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Development, Vol 122, Issue 3 983-995, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

MF Offield, TL Jetton, PA Labosky, M Ray, RW Stein, MA Magnuson, BL Hogan and CV Wright
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-2175, USA.

It has been proposed that the Xenopus homeobox gene, XlHbox8, is involved in endodermal differentiation during pancreatic and duodenal development (Wright, C.V.E., Schnegelsberg, P. and De Robertis, E.M. (1988). Development 105, 787-794). To test this hypothesis directly, gene targeting was used to make two different null mutations in the mouse XlHbox8 homolog, pdx-1. In the first, the second pdx-1 exon, including the homeobox, was replaced by a neomycin resistance cassette. In the second, a lacZ reporter was fused in-frame with the N terminus of PDX-1, replacing most of the homeodomain. Neonatal pdx-1 -/- mice are apancreatic, in confirmation of previous reports (Jonsson, J., Carlsson, L., Edlund, T. and Edlund, H. (1994). Nature 371, 606-609). However, the pancreatic buds do form in homozygous mutants, and the dorsal bud undergoes limited proliferation and outgrowth to form a small, irregularly branched, ductular tree. This outgrowth does not contain insulin or amylase-positive cells, but glucagon-expressing cells are found. The rostral duodenum shows a local absence of the normal columnar epithelial lining, villi, and Brunner's glands, which are replaced by a GLUT2-positive cuboidal epithelium resembling the bile duct lining. Just distal of the abnormal epithelium, the numbers of enteroendocrine cells in the villi are greatly reduced. The PDX-1/beta-galactosidase fusion allele is expressed in pancreatic and duodenal cells in the absence of functional PDX-1, with expression continuing into perinatal stages with similar boundaries and expression levels. These results offer additional insight into the role of pdx-1 in the determination and differentiation of the posterior foregut, particularly regarding the proliferation and differentiation of the pancreatic progenitors.
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P. W. Heiser, J. Lau, M. M. Taketo, P. L. Herrera, and M. Hebrok
Stabilization of {beta}-catenin impacts pancreas growth
Development, May 15, 2006; 133(10): 2023 - 2032.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
W. V. Cardoso and J. Lu
Regulation of early lung morphogenesis: questions, facts and controversies
Development, May 1, 2006; 133(9): 1611 - 1624.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
P. Wang, T. Liu, Z. Li, X. Ma, and T. Jin
Redundant and Synergistic Effect of Cdx-2 and Brn-4 on Regulating Proglucagon Gene Expression
Endocrinology, April 1, 2006; 147(4): 1950 - 1958.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
M.-J. Boucher, L. Selander, L. Carlsson, and H. Edlund
Phosphorylation Marks IPF1/PDX1 Protein for Degradation by Glycogen Synthase Kinase 3-dependent Mechanisms
J. Biol. Chem., March 10, 2006; 281(10): 6395 - 6403.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
B. Duvillie, M. Attali, A. Bounacer, P. Ravassard, A. Basmaciogullari, and R. Scharfmann
The Mesenchyme Controls the Timing of Pancreatic {beta}-Cell Differentiation
Diabetes, March 1, 2006; 55(3): 582 - 589.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
I. Artner, J. Le Lay, Y. Hang, L. Elghazi, J. C. Schisler, E. Henderson, B. Sosa-Pineda, and R. Stein
MafB: An Activator of the Glucagon Gene Expressed in Developing Islet {alpha}- and {beta}-Cells
Diabetes, February 1, 2006; 55(2): 297 - 304.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
Y. Fujitani, S. Fujitani, D. F. Boyer, M. Gannon, Y. Kawaguchi, M. Ray, M. Shiota, R. W. Stein, M. A. Magnuson, and C. V.E. Wright
Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation
Genes & Dev., January 15, 2006; 20(2): 253 - 266.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
D. Kawamori, H. Kaneto, Y. Nakatani, T.-a. Matsuoka, M. Matsuhisa, M. Hori, and Y. Yamasaki
The Forkhead Transcription Factor Foxo1 Bridges the JNK Pathway and the Transcription Factor PDX-1 through Its Intracellular Translocation
J. Biol. Chem., January 13, 2006; 281(2): 1091 - 1098.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
R. H. Hruban, N. V. Adsay, J. Albores-Saavedra, M. R. Anver, A. V. Biankin, G. P. Boivin, E. E. Furth, T. Furukawa, A. Klein, D. S. Klimstra, et al.
Pathology of Genetically Engineered Mouse Models of Pancreatic Exocrine Cancer: Consensus Report and Recommendations
Cancer Res., January 1, 2006; 66(1): 95 - 106.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
A. V. Poll, C. E. Pierreux, L. Lokmane, C. Haumaitre, Y. Achouri, P. Jacquemin, G. G. Rousseau, S. Cereghini, and F. P. Lemaigre
A vHNF1/TCF2-HNF6 Cascade Regulates the Transcription Factor Network That Controls Generation of Pancreatic Precursor Cells
Diabetes, January 1, 2006; 55(1): 61 - 69.
[Abstract] [Full Text] [PDF]

