Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Full Text (PDF)
	References
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Bellusci, S.
	Articles by Hogan, B. L.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Bellusci, S.
	Articles by Hogan, B. L.

JOURNAL ARTICLES

Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis

S Bellusci, R Henderson, G Winnier, T Oikawa and BL Hogan
Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232-2175, USA.

Epithelial-mesenchymal interactions are critical for the branching and differentiation of the lung, but the mechanisms involved are still unclear. To investigate this problem in mouse embryonic lung, we have studied the temporal and spatial expression of genes implicated in the morphogenesis of other organs. At 11.5 days p.c., hepatocyte nuclear factor-3beta (Hnf-3beta) is expressed uniformly throughout the epithelium, while Wnt-2 expression is confined to the distal mesenchyme. Sonic hedgehog (Shh) transcripts are found throughout the epithelium, with high levels in the distal tips of the terminal buds, while bone morphogenetic protein-4 (Bmp-4) transcripts are localized at high levels in the distal tips of the epithelium, with lower levels in the adjacent mesenchyme. Epithelial expression is also seen for Bmp-7, but transcripts are less dramatically upregulated at the distal tips. The Type I Bone morphogenetic protein receptor gene (Bmpr/Tfr-11/Brk-1) is expressed at low levels in the epithelium and in the distal mesenchyme. To investigate the role of Bmp-4 in lung development, we have misexpressed the gene throughout the distal epithelium of transgenic lungs using a surfactant protein C enhancer/promoter. From 15.5 days p.c., transgenic lungs are smaller than normal, with grossly distended terminal buds and, at birth, contain large air-filled sacs which do not support normal lung function. Labeling with BrdU reveals an inhibition of epithelia] proliferation in 15.5 days p.c. transgenic lungs. A small but significant stimulation of proliferation of mesenchymal cells is also observed, but this is accompanied by an increase in cell death. In situ hybridization with riboprobes for the proximal airway marker, CC10, and the distal airway marker, SP-C, shows normal differentiation of bronchiolar Clara cells but a reduction in the number of differentiated Type II cells in transgenic lungs. A model is proposed for the role of BMP4 and other signalling molecules in embryonic lung morphogenesis.

This article has been cited by other articles:

M. Loscertales, A. J. Mikels, J. K.-H. Hu, P. K. Donahoe, and D. J. Roberts
Chick pulmonary Wnt5a directs airway and vascular tubulogenesis
Development, April 1, 2008; 135(7): 1365 - 1376.
[Abstract] [Full Text] [PDF]

J. Sun, H. Chen, C. Chen, J. A. Whitsett, Y. Mishina, P. Bringas Jr., J. C. Ma, D. Warburton, and W. Shi
Prenatal Lung Epithelial Cell-Specific Abrogation of Alk3-Bone Morphogenetic Protein Signaling Causes Neonatal Respiratory Distress by Disrupting Distal Airway Formation
Am. J. Pathol., March 1, 2008; 172(3): 571 - 582.
[Abstract] [Full Text] [PDF]

M. Myllarniemi, P. Lindholm, M. J. Ryynanen, C. R. Kliment, K. Salmenkivi, J. Keski-Oja, V. L. Kinnula, T. D. Oury, and K. Koli
Gremlin-mediated Decrease in Bone Morphogenetic Protein Signaling Promotes Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., February 1, 2008; 177(3): 321 - 329.
[Abstract] [Full Text] [PDF]

K. R. Badri, Y. Zhou, and L. Schuger
Embryological Origin of Airway Smooth Muscle
Proceedings of the ATS, January 1, 2008; 5(1): 4 - 10.
[Abstract] [Full Text] [PDF]

Y. Ishii, J. D. Langberg, R. Hurtado, S. Lee, and T. Mikawa
Induction of proepicardial marker gene expression by the liver bud
Development, October 15, 2007; 134(20): 3627 - 3637.
[Abstract] [Full Text] [PDF]

Y. Yao, S. Nowak, A. Yochelis, A. Garfinkel, and K. I. Bostrom
Matrix GLA Protein, an Inhibitory Morphogen in Pulmonary Vascular Development
J. Biol. Chem., October 12, 2007; 282(41): 30131 - 30142.
[Abstract] [Full Text] [PDF]

J. Lu, J. Qian, D. Keppler, and W. V. Cardoso
Cathespin H Is an Fgf10 Target Involved in Bmp4 Degradation during Lung Branching Morphogenesis
J. Biol. Chem., July 27, 2007; 282(30): 22176 - 22184.
[Abstract] [Full Text] [PDF]

