spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fernandes, J. J.
Right arrow Articles by Keshishian, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fernandes, J. J.
Right arrow Articles by Keshishian, H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 122, Issue 12 3755-3763, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

Patterning the dorsal longitudinal flight muscles (DLM) of Drosophila: insights from the ablation of larval scaffolds

JJ Fernandes and H Keshishian
Biology Department, Yale University, New Haven, CT 06520-8103, USA. jjfse@yalevm.ycc.yale.edu

The six Dorsal Longitudinal flight Muscles (DLMs) of Drosophila develop from three larval muscles that persist into metamorphosis and serve as scaffolds for the formation of the adult fibers. We have examined the effect of muscle scaffold ablation on the development of DLMs during metamorphosis. Using markers that are specific to muscle and myoblasts we show that in response to the ablation, myoblasts which would normally fuse with the larval muscle, fuse with each other instead, to generate the adult fibers in the appropriate regions of the thorax. The development of these de novo DLMs is delayed and is reflected in the delayed expression of erect wing, a transcription factor thought to control differentiation events associated with myoblast fusion. The newly arising muscles express the appropriate adult-specific Actin isoform (88F), indicating that they have the correct muscle identity. However, there are frequent errors in the number of muscle fibers generated. Ablation of the larval scaffolds for the DLMs has revealed an underlying potential of the DLM myoblasts to initiate de novo myogenesis in a manner that resembles the mode of formation of the Dorso-Ventral Muscles, DVMs, which are the other group of indirect flight muscles. Therefore, it appears that the use of larval scaffolds is a superimposition on a commonly used mechanism of myogenesis in Drosophila. Our results show that the role of the persistent larval muscles in muscle patterning involves the partitioning of DLM myoblasts, and in doing so, they regulate formation of the correct number of DLM fibers.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Proc R Soc BHome page
H. Iwamoto, K. Inoue, T. Matsuo, and N. Yagi
Flight muscle myofibrillogenesis in the pupal stage of Drosophila as examined by X-ray microdiffraction and conventional diffraction
Proc R Soc B, September 22, 2007; 274(1623): 2297 - 2305.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Soler, M. Daczewska, J. P. Da Ponte, B. Dastugue, and K. Jagla
Coordinated development of muscles and tendons of the Drosophila leg
Development, December 15, 2004; 131(24): 6041 - 6051.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
L. van der Weyden, D. J. Adams, and A. Bradley
Tools for targeted manipulation of the mouse genome
Physiol Genomics, December 3, 2002; 11(3): 133 - 164.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. W. Williams and D. Shepherd
Persistent larval sensory neurones are required for the normal development of the adult sensory afferent projections in Drosophila
Development, January 2, 2002; 129(3): 617 - 624.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. D. Crispino, M. B. Lodish, B. L. Thurberg, S. H. Litovsky, T. Collins, J. D. Molkentin, and S. H. Orkin
Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors
Genes & Dev., April 1, 2001; 15(7): 839 - 844.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
A Schmid, A Chiba, and C. Doe
Clonal analysis of Drosophila embryonic neuroblasts: neural cell types, axon projections and muscle targets
Development, January 11, 1999; 126(21): 4653 - 4689.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M Koutsourakis, A Langeveld, R Patient, R Beddington, and F Grosveld
The transcription factor GATA6 is essential for early extraembryonic development
Development, January 2, 1999; 126(4): 723 - 732.
[Abstract] [PDF]

Home page
 BloodHome page
W. L. Stanford, G. Caruana, K. A. Vallis, M. Inamdar, M. Hidaka, V. L. Bautch, and A. Bernstein
Expression Trapping: Identification of Novel Genes Expressed in Hematopoietic and Endothelial Lineages by Gene Trapping in ES Cells
Blood, December 15, 1998; 92(12): 4622 - 4631.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
S. Roy and K. VijayRaghavan
Patterning Muscles Using Organizers: Larval Muscle Templates and Adult Myoblasts Actively Interact to Pattern the Dorsal Longitudinal Flight Muscles of Drosophila
J. Cell Biol., June 1, 1998; 141(5): 1135 - 1145.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Fernandes and H Keshishian
Nerve-muscle interactions during flight muscle development in Drosophila
Development, January 5, 1998; 125(9): 1769 - 1779.
[Abstract] [PDF]


© The Company of Biologists Ltd 1996