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 J EndocrinolHome page
E N Fazio, M Everest, R Colman, R Wang, and C L Pin
Altered Glut-2 accumulation and {beta}-cell function in mice lacking the exocrine-specific transcription factor, Mist1
J. Endocrinol., December 1, 2005; 187(3): 407 - 418.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
M. E. Wilson, K. Y. Yang, A. Kalousova, J. Lau, Y. Kosaka, F. C. Lynn, J. Wang, C. Mrejen, V. Episkopou, H. C. Clevers, et al.
The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas
Diabetes, December 1, 2005; 54(12): 3402 - 3409.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. R. West and P. S. Oates
Decreased sucrase and lactase activity in iron deficiency is accompanied by reduced gene expression and upregulation of the transcriptional repressor PDX-1
Am J Physiol Gastrointest Liver Physiol, December 1, 2005; 289(6): G1108 - G1114.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. C. Van Velkinburgh, S. E. Samaras, K. Gerrish, I. Artner, and R. Stein
Interactions between Areas I and II Direct pdx-1 Expression Specifically to Islet Cell Types of the Mature and Developing Pancreas
J. Biol. Chem., November 18, 2005; 280(46): 38438 - 38444.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. Francis, S. K. Chakrabarti, J. C. Garmey, and R. G. Mirmira
Pdx-1 Links Histone H3-Lys-4 Methylation to RNA Polymerase II Elongation during Activation of Insulin Transcription
J. Biol. Chem., October 28, 2005; 280(43): 36244 - 36253.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
S. Papadopoulou and H. Edlund
Attenuated Wnt Signaling Perturbs Pancreatic Growth but Not Pancreatic Function
Diabetes, October 1, 2005; 54(10): 2844 - 2851.
[Abstract] [Full Text] [PDF]

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 J. Histochem. Cytochem.Home page
M. Brissova, M. J. Fowler, W. E. Nicholson, A. Chu, B. Hirshberg, D. M. Harlan, and A. C. Powers
Assessment of Human Pancreatic Islet Architecture and Composition by Laser Scanning Confocal Microscopy
J. Histochem. Cytochem., September 1, 2005; 53(9): 1087 - 1097.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
A. M. Holland, L. J. Gonez, G. Naselli, R. J. MacDonald, and L. C. Harrison
Conditional Expression Demonstrates the Role of the Homeodomain Transcription Factor Pdx1 in Maintenance and Regeneration of {beta}-Cells in the Adult Pancreas
Diabetes, September 1, 2005; 54(9): 2586 - 2595.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Endocrinol. Metab.Home page
A. M. Hennige, U. Ozcan, T. Okada, U. S. Jhala, M. Schubert, M. F. White, and R. N. Kulkarni
Alterations in growth and apoptosis of insulin receptor substrate-1-deficient {beta}-cells
Am J Physiol Endocrinol Metab, August 1, 2005; 289(2): E337 - E346.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
K. Shanmukhappa, R. Mourya, G. E. Sabla, J. L. Degen, and J. A. Bezerra
Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice
PNAS, July 19, 2005; 102(29): 10182 - 10187.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
K. D. Henseleit, S. B. Nelson, K. Kuhlbrodt, J. C. Hennings, J. Ericson, and M. Sander
NKX6 transcription factor activity is required for {alpha}- and {beta}-cell development in the pancreas
Development, July 1, 2005; 132(13): 3139 - 3149.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
P. Collombat, J. Hecksher-Sorensen, V. Broccoli, J. Krull, I. Ponte, T. Mundiger, J. Smith, P. Gruss, P. Serup, and A. Mansouri
The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the {alpha}- and {beta}-cell lineages in the mouse endocrine pancreas
Development, July 1, 2005; 132(13): 2969 - 2980.
[Abstract] [Full Text] [PDF]

