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Development, Vol 122, Issue 6 1737-1750, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
A Vogel, C Rodriguez and JC Izpisua-Belmonte
Gene expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Fibroblast Growth Factors (FGFs) are signaling molecules that are important in patterning and growth control during vertebrate limb development. Beads soaked in FGF-1, FGF-2 and FGF-4 are able to induce additional limbs when applied to the flank of young chick embryos (Cohn, M.J., Izpisua-Belmonte, J-C., Abud, H., Heath, J. K., Tickle, C. (1995) Cell 80, 739-746). However, biochemical and expression studies suggest that none of these FGFs is the endogenous signal that initiates limb development. During chick limb development, Fgf-8 transcripts are detected in the intermediate mesoderm and subsequently in the prelimb field ectoderm prior to the formation of the apical ectodermal ridge, structures required for limb initiation and outgrowth, respectively. Later on, Fgf-8 expression is restricted to the ridge cells and expression disappears when the ridge regresses. Application of FGF-8 protein to the flank induces the development of additional limbs. Moreover, we show that FGF-8 can replace the apical ectodermal ridge to maintain Shh expression and outgrowth and patterning of the developing chick limb. Furthermore, continuous and widespread misexpression of FGF-8 causes limb truncations and skeletal alterations with phocomelic or achondroplasia phenotype. Thus, FGF-8 appears to be a key signal involved in initiation, outgrowth and patterning of the developing vertebrate limb.
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|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
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|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
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|
|
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|
|
|
|
|
|
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|
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|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
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|
|
|
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|
|
|
|
|
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C Logan, A Hornbruch, I Campbell, and A Lumsden The role of Engrailed in establishing the dorsoventral axis of the chick limb Development, January 6, 1997; 124(12): 2317 - 2324. [Abstract] [PDF]
|
|
|
|
|
|
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|
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|
|
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|
|
|
|
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S. Lee, P. Danielian, B Fritzsch, and A. McMahon Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain Development, January 3, 1997; 124(5): 959 - 969. [Abstract] [PDF]
|
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|
 |
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 M. Lewandoski, E.N. Meyers, and G.R. Martin Analysis of Fgf8 Gene Function in Vertebrate Development Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 159 - 168. [Abstract] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
J Kuhlman and L Niswander Limb deformity proteins: role in mesodermal induction of the apical ectodermal ridge Development, January 1, 1997; 124(1): 133 - 139. [Abstract] [PDF]
|
|
|
|
|
|
U Grieshammer, G Minowada, J. Pisenti, U. Abbott, and G. Martin The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation Development, January 12, 1996; 122(12): 3851 - 3861. [Abstract] [PDF]
|
|
|
|
|
|
M. Ros, A Lopez-Martinez, B. Simandl, C Rodriguez, J. Izpisua Belmonte, R Dahn, and J. Fallon The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions Development, January 8, 1996; 122(8): 2319 - 2330. [Abstract] [PDF]
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