J. R. Hens, P. Dann, J.-P. Zhang, S. Harris, G. W. Robinson, and J. Wysolmerski
BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction
Development, March 15, 2007; 134(6): 1221 - 1230.
[Abstract] [Full Text] [PDF]

T. Schmelzle, A. A. Mailleux, M. Overholtzer, J. S. Carroll, N. L. Solimini, E. S. Lightcap, O. P. Veiby, and J. S. Brugge
Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis
PNAS, March 6, 2007; 104(10): 3787 - 3792.
[Abstract] [Full Text] [PDF]

T. Berg, L. Didon, and M. Nord
Ectopic expression of C/EBP{alpha} in the lung epithelium disrupts late lung development
Am J Physiol Lung Cell Mol Physiol, October 1, 2006; 291(4): L683 - L693.
[Abstract] [Full Text] [PDF]

K. Koli, M. Myllarniemi, K. Vuorinen, K. Salmenkivi, M. J. Ryynanen, V. L. Kinnula, and J. Keski-Oja
Bone Morphogenetic Protein-4 Inhibitor Gremlin Is Overexpressed in Idiopathic Pulmonary Fibrosis
Am. J. Pathol., July 1, 2006; 169(1): 61 - 71.
[Abstract] [Full Text] [PDF]

W. V. Cardoso and J. Lu
Regulation of early lung morphogenesis: questions, facts and controversies
Development, May 1, 2006; 133(9): 1611 - 1624.
[Abstract] [Full Text] [PDF]

A. C. White, J. Xu, Y. Yin, C. Smith, G. Schmid, and D. M. Ornitz
FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains
Development, April 15, 2006; 133(8): 1507 - 1517.
[Abstract] [Full Text] [PDF]

M. van Tuyl, J. Liu, F. Groenman, R. Ridsdale, R. N. N. Han, V. Venkatesh, D. Tibboel, and M. Post
Iroquois genes influence proximo-distal morphogenesis during rat lung development
Am J Physiol Lung Cell Mol Physiol, April 1, 2006; 290(4): L777 - L789.
[Abstract] [Full Text] [PDF]

R. L. Caldwell, R. Gadipatti, K. B. Lane, and V. L. Shepherd
HIV-1 TAT represses transcription of the bone morphogenic protein receptor-2 in U937 monocytic cells
J. Leukoc. Biol., January 1, 2006; 79(1): 192 - 201.
[Abstract] [Full Text] [PDF]

X. Zhang, T. S. Stappenbeck, A. C. White, K. J. Lavine, J. I. Gordon, and D. M. Ornitz
Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development
Development, January 1, 2006; 133(1): 173 - 180.
[Abstract] [Full Text] [PDF]

A.-K. T. Perl, S. E. Wert, D. E. Loudy, Z. Shan, P. A. Blair, and J. A. Whitsett
Conditional Recombination Reveals Distinct Subsets of Epithelial Cells in Trachea, Bronchi, and Alveoli
Am. J. Respir. Cell Mol. Biol., November 1, 2005; 33(5): 455 - 462.
[Abstract] [Full Text] [PDF]

L. Yu, S. Gu, S. Alappat, Y. Song, M. Yan, X. Zhang, G. Zhang, Y. Jiang, Z. Zhang, Y. Zhang, et al.
Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate
Development, October 1, 2005; 132(19): 4397 - 4406.
[Abstract] [Full Text] [PDF]

C. Colarossi, Y. Chen, H. Obata, V. Jurukovski, L. Fontana, B. Dabovic, and D. B. Rifkin
Lung Alveolar Septation Defects in Ltbp-3-Null Mice
Am. J. Pathol., August 1, 2005; 167(2): 419 - 428.
[Abstract] [Full Text] [PDF]

I.-M. Kim, S. Ramakrishna, G. A. Gusarova, H. M. Yoder, R. H. Costa, and V. V. Kalinichenko
The Forkhead Box M1 Transcription Factor Is Essential for Embryonic Development of Pulmonary Vasculature
J. Biol. Chem., June 10, 2005; 280(23): 22278 - 22286.
[Abstract] [Full Text] [PDF]

