 10, 1997; 124(20): 3919 - 3928.
[Abstract] [PDF]


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DevelopmentHome page
R Macdonald, J Scholes, U Strahle, C Brennan, N Holder, M Brand, and S. Wilson
The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain
Development, January 6, 1997; 124(12): 2397 - 2408.
[Abstract] [PDF]


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Cold Spring Harb Symp Quant BiolHome page
D.H. Rowitch, P.S. Danielian, S.M.K. Lee, Y. Echelard, and A.P. McMahon
Cell Interactions in Patterning the Mammalian Midbrain
Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 535 - 544.
[Abstract] [PDF]


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J. Biol. Chem.Home page
B. Ritz-Laser, A. Estreicher, B. Gauthier, and J. Philippe
The Paired Homeodomain Transcription Factor Pax-2 Is Expressed in the Endocrine Pancreas and Transactivates the Glucagon Gene Promoter
J. Biol. Chem., October 13, 2000; 275(42): 32708 - 32715.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
N. Planque, L. Leconte, F. M. Coquelle, P. Martin, and S. Saule
Specific Pax-6/Microphthalmia Transcription Factor Interactions Involve Their DNA-binding Domains and Inhibit Transcriptional Properties of Both Proteins
J. Biol. Chem., July 27, 2001; 276(31): 29330 - 29337.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
Y. Cai, M. S. Lechner, D. Nihalani, M. J. Prindle, L. B. Holzman, and G. R. Dressler
Phosphorylation of Pax2 by the c-Jun N-terminal Kinase and Enhanced Pax2-dependent Transcription Activation
J. Biol. Chem., January 4, 2002; 277(2): 1217 - 1222.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
R. T. Yu, M.-Y. Chiang, T. Tanabe, M. Kobayashi, K. Yasuda, R. M. Evans, and K. Umesono
The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision
PNAS, March 14, 2000; 97(6): 2621 - 2625.
[Abstract] [Full Text] [PDF]




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