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Development, Vol 122, Issue 3 881-894, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells

YI Yeom, G Fuhrmann, CE Ovitt, A Brehm, K Ohbo, M Gross, K Hubner and HR Scholer
Gene Expression Programme, EMBL, Heidelberg, FRG.

The totipotent stem cells of the pregastrulation mouse embryo which give rise to all embryonic somatic tissues and germ cells express Oct-4. The expression is downregulated during gastrulation and is thereafter only maintained in the germline lineage. Oct-4/lacZ transgenes were used to determine how this pattern of expression was achieved, and resulted in the identification of two separate regulatory elements. The distal element drives Oct-4 expression in preimplantation embryos, in migratory and postmigratory primordial germ cells but is inactive in cells of the epiblast. In cell lines this element is specifically active in embryonic stem and embryonic germ cells. The proximal element directs the epiblast-specific expression pattern, including downregulation during gastrulation; in cell lines its activity is restricted to epiblast-derived cells. Thus, Oct-4 expression in the germline is regulated separately from epiblast expression. This provides the first marker for the identification of totipotent cells in the embryo, and suggests that expression of Oct-4 in the totipotent cycle is dependent on a set of factors unique to the germline.
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J. Lee, K. Inoue, R. Ono, N. Ogonuki, T. Kohda, T. Kaneko-Ishino, A. Ogura, and F. Ishino
Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells
Development, March 6, 2003; 129(8): 1807 - 1817.
[Abstract] [Full Text] [PDF]

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 Biol. Reprod.Home page
M. Buehr, J. Nichols, F. Stenhouse, P. Mountford, C.J. Greenhalgh, S. Kantachuvesiri, G. Brooker, J. Mullins, and A.G. Smith
Rapid Loss of Oct-4 and Pluripotency in Cultured Rodent Blastocysts and Derivative Cell Lines
Biol Reprod, January 1, 2003; 68(1): 222 - 229.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
S. Gidekel and Y. Bergman
A Unique Developmental Pattern of Oct-3/4 DNA Methylation Is Controlled by a cis-demodification Element
J. Biol. Chem., September 6, 2002; 277(37): 34521 - 34530.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
N. Hori, H. Nakano, T. Takeuchi, H. Kato, S. Hamaguchi, M. Oshimura, and K. Sato
A Dyad Oct-binding Sequence Functions as a Maintenance Sequence for the Unmethylated State within the H19/Igf2-imprinted Control Region
J. Biol. Chem., July 26, 2002; 277(31): 27960 - 27967.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
S. Marchetti, C. Gimond, K. Iljin, C. Bourcier, K. Alitalo, J. Pouyssegur, and G. Pages
Endothelial cells genetically selected from differentiating mouse embryonic stem cells incorporate at sites of neovascularization in vivo
J. Cell Sci., May 15, 2002; 115(10): 2075 - 2085.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
D. Solter
Cloning v. clowning
Genes & Dev., May 15, 2002; 16(10): 1163 - 1166.
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 Genes Dev.Home page
M. Boiani, S. Eckardt, H. R. Scholer, and K. J. McLaughlin
Oct4 distribution and level in mouse clones: consequences for pluripotency
Genes & Dev., May 15, 2002; 16(10): 1209 - 1219.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
S. Levenberg, J. S. Golub, M. Amit, J. Itskovitz-Eldor, and R. Langer
Endothelial cells derived from human embryonic stem cells
PNAS, March 21, 2002; (2002) 32074999.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
H. Niwa, S. Masui, I. Chambers, A. G. Smith, and J.-i. Miyazaki
Phenotypic Complementation Establishes Requirements for Specific POU Domain and Generic Transactivation Function of Oct-3/4 in Embryonic Stem Cells
Mol. Cell. Biol., March 1, 2002; 22(5): 1526 - 1536.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
S. Assady, G. Maor, M. Amit, J. Itskovitz-Eldor, K. L. Skorecki, and M. Tzukerman
Insulin Production by Human Embryonic Stem Cells
Diabetes, August 1, 2001; 50(8): 1691 - 1697.
[Abstract] [Full Text] [PDF]

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 Stem CellsHome page
M. Pesce and H. R. Scholer
Oct-4: Gatekeeper in the Beginnings of Mammalian Development
Stem Cells, July 1, 2001; 19(4): 271 - 278.
[Abstract] [Full Text] [PDF]

