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Development, Vol 122, Issue 3 881-894, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
YI Yeom, G Fuhrmann, CE Ovitt, A Brehm, K Ohbo, M Gross, K Hubner and HR Scholer
Gene Expression Programme, EMBL, Heidelberg, FRG.
The totipotent stem cells of the pregastrulation mouse embryo which give rise to all embryonic somatic tissues and germ cells express Oct-4. The expression is downregulated during gastrulation and is thereafter only maintained in the germline lineage. Oct-4/lacZ transgenes were used to determine how this pattern of expression was achieved, and resulted in the identification of two separate regulatory elements. The distal element drives Oct-4 expression in preimplantation embryos, in migratory and postmigratory primordial germ cells but is inactive in cells of the epiblast. In cell lines this element is specifically active in embryonic stem and embryonic germ cells. The proximal element directs the epiblast-specific expression pattern, including downregulation during gastrulation; in cell lines its activity is restricted to epiblast-derived cells. Thus, Oct-4 expression in the germline is regulated separately from epiblast expression. This provides the first marker for the identification of totipotent cells in the embryo, and suggests that expression of Oct-4 in the totipotent cycle is dependent on a set of factors unique to the germline.
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V. Botquin, H. Hess, G. Fuhrmann, C. Anastassiadis, M. K. Gross, G. Vriend, and H. R. Schöler New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2 Genes & Dev., July 1, 1998; 12(13): 2073 - 2090. [Abstract] [Full Text]
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E. Ben-Shushan, J. R. Thompson, L. J. Gudas, and Y. Bergman Rex-1, a Gene Encoding a Transcription Factor Expressed in the Early Embryo, Is Regulated via Oct-3/4 and Oct-6 Binding to an Octamer Site and a Novel Protein, Rox-1, Binding to an Adjacent Site Mol. Cell. Biol., April 1, 1998; 18(4): 1866 - 1878. [Abstract] [Full Text]
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A K Ryan and M G Rosenfeld POU domain family values: flexibility, partnerships, and developmental codes. Genes & Dev., May 15, 1997; 11(10): 1207 - 1225. [PDF]
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T Ludwig, D L Chapman, V E Papaioannou, and A Efstratiadis Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes & Dev., May 15, 1997; 11(10): 1226 - 1241. [Abstract] [PDF]
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T. Natoli, M. Ellsworth, C Wu, K. Gross, and S. Pruitt Positive and negative DNA sequence elements are required to establish the pattern of Pax3 expression Development, January 2, 1997; 124(3): 617 - 626. [Abstract] [PDF]
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