C. Chen, H. Chen, J. Sun, P. Bringas Jr., Y. Chen, D. Warburton, and W. Shi
Smad1 expression and function during mouse embryonic lung branching morphogenesis
Am J Physiol Lung Cell Mol Physiol, June 1, 2005; 288(6): L1033 - L1039.
[Abstract] [Full Text] [PDF]

A. A. Mailleux, R. Kelly, J. M. Veltmaat, S. P. De Langhe, S. Zaffran, J. P. Thiery, and S. Bellusci
Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage
Development, May 1, 2005; 132(9): 2157 - 2166.
[Abstract] [Full Text] [PDF]

S. Li, Y. Li, W. Du, L. Zhang, S. Yu, Y. Dai, C. Zhao, and N. Li
Aberrant Gene Expression in Organs of Bovine Clones That Die Within Two Days after Birth
Biol Reprod, February 1, 2005; 72(2): 258 - 265.
[Abstract] [Full Text] [PDF]

M. van Tuyl, J. Liu, J. Wang, M. Kuliszewski, D. Tibboel, and M. Post
Role of oxygen and vascular development in epithelial branching morphogenesis of the developing mouse lung
Am J Physiol Lung Cell Mol Physiol, January 1, 2005; 288(1): L167 - L178.
[Abstract] [Full Text] [PDF]

B. A. Hyatt, X. Shangguan, and J. M. Shannon
FGF-10 induces SP-C and Bmp4 and regulates proximal-distal patterning in embryonic tracheal epithelium
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1116 - L1126.
[Abstract] [Full Text] [PDF]

H. Beppu, F. Ichinose, N. Kawai, R. C. Jones, P. B. Yu, W. M. Zapol, K. Miyazono, E. Li, and K. D. Bloch
BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1241 - L1247.
[Abstract] [Full Text] [PDF]

K. Koli, F. Wempe, A. Sterner-Kock, A. Kantola, M. Komor, W.-K. Hofmann, H. von Melchner, and J. Keski-Oja
Disruption of LTBP-4 function reduces TGF-{beta} activation and enhances BMP-4 signaling in the lung
J. Cell Biol., October 11, 2004; 167(1): 123 - 133.
[Abstract] [Full Text] [PDF]

L. Kan, M. Hu, W. A. Gomes, and J. A. Kessler
Transgenic Mice Overexpressing BMP4 Develop a Fibrodysplasia Ossificans Progressiva (FOP)-Like Phenotype
Am. J. Pathol., October 1, 2004; 165(4): 1107 - 1115.
[Abstract] [Full Text] [PDF]

C. Dean, M. Ito, H. P. Makarenkova, S. C. Faber, and R. A. Lang
Bmp7 regulates branching morphogenesis of the lacrimal gland by promoting mesenchymal proliferation and condensation
Development, September 1, 2004; 131(17): 4155 - 4165.
[Abstract] [Full Text] [PDF]

J. A. Whitsett, C. J. Bachurski, K. C. Barnes, P. A. Bunn Jr., L. M. Case, D. N. Cook, D. Crooks, M. W. Duncan, L. Dwyer-Nield, R. C. Elston, et al.
Functional Genomics of Lung Disease
Am. J. Respir. Cell Mol. Biol., August 1, 2004; 31(2/S1): S1 - S81.
[Full Text] [PDF]

L. Chi, S. Zhang, Y. Lin, R. Prunskaite-Hyyrylainen, R. Vuolteenaho, P. Itaranta, and S. Vainio
Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development
Development, July 15, 2004; 131(14): 3345 - 3356.
[Abstract] [Full Text] [PDF]

K. A. Gilbert and S. R. Rannels
Matrix GLA protein modulates branching morphogenesis in fetal rat lung
Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1179 - L1187.
[Abstract] [Full Text] [PDF]

J. West, K. Fagan, W. Steudel, B. Fouty, K. Lane, J. Harral, M. Hoedt-Miller, Y. Tada, J. Ozimek, R. Tuder, et al.
Pulmonary Hypertension in Transgenic Mice Expressing a Dominant-Negative BMPRII Gene in Smooth Muscle
Circ. Res., April 30, 2004; 94(8): 1109 - 1114.
[Abstract] [Full Text] [PDF]

V. V. Kalinichenko, G. A. Gusarova, I.-M. Kim, B. Shin, H. M. Yoder, J. Clark, A. M. Sapozhnikov, J. A. Whitsett, and R. H. Costa
Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development
Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L521 - L530.
[Abstract] [Full Text] [PDF]

