|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 122, Issue 3 735-746, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
D Alexandre, JD Clarke, E Oxtoby, YL Yan, T Jowett and N Holder
Developmental Biology Research Centre, Randall Institute, King's College, London, UK.
Considerable evidence has demonstrated that retinoic acid influences the formation of the primary body axis in vertebrates and that this may occur through the regulation of Hox gene expression. In this study, we show that the phenotype induced by exogenous retinoic acid in the zebrafish can also be generated by the overexpression of Hoxa-1 following injection of synthetic RNA into the fertilised egg. The isolation, sequence and expression pattern of the zebrafish Hoxa-1 gene is described. We show that exogenously applied retinoic acid causes the ectopic accumulation of Hoxa-1 message during gastrulation in the hypoblast in the head region. Overexpression of Hoxa-1 following injection of RNA causes abnormal growth of the anterior hindbrain, duplication of Mauthner neurons in rhombomere (r) 2 and fate changes of r2 mesenchymal and neurogenic neural crest. These results are discussed in terms of the role of Hoxa-1 in controlling anterior hindbrain patterning and the relationship between expression of Hoxa-1 and retinoic acid.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  R. J. Sherwood, D. L. Duren, L. M. Havill, J. Rogers, L. A. Cox, B. Towne, and M. C. Mahaney A Genomewide Linkage Scan for Quantitative Trait Loci Influencing the Craniofacial Complex in Baboons (Papio hamadryas spp.) Genetics, September 1, 2008; 180(1): 619 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hans and M. Westerfield Changes in retinoic acid signaling alter otic patterning Development, July 1, 2007; 134(13): 2449 - 2458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Martinez-Ceballos, P. Chambon, and L. J. Gudas Differences in Gene Expression between Wild Type and Hoxa1 Knockout Embryonic Stem Cells after Retinoic Acid Treatment or Leukemia Inhibitory Factor (LIF) Removal J. Biol. Chem., April 22, 2005; 280(16): 16484 - 16498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. H. Li, Z. Lao, and A. L. Joyner New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression Development, April 15, 2005; 132(8): 1971 - 1981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schubert, J.-K. Yu, N. D. Holland, H. Escriva, V. Laudet, and L. Z. Holland Retinoic acid signaling acts via Hox1 to establish the posterior limit of the pharynx in the chordate amphioxus Development, January 1, 2005; 132(1): 61 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Hernandez, H. A. Rikhof, R. Bachmann, and C. B. Moens vhnf1 integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafish Development, September 15, 2004; 131(18): 4511 - 4520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Hale, M. A. Kheirbek, J. E. Schriefer, and V. E. Prince Hox Gene Misexpression and Cell-Specific Lesions Reveal Functionality of Homeotically Transformed Neurons J. Neurosci., March 24, 2004; 24(12): 3070 - 3076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Murakami, M. Pasqualetti, Y. Takio, S. Hirano, F. M. Rijli, and S. Kuratani Segmental development of reticulospinal and branchiomotor neurons in lamprey: insights into the evolution of the vertebrate hindbrain Development, March 1, 2004; 131(5): 983 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Deflorian, N. Tiso, E. Ferretti, D. Meyer, F. Blasi, M. Bortolussi, and F. Argenton Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation Development, February 1, 2004; 131(3): 613 - 627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Wiellette and H. Sive vhnf1 and Fgf signals synergize to specify rhombomere identity in the zebrafish hindbrain Development, August 15, 2003; 130(16): 3821 - 3829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-K. Bae, T. Shimizu, T. Yabe, C.