|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 122, Issue 11 3549-3556, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
OB Cleaver, KD Patterson and PA Krieg
Department of Zoology, University of Texas at Austin, 78712, USA.
Drosophila tinman is an NK-class homeobox gene required for formation of the dorsal vessel, the insect equivalent of the vertebrate heart. Vertebrate sequences related to tinman, such as mouse Nkx-2.5, chicken cNkx-2.5, Xenopus XNkx-2.5 and XNkx-2.3 are expressed in cardiac precursors and in tissues involved in induction of cardiac mesoderm. Mice which lack a functional Nkx-2.5 gene die due to cardiac defects. To determine the role of tinman-related sequences in heart development, we have overexpressed both XNkx-2.3 and XNkx-2.5 in Xenopus laevis embryos. The resulting embryos are morphologically normal except that they have enlarged hearts. The enlarged heart phenotype is due to a thickening of the myocardium caused by an increase in the overall number of myocardial cells (hyperplasia). Neither ectopic nor precocious expression of cardiac differentiation markers is detectable in overexpressing embryos. These results suggest that both XNkx-2.3 and XNkx-2.5 are functional homologues of tinman, responsible for maintenance of the heart field.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Weber, J. C. Taylor, P. Winyard, K. F. Baker, J. Sullivan-Brown, R. Schild, T. Knuppel, A. M. Zurowska, A. Caldas-Alfonso, M. Litwin, et al. SIX2 and BMP4 Mutations Associate With Anomalous Kidney Development J. Am. Soc. Nephrol., May 1, 2008; 19(5): 891 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen, W. H. Yuen, J. Fu, G. Huang, A. J. Melendez, F. B. M. Ibrahim, H. Lu, and X. Cao The Mitochondrial Respiratory Chain Controls Intracellular Calcium Signaling and NFAT Activity Essential for Heart Formation in Xenopus laevis Mol. Cell. Biol., September 15, 2007; 27(18): 6420 - 6432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Chopin, M. Orsel, M.-F. Dorbe, F. Chardon, H.-N. Truong, A. J. Miller, A. Krapp, and F. Daniel-Vedele The Arabidopsis ATNRT2.7 Nitrate Transporter Controls Nitrate Content in Seeds PLANT CELL, May 1, 2007; 19(5): 1590 - 1602. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Schottenfeld, J. Sullivan-Brown, and R. D. Burdine Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw Development, April 15, 2007; 134(8): 1605 - 1615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Orsel, F. Chopin, O. Leleu, S. J. Smith, A. Krapp, F. Daniel-Vedele, and A. J. Miller Characterization of a Two-Component High-Affinity Nitrate Uptake System in Arabidopsis. Physiology and Protein-Protein Interaction Plant Physiology, November 1, 2006; 142(3): 1304 - 1317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. N. Olson Gene regulatory networks in the evolution and development of the heart. Science, September 29, 2006; 313(5795): 1922 - 1927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Goetz, D. D. Brown, and F. L. Conlon TBX5 is required for embryonic cardiac cell cycle progression Development, July 1, 2006; 133(13): 2575 - 2584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Small, A. S. Warkman, D.-Z. Wang, L. B. Sutherland, E. N. Olson, and P. A. Krieg Myocardin is sufficient and necessary for cardiac gene expression in Xenopus Development, March 1, 2005; 132(5): 987 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. N. Olson and M. D. Schneider Sizing up the heart: development redux in disease Genes & Dev., August 15, 2003; 17(16): 1937 - 1956. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dentice, C. Morisco, M. Vitale, G. Rossi, G. Fenzi, and D. Salvatore The Different Cardiac Expression of the Type 2 Iodothyronine Deiodinase Gene between Human and Rat Is Related to the Differential Response of the dio2 Genes to Nkx-2.5 and GATA-4 Transcription Factors Mol. Endocrinol., August 1, 2003; 17(8): 1508 - 1521. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-H. Wang, R. Chmelik, and M. Nirenberg Sequence-specific DNA binding by the vnd/NK-2 homeodomain of Drosophila PNAS, October 1, 2002; 99(20): 12721 - 12726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Toko, W. Zhu, E. Takimoto, I. Shiojima, Y. Hiroi, Y. Zou, T. Oka, H. Akazawa, M. Mizukami, M. Sakamoto, et al. Csx/Nkx2-5 Is Required for Homeostasis and Survival of Cardiac Myocytes in the Adult Heart J. Biol. Chem., June 28, 2002; 277(27): 24735 - 24743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Paillard, V. Legagneux, D. Maniey, and H. B. Osborne c-Jun ARE Targets mRNA Deadenylation by an EDEN-BP (Embryo Deadenylation Element-binding Protein)-dependent Pathway J. Biol. Chem., January 25, 2002; 277(5): 3232 - 3235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. WANG, R. PASSIER, Z.-P. LIU, C.H. SHIN, Z. WANG, S. LI, L.B. SUTHERLAND, E. SMALL, P.A. KRIEG, and E.N. OLSON Regulation of Cardiac Growth and Development by SRF and Its Cofactors Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 97 - 106. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Palmer, N. Groves, A. Schindeler, T. Yeoh, C. Biben, C.