W. Shi, H. Chen, J. Sun, C. Chen, J. Zhao, Y.-L. Wang, K. D. Anderson, and D. Warburton
Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins
Am J Physiol Lung Cell Mol Physiol, February 1, 2004; 286(2): L293 - L300.
[Abstract] [Full Text] [PDF]

D. L. Glaser, A. N. Economides, L. Wang, X. Liu, R. D. Kimble, J. P. Fandl, J. M. Wilson, N. Stahl, F. S. Kaplan, and E. M. Shore
In Vivo Somatic Cell Gene Transfer of an Engineered Noggin Mutein Prevents BMP4-Induced Heterotopic Ossification
J. Bone Joint Surg. Am., December 1, 2003; 85(12): 2332 - 2342.
[Abstract] [Full Text] [PDF]

J. M. Shannon, K. McCormick-Shannon, M. S. Burhans, X. Shangguan, K. Srivastava, and B. A. Hyatt
Chondroitin sulfate proteoglycans are required for lung growth and morphogenesis in vitro
Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1323 - L1336.
[Abstract] [Full Text] [PDF]

M. L. Mucenski, S. E. Wert, J. M. Nation, D. E. Loudy, J. Huelsken, W. Birchmeier, E. E. Morrisey, and J. A. Whitsett
{beta}-Catenin Is Required for Specification of Proximal/Distal Cell Fate during Lung Morphogenesis
J. Biol. Chem., October 10, 2003; 278(41): 40231 - 40238.
[Abstract] [Full Text] [PDF]

C. A. Podlasek, D. J. Zelner, J. D. Harris, C. L. Meroz, Y. Tang, K. E. McKenna, and K. T. McVary
Altered Sonic Hedgehog Signaling Is Associated with Morphological Abnormalities in the Penis of the BB/WOR Diabetic Rat
Biol Reprod, September 1, 2003; 69(3): 816 - 827.
[Abstract] [Full Text] [PDF]

S. Vainio, Y. Lin, and T. Pihlajaniemi
Induced Repatterning of Type XVIII Collagen Associates with Ectopic Sonic Hedgehog and Lung Surfactant C Gene Expression and Changes in Epithelial Epigenesis in the Ureteric Bud
J. Am. Soc. Nephrol., June 1, 2003; 14(90001): S3 - 8.
[Abstract] [Full Text] [PDF]

W. Shu, Y. Q. Jiang, M. M. Lu, and E. E. Morrisey
Wnt7b regulates mesenchymal proliferation and vascular development in the lung
Development, March 12, 2003; 129(20): 4831 - 4842.
[Abstract] [Full Text] [PDF]

S. Unger, I. Copland, D. Tibboel, and M. Post
Down-Regulation of Sonic Hedgehog Expression in Pulmonary Hypoplasia Is Associated with Congenital Diaphragmatic Hernia
Am. J. Pathol., February 1, 2003; 162(2): 547 - 555.
[Abstract] [Full Text] [PDF]

C. A. Podlasek, D. J. Zelner, H. B. Jiang, Y. Tang, J. Houston, K. E. McKenna, and K. T. McVary
Sonic hedgehog Cascade Is Required for Penile Postnatal Morphogenesis, Differentiation, and Adult Homeostasis
Biol Reprod, February 1, 2003; 68(2): 423 - 438.
[Abstract] [Full Text] [PDF]

J. Aubin, U. Dery, M. Lemieux, P. Chailler, and L. Jeannotte
Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling
Development, September 1, 2002; 129(17): 4075 - 4087.
[Abstract] [Full Text] [PDF]

Z. Zhang, Y. Song, X. Zhao, X. Zhang, C. Fermin, and Y. Chen
Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis
Development, September 1, 2002; 129(17): 4135 - 4146.
[Abstract] [Full Text] [PDF]

A. Rosendahl, E. Pardali, M. Speletas, P. ten Dijke, C.-H. Heldin, and P. Sideras
Activation of Bone Morphogenetic Protein/Smad Signaling in Bronchial Epithelial Cells during Airway Inflammation
Am. J. Respir. Cell Mol. Biol., August 1, 2002; 27(2): 160 - 169.
[Abstract] [Full Text] [PDF]

A. Ricken*, P. Lochhead, M. Kontogiannea, and R. Farookhi
Wnt Signaling in the Ovary: Identification and Compartmentalized Expression of wnt-2, wnt-2b, and Frizzled-4 mRNAs
Endocrinology, July 1, 2002; 143(7): 2741 - 2749.
[Abstract] [Full Text] [PDF]

