|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 122, Issue 5 1555-1565, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
V Twombly, RK Blackman, H Jin, JM Graff, RW Padgett and WM Gelbart
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
We examine roles of signaling by secreted ligands of the TGF-beta family during Drosophila oogenesis. One family member, the DPP ligand encoded by the decapentaplegic (dpp) gene, is required for patterning of anterior eggshell structures. This requirement presumably reflects the expression pattern of dpp in an anterior subset of somatic follicle cells: the centripetally migrating and the nurse cell-associated follicle cells. Similar requirements are also revealed by mutations in the saxophone (sax)-encoded receptor, consistent with the idea that DPP signaling is, at least in part, mediated by the SAX receptor. A loss of germline sax function results in a block in oogenesis associated with egg chamber degeneration and a failure of the transfer of nurse cell contents to the oocyte, indicating that TGF-beta signaling is required for these events. Some phenotypes of sax mutations during oogenesis suggest that SAX responds to at least one other TGF-beta ligand as well in the posterior follicle cells.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  V. Twombly, E. Bangi, V. Le, B. Malnic, M. A. Singer, and K. A. Wharton Functional Analysis of saxophone, the Drosophila Gene Encoding the BMP Type I Receptor Ortholog of Human ALK1/ACVRL1 and ACVR1/ALK2 Genetics, October 1, 2009; 183(2): 563 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-F. B. Lachance, M. F. Lomas, A. Eleiche, P. B. Kerr, and L. A. Nilson Graded Egfr activity patterns the Drosophila eggshell independently of autocrine feedback Development, September 1, 2009; 136(17): 2893 - 2902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Zartman, J. S. Kanodia, L. S. Cheung, and S. Y. Shvartsman Feedback control of the EGFR signaling gradient: superposition of domain-splitting events in Drosophila oogenesis Development, September 1, 2009; 136(17): 2903 - 2911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Bornemann, S. Park, S. Phin, and R. Warrior A translational block to HSPG synthesis permits BMP signaling in the early Drosophila embryo Development, March 15, 2008; 135(6): 1039 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yakoby, J. Lembong, T. Schupbach, and S. Y. Shvartsman Drosophila eggshell is patterned by sequential action of feedforward and feedback loops Development, January 15, 2008; 135(2): 343 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Furriols, G. Ventura, and J. Casanova Two distinct but convergent groups of cells trigger Torso receptor tyrosine kinase activation by independently expressing torso-like PNAS, July 10, 2007; 104(28): 11660 - 11665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. V. Shravage, G. Altmann, M. Technau, and S. Roth The role of Dpp and its inhibitors during eggshell patterning in Drosophila Development, June 15, 2007; 134(12): 2261 - 2271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. F. de Navas, D. L. Garaulet, and E. Sanchez-Herrero The Ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway Development, November 15, 2006; 133(22): 4495 - 4506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Bangi and K. Wharton Dual function of the Drosophila Alk1/Alk2 ortholog Saxophone shapes the Bmp activity gradient in the wing imaginal disc Development, September 1, 2006; 133(17): 3295 - 3303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Poulton and W.-M. Deng Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte PNAS, August 22, 2006; 103(34): 12775 - 12780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Atkey, J.