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 GENES CELLSHome page
N. Shiraki, C.-J. Lai, Y. Hishikari, and S. Kume
TGF-{beta} signaling potentiates differentiation of embryonic stem cells to Pdx-1 expressing endodermal cells
Genes Cells, June 1, 2005; 10(6): 503 - 516.
[Abstract] [Full Text] [PDF]

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 Mol. Endocrinol.Home page
M. F. Pino, D. Z. Ye, K. D. Linning, C. D. Green, B. Wicksteed, V. Poitout, and L. K. Olson
Elevated Glucose Attenuates Human Insulin Gene Promoter Activity in INS-1 Pancreatic {beta}-Cells via Reduced Nuclear Factor Binding to the A5/Core and Z Element
Mol. Endocrinol., May 1, 2005; 19(5): 1343 - 1360.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
T. Iype, J. Francis, J. C. Garmey, J. C. Schisler, R. Nesher, G. C. Weir, T. C. Becker, C. B. Newgard, S. C. Griffen, and R. G. Mirmira
Mechanism of insulin Gene Regulation by the Pancreatic Transcription Factor Pdx-1: APPLICATION OF PRE-mRNA ANALYSIS AND CHROMATIN IMMUNOPRECIPITATION TO ASSESS FORMATION OF FUNCTIONAL TRANSCRIPTIONAL COMPLEXES
J. Biol. Chem., April 29, 2005; 280(17): 16798 - 16807.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
H. Kaneto, Y. Nakatani, T. Miyatsuka, T.-a. Matsuoka, M. Matsuhisa, M. Hori, and Y. Yamasaki
PDX-1/VP16 Fusion Protein, Together With NeuroD or Ngn3, Markedly Induces Insulin Gene Transcription and Ameliorates Glucose Tolerance
Diabetes, April 1, 2005; 54(4): 1009 - 1022.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Endocrinol. Metab.Home page
M. Brissova, M. Blaha, C. Spear, W. Nicholson, A. Radhika, M. Shiota, M. J. Charron, C. V. E. Wright, and A. C. Powers
Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis
Am J Physiol Endocrinol Metab, April 1, 2005; 288(4): E707 - E714.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
L. Zhao, M. Guo, T.-a. Matsuoka, D. K. Hagman, S. D. Parazzoli, V. Poitout, and R. Stein
The Islet {beta} Cell-enriched MafA Activator Is a Key Regulator of Insulin Gene Transcription
J. Biol. Chem., March 25, 2005; 280(12): 11887 - 11894.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
J. F. Habener, D. M. Kemp, and M. K. Thomas
Minireview: Transcriptional Regulation in Pancreatic Development
Endocrinology, March 1, 2005; 146(3): 1025 - 1034.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
Y. Li, X. Cao, L.-X. Li, P. L. Brubaker, H. Edlund, and D. J. Drucker
{beta}-Cell Pdx1 Expression Is Essential for the Glucoregulatory, Proliferative, and Cytoprotective Actions of Glucagon-Like Peptide-1
Diabetes, February 1, 2005; 54(2): 482 - 491.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
C. Haumaitre, E. Barbacci, M. Jenny, M. O. Ott, G. Gradwohl, and S. Cereghini
Lack of TCF2/vHNF1 in mice leads to pancreas agenesis
PNAS, February 1, 2005; 102(5): 1490 - 1495.
[Abstract] [Full Text] [PDF]


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