|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 122, Issue 6 1673-1682, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
M Gho, M Lecourtois, G Geraud, JW Posakony and F Schweisguth
Institut Jacques Monod - CNRS, Universite Paris VII, France.
During imaginal development of Drosophila, Suppressor of Hairless [Su(H)], an evolutionarily conserved transcription factor that mediates intracellular signalling by the Notch (N) receptor, controls successive alternative cell fate decisions leading to the differentiation of multicellular sensory organs. We describe here the distribution of the Su(H) protein in the wing disc epithelium throughout development of adult sense organs. Su(H) was found to be evenly distributed in the nuclei of all imaginal disc cells during sensory organ precursor cells selection. Thus differential expression and/or subcellular localization of Su(H) is not essential for its function. Soon after division of the pIIa secondary precursor cell, Su(H) specifically accumulates in the nucleus of the future socket cell. At the onset of differentiation of the socket cell, Su(H) is also detected in the cytoplasm. In this differentiating cell, N and deltex participate in the cytoplasmic retention of Su(H). Still, Su(H) does not colocalize with N at the apical-lateral membranes. These observations suggest that N regulates in an indirect manner the cytoplasmic localization of Su(H) in the socket cell. Finally, the pIIb, shaft and socket cells are found to adopt invariant positions along the anteroposterior axis of the notum. This raises the possibility that tissue-polarity biases these N-mediated cell fate choices.
This article has been cited by other articles:
|
|
 |
|
  M. Balakireva, C. Rosse, J. Langevin, Y.-c. Chien, M. Gho, G. Gonzy-Treboul, S. Voegeling-Lemaire, S. Aresta, J.-A. Lepesant, Y. Bellaiche, et al. The Ral/Exocyst Effector Complex Counters c-Jun N-Terminal Kinase-Dependent Apoptosis in Drosophila melanogaster Mol. Cell. Biol., December 1, 2006; 26(23): 8953 - 8963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Jafar-Nejad, A.-C. Tien, M. Acar, and H. J. Bellen Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin Development, May 1, 2006; 133(9): 1683 - 1692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. L. Katanaev and A. Tomlinson Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila PNAS, April 25, 2006; 103(17): 6524 - 6529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Nagel, A. Krejci, G. Tenin, A. Bravo-Patino, S. Bray, D. Maier, and A. Preiss Hairless-Mediated Repression of Notch Target Genes Requires the Combined Activity of Groucho and CtBP Corepressors Mol. Cell. Biol., December 1, 2005; 25(23): 10433 - 10441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Audibert, F. Simon, and M. Gho Cell cycle diversity involves differential regulation of Cyclin E activity in the Drosophila bristle cell lineage Development, May 15, 2005; 132(10): 2287 - 2297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. Moore, F. Roegiers, L. Y. Jan, and Y.-N. Jan Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification Genes & Dev., March 15, 2004; 18(6): 623 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Wesley and L.-P. Mok Regulation of Notch Signaling by a Novel Mechanism Involving Suppressor of Hairless Stability and Carboxyl Terminus-Truncated Notch Mol. Cell. Biol., August 15, 2003; 23(16): 5581 - 5593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Inbal, D. Levanon, and A. Salzberg Multiple roles for u-turn/ventral veinless in the development of Drosophila PNS Development, June 1, 2003; 130(11): 2467 - 2478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Dansereau, M. D. Lunke, A. Finkielsztein, M. A. Russell, and W. J. Brook hephaestus encodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development in Drosophila melanogaster Development, March 14, 2003; 129(24): 5553 - 5566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Orgogozo, F. Schweisguth, and Y. Bellaiche Binary cell death decision regulated by unequal partitioning of Numb at mitosis Development, March 12, 2003; 129(20): 4677 - 4684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Fichelson and M. Gho The glial cell undergoes apoptosis in the microchaete lineage of Drosophila Development, January 1, 2003; 130(1): 123 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Pi, H.-J. Wu, and C.