|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 122, Issue 3 983-995, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
MF Offield, TL Jetton, PA Labosky, M Ray, RW Stein, MA Magnuson, BL Hogan and CV Wright
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-2175, USA.
It has been proposed that the Xenopus homeobox gene, XlHbox8, is involved in endodermal differentiation during pancreatic and duodenal development (Wright, C.V.E., Schnegelsberg, P. and De Robertis, E.M. (1988). Development 105, 787-794). To test this hypothesis directly, gene targeting was used to make two different null mutations in the mouse XlHbox8 homolog, pdx-1. In the first, the second pdx-1 exon, including the homeobox, was replaced by a neomycin resistance cassette. In the second, a lacZ reporter was fused in-frame with the N terminus of PDX-1, replacing most of the homeodomain. Neonatal pdx-1 -/- mice are apancreatic, in confirmation of previous reports (Jonsson, J., Carlsson, L., Edlund, T. and Edlund, H. (1994). Nature 371, 606-609). However, the pancreatic buds do form in homozygous mutants, and the dorsal bud undergoes limited proliferation and outgrowth to form a small, irregularly branched, ductular tree. This outgrowth does not contain insulin or amylase-positive cells, but glucagon-expressing cells are found. The rostral duodenum shows a local absence of the normal columnar epithelial lining, villi, and Brunner's glands, which are replaced by a GLUT2-positive cuboidal epithelium resembling the bile duct lining. Just distal of the abnormal epithelium, the numbers of enteroendocrine cells in the villi are greatly reduced. The PDX-1/beta-galactosidase fusion allele is expressed in pancreatic and duodenal cells in the absence of functional PDX-1, with expression continuing into perinatal stages with similar boundaries and expression levels. These results offer additional insight into the role of pdx-1 in the determination and differentiation of the posterior foregut, particularly regarding the proliferation and differentiation of the pancreatic progenitors.
This article has been cited by other articles:
|
|
 |
|
  C. Haumaitre, O. Lenoir, and R. Scharfmann Histone Deacetylase Inhibitors Modify Pancreatic Cell Fate Determination and Amplify Endocrine Progenitors Mol. Cell. Biol., October 15, 2008; 28(20): 6373 - 6383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J King, L. Guasti, and E. Laufer Hedgehog signalling in endocrine development and disease J. Endocrinol., September 1, 2008; 198(3): 439 - 450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. T. Ku Pancreatic Progenitor Cells--Recent Studies Endocrinology, September 1, 2008; 149(9): 4312 - 4316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Edfalk, P. Steneberg, and H. Edlund Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion Diabetes, September 1, 2008; 57(9): 2280 - 2287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Fukuda, Y. Kawaguchi, K. Furuyama, S. Kodama, M. Horiguchi, T. Kuhara, M. Kawaguchi, M. Terao, R. Doi, C. V.E. Wright, et al. Reduction of Ptf1a Gene Dosage Causes Pancreatic Hypoplasia and Diabetes in Mice Diabetes, September 1, 2008; 57(9): 2421 - 2431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Vanhoose, S. Samaras, I. Artner, E. Henderson, Y. Hang, and R. Stein MafA and MafB Regulate Pdx1 Transcription through the Area II Control Region in Pancreatic {beta} Cells J. Biol. Chem., August 15, 2008; 283(33): 22612 - 22619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Artner, Y. Hang, M. Guo, G. Gu, and R. Stein MafA is a dedicated activator of the insulin gene in vivo J. Endocrinol., August 1, 2008; 198(2): 271 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Oliver-Krasinski and D. A. Stoffers On the origin of the {beta} cell Genes & Dev., August 1, 2008; 22(15): 1998 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. F. Souza, K. Krishnan, and S. J. Spechler Acid, Bile, and CDX: the ABCs of making Barrett's metaplasia Am J Physiol Gastrointest Liver Physiol, August 1, 2008; 295(2): G211 - G218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yoshida, N. Shiraki, H. Baba, M. Goto, S. Fujiwara, K. Kume, and S. Kume Expression patterns of epiplakin1 in pancreas, pancreatic cancer and regenerating pancreas. Genes Cells, July 1, 2008; 13(7): 667 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Nekrep, J. Wang, T. Miyatsuka, and