|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 122, Issue 11 3409-3418, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
N Papalopulu and C Kintner
Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037,USA.
During early development of the Xenopus central nervous system (CNS), neuronal differentiation can be detected posteriorly at neural plate stages but is delayed anteriorly until after neural tube closure. A similar delay in neuronal differentiation also occurs in the anterior neural tissue that forms in vitro when isolated ectoderm is treated with the neural inducer noggin. Here we examine the factors that control the timing of neuronal differentiation both in embryos and in neural tissue induced by noggin (noggin caps). We show that the delay in neuronal differentiation that occurs in noggin caps cannot be overcome by inhibiting the activity of the neurogenic gene, X-Delta-1, which normally inhibits neuronal differentiation, suggesting that it represents a novel level of regulation. Conversely, we show that the timing of neuronal differentiation can be changed from late to early after treating noggin caps or embryos with retinoic acid (RA), a putative posteriorising agent. Concommittal with changes in the timing of neuronal differentiation, RA suppresses the expression of anterior neural genes and promotes the expression of posterior neural genes. The level of early neuronal differentiation induced by RA alone is greatly increased by the additional expression of the proneural gene, XASH3. These results indicate that early neuronal differentiation in neuralised ectoderm requires posteriorising signals, as well as signals that promote the activity of proneural genes such as XASH3. In addition, these result suggest that neuronal differentiation is controlled by anteroposterior (A-P) patterning, which exerts a temporal control on the onset of neuronal differentiation.
This article has been cited by other articles:
|
|
 |
|
  J. Wu, M. O'Donnell, A. D. Gitler, and P. S. Klein Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development Development, September 15, 2006; 133(18): 3651 - 3660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lamar and C. Kintner The Notch targets Esr1 and Esr10 are differentially regulated in Xenopus neural precursors Development, August 15, 2005; 132(16): 3619 - 3630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Huang, C.-S. Hong, M. O'Donnell, and J.-P. Saint-Jeannet The doublesex-related gene, XDmrt4, is required for neurogenesis in the olfactory system PNAS, August 9, 2005; 102(32): 11349 - 11354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Shiotsugu, Y. Katsuyama, K. Arima, A. Baxter, T. Koide, J. Song, R. A. S. Chandraratna, and B. Blumberg Multiple points of interaction between retinoic acid and FGF signaling during embryonic axis formation Development, June 1, 2004; 131(11): 2653 - 2667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Andreazzoli, G. Gestri, F. Cremisi, S. Casarosa, I. B. Dawid, and G. Barsacchi Xrx1 controls proliferation and neurogenesis in Xenopus anterior neural plate Development, November 1, 2003; 130(21): 5143 - 5155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Sajithlal, H. Huttunen, H. Rauvala, and G. Munch Receptor for Advanced Glycation End Products Plays a More Important Role in Cellular Survival than in Neurite Outgrowth during Retinoic Acid-induced Differentiation of Neuroblastoma Cells J. Biol. Chem., February 22, 2002; 277(9): 6888 - 6897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lupo, W. A. Harris, G. Barsacchi, and R. Vignali Induction and patterning of the telencephalon in Xenopus laevis Development, January 12, 2002; 129(23): 5421 - 5436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. del Corral, D. N. Breitkreuz, and K. G. Storey Onset of neuronal differentiation is regulated by paraxial mesoderm and requires attenuation of FGF signalling Development, January 4, 2002; 129(7): 1681 - 1691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Trousse, E. Marti, P. Gruss, M. Torres, and P. Bovolenta Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog Development, October 15, 2001; 128(20): 3927 - 3936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dibner, S. Elias, and D. Frank XMeis3 protein activity is required for proper hindbrain patterning in Xenopus laevis embryos Development, September 15, 2001; 128(18): 3415 - 3426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E Lamar, C Kintner, and M Goulding Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation Development, January 4, 2001; 128(8): 1335 - 1346. [Abstract] [PDF]
|
|
|
|
|
|
Z Hardcastle and N Papalopulu Distinct effects of XBF-1 in regulating the cell cycle inhibitor p27(XIC1) and imparting a neural fate Development, January 3, 2000; 127(6): 1303 - 1314. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Kato, Y. Shi, and X. He Neuralization of the Xenopus Embryo by Inhibition of p300/ CREB-Binding Protein Function J. Neurosci., November 1, 1999; 19(21): 9364 - 9373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Franco, A. Paganelli, S. Lopez, and A. Carrasco Functional association of retinoic acid and hedgehog signaling in Xenopus primary neurogenesis Development, January 10, 1999; 126(19): 4257 - 4265. [Abstract] [PDF]
|
|
|
|
|
|
M Andreazzoli, G Gestri, D Angeloni, E Menna, and G Barsacchi Role of Xrx1 in Xenopus eye and anterior brain development Development, January 6, 1999; 126(11): 2451 - 2460. [Abstract] [PDF]
|
|
|
|
|
|
C Bourguignon, J Li, and N Papalopulu XBF-1, a winged helix transcription factor with dual activity, has a role in positioning neurogenesis in Xenopus competent ectoderm Development, January 12, 1998; 125(24): 4889 - 4900. [Abstract] [PDF]
|
|
|
|
|
|
K. Storey, A Goriely, C. Sargent, J. Brown, H. Burns, H. Abud, and J. Heath Early posterior neural tissue is induced by FGF in the chick embryo Development, January 2, 1998; 125(3): 473 - 484. [Abstract] [PDF]
|
|
|
|
|
|
J van der Wees, J. Schilthuis, C. Koster, H Diesveld-Schipper, G. Folkers, P. van der Saag, M. Dawson, K Shudo, B van der Burg, and A. Durston Inhibition of retinoic acid receptor-mediated signalling alters positional identity in the developing hindbrain Development, January 2, 1998; 125(3): 545 - 556. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Boudjelal, R. Taneja, S. Matsubara, P. Bouillet, P. Dolle, and P. Chambon Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells Genes & Dev., August 15, 1997; 11(16): 2052 - 2065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bovolenta, A. Mallamaci, P. Briata, G. Corte, and E. Boncinelli Implication of OTX2 in Pigment Epithelium Determination and Neural Retina Differentiation J. Neurosci., June 1, 1997; 17(11): 4243 - 4252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Epstein, G Pillemer, R Yelin, J. Yisraeli, and A Fainsod Patterning of the embryo along the anterior-posterior axis: the role of the caudal genes Development, January 10, 1997; 124(19): 3805 - 3814. [Abstract] [PDF]
|
|
|
|
|
|
A. Knecht and R. Harland Mechanisms of dorsal-ventral patterning in noggin-induced neural tissue Development, January 6, 1997; 124(12): 2477 - 2488. [Abstract] [PDF]
|
|
|
|
|
|
A. Bang, N Papalopulu, C Kintner, and M. Goulding Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm Development, January 5, 1997; 124(10): 2075 - 2085. [Abstract] [PDF]
|
|
|
|
|
|
B Blumberg, J Bolado, T. Moreno, C Kintner, R. Evans, and N Papalopulu An essential role for retinoid signaling in anteroposterior neural patterning Development, January 1, 1997; 124(2): 373 - 379. [Abstract] [PDF]
|
|
