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Development, Vol 122, Issue 3 805-814, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
IA Sulston and KV Anderson
Division of Genetics, Department of Molecular and Cell Biology, University of California at Berkeley 94720, USA.
The identification and analysis of genes controlling segmentation in Drosophila melanogaster has opened the way for understanding similarities and differences in mechanisms of segmentation among the insects. Homologues of Drosophila segmentation genes have been cloned and their expression patterns have been analyzed in a variety of insects, revealing that the patterns of expression of many genes are conserved. Conserved expression patterns do not, however, necessarily reflect conserved gene function. To address gene function, we have conducted a screen for mutations that alter embryonic patterning of the beetle, Tribolium castaneum. One of the mutations isolated, godzilla, affects early steps in the segmentation process in the whole animal, like Drosophila pair-rule mutants. Another mutation, jaws, is novel: it caused both a dramatic homeotic transformation in the thorax and first abdominal segment as well as a deletion of most of the segments of the abdomen. In Tribolium and other intermediated germ band insects, the anterior segments of the embryo are determined in the syncytium of the blastoderm, whereas the abdominal segments proliferated in the cellular environment. Both the godzilla and jaws mutations affect segments that are formed in the syncytium differently from those that are formed after cellularization. These regionally specific phenotypes may reflect the different patterning mechanisms that must be employed by the anterior and posterior regions of an intermediated germ insect.
This article has been cited by other articles:
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  C. P. Choe, S. C. Miller, and S. J. Brown A pair-rule gene circuit defines segments sequentially in the short-germ insect Tribolium castaneum PNAS, April 25, 2006; 103(17): 6560 - 6564. [Abstract] [Full Text] [PDF]
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 A. C. Cerny, G. Bucher, R. Schroder, and M. Klingler Breakdown of abdominal patterning in the Tribolium Kruppel mutant jaws Development, December 15, 2005; 132(24): 5353 - 5363. [Abstract] [Full Text] [PDF]
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P. Z. Liu and T. C. Kaufman Kruppel is a gap gene in the intermediate germband insect Oncopeltus fasciatus and is required for development of both blastoderm and germband-derived segments Development, September 15, 2004; 131(18): 4567 - 4579. [Abstract] [Full Text] [PDF]
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G. Bucher and M. Klingler Divergent segmentation mechanism in the short germ insect Tribolium revealed by giant expression and function Development, April 15, 2004; 131(8): 1729 - 1740. [Abstract] [Full Text] [PDF]
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A Beermann, D. Jay, R. Beeman, M Hulskamp, D Tautz, and G Jurgens The Short antennae gene of Tribolium is required for limb development and encodes the orthologue of the Drosophila Distal-less protein Development, January 1, 2001; 128(2): 287 - 297. [Abstract] [PDF]
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 M.-L. Dichtel, S. Louvet-Vallée, M. E. Viney, M.-A. Félix, and P. W. Sternberg Control of Vulval Cell Division Number in the Nematode Oscheius/Dolichorhabditis sp. CEW1 Genetics, January 1, 2001; 157(1): 183 - 197. [Abstract] [Full Text]
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D. L. Lewis, M. DeCamillis, and R. L. Bennett Special Feature: Distinct roles of the homeotic genes Ubx and abd-A in beetle embryonic abdominal appendage development PNAS, April 25, 2000; 97(9): 4504 - 4509. [Abstract] [Full Text] [PDF]
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M. A. Pultz, K. K. Zimmerman, N. M. Alto, M. Kaeberlein, S. K. Lange, J. N. Pitt, N. L. Reeves, and D. L. Zehrung A Genetic Screen for Zygotic Embryonic Lethal Mutations Affecting Cuticular Morphology in the Wasp Nasonia vitripennis Genetics, March 1, 2000; 154(3): 1213 - 1229. [Abstract] [Full Text]
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R. Schroder, C. Eckert, C. Wolff, and D. Tautz Conserved and divergent aspects of terminal patterning in the beetle Tribolium castaneum PNAS, June 6, 2000; 97(12): 6591 - 6596. [Abstract] [Full Text] [PDF]
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