-H. Kim, T. Hirata, H. Nojima, O. Muraoka, T. Hirano, and M. Hibi A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish Development, May 1, 2003; 130(9): 1853 - 1865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kudoh, S. W. Wilson, and I. B. Dawid Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm Development, March 11, 2003; 129(18): 4335 - 4346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Escriva, N. D. Holland, H. Gronemeyer, V. Laudet, and L. Z. Holland The retinoic acid signaling pathway regulates anterior/posterior patterning in the nerve cord and pharynx of amphioxus, a chordate lacking neural crest Development, March 8, 2003; 129(12): 2905 - 2916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Itoh, T. Kudoh, M. Dedekian, C.-H. Kim, and A. B. Chitnis A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary Development, March 7, 2003; 129(10): 2317 - 2327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. McClintock, M. A. Kheirbek, and V. E. Prince Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention Development, March 7, 2003; 129(10): 2339 - 2354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Theil, L. Ariza-McNaughton, M. Manzanares, J. Brodie, R. Krumlauf, and D. G. Wilkinson Requirement for downregulation of kreisler during late patterning of the hindbrain Development, March 5, 2003; 129(6): 1477 - 1485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hauptmann, H.-G. Belting, U. Wolke, K. Lunde, I. Soll, S. Abdelilah-Seyfried, V. Prince, and W. Driever spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation Development, January 4, 2002; 129(7): 1645 - 1655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Golding, M. Dixon, and M. Gassmann Cues from neuroepithelium and surface ectoderm maintain neural crest-free regions within cranial mesenchyme of the developing chick Development, January 3, 2002; 129(5): 1095 - 1105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Voiculescu, E. Taillebourg, C. Pujades, C. Kress, S. Buart, P. Charnay, and S. Schneider-Maunoury Hindbrain patterning: Krox20 couples segmentation and specification of regional identity Development, December 15, 2001; 128(24): 4967 - 4978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Waskiewicz, H. A. Rikhof, R. E. Hernandez, and C. B. Moens Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning Development, November 1, 2001; 128(21): 4139 - 4151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Manzanares, S. Bel-Vialar, L. Ariza-McNaughton, E. Ferretti, H. Marshall, M. M. Maconochie, F. Blasi, and R. Krumlauf Independent regulation of initiation and maintenance phases of Hoxa3 expression in the vertebrate hindbrain involve auto- and cross-regulatory mechanisms Development, September 15, 2001; 128(18): 3595 - 3607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhao and S. S. Potter Functional specificity of the Hoxa13 homeobox Development, August 15, 2001; 128(16): 3197 - 3207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. McClintock, R. Carlson, D. M. Mann, and V. E. Prince Consequences of Hox gene duplication in the vertebrates: an investigation of the zebrafish Hox paralogue group 1 genes Development, July 1, 2001; 128(13): 2471 - 2484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N Vlachakis, S. Choe, and C. Sagerstrom Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish Development, January 4, 2001; 128(8): 1299 - 1312. [Abstract] [PDF]
|
|
|
|
|
|
G. Grammatopoulos, E Bell, L Toole, A Lumsden, and A. Tucker Homeotic transformation of branchial arch identity after Hoxa2 overexpression Development, January 12, 2000; 127(24): 5355 - 5365. [Abstract] [PDF]
|
|
|
|
|
|
M Pasqualetti, M Ori, I Nardi, and F. Rijli Ectopic Hoxa2 induction after neural crest migration results in homeosis of jaw elements in Xenopus Development, January 12, 2000; 127(24): 5367 - 5378. [Abstract] [PDF]
|
|
|
|
|
|
E Ferretti, H Marshall, H Popperl, M Maconochie, R Krumlauf, and F Blasi Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins Development, January 1, 2000; 127(1): 155 - 166. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Bell, R. J. Wingate, and A. Lumsden Homeotic Transformation of Rhombomere Identity After Localized Hoxb1 Misexpression Science, June 25, 1999; 284(5423): 2168 - 2171. [Abstract] [Full Text]
