Development, Vol 122, Issue 12 4149-4157, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

cdh-3, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in Caenorhabditis elegans

J Pettitt, WB Wood and RH Plasterk
Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam.

Several genes that encode members of the cadherin superfamily have been identified in Caenorhabditis elegans. Based on the roles of cadherins in vertebrates and Drosophila, it is expected that they function in the control of epithelial morphogenesis, an event which is poorly understood at the molecular level in C. elegans. Reporter genes under the control of upstream sequences from one of these genes, cdh-3, are expressed in developing epithelial cells, but also in a number of neuroectodermal cells that extend processes along some of these epithelial cells. We generated a loss-of-function mutation in cdh-3 by transposon-mediated deletion mutagenesis. This mutation affects the morphogenesis of a single cell, hyp10, which forms the tip of the nematode tail. The lack of detectable defects associated with the other cells expressing cdh-3 reporter constructs hints at the existence of other genes that can compensate for cdh-3 loss of function.

This article has been cited by other articles:

				H. Kagoshima, R. Nimmo, N. Saad, J. Tanaka, Y. Miwa, S. Mitani, Y. Kohara, and A. Woollard The C. elegans CBF{beta} homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal Development, November 1, 2007; 134(21): 3905 - 3915. [Abstract] [Full Text] [PDF]

				A. Margalit, E. Neufeld, N. Feinstein, K. L. Wilson, B. Podbilewicz, and Y. Gruenbaum Barrier to autointegration factor blocks premature cell fusion and maintains adult muscle integrity in C. elegans J. Cell Biol., August 9, 2007; 178(4): 661 - 673. [Abstract] [Full Text] [PDF]

				Y. Liu and E. M. Maine The Bro1-Domain Protein, EGO-2, Promotes Notch Signaling in Caenorhabditis elegans Genetics, August 1, 2007; 176(4): 2265 - 2277. [Abstract] [Full Text] [PDF]

				B. J. Hwang, A. D. Meruelo, and P. W. Sternberg C. elegans EVI1 proto-oncogene, EGL-43, is necessary for Notch-mediated cell fate specification and regulates cell invasion Development, February 15, 2007; 134(4): 669 - 679. [Abstract] [Full Text] [PDF]

				A.-F. Ruaud and J.-L. Bessereau Activation of nicotinic receptors uncouples a developmental timer from the molting timer in C. elegans Development, June 1, 2006; 133(11): 2211 - 2222. [Abstract] [Full Text] [PDF]

				B. E. Thompson, L. B. Lamont, and J. Kimble Germ-line induction of the Caenorhabditis elegans vulva PNAS, January 17, 2006; 103(3): 620 - 625. [Abstract] [Full Text] [PDF]

				T. Inoue, M. Wang, T. O. Ririe, J. S. Fernandes, and P. W. Sternberg Gene Regulatory Networks Special Feature: Transcriptional network underlying Caenorhabditis elegans vulval development PNAS, April 5, 2005; 102(14): 4972 - 4977. [Abstract] [Full Text] [PDF]

				K W Kjaer, L Hansen, G C Schwabe, A P Marques-de-Faria, H Eiberg, S Mundlos, N Tommerup, and T Rosenberg Distinct CDH3 mutations cause ectodermal dysplasia, ectrodactyly, macular dystrophy (EEM syndrome) J. Med. Genet., April 1, 2005; 42(4): 292 - 298. [Abstract] [Full Text] [PDF]

				M. Silhankova, M. Jindra, and M. Asahina Nuclear receptor NHR-25 is required for cell-shape dynamics during epidermal differentiation in Caenorhabditis elegans J. Cell Sci., January 1, 2005; 118(1): 223 - 232. [Abstract] [Full Text] [PDF]

				W. P.-v. Berkel, M.H.G. Verheijen, E. Cuppen, M. Asahina, J. de Rooij, G. Jansen, R.H.A. Plasterk, J. L. Bos, and F.J.T. Zwartkruis Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for Epithelial Integrity Mol. Biol. Cell, January 1, 2005; 16(1): 106 - 116. [Abstract] [Full Text] [PDF]

				C. Castillejo-Lopez, W. M. Arias, and S. Baumgartner The fat-like Gene of Drosophila Is the True Orthologue of Vertebrate Fat Cadherins and Is Involved in the Formation of Tubular Organs J. Biol. Chem., June 4, 2004; 279(23): 24034 - 24043. [Abstract] [Full Text] [PDF]