-F. B. Lachance, M. Walczak, T. Rebello, and L. A. Nilson Capicua regulates follicle cell fate in the Drosophila ovary through repression of mirror Development, June 1, 2006; 133(11): 2115 - 2123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Muzzopappa and P. Wappner Multiple roles of the F-box protein Slimb in Drosophila egg chamber development Development, June 1, 2005; 132(11): 2561 - 2571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Kankel, D. M. Duncan, and I. Duncan A Screen for Genes That Interact With the Drosophila Pair-Rule Segmentation Gene fushi tarazu Genetics, September 1, 2004; 168(1): 161 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Tran and C. A. Berg bullwinkle and shark regulate dorsal-appendage morphogenesis in Drosophila oogenesis Development, December 22, 2003; 130(25): 6273 - 6282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gupta and T. Schupbach Cct1, a phosphatidylcholine biosynthesis enzyme, is required for Drosophila oogenesis and ovarian morphogenesis Development, December 15, 2003; 130(24): 6075 - 6087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Marques, T. E. Haerry, M. L. Crotty, M. Xue, B. Zhang, and M. B. O'Connor Retrograde Gbb signaling through the Bmp type 2 receptor Wishful Thinking regulates systemic FMRFa expression in Drosophila Development, November 15, 2003; 130(22): 5457 - 5470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Peri, M. Technau, and S. Roth Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in Drosophila Development, March 8, 2003; 129(12): 2965 - 2975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Volpe, H. Horowitz, C. M. Grafer, S. M. Jackson, and C. A. Berg Drosophila rhino Encodes a Female-Specific Chromo-domain Protein That Affects Chromosome Structure and Egg Polarity Genetics, November 1, 2001; 159(3): 1117 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Torres-Vazquez, S Park, R Warrior, and K Arora The transcription factor Schnurri plays a dual role in mediating Dpp signaling during embryogenesis Development, January 5, 2001; 128(9): 1657 - 1670. [Abstract] [PDF]
|
|
|
|
|
|
K. Yu, S. Srinivasan, O. Shimmi, B. Biehs, K. E. Rashka, D. Kimelman, M. B. O'Connor, and E. Bier Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity Development, May 15, 2000; 127(10): 2143 - 2154. [Abstract] [PDF]
|
|
|
|
|
|
H Araujo and E Bier sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryo Development, January 8, 2000; 127(16): 3631 - 3644. [Abstract] [PDF]
|
|
|
|
|
|
L. Dobens, J. Peterson, J Treisman, and L. Raftery Drosophila bunched integrates opposing DPP and EGF signals to set the operculum boundary Development, January 2, 2000; 127(4): 745 - 754. [Abstract] [PDF]
|
|
|
|
|
|
F Peri and S Roth Combined activities of Gurken and decapentaplegic specify dorsal chorion structures of the Drosophila egg Development, January 2, 2000; 127(4): 841 - 850. [Abstract] [PDF]
|
|
|
|
|
|
E. Y. Mantrova, R. A. Schulz, and T. Hsu Oogenic function of the myogenic factor D-MEF2: Negative regulation of the Decapentaplegic receptor gene thick veins PNAS, October 12, 1999; 96(21): 11889 - 11894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Spradling, D. Stern, A. Beaton, E. J. Rhem, T. Laverty, N. Mozden, S. Misra, and G. M. Rubin The Berkeley Drosophila Genome Project Gene Disruption Project: Single P-Element Insertions Mutating 25% of Vital Drosophila Genes Genetics, September 1, 1999; 153(1): 135 - 177. [Abstract] [Full Text]
|
|
|
|
|
|
K. A. Wharton, J. M. Cook, S. Torres-Schumann, K. de Castro, E. Borod, and D. A. Phillips Genetic Analysis of the Bone Morphogenetic Protein-Related Gene, gbb, Identifies Multiple Requirements During Drosophila Development Genetics, June 1, 1999; 152(2): 629 - 640. [Abstract] [Full Text]
|
|
|
|
|
|
Z. Bryant, L. Subrahmanyan, M. Tworoger, L. LaTray, C.-R. Liu, M.-J. Li, G. van den Engh, and H. Ruohola-Baker Characterization of differentially expressed genes in purified Drosophila follicle cells: Toward a general strategy for cell type-specific developmental analysis PNAS, May 11, 1999; 96(10): 5559 - 5564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N Matova, S Mahajan-Miklos, M. Mooseker, and L Cooley Drosophila quail, a villin-related protein, bundles actin filaments in apoptotic nurse cells Development, January 12, 1999; 126(24): 5645 - 5657. [Abstract] [PDF]