-C. Wang, D. B. Sparrow, L. Barnett, N. A. Jenkins, N. G. Copeland, et al. The Small Muscle-Specific Protein Csl Modifies Cell Shape and Promotes Myocyte Fusion in an Insulin-like Growth Factor 1-Dependent Manner J. Cell Biol., May 28, 2001; 153(5): 985 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Biben, R. Weber, S. Kesteven, E. Stanley, L. McDonald, D. A. Elliott, L. Barnett, F. Koentgen, L. Robb, M. Feneley, et al. Cardiac Septal and Valvular Dysmorphogenesis in Mice Heterozygous for Mutations in the Homeobox Gene Nkx2-5 Circ. Res., November 10, 2000; 87(10): 888 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O Cleaver, D. Seufert, and P. Krieg Endoderm patterning by the notochord: development of the hypochord in Xenopus Development, January 2, 2000; 127(4): 869 - 879. [Abstract] [PDF]
|
|
|
|
|
|
F Reifers, E. Walsh, S Leger, D. Stainier, and M Brand Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar) Development, January 1, 2000; 127(2): 225 - 235. [Abstract] [PDF]
|
|
|
|
|
|
K. Monzen, I. Shiojima, Y. Hiroi, S. Kudoh, T. Oka, E. Takimoto, D. Hayashi, T. Hosoda, A. Habara-Ohkubo, T. Nakaoka, et al. Bone Morphogenetic Proteins Induce Cardiomyocyte Differentiation through the Mitogen-Activated Protein Kinase Kinase Kinase TAK1 and Cardiac Transcription Factors Csx/Nkx-2.5 and GATA-4 Mol. Cell. Biol., October 1, 1999; 19(10): 7096 - 7105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Horb and G. Thomsen Tbx5 is essential for heart development Development, January 4, 1999; 126(8): 1739 - 1751. [Abstract] [PDF]
|
|
|
|
|
|
M Campione, H Steinbeisser, A Schweickert, K Deissler, F van Bebber, L. Lowe, S Nowotschin, C Viebahn, P Haffter, M. Kuehn, et al. The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping Development, January 3, 1999; 126(6): 1225 - 1234. [Abstract] [PDF]
|
|
|
|
|
|
C. Lien, C Wu, B Mercer, R Webb, J. Richardson, and E. Olson Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer Development, January 1, 1999; 126(1): 75 - 84. [Abstract] [PDF]
|
|
|
|
|
|
I. S. Skerjanc, H. Petropoulos, A. G. Ridgeway, and S. Wilton Myocyte Enhancer Factor 2C and Nkx2-5 Up-regulate Each Other's Expression and Initiate Cardiomyogenesis in P19 Cells J. Biol. Chem., December 25, 1998; 273(52): 34904 - 34910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Park, C. Lewis, D. Turbay, A. Chung, J.-N. Chen, S. Evans, R. E. Breitbart, M. C. Fishman, S. Izumo, and R. Bodmer Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes PNAS, August 4, 1998; 95(16): 9366 - 9371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Thompson, M. S. Rackley, and T. X. O'Brien Upregulation of the cardiac homeobox gene Nkx2-5 (CSX) in feline right ventricular pressure overload Am J Physiol Heart Circ Physiol, May 1, 1998; 274(5): H1569 - H1573. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Franco, W. H Lamers, and A. F.M Moorman Patterns of expression in the developing myocardium: towards a morphologically integrated transcriptional model Cardiovasc Res, April 1, 1998; 38(1): 25 - 53. [Full Text] [PDF]
|
|
|
|
|
|
Y Fu, W Yan, T. Mohun, and S. Evans Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner Development, January 11, 1998; 125(22): 4439 - 4449. [Abstract] [PDF]
|
|
|
|
|
|
G Ranganayakulu, D. Elliott, R. Harvey, and E. Olson Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice Development, January 8, 1998; 125(16): 3037 - 3048. [Abstract] [PDF]
|
|
|
|
|
|
D. Sparrow, W. Jen, S Kotecha, N Towers, C Kintner, and T. Mohun Thylacine 1 is expressed segmentally within the paraxial mesoderm of the Xenopus embryo and interacts with the Notch pathway Development, January 6, 1998; 125(11): 2041 - 2051. [Abstract] [PDF]
|
|
|
|
|
|
G. Serbedzija, J. Chen, and M. Fishman Regulation in the heart field of zebrafish Development, January 3, 1998; 125(6): 1095 - 1101. [Abstract] [PDF]
|
|
|
|
|
|
C Biben and R P Harvey Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. Genes & Dev., June 1, 1997; 11(11): 1357 - 1369. [Abstract] [PDF]
|
|
|
|
|
|
S. Fisher, E Siwik, D Branellec, K Walsh, and M Watanabe Forced expression of the homeodomain protein Gax inhibits cardiomyocyte proliferation and perturbs heart morphogenesis Development, January 11, 1997; 124(21): 4405 - 4413. [Abstract] [PDF]
|
|
|
|
|
|
P. Okkema, E Ha, C Haun, W Chen, and A Fire The Caenorhabditis elegans NK-2 homeobox gene ceh-22 activates pharyngeal muscle gene expression in combination with pha-1 and is required for normal pharyngeal development Development, January 10, 1997; 124(20): 3965 - 3973. [Abstract] [PDF]
|
|
|
|
|
|
M. Fishman and K. Chien Fashioning the vertebrate heart: earliest embryonic decisions Development, January 6, 1997; 124(11): 2099 - 2117. [Abstract] [PDF]
|
|
|
|
|
|
J. Chen and M. Fishman Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation Development, January 12, 1996; 122(12): 3809 - 3816. [Abstract] [PDF]
|
|
|
|
|
|
L. M. Pabon-Pena, R. L. Goodwin, L. J. Cise, and D. Bader Analysis of CMF1 Reveals a Bone Morphogenetic Protein-independent Component of the Cardiomyogenic Pathway J. Biol. Chem., July 7, 2000; 275(28): 21453 - 21459. [Abstract] [Full Text] [PDF]
|
|