M. S. German Signals from the neural crest regulate beta-cell mass in the pancreas Development, June 15, 2008; 135(12): 2151 - 2160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. S. Dong, E. Provost, S. D. Leach, and D. Y.R. Stainier Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas Genes & Dev., June 1, 2008; 22(11): 1445 - 1450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Y. Choi, A. I. Romer, Y. Wang, M. P. Wu, S. Ito, A. B. Leiter, and R. A. Shivdasani Requirement of the Tissue-Restricted Homeodomain Transcription Factor Nkx6.3 in Differentiation of Gastrin-Producing G Cells in the Stomach Antrum Mol. Cell. Biol., May 15, 2008; 28(10): 3208 - 3218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Shiraki, T. Yoshida, K. Araki, A. Umezawa, Y. Higuchi, H. Goto, K. Kume, and S. Kume Guided Differentiation of Embryonic Stem Cells into Pdx1-Expressing Regional-Specific Definitive Endoderm Stem Cells, April 1, 2008; 26(4): 874 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Babu, S. K. Chakrabarti, J. C. Garmey, and R. G. Mirmira Pdx1 and BETA2/NeuroD1 Participate in a Transcriptional Complex That Mediates Short-range DNA Looping at the Insulin Gene J. Biol. Chem., March 28, 2008; 283(13): 8164 - 8172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sun, L. Zhang, H. F. Gu, W. Han, M. Ren, F. Wang, B. Gong, L. Wang, H. Guo, W. Xin, et al. Peroxisome Proliferator-Activated Receptor-{alpha} Regulates the Expression of Pancreatic/Duodenal Homeobox-1 in Rat Insulinoma (INS-1) Cells and Ameliorates Glucose-Induced Insulin Secretion Impaired by Palmitate Endocrinology, February 1, 2008; 149(2): 662 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. Spagnoli and A. H. Brivanlou The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm Development, February 1, 2008; 135(3): 451 - 461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kokubu, T. Ohtsuka, and R. Kageyama Mash1 is required for neuroendocrine cell development in the glandular stomach. Genes Cells, January 1, 2008; 13(1): 41 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Masui, Q. Long, T. M. Beres, M. A. Magnuson, and R. J. MacDonald Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex Genes & Dev., October 15, 2007; 21(20): 2629 - 2643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-M. Kim, I. Miletich, J. Mao, A. P. McMahon, P. A. Sharpe, and R. A. Shivdasani Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen Development, October 15, 2007; 134(20): 3603 - 3613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Xu, G. Xu, B. Liu, and G. Gu Cre reconstitution allows for DNA recombination selectively in dual-marker-expressing cells in transgenic mice Nucleic Acids Res., October 8, 2007; 35(19): e126 - e126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Jorgensen, J. Ahnfelt-Ronne, J. Hald, O. D. Madsen, P. Serup, and J. Hecksher-Sorensen An Illustrated Review of Early Pancreas Development in the Mouse Endocr. Rev., October 1, 2007; 28(6): 685 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Nelson, A. E. Schaffer, and M. Sander The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells Development, July 1, 2007; 134(13): 2491 - 2500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. O. Wiebe, J. D. Kormish, V. T. Roper, Y. Fujitani, N. I. Alston, K. S. Zaret, C. V. E. Wright, R. W. Stein, and M. Gannon Ptf1a Binds to and Activates Area III, a Highly Conserved Region of the Pdx1 Promoter That Mediates Early Pancreas-Wide Pdx1 Expression Mol. Cell. Biol., June 1, 2007; 27(11): 4093 - 4104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Guillemain, G. Filhoulaud, G. Da Silva-Xavier, G. A. Rutter, and R. Scharfmann Glucose Is Necessary for Embryonic Pancreatic Endocrine Cell Differentiation J. Biol. Chem., May 18, 2007; 282(20): 15228 - 15237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen, H.-X. Yan, J. Chen, W. Yang, Q. Liu, B. Zhai, H.-F. Cao, S.-Q. Liu, M.-C. Wu, and H.