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Development, Vol 122, Issue 12 3765-3773, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway

C Shawber, D Nofziger, JJ Hsieh, C Lindsell, O Bogler, D Hayward and G Weinmaster
Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, CA 90095-1737, USA.

Notch controls cell fate by inhibiting cellular differentiation, presumably through activation of the transcriptional regulator human C promoter Binding Factor (CBF1), which transactivates the hairy and Enhancer of split (HES-1) gene. However, we describe constitutively active forms of Notch1, which inhibit muscle cell differentiation but do not interact with CBF1 or upregulate endogenous HES-1 expression. In addition, Jagged-Notch interactions that prevent the expression of muscle cell specific genes do not involve the upregulation of endogenous HES-1. In fact, exogenous expression of HES-1 in C2C12 myoblasts does not block myogenesis. Our data demonstrate the existence of a CBF1-independent pathway by which Notch inhibits differentiation. We therefore propose that Notch signaling activates at least two different pathways: one which involves CBF1 as an intermediate and one which does not.
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S. Jarriault, O. Le Bail, E. Hirsinger, O. Pourquié, F. Logeat, C. F. Strong, C. Brou, N. G. Seidah, and A. Israël
Delta-1 Activation of Notch-1 Signaling Results in HES-1 Transactivation
Mol. Cell. Biol., December 1, 1998; 18(12): 7423 - 7431.
[Abstract] [Full Text]

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 GeneticsHome page
M. J. Go and S. Artavanis-Tsakonas
A Genetic Screen for Novel Components of the Notch Signaling Pathway During Drosophila Bristle Development
Genetics, September 1, 1998; 150(1): 211 - 220.
[Abstract] [Full Text]

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 Proc. Natl. Acad. Sci. USAHome page
F. Logeat, C. Bessia, C. Brou, O. LeBail, S. Jarriault, N. G. Seidah, and A. Israel
The Notch1 receptor is cleaved constitutively by a furin-like convertase
PNAS, July 7, 1998; 95(14): 8108 - 8112.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
I. Greenwald
LIN-12/Notch signaling: lessons from worms and flies
Genes & Dev., June 15, 1998; 12(12): 1751 - 1762.
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 DevelopmentHome page
P Ligoxygakis, S. Yu, C Delidakis, and N. Baker
A subset of notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex
Development, January 8, 1998; 125(15): 2893 - 2900.
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 DevelopmentHome page
M. Go, D. Eastman, and S Artavanis-Tsakonas
Cell proliferation control by Notch signaling in Drosophila development
Development, January 6, 1998; 125(11): 2031 - 2040.
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 DevelopmentHome page
K Matsuno, M. Go, X Sun, D. Eastman, and S Artavanis-Tsakonas
Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements
Development, January 11, 1997; 124(21): 4265 - 4273.
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 DevelopmentHome page
S Wang, S Younger-Shepherd, L. Jan, and Y. Jan
Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless
Development, January 11, 1997; 124(22): 4435 - 4446.
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 DevelopmentHome page
H Kato, Y Taniguchi, H Kurooka, S Minoguchi, T Sakai, S Nomura-Okazaki, K Tamura, and T Honjo
Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives
Development, January 10, 1997; 124(20): 4133 - 4141.
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 J. Biol. Chem.Home page
L. T. Lam, C. Ronchini, J. Norton, A. J. Capobianco, and E. H. Bresnick
Suppression of Erythroid but Not Megakaryocytic Differentiation of Human K562 Erythroleukemic Cells by Notch-1
J. Biol. Chem., June 23, 2000; 275(26): 19676 - 19684.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
D. Small, D. Kovalenko, D. Kacer, L. Liaw, M. Landriscina, C. Di Serio, I. Prudovsky, and T. Maciag
Soluble Jagged 1 Represses the Function of Its Transmembrane Form to Induce the Formation of the Src-dependent Chord-like Phenotype
J. Biol. Chem., August 17, 2001; 276(34): 32022 - 32030.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. Ingles-Esteve, L. Espinosa, L. A. Milner, C. Caelles, and A. Bigas
Phosphorylation of Ser2078 Modulates the Notch2 Function in 32D Cell Differentiation
J. Biol. Chem., November 21, 2001; 276(48): 44873 - 44880.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
N. Yamamoto, S.-i. Yamamoto, F. Inagaki, M. Kawaichi, A. Fukamizu, N. Kishi, K. Matsuno, K. Nakamura, G. Weinmaster, H. Okano, et al.
Role of Deltex-1 as a Transcriptional Regulator Downstream of the Notch Receptor
J. Biol. Chem., November 21, 2001; 276(48): 45031 - 45040.
[Abstract] [Full Text] [PDF]

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 JCBHome page
X. Gao, T. Chandra, M.-O. Gratton, I. Quelo, J. Prud'homme, S. Stifani, and R. St-Arnaud
HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program
J. Cell Biol., September 17, 2001; 154(6): 1161 - 1172.
[Abstract] [Full Text] [PDF]


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