K. D. Tremblay, N. R. Dunn, and E. J. Robertson
Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation
Development, September 15, 2001; 128(18): 3609 - 3621.
[Abstract] [Full Text] [PDF]

M. Mahlapuu, S. Enerback, and P. Carlsson
Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations
Development, June 15, 2001; 128(12): 2397 - 2406.
[Abstract] [Full Text] [PDF]

C. Liu, W. Liu, M.-F. Lu, N. A. Brown, and J. F. Martin
Regulation of left-right asymmetry by thresholds of Pitx2c activity
Development, June 1, 2001; 128(11): 2039 - 2048.
[Abstract] [Full Text] [PDF]

R. H. Costa, V. V. Kalinichenko, and L. Lim
Transcription factors in mouse lung development and function
Am J Physiol Lung Cell Mol Physiol, May 1, 2001; 280(5): L823 - L838.
[Abstract] [Full Text] [PDF]

W. Shi, J. Zhao, K. D. Anderson, and D. Warburton
Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis
Am J Physiol Lung Cell Mol Physiol, May 1, 2001; 280(5): L1030 - L1039.
[Abstract] [Full Text] [PDF]

F. Trousse, P. Esteve, and P. Bovolenta
BMP4 Mediates Apoptotic Cell Death in the Developing Chick Eye
J. Neurosci., February 15, 2001; 21(4): 1292 - 1301.
[Abstract] [Full Text] [PDF]

Y Lin, S Zhang, M Rehn, P Itaranta, J Tuukkanen, R Heljasvaara, H Peltoketo, T Pihlajaniemi, and S Vainio
Induced repatterning of type XVIII collagen expression in ureter bud from kidney to lung type: association with sonic hedgehog and ectopic surfactant protein C
Development, January 5, 2001; 128(9): 1573 - 1585.
[Abstract] [PDF]

R Keijzer, M van Tuyl, C Meijers, M Post, D Tibboel, F Grosveld, and M Koutsourakis
The transcription factor GATA6 is essential for branching morphogenesis and epithelial cell differentiation during fetal pulmonary development
Development, January 2, 2001; 128(4): 503 - 511.
[Abstract] [PDF]

B. S. Tseng, S. T. Cavin, F. W. Booth, E. N. Olson, M. C. Marin, T. J. McDonnell, and I. J. Butler
Pulmonary Hypoplasia in the myogenin Null Mouse Embryo
Am. J. Respir. Cell Mol. Biol., March 1, 2000; 22(3): 304 - 315.
[Abstract] [Full Text]

J Shou, R. Murray, P. Rim, and A. Calof
Opposing effects of bone morphogenetic proteins on neuron production and survival in the olfactory receptor neuron lineage
Development, January 12, 2000; 127(24): 5403 - 5413.
[Abstract] [PDF]

D. Smith, C Nielsen, C. Tabin, and D. Roberts
Roles of BMP signaling and Nkx2.5 in patterning at the chick midgut-foregut boundary
Development, January 9, 2000; 127(17): 3671 - 3681.
[Abstract] [PDF]

T Ito, N Udaka, T Yazawa, K Okudela, H Hayashi, T Sudo, F Guillemot, R Kageyama, and H Kitamura
Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium
Development, January 9, 2000; 127(18): 3913 - 3921.
[Abstract] [PDF]

L Karlsson, P Lindahl, J. Heath, and C Betsholtz
Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis
Development, January 8, 2000; 127(16): 3457 - 3466.
[Abstract] [PDF]

				J. Sun, H. Chen, C. Chen, J. A. Whitsett, Y. Mishina, P. Bringas Jr., J. C. Ma, D. Warburton, and W. Shi Prenatal Lung Epithelial Cell-Specific Abrogation of Alk3-Bone Morphogenetic Protein Signaling Causes Neonatal Respiratory Distress by Disrupting Distal Airway Formation Am. J. Pathol., March 1, 2008; 172(3): 571 - 582. [Abstract] [Full Text] [PDF]

				M. Myllarniemi, P. Lindholm, M. J. Ryynanen, C. R. Kliment, K. Salmenkivi, J. Keski-Oja, V. L. Kinnula, T. D. Oury, and K. Koli Gremlin-mediated Decrease in Bone Morphogenetic Protein Signaling Promotes Pulmonary Fibrosis Am. J. Respir. Crit. Care Med., February 1, 2008; 177(3): 321 - 329. [Abstract] [Full Text] [PDF]