-T. Chien A dual function of phyllopod in Drosophila external sensory organ development: cell fate specification of sensory organ precursor and its progeny Development, July 15, 2001; 128(14): 2699 - 2710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ben-Yaacov, R. Le Borgne, I. Abramson, F. Schweisguth, and E. D. Schejter Wasp, the Drosophila Wiskott-Aldrich Syndrome Gene Homologue, Is Required for Cell Fate Decisions Mediated by Notch Signaling J. Cell Biol., January 2, 2001; 152(1): 1 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Lehembre, P. Badenhorst, S. Müller, A. Travers, F. Schweisguth, and A. Dejean Covalent Modification of the Transcriptional Repressor Tramtrack by the Ubiquitin-Related Protein Smt3 in Drosophila Flies Mol. Cell. Biol., February 1, 2000; 20(3): 1072 - 1082. [Abstract] [Full Text]
|
|
|
|
|
|
T Klein, L Seugnet, M Haenlin, and A Martinez Arias Two different activities of Suppressor of Hairless during wing development in Drosophila Development, January 8, 2000; 127(16): 3553 - 3566. [Abstract] [PDF]
|
|
|
|
|
|
F. Schweisguth Dominant-negative mutation in the beta 2 and beta 6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage PNAS, September 28, 1999; 96(20): 11382 - 11386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Artavanis-Tsakonas, M. D. Rand, and R. J. Lake Notch Signaling: Cell Fate Control and Signal Integration in Development Science, April 30, 1999; 284(5415): 770 - 776. [Abstract] [Full Text]
|
|
|
|
|
|
G. Reddy and V Rodrigues A glial cell arises from an additional division within the mechanosensory lineage during development of the microchaete on the Drosophila notum Development, January 10, 1999; 126(20): 4617 - 4622. [Abstract] [PDF]
|
|
|
|
|
|
M Gho, Y Bellaiche, and F Schweisguth Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell Development, January 8, 1999; 126(16): 3573 - 3584. [Abstract] [PDF]
|
|
|
|
|
|
L Manning and C. Doe Prospero distinguishes sibling cell fate without asymmetric localization in the Drosophila adult external sense organ lineage Development, January 5, 1999; 126(10): 2063 - 2071. [Abstract] [PDF]
|
|
|
|
|
|
G. Reddy and V Rodrigues Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch Development, January 5, 1999; 126(10): 2083 - 2092. [Abstract] [PDF]
|
|
|
|
|
|
M Crozatier and A Vincent Requirement for the Drosophila COE transcription factor Collier in formation of an embryonic muscle: transcriptional response to notch signalling Development, January 4, 1999; 126(7): 1495 - 1504. [Abstract] [PDF]
|
|
|
|
|
|
N. Hawkins and G. Garriga Asymmetric cell division: from A to Z Genes & Dev., December 1, 1998; 12(23): 3625 - 3638. [Full Text]
|
|
|
|
|
|
S. Kidd, T. Lieber, and M. W. Young Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos Genes & Dev., December 1, 1998; 12(23): 3728 - 3740. [Abstract] [Full Text]
|
|
|
|
|
|
I. Greenwald LIN-12/Notch signaling: lessons from worms and flies Genes & Dev., June 15, 1998; 12(12): 1751 - 1762. [Full Text]
|
|
|
|
|
|
T. Jacobsen, K Brennan, A. Arias, and M. Muskavitch Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila Development, January 11, 1998; 125(22): 4531 - 4540. [Abstract] [PDF]
|
|
|
|
|
|
D Levitan and I Greenwald LIN-12 protein expression and localization during vulval development in C. elegans Development, January 8, 1998; 125(16): 3101 - 3109. [Abstract] [PDF]
|
|
|
|
|
|
S Sotillos, F Roch, and S Campuzano The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs Development, January 12, 1997; 124(23): 4769 - 4779. [Abstract] [PDF]
|
|
|
|
|
|
S Wang, S Younger-Shepherd, L. Jan, and Y. Jan Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless Development, January 11, 1997; 124(22): 4435 - 4446. [Abstract] [PDF]
|
|
|
|
|
|
D Doherty, L. Jan, and Y. Jan The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta Development, January 10, 1997; 124(19): 3881 - 3893. [Abstract] [PDF]
|
|
|
|
|
|
L Seugnet, P Simpson, and M Haenlin Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila Development, January 5, 1997; 124(10): 2015 - 2025. [Abstract] [PDF]
|
|
|
|
|
|
J. de la Pompa, A Wakeham, K. Correia, E Samper, S Brown, R. Aguilera, T Nakano, T Honjo, T. Mak, J Rossant, et al. Conservation of the Notch signalling pathway in mammalian neurogenesis Development, January 3, 1997; 124(6): 1139 - 1148. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Yamamoto, S.-i. Yamamoto, F. Inagaki, M. Kawaichi, A. Fukamizu, N. Kishi, K. Matsuno, K. Nakamura, G. Weinmaster, H. Okano, et al. Role of Deltex-1 as a Transcriptional Regulator Downstream of the Notch Receptor J. Biol. Chem., November 21, 2001; 276(48): 45031 - 45040. [Abstract] [Full Text] [PDF]
|
|