|
|
|
|
|
|
A Kopp, R. Blackman, and I Duncan Wingless, decapentaplegic and EGF receptor signaling pathways interact to specify dorso-ventral pattern in the adult abdomen of Drosophila Development, January 8, 1999; 126(16): 3495 - 3507. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Brummel, S. Abdollah, T. E. Haerry, M. J. Shimell, J. Merriam, L. Raftery, J. L. Wrana, and M. B. O'Connor The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development Genes & Dev., January 1, 1999; 13(1): 98 - 111. [Abstract] [Full Text]
|
|
|
|
|
|
S. J. Newfeld and N. T. Takaesu Local Transposition of a hobo Element Within the decapentaplegic Locus of Drosophila Genetics, January 1, 1999; 151(1): 177 - 187. [Abstract] [Full Text]
|
|
|
|
|
|
A. Ghabrial, R. P. Ray, and T. Schüpbach okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis Genes & Dev., September 1, 1998; 12(17): 2711 - 2723. [Abstract] [Full Text]
|
|
|
|
|
|
R. E. Nicholls and W. M. Gelbart Identification of Chromosomal Regions Involved in decapentaplegic Function in Drosophila Genetics, May 1, 1998; 149(1): 203 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Simin, E. A. Bates, M. A. Horner, and A. Letsou Genetic Analysis of Punt, a Type II Dpp Receptor That Functions Throughout the Drosophila melanogaster Life Cycle Genetics, February 1, 1998; 148(2): 801 - 814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O Khalsa, J. Yoon, S Torres-Schumann, and K. Wharton TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing Development, January 7, 1998; 125(14): 2723 - 2734. [Abstract] [PDF]
|
|
|
|
|
|
Y Chen, M. Riese, M. Killinger, and F. Hoffmann A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A Development, January 5, 1998; 125(9): 1759 - 1768. [Abstract] [PDF]
|
|
|
|
|
|
J. Hudson, S. Podos, K Keith, S. Simpson, and E. Ferguson The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4 Development, January 4, 1998; 125(8): 1407 - 1420. [Abstract] [PDF]
|
|
|
|
|
|
R. Wisotzkey, A Mehra, D. Sutherland, L. Dobens, X Liu, C Dohrmann, L Attisano, and L. Raftery Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses Development, January 4, 1998; 125(8): 1433 - 1445. [Abstract] [PDF]
|
|
|
|
|
|
A Sapir, R Schweitzer, and B. Shilo Sequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axis Development, January 1, 1998; 125(2): 191 - 200. [Abstract] [PDF]
|
|
|
|
|
|
W. Deng and M Bownes Two signalling pathways specify localised expression of the Broad-Complex in Drosophila eggshell patterning and morphogenesis Development, January 11, 1997; 124(22): 4639 - 4647. [Abstract] [PDF]
|
|
|
|
|
|
A. Queenan, A Ghabrial, and T Schupbach Ectopic activation of torpedo/Egfr, a Drosophila receptor tyrosine kinase, dorsalizes both the eggshell and the embryo Development, January 10, 1997; 124(19): 3871 - 3880. [Abstract] [PDF]
|
|
|
|
|
|
L. Schneider and A. Spradling The Drosophila G-protein-coupled receptor kinase homologue Gprk2 is required for egg morphogenesis Development, January 7, 1997; 124(13): 2591 - 2602. [Abstract] [PDF]
|
|
|
|
|
|
M. Singer, A Penton, V Twombly, F. Hoffmann, and W. Gelbart Signaling through both type I DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing Development, January 1, 1997; 124(1): 79 - 89. [Abstract] [PDF]
|
|
|
|
|
|
A. Forbes, A. Spradling, P. Ingham, and H Lin The role of segment polarity genes during early oogenesis in Drosophila Development, January 10, 1996; 122(10): 3283 - 3294. [Abstract] [PDF]
|
|
|
|
|
|
S. Newfeld, E. Chartoff, J. Graff, D. Melton, and W. Gelbart Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells Development, January 7, 1996; 122(7): 2099 - 2108. [Abstract] [PDF]
|
|
|
|
|
|
K. Edwards and D. Kiehart Drosophila nonmuscle myosin II has multiple essential roles in imaginal disc and egg chamber morphogenesis Development, January 5, 1996; 122(5): 1499 - 1511. [Abstract] [PDF]
|
|