				K. R. Badri, Y. Zhou, and L. Schuger Embryological Origin of Airway Smooth Muscle Proceedings of the ATS, January 1, 2008; 5(1): 4 - 10. [Abstract] [Full Text] [PDF]

				Y. Ishii, J. D. Langberg, R. Hurtado, S. Lee, and T. Mikawa Induction of proepicardial marker gene expression by the liver bud Development, October 15, 2007; 134(20): 3627 - 3637. [Abstract] [Full Text] [PDF]

				Y. Yao, S. Nowak, A. Yochelis, A. Garfinkel, and K. I. Bostrom Matrix GLA Protein, an Inhibitory Morphogen in Pulmonary Vascular Development J. Biol. Chem., October 12, 2007; 282(41): 30131 - 30142. [Abstract] [Full Text] [PDF]

				J. Lu, J. Qian, D. Keppler, and W. V. Cardoso Cathespin H Is an Fgf10 Target Involved in Bmp4 Degradation during Lung Branching Morphogenesis J. Biol. Chem., July 27, 2007; 282(30): 22176 - 22184. [Abstract] [Full Text] [PDF]

				J. R. Hens, P. Dann, J.-P. Zhang, S. Harris, G. W. Robinson, and J. Wysolmerski BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction Development, March 15, 2007; 134(6): 1221 - 1230. [Abstract] [Full Text] [PDF]

				T. Schmelzle, A. A. Mailleux, M. Overholtzer, J. S. Carroll, N. L. Solimini, E. S. Lightcap, O. P. Veiby, and J. S. Brugge Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis PNAS, March 6, 2007; 104(10): 3787 - 3792. [Abstract] [Full Text] [PDF]

				T. Berg, L. Didon, and M. Nord Ectopic expression of C/EBP{alpha} in the lung epithelium disrupts late lung development Am J Physiol Lung Cell Mol Physiol, October 1, 2006; 291(4): L683 - L693. [Abstract] [Full Text] [PDF]

				K. Koli, M. Myllarniemi, K. Vuorinen, K. Salmenkivi, M. J. Ryynanen, V. L. Kinnula, and J. Keski-Oja Bone Morphogenetic Protein-4 Inhibitor Gremlin Is Overexpressed in Idiopathic Pulmonary Fibrosis Am. J. Pathol., July 1, 2006; 169(1): 61 - 71. [Abstract] [Full Text] [PDF]

				W. V. Cardoso and J. Lu Regulation of early lung morphogenesis: questions, facts and controversies Development, May 1, 2006; 133(9): 1611 - 1624. [Abstract] [Full Text] [PDF]

				A. C. White, J. Xu, Y. Yin, C. Smith, G. Schmid, and D. M. Ornitz FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains Development, April 15, 2006; 133(8): 1507 - 1517. [Abstract] [Full Text] [PDF]

				M. van Tuyl, J. Liu, F. Groenman, R. Ridsdale, R. N. N. Han, V. Venkatesh, D. Tibboel, and M. Post Iroquois genes influence proximo-distal morphogenesis during rat lung development Am J Physiol Lung Cell Mol Physiol, April 1, 2006; 290(4): L777 - L789. [Abstract] [Full Text] [PDF]

				R. L. Caldwell, R. Gadipatti, K. B. Lane, and V. L. Shepherd HIV-1 TAT represses transcription of the bone morphogenic protein receptor-2 in U937 monocytic cells J. Leukoc. Biol., January 1, 2006; 79(1): 192 - 201. [Abstract] [Full Text] [PDF]

				X. Zhang, T. S. Stappenbeck, A. C. White, K. J. Lavine, J. I. Gordon, and D. M. Ornitz Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development Development, January 1, 2006; 133(1): 173 - 180. [Abstract] [Full Text] [PDF]

				A.-K. T. Perl, S. E. Wert, D. E. Loudy, Z. Shan, P. A. Blair, and J. A. Whitsett Conditional Recombination Reveals Distinct Subsets of Epithelial Cells in Trachea, Bronchi, and Alveoli Am. J. Respir. Cell Mol. Biol., November 1, 2005; 33(5): 455 - 462. [Abstract] [Full Text] [PDF]