				E. A. Cox, C. Tuskey, and J. Hardin Cell adhesion receptors in C. elegans J. Cell Sci., April 15, 2004; 117(10): 1867 - 1870. [Full Text] [PDF]

				E. A. Cox and J. Hardin Sticky worms: adhesion complexes in C. elegans J. Cell Sci., April 15, 2004; 117(10): 1885 - 1897. [Abstract] [Full Text] [PDF]

				W. Chang, C. Tilmann, K. Thoemke, F.-H. Markussen, L. D. Mathies, J. Kimble, and D. Zarkower A forkhead protein controls sexual identity of the C. elegans male somatic gonad Development, March 15, 2004; 131(6): 1425 - 1436. [Abstract] [Full Text] [PDF]

				J. Chen, X. Li, and I. Greenwald sel-7, a Positive Regulator of lin-12 Activity, Encodes a Novel Nuclear Protein in Caenorhabditis elegans Genetics, January 1, 2004; 166(1): 151 - 160. [Abstract] [Full Text] [PDF]

				K. R. Siegfried, A. R. Kidd III, M. A. Chesney, and J. Kimble The sys-1 and sys-3 Genes Cooperate With Wnt Signaling to Establish the Proximal-Distal Axis of the Caenorhabditis elegans Gonad Genetics, January 1, 2004; 166(1): 171 - 186. [Abstract] [Full Text] [PDF]

				X. Karp and I. Greenwald Post-transcriptional regulation of the E/Daughterless ortholog HLH-2, negative feedback, and birth order bias during the AC/VU decision in C. elegans Genes & Dev., December 15, 2003; 17(24): 3100 - 3111. [Abstract] [Full Text] [PDF]

				B. P. Gupta, M. Wang, and P. W. Sternberg The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development Development, June 15, 2003; 130(12): 2589 - 2601. [Abstract] [Full Text] [PDF]

				K. R. Siegfried and J. Kimble POP-1 controls axis formation during early gonadogenesis in C. elegans Development, March 3, 2003; 129(2): 443 - 453. [Abstract] [Full Text] [PDF]

				S. Jarriault and I. Greenwald Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans Genes & Dev., October 15, 2002; 16(20): 2713 - 2728. [Abstract] [Full Text] [PDF]

				P. Dufourcq, M. Victor, F. Gay, D. Calvo, J. Hodgkin, and Y. Shi Functional Requirement for Histone Deacetylase 1 in Caenorhabditis elegans Gonadogenesis Mol. Cell. Biol., May 1, 2002; 22(9): 3024 - 3034. [Abstract] [Full Text] [PDF]

				T. Fujii, F. Nakao, Y. Shibata, G. Shioi, E. Kodama, H. Fujisawa, and S. Takagi Caenorhabditis elegans PlexinA, PLX-1, interacts with transmembrane semaphorins and regulates epidermal morphogenesis Development, January 5, 2002; 129(9): 2053 - 2063. [Abstract] [Full Text] [PDF]

				V. E. Ginzburg, P. J. Roy, and J. G. Culotti Semaphorin 1a and semaphorin 1b are required for correct epidermal cell positioning and adhesion during morphogenesis in C. elegans Development, January 5, 2002; 129(9): 2065 - 2078. [Abstract] [Full Text] [PDF]

				T. R. Sarafi-Reinach, T. Melkman, O. Hobert, and P. Sengupta The lin-11 LIM homeobox gene specifies olfactory and chemosensory neuron fates in C. elegans Development, September 1, 2001; 128(17): 3269 - 3281. [Abstract] [Full Text] [PDF]

				H. M. Chamberlin, K. B. Brown, P. W. Sternberg, and J. H. Thomas Characterization of Seven Genes Affecting Caenorhabditis elegans Hindgut Development Genetics, October 1, 1999; 153(2): 731 - 742. [Abstract] [Full Text] [PDF]

				A. Newman, G. Acton, E Hartwieg, H. Horvitz, and P. Sternberg The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells Development, January 12, 1999; 126(23): 5319 - 5326. [Abstract] [PDF]

				W Hanna-Rose and M Han COG-2, a sox domain protein necessary for establishing a functional vulval-uterine connection in Caenorhabditis elegans Development, January 1, 1999; 126(1): 169 - 179. [Abstract] [PDF]

				M. Costa, W. Raich, C. Agbunag, B. Leung, J. Hardin, and J. R. Priess A Putative Catenin-Cadherin System Mediates Morphogenesis of the Caenorhabditis elegans Embryo J. Cell Biol., April 6, 1998; 141(1): 297 - 308. [Abstract] [Full Text] [PDF]