-Y. Wang Negative Regulation of c-Myc Transcription by Pancreas Duodenum Homeobox-1 Endocrinology, May 1, 2007; 148(5): 2168 - 2180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Attali, V. Stetsyuk, A. Basmaciogullari, V. Aiello, M. A. Zanta-Boussif, B. Duvillie, and R. Scharfmann Control of {beta}-Cell Differentiation by the Pancreatic Mesenchyme Diabetes, May 1, 2007; 56(5): 1248 - 1258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. C. Rulifson, S. K. Karnik, P. W. Heiser, D. ten Berge, H. Chen, X. Gu, M. M. Taketo, R. Nusse, M. Hebrok, and S. K. Kim Wnt signaling regulates pancreatic beta cell proliferation PNAS, April 10, 2007; 104(15): 6247 - 6252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Artner, B. Blanchi, J. C. Raum, M. Guo, T. Kaneko, S. Cordes, M. Sieweke, and R. Stein MafB is required for islet beta cell maturation PNAS, March 6, 2007; 104(10): 3853 - 3858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Eto, V. Kaur, and M. K. Thomas Regulation of Pancreas Duodenum Homeobox-1 Expression by Early Growth Response-1 J. Biol. Chem., March 2, 2007; 282(9): 5973 - 5983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. O. Gillard, J. Dooley, M. Erickson, L. Peltonen, and A. G. Farr Aire-Dependent Alterations in Medullary Thymic Epithelium Indicate a Role for Aire in Thymic Epithelial Differentiation J. Immunol., March 1, 2007; 178(5): 3007 - 3015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Seymour, K. K. Freude, M. N. Tran, E. E. Mayes, J. Jensen, R. Kist, G. Scherer, and M. Sander From the Cover: SOX9 is required for maintenance of the pancreatic progenitor cell pool PNAS, February 6, 2007; 104(6): 1865 - 1870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M Ackermann and M. Gannon Molecular regulation of pancreatic {beta}-cell mass development, maintenance, and expansion J. Mol. Endocrinol., February 1, 2007; 38(2): 193 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gromada, I. Franklin, and C. B. Wollheim {alpha}-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains Endocr. Rev., February 1, 2007; 28(1): 84 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Murtaugh Pancreas and beta-cell development: from the actual to the possible Development, February 1, 2007; 134(3): 427 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Doyle, Z. L. Loomis, and L. Sussel Nkx2.2-repressor activity is sufficient to specify {alpha}-cells and a small number of {beta}-cells in the pancreatic islet Development, February 1, 2007; 134(3): 515 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Dutton, N. L. Chillingworth, D. Eberhard, C. R. Brannon, M. A. Hornsey, D. Tosh, and J. M. W. Slack beta cells occur naturally in extrahepatic bile ducts of mice J. Cell Sci., January 15, 2007; 120(2): 239 - 245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Vedtofte, T. B. Bodvarsdottir, A. E. Karlsen, and R. S. Heller Developmental Biology of the Psammomys obesus Pancreas: Cloning and Expression of the Neurogenin-3 Gene J. Histochem. Cytochem., January 1, 2007; 55(1): 97 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Johnson, E. Bernal-Mizrachi, E. U. Alejandro, Z. Han, T. B. Kalynyak, H. Li, J. L. Beith, J. Gross, G. L. Warnock, R. R. Townsend, et al. Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome PNAS, December 19, 2006; 103(51): 19575 - 19580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. Deramaudt, M. M. Sachdeva, M. P. Wescott, Y. Chen, D. A. Stoffers, and A. K. Rustgi The PDX1 Homeodomain Transcription Factor Negatively Regulates the Pancreatic Ductal Cell-specific Keratin 19 Promoter J. Biol. Chem., December 15, 2006; 281(50): 38385 - 38395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Rustgi The molecular pathogenesis of pancreatic cancer: clarifying a complex circuitry. Genes & Dev., November 15, 2006; 20(22): 3049 - 3053. [Full Text] [PDF]
|
|
|
|
|
|
H. Ijichi, A. Chytil, A. E. Gorska, M. E. Aakre, Y. Fujitani, S. Fujitani, C. V.E. Wright, and H. L. Moses Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes & Dev., November 15, 2006; 20(22): 3147 - 3160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Y. Choi, A. I. Romer, M. Hu, M. Lepourcelet, A. Mechoor, A. Yesilaltay, M. Krieger, P. A. Gray, and R. A. Shivdasani A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development Development, October 15, 2006; 133(20): 4119 - 4129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Raum, K. Gerrish, I. Artner, E. Henderson, M. Guo, L. Sussel, J. C. Schisler, C. B. Newgard, and R. Stein FoxA2, Nkx2.2, and PDX-1 Regulate Islet {beta}-Cell-Specific mafA Expression through Conserved Sequences Located between Base Pairs -8118 and -7750 Upstream from the Transcription Start Site Mol. Cell. Biol., August 1, 2006; 26(15): 5735 - 5743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Mulley, C.