				L. Yu, S. Gu, S. Alappat, Y. Song, M. Yan, X. Zhang, G. Zhang, Y. Jiang, Z. Zhang, Y. Zhang, et al. Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate Development, October 1, 2005; 132(19): 4397 - 4406. [Abstract] [Full Text] [PDF]

				C. Colarossi, Y. Chen, H. Obata, V. Jurukovski, L. Fontana, B. Dabovic, and D. B. Rifkin Lung Alveolar Septation Defects in Ltbp-3-Null Mice Am. J. Pathol., August 1, 2005; 167(2): 419 - 428. [Abstract] [Full Text] [PDF]

				I.-M. Kim, S. Ramakrishna, G. A. Gusarova, H. M. Yoder, R. H. Costa, and V. V. Kalinichenko The Forkhead Box M1 Transcription Factor Is Essential for Embryonic Development of Pulmonary Vasculature J. Biol. Chem., June 10, 2005; 280(23): 22278 - 22286. [Abstract] [Full Text] [PDF]

				C. Chen, H. Chen, J. Sun, P. Bringas Jr., Y. Chen, D. Warburton, and W. Shi Smad1 expression and function during mouse embryonic lung branching morphogenesis Am J Physiol Lung Cell Mol Physiol, June 1, 2005; 288(6): L1033 - L1039. [Abstract] [Full Text] [PDF]

				A. A. Mailleux, R. Kelly, J. M. Veltmaat, S. P. De Langhe, S. Zaffran, J. P. Thiery, and S. Bellusci Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage Development, May 1, 2005; 132(9): 2157 - 2166. [Abstract] [Full Text] [PDF]

				S. Li, Y. Li, W. Du, L. Zhang, S. Yu, Y. Dai, C. Zhao, and N. Li Aberrant Gene Expression in Organs of Bovine Clones That Die Within Two Days after Birth Biol Reprod, February 1, 2005; 72(2): 258 - 265. [Abstract] [Full Text] [PDF]

				M. van Tuyl, J. Liu, J. Wang, M. Kuliszewski, D. Tibboel, and M. Post Role of oxygen and vascular development in epithelial branching morphogenesis of the developing mouse lung Am J Physiol Lung Cell Mol Physiol, January 1, 2005; 288(1): L167 - L178. [Abstract] [Full Text] [PDF]

				B. A. Hyatt, X. Shangguan, and J. M. Shannon FGF-10 induces SP-C and Bmp4 and regulates proximal-distal patterning in embryonic tracheal epithelium Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1116 - L1126. [Abstract] [Full Text] [PDF]

				H. Beppu, F. Ichinose, N. Kawai, R. C. Jones, P. B. Yu, W. M. Zapol, K. Miyazono, E. Li, and K. D. Bloch BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1241 - L1247. [Abstract] [Full Text] [PDF]

				K. Koli, F. Wempe, A. Sterner-Kock, A. Kantola, M. Komor, W.-K. Hofmann, H. von Melchner, and J. Keski-Oja Disruption of LTBP-4 function reduces TGF-{beta} activation and enhances BMP-4 signaling in the lung J. Cell Biol., October 11, 2004; 167(1): 123 - 133. [Abstract] [Full Text] [PDF]

				L. Kan, M. Hu, W. A. Gomes, and J. A. Kessler Transgenic Mice Overexpressing BMP4 Develop a Fibrodysplasia Ossificans Progressiva (FOP)-Like Phenotype Am. J. Pathol., October 1, 2004; 165(4): 1107 - 1115. [Abstract] [Full Text] [PDF]

				C. Dean, M. Ito, H. P. Makarenkova, S. C. Faber, and R. A. Lang Bmp7 regulates branching morphogenesis of the lacrimal gland by promoting mesenchymal proliferation and condensation Development, September 1, 2004; 131(17): 4155 - 4165. [Abstract] [Full Text] [PDF]

				J. A. Whitsett, C. J. Bachurski, K. C. Barnes, P. A. Bunn Jr., L. M. Case, D. N. Cook, D. Crooks, M. W. Duncan, L. Dwyer-Nield, R. C. Elston, et al. Functional Genomics of Lung Disease Am. J. Respir. Cell Mol. Biol., August 1, 2004; 31(2/S1): S1 - S81. [Full Text] [PDF]

				L. Chi, S. Zhang, Y. Lin, R. Prunskaite-Hyyrylainen, R. Vuolteenaho, P. Itaranta, and S. Vainio Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development Development, July 15, 2004; 131(14): 3345 - 3356. [Abstract] [Full Text] [PDF]