|
|
|
|
|
|
K. Barth, Y Kishimoto, K. Rohr, C Seydler, S Schulte-Merker, and S. Wilson Bmp activity establishes a gradient of positional information throughout the entire neural plate Development, January 11, 1999; 126(22): 4977 - 4987. [Abstract] [PDF]
|
|
|
|
|
|
S Jungbluth, E Bell, and A Lumsden Specification of distinct motor neuron identities by the singular activities of individual Hox genes Development, January 6, 1999; 126(12): 2751 - 2758. [Abstract] [PDF]
|
|
|
|
|
|
L. Roth, P Bormann, A Bonnet, and E Reinhard beta-thymosin is required for axonal tract formation in developing zebrafish brain Development, January 4, 1999; 126(7): 1365 - 1374. [Abstract] [PDF]
|
|
|
|
|
|
M Manzanares, S Cordes, L Ariza-McNaughton, V Sadl, K Maruthainar, G Barsh, and R Krumlauf Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes Development, January 2, 1999; 126(4): 759 - 769. [Abstract] [PDF]
|
|
|
|
|
|
M Nikaido, M Tada, H Takeda, A Kuroiwa, and N Ueno In vivo analysis using variants of zebrafish BMPR-IA: range of action and involvement of BMP in ectoderm patterning Development, January 1, 1999; 126(1): 181 - 190. [Abstract] [PDF]
|
|
|
|
|
|
F Helmbacher, C Pujades, C Desmarquet, M Frain, F. Rijli, P Chambon, and P Charnay Hoxa1 and Krox-20 synergize to control the development of rhombomere 3 Development, January 12, 1998; 125(23): 4739 - 4748. [Abstract] [PDF]
|
|
|
|
|
|
G Couly, A Grapin-Botton, P Coltey, B Ruhin, and N. Le Douarin Determination of the identity of the derivatives of the cephalic neural crest: incompatibility between Hox gene expression and lower jaw development Development, January 9, 1998; 125(17): 3445 - 3459. [Abstract] [PDF]
|
|
|
|
|
|
S Koshida, M Shinya, T Mizuno, A Kuroiwa, and H Takeda Initial anteroposterior pattern of the zebrafish central nervous system is determined by differential competence of the epiblast Development, January 5, 1998; 125(10): 1957 - 1966. [Abstract] [PDF]
|
|
|
|
|
|
A Grapin-Botton, M. Bonnin, M Sieweke, and N. Le Douarin Defined concentrations of a posteriorizing signal are critical for MafB/Kreisler segmental expression in the hindbrain Development, January 4, 1998; 125(7): 1173 - 1181. [Abstract] [PDF]
|
|
|
|
|
|
M Studer, A Gavalas, H Marshall, L Ariza-McNaughton, F. Rijli, P Chambon, and R Krumlauf Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning Development, January 3, 1998; 125(6): 1025 - 1036. [Abstract] [PDF]
|
|
|
|
|
|
V. Prince, C. Moens, C. Kimmel, and R. Ho Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino Development, January 2, 1998; 125(3): 393 - 406. [Abstract] [PDF]
|
|
|
|
|
|
V. Prince, L Joly, M Ekker, and R. Ho Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk Development, January 2, 1998; 125(3): 407 - 420. [Abstract] [PDF]
|
|
|
|
|
|
J van der Wees, J. Schilthuis, C. Koster, H Diesveld-Schipper, G. Folkers, P. van der Saag, M. Dawson, K Shudo, B van der Burg, and A. Durston Inhibition of retinoic acid receptor-mediated signalling alters positional identity in the developing hindbrain Development, January 2, 1998; 125(3): 545 - 556. [Abstract] [PDF]
|
|
|
|
 |
|
 M K Maconochie, S Nonchev, M Studer, S K Chan, H Popperl, M H Sham, R S Mann, and R Krumlauf Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1. Genes & Dev., July 15, 1997; 11(14): 1885 - 1895. [Abstract] [PDF]
|
|
|
|
|
|
A Grapin-Botton, M. Bonnin, and N. Le Douarin Hox gene induction in the neural tube depends on three parameters: competence, signal supply and paralogue group Development, January 2, 1997; 124(4): 849 - 859. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Nonchev, M. Maconochie, A. Gould, A. Morrison, and R. Krumlauf Cross-Regulatory Interactions between Hox Genes and the Control of Segmental Expression in the Vertebrate Central Nervous System Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 313 - 323. [Abstract] [PDF]
|
|
|
|
|
|
P. J. Kolm and H. L. Sive Retinoids and Posterior Neural Induction: A Reevaluation of Nieuwkoop's Two-step Hypothesis Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 511 - 521. [Abstract] [PDF]
|
|