-h. Chiu, and P. W. H. Holland Breakup of a homeobox cluster after genome duplication in teleosts PNAS, July 5, 2006; 103(27): 10369 - 10372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Oyama, K. Minami, K. Ishizaki, M. Fuse, T. Miki, and S. Seino Spontaneous Recovery From Hyperglycemia by Regeneration of Pancreatic {beta}-Cells in Kir6.2G132S Transgenic Mice. Diabetes, July 1, 2006; 55(7): 1930 - 1938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Narang and R. I. Mahato Biological and biomaterial approaches for improved islet transplantation. Pharmacol. Rev., June 1, 2006; 58(2): 194 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Miyatsuka, H. Kaneto, T. Shiraiwa, T.-a. Matsuoka, K. Yamamoto, K. Kato, Y. Nakamura, S. Akira, K. Takeda, Y. Kajimoto, et al. Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation Genes & Dev., June 1, 2006; 20(11): 1435 - 1440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Afelik, Y. Chen, and T. Pieler Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue Genes & Dev., June 1, 2006; 20(11): 1441 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Hezel, A. C. Kimmelman, B. Z. Stanger, N. Bardeesy, and R. A. DePinho Genetics and biology of pancreatic ductal adenocarcinoma. Genes & Dev., May 15, 2006; 20(10): 1218 - 1249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. O. Gillard and A. G. Farr Features of Medullary Thymic Epithelium Implicate Postnatal Development in Maintaining Epithelial Heterogeneity and Tissue-Restricted Antigen Expression J. Immunol., May 15, 2006; 176(10): 5815 - 5824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Heiser, J. Lau, M. M. Taketo, P. L. Herrera, and M. Hebrok Stabilization of {beta}-catenin impacts pancreas growth Development, May 15, 2006; 133(10): 2023 - 2032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. V. Cardoso and J. Lu Regulation of early lung morphogenesis: questions, facts and controversies Development, May 1, 2006; 133(9): 1611 - 1624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wang, T. Liu, Z. Li, X. Ma, and T. Jin Redundant and Synergistic Effect of Cdx-2 and Brn-4 on Regulating Proglucagon Gene Expression Endocrinology, April 1, 2006; 147(4): 1950 - 1958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Boucher, L. Selander, L. Carlsson, and H. Edlund Phosphorylation Marks IPF1/PDX1 Protein for Degradation by Glycogen Synthase Kinase 3-dependent Mechanisms J. Biol. Chem., March 10, 2006; 281(10): 6395 - 6403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Duvillie, M. Attali, A. Bounacer, P. Ravassard, A. Basmaciogullari, and R. Scharfmann The Mesenchyme Controls the Timing of Pancreatic {beta}-Cell Differentiation Diabetes, March 1, 2006; 55(3): 582 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Artner, J. Le Lay, Y. Hang, L. Elghazi, J. C. Schisler, E. Henderson, B. Sosa-Pineda, and R. Stein MafB: An Activator of the Glucagon Gene Expressed in Developing Islet {alpha}- and {beta}-Cells Diabetes, February 1, 2006; 55(2): 297 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fujitani, S. Fujitani, D. F. Boyer, M. Gannon, Y. Kawaguchi, M. Ray, M. Shiota, R. W. Stein, M. A. Magnuson, and C. V.E. Wright Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation Genes & Dev., January 15, 2006; 20(2): 253 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kawamori, H. Kaneto, Y. Nakatani, T.-a. Matsuoka, M. Matsuhisa, M. Hori, and Y. Yamasaki The Forkhead Transcription Factor Foxo1 Bridges the JNK Pathway and the Transcription Factor PDX-1 through Its Intracellular Translocation J. Biol. Chem., January 13, 2006; 281(2): 1091 - 1098. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Hruban, N. V. Adsay, J. Albores-Saavedra, M. R. Anver, A. V. Biankin, G. P. Boivin, E. E. Furth, T. Furukawa, A. Klein, D. S. Klimstra, et al. Pathology of Genetically Engineered Mouse Models of Pancreatic Exocrine Cancer: Consensus Report and Recommendations Cancer Res., January 1, 2006; 66(1): 95 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Poll, C. E. Pierreux, L. Lokmane, C. Haumaitre, Y. Achouri, P. Jacquemin, G. G. Rousseau, S. Cereghini, and F. P. Lemaigre A vHNF1/TCF2-HNF6 Cascade Regulates the Transcription Factor Network That Controls Generation of Pancreatic Precursor Cells Diabetes, January 1, 2006; 55(1): 61 - 69. [Abstract] [Full Text] [PDF]
|
|
<
