|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 122, Issue 5 1631-1639, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
JE Wilson, JE Connell and PM Macdonald
Department of Biological Sciences, Stanford University, CA 94305-5020, USA.
Although translational regulation of maternal mRNA is important for proper development of the Drosophila embryo, few genes involved in this process have been identified. In this report, we describe the role of aubergine in oskar translation. Previously, aubergine has been implicated in dorsoventral patterning, as eggs from aubergine mutant mothers are ventralized and seldom fertilized (Schupbach, T. and Wieschaus, E. (1991) Genetics 129, 1119-1136). We have isolated two new alleles of aubergine in a novel genetic screen and have shown that aubergine is also required for posterior body patterning, as the small fraction of eggs from aubergine- mothers that are fertilized develop into embryos which lack abdominal segmentation. Although aubergine mutations do not appear to affect the stability of either oskar mRNA or protein, the level of oskar protein is significantly reduced in aubergine mutants. Thus, aubergine is required to enhance oskar translation. While aubergine-dependence is conferred upon oskar mRNA by sequences in the oskar 3' UTR, aubergine may influence oskar translation through an interaction with sequences upstream of the oskar 3' UTR.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. K. Lim, L. Tao, and T. Kai piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline J. Cell Biol., August 10, 2009; 186(3): 333 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Navarro, S. Bullock, and R. Lehmann Altered dynein-dependent transport in piRNA pathway mutants PNAS, June 16, 2009; 106(24): 9691 - 9696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Unhavaithaya, Y. Hao, E. Beyret, H. Yin, S. Kuramochi-Miyagawa, T. Nakano, and H. Lin MILI, a PIWI-interacting RNA-binding Protein, Is Required for Germ Line Stem Cell Self-renewal and Appears to Positively Regulate Translation J. Biol. Chem., March 6, 2009; 284(10): 6507 - 6519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Palakodeti, M. Smielewska, Y.-C. Lu, G. W. Yeo, and B. R. Graveley The PIWI proteins SMEDWI-2 and SMEDWI-3 are required for stem cell function and piRNA expression in planarians RNA, June 1, 2008; 14(6): 1174 - 1186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Specchia, C. Benna, G. M. Mazzotta, A. Piccin, M. A. Zordan, R. Costa, and M. P. Bozzetti aubergine Gene Overexpression in Somatic Tissues of auberginesting Mutants Interferes With the RNAi Pathway of a yellow Hairpin dsRNA in Drosophila melanogaster Genetics, March 1, 2008; 178(3): 1271 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Aravin, G. J. Hannon, and J. Brennecke The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race Science, November 2, 2007; 318(5851): 761 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Nishida, K. Saito, T. Mori, Y. Kawamura, T. Nagami-Okada, S. Inagaki, H. Siomi, and M. C. Siomi Gene silencing mechanisms mediated by Aubergine piRNA complexes in Drosophila male gonad RNA, November 1, 2007; 13(11): 1911 - 1922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lin piRNAs in the Germ Line Science, April 20, 2007; 316(5823): 397 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Lim and T. Kai Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster PNAS, April 17, 2007; 104(16): 6714 - 6719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. McCaffrey, D. St Johnston, and A. Gonzalez-Reyes Drosophila mus301/spindle-C Encodes a Helicase With an Essential Role in Double-Strand DNA Break Repair and Meiotic Progression Genetics, November 1, 2006; 174(3): 1273 - 1285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tsukioka, M. Takahashi, H. Mon, K. Okano, K. Mita, T. Shimada, J. M. Lee, Y. Kawaguchi, K. Koga, and T. Kusakabe Role of the silkworm argonaute2 homolog gene in double-strand break repair of extrachromosomal DNA Nucleic Acids Res., February 14, 2006; 34(4): 1092 - 1101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. P. Munro, S. Kwon, B. J. Schnapp, and D. St Johnston A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP. J. Cell Biol., February 13, 2006; 172(4): 577 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Savitsky, D. Kwon, P. Georgiev, A. Kalmykova, and V. Gvozdev Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline Genes & Dev., February 1, 2006; 20(3): 345 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. RODRIGUEZ, S. A. SEIPEL, D. R. HAMILL, D. P. ROMANCINO, M. DI CARLO, K. A. SUPRENANT, and E. M. BONDER Seawi--a sea urchin piwi/argonaute family member is a component of MT-RNP complexes RNA, May 1, 2005; 11(5): 646 - 656. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Anne and B. M. Mechler Valois, a component of the nuage and pole plasm, is involved in assembly of these structures, and binds to Tudor and the methyltransferase Capsuleen Development, May 1, 2005; 132(9): 2167 - 2177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. I. Kalmykova, M. S. Klenov, and V. A. Gvozdev Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline Nucleic Acids Res., April 7, 2005; 33(6): 2052 - 2059. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cavey, S. Hijal, X. Zhang, and B. Suter Drosophila valois encodes a divergent WD protein that is required for Vasa localization and Oskar protein accumulation Development, February 1, 2005; 132(3): 459 - 468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kloc and L. D. Etkin RNA localization mechanisms in oocytes J. Cell Sci., January 15, 2005; 118(2): 269 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Snee and P. M. Macdonald Live imaging of nuage and polar granules: evidence against a precursor-product relationship and a novel role for Oskar in stabilization of polar granule components J. Cell Sci., April 15, 2004; 117(10): 2109 - 2120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. K. Smulders-Srinivasan and H. Lin Screens for piwi Suppressors in Drosophila Identify Dosage-Dependent Regulators of Germline Stem Cell Division Genetics, December 1, 2003; 165(4): 1971 - 1991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sinka, F. Jankovics, K. Somogyi, T. Szlanka, T. Lukacsovich, and M. Erdelyi poirot, a new regulatory gene of Drosophila oskar acts at the level of the short Oskar protein isoform Development, March 9, 2003; 129(14): 3469 - 3478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Findley, M. Tamanaha, N. J. Clegg, and H. Ruohola-Baker Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage Development, March 1, 2003; 130(5): 859 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Newman, A. G. Fernandez, and M. K. Barton Regulation of Axis Determinacy by the Arabidopsis PINHEAD Gene PLANT CELL, December 1, 2002; 14(12): 3029 - 3042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Carmell, Z. Xuan, M. Q. Zhang, and G. J. Hannon The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis Genes & Dev., November 1, 2002; 16(21): 2733 - 2742. [Full Text] [PDF]
|
|
|
|
|
|
J. R. Kennerdell, S. Yamaguchi, and R. W. Carthew RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E Genes & Dev., August 1, 2002; 16(15): 1884 - 1889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Williams and G. M. Rubin ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos PNAS, May 14, 2002; 99(10): 6889 - 6894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Schwarz and P. D. Zamore Why do miRNAs live in the miRNP? Genes & Dev., May 1, 2002; 16(9): 1025 - 1031. [Full Text] [PDF]
|
|
|
|
|
|
J. H. Mansfield, J. E. Wilhelm, and T. Hazelrigg Ypsilon Schachtel, a Drosophila Y-box protein, acts antagonistically to Orb in the oskar mRNA localization and translation pathway Development, January 1, 2002; 129(1): 197 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Tahbaz, J. B. Carmichael, and T. C. Hobman GERp95 Belongs to a Family of Signal-transducing Proteins and Requires Hsp90 Activity for Stability and Golgi Localization J. Biol. Chem., November 9, 2001; 276(46): 43294 - 43299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Harris and P. M. Macdonald aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C Development, July 15, 2001; 128(14): 2823 - 2832. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. Bibb, J. K.L. Holt, E. E. Tarttelin, M. D. Hodges, K. Gregory-Evans, A. Rutherford, R. J. Lucas, J. C. Sowden, and C. Y. Gregory-Evans Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development. Hum. Mol. Genet., July 1, 2001; 10(15): 1571 - 1579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Sharp RNA interference{---}2001 Genes & Dev., March 1, 2001; 15(5): 485 - 490. [Full Text]
|
|
|
|
|
|
C Van Buskirk, N. Hawkins, and T Schupbach Encore is a member of a novel family of proteins and affects multiple processes in Drosophila oogenesis Development, January 11, 2000; 127(22): 4753 - 4762. [Abstract] [PDF]
|
|
|
|
|
|
D. Myster, P. Bonnette, and R. Duronio A role for the DP subunit of the E2F transcription factor in axis determination during Drosophila oogenesis Development, January 8, 2000; 127(15): 3249 - 3261. [Abstract] [PDF]
|
|
|
|
|
|
S Castagnetti, M. Hentze, A Ephrussi, and F Gebauer Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries Development, January 3, 2000; 127(5): 1063 - 1068. [Abstract] [PDF]
|
|
|
|
|
|
S. Kwon, E. Barbarese, and J. H. Carson The Cis-Acting RNA Trafficking Signal from Myelin Basic Protein mRNA and Its Cognate Trans-Acting Ligand Hnrnp A2 Enhance CaP-Dependent Translation J. Cell Biol., October 18, 1999; 147(2): 247 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Suzanne, K. Irie, B. Glise, F. Agnès, E. Mori, K. Matsumoto, and S. Noselli The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development Genes & Dev., June 1, 1999; 13(11): 1464 - 1474. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. LASKO RNA sorting in Drosophila oocytes and embryos FASEB J, March 1, 1999; 13(3): 421 - 433. [Abstract] [Full Text]
|
|
|
|
|
|
A. Ghabrial, R. P. Ray, and T. Schüpbach okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis Genes & Dev., September 1, 1998; 12(17): 2711 - 2723. [Abstract] [Full Text]
|
|
|
|
|
|
S Styhler, A Nakamura, A Swan, B Suter, and P Lasko vasa is required for GURKEN accumulation in the oocyte, and is involved in oocyte differentiation and germline cyst development Development, January 5, 1998; 125(9): 1569 - 1578. [Abstract] [PDF]
|
|
|
|
|
|
P Tomancak, A Guichet, P Zavorszky, and A Ephrussi Oocyte polarity depends on regulation of gurken by Vasa Development, January 5, 1998; 125(9): 1723 - 1732. [Abstract] [PDF]
|
|
|
|
|
|
P. J. Webster, L. Liang, C. A. Berg, P. Lasko, and P. M. Macdonald Translational repressor bruno plays multiple roles in development and is widely conserved Genes & Dev., October 1, 1997; 11(19): 2510 - 2521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Hawkins, C Van Buskirk, U Grossniklaus, and T Schupbach Post-transcriptional regulation of gurken by encore is required for axis determination in Drosophila Development, January 12, 1997; 124(23): 4801 - 4810. [Abstract] [PDF]
|
|
|
|
|
|
A Gonzalez-Reyes, H Elliott, and D St Johnston Oocyte determination and the origin of polarity in Drosophila: the role of the spindle genes Development, January 12, 1997; 124(24): 4927 - 4937. [Abstract] [PDF]
|
|