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 Endocr. Rev.Home page
B. Andersen and M. G. Rosenfeld
POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human Disease
Endocr. Rev., February 1, 2001; 22(1): 2 - 35.
[Abstract] [Full Text]

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 Genes Dev.Home page
S. S. Tanaka, Y. Toyooka, R. Akasu, Y. Katoh-Fukui, Y. Nakahara, R. Suzuki, M. Yokoyama, and T. Noce
The mouse homolog of Drosophila Vasa is required for the development of male germ cells
Genes & Dev., April 1, 2000; 14(7): 841 - 853.
[Abstract] [Full Text]

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 Nucleic Acids ResHome page
H. Wallace, R. Ansell, J. Clark, and J. McWhir
Pre-selection of integration sites imparts repeatable transgene expression
Nucleic Acids Res., March 15, 2000; 28(6): 1455 - 1464.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
E. Barnea and Y. Bergman
Synergy of SF1 and RAR in Activation of Oct-3/4 Promoter
J. Biol. Chem., February 25, 2000; 275(9): 6608 - 6619.
[Abstract] [Full Text] [PDF]

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 Biol. Reprod.Home page
N. C. Talbot, T. J. Caperna, J. L. Edwards, W. Garrett, K. D. Wells, and A. D. Ealy
Bovine Blastocyst-Derived Trophectoderm and Endoderm Cell Cultures: Interferon Tau and Transferrin Expression as Respective In Vitro Markers
Biol Reprod, February 1, 2000; 62(2): 235 - 247.
[Abstract] [Full Text]

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 Mol. Cell. Biol.Home page
M. Nishimoto, A. Fukushima, A. Okuda, and M. Muramatsu
The Gene for the Embryonic Stem Cell Coactivator UTF1 Carries a Regulatory Element Which Selectively Interacts with a Complex Composed of Oct-3/4 and Sox-2
Mol. Cell. Biol., August 1, 1999; 19(8): 5453 - 5465.
[Abstract] [Full Text] [PDF]

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 Mol Hum ReprodHome page
R.G. Edwards and H. K. Beard
Hypothesis: sex determination and germline formation are committed at the pronucleate stage in mammalian embryos
Mol. Hum. Reprod., July 1, 1999; 5(7): 595 - 606.
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 Biol. Reprod.Home page
M.J.T. van Eijk, M.A. van Rooijen, S. Modina, L. Scesi, G. Folkers, H.T.A. van Tol, M.M. Bevers, S.R. Fisher, H.A. Lewin, D. Rakacolli, et al.
Molecular Cloning, Genetic Mapping, and Developmental Expression of Bovine POU5F1
Biol Reprod, May 1, 1999; 60(5): 1093 - 1103.
[Abstract] [Full Text]

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 DevelopmentHome page
R Anderson, R Fassler, E Georges-Labouesse, R. Hynes, B. Bader, J. Kreidberg, K Schaible, J Heasman, and C Wylie
Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads
Development, January 4, 1999; 126(8): 1655 - 1664.
[Abstract] [PDF]

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 Genes Dev.Home page
V. Botquin, H. Hess, G. Fuhrmann, C. Anastassiadis, M. K. Gross, G. Vriend, and H. R. Schöler
New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2
Genes & Dev., July 1, 1998; 12(13): 2073 - 2090.
[Abstract] [Full Text]

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 Mol. Cell. Biol.Home page
E. Ben-Shushan, J. R. Thompson, L. J. Gudas, and Y. Bergman
Rex-1, a Gene Encoding a Transcription Factor Expressed in the Early Embryo, Is Regulated via Oct-3/4 and Oct-6 Binding to an Octamer Site and a Novel Protein, Rox-1, Binding to an Adjacent Site
Mol. Cell. Biol., April 1, 1998; 18(4): 1866 - 1878.
[Abstract] [Full Text]

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 Genes Dev.Home page
A K Ryan and M G Rosenfeld
POU domain family values: flexibility, partnerships, and developmental codes.
Genes & Dev., May 15, 1997; 11(10): 1207 - 1225.
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 Genes Dev.Home page
T Ludwig, D L Chapman, V E Papaioannou, and A Efstratiadis
Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.
Genes & Dev., May 15, 1997; 11(10): 1226 - 1241.
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 DevelopmentHome page
T. Natoli, M. Ellsworth, C Wu, K. Gross, and S. Pruitt
Positive and negative DNA sequence elements are required to establish the pattern of Pax3 expression
Development, January 2, 1997; 124(3): 617 - 626.
[Abstract] [PDF]


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