|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 122, Issue 6 1909-1917, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
YM Kuo, N Jones, B Zhou, S Panzer, V Larson and SK Beckendorf
Department of Molecular and Cell Biology, Division of Genetics, University of California, Berkeley, 94720, USA.
Organogenesis in Drosophila embryos begins at 4-5 hours of development as the expression of organ-specific genes is initiated. The salivary primordium, which occupies the ventral epidermis of parasegment 2, is among the earliest to be defined. It is soon divided into two distinct regions: the more dorsal pregland cells and the more ventral preduct cells. We show that it is the opposing activities of the Drosophila EGF receptor (DER) signaling pathway and the Fork head transcription factor that distinguish these cell types and set up the boundary between them. DER signaling acts ventrally to block fork head expression in the preduct cells, thereby restricting gland identity to the more dorsal cells. Fork head in turn blocks expression of duct-specific genes in the pregland cells, thereby restricting duct identity to the more ventral cells. A third regulatory activity, the Trachealess transcription factor, is also required to establish the identity of the preduct cells, but we show that it acts independently or downstream from the DER:fork head confrontation. In trachealess mutants, subdivision of the salivary primordium occurs normally and the dorsal cells form glands, but the ventral cells are undetermined. We present a model proposing that trachealess is the crucial duct-specific gene that Fork head represses to distinguish pregland from preduct cells.
This article has been cited by other articles:
|
|
 |
|
  C. S. Thummel To die or not to die--a role for Fork head J. Cell Biol., March 12, 2007; 176(6): 737 - 739. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. W. Abrams, W. K. Mihoulides, and D. J. Andrew Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4{alpha}SG1 and PH4{alpha}SG2 Development, September 15, 2006; 133(18): 3517 - 3527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. t. Bosch, J. A. Benavides, and T. W. Cline The TAGteam DNA motif controls the timing of Drosophila pre-blastoderm transcription Development, May 15, 2006; 133(10): 1967 - 1977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Chandrasekaran and S. K. Beckendorf senseless is necessary for the survival of embryonic salivary glands in Drosophila Development, October 1, 2003; 130(19): 4719 - 4728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Shaw, X. Zhang, A. F. Russo, B. A. Amendt, S. Henderson, and V. Williams Homeobox Protein, Hmx3, in Postnatally Developing Rat Submandibular Glands J. Histochem. Cytochem., March 1, 2003; 51(3): 385 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Myat and D. Andrew Fork head prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands Development, January 10, 2000; 127(19): 4217 - 4226. [Abstract] [PDF]
|
|
|
|
 |
|
 H. D. Ryoo and R. S. Mann The control of trunk Hox specificity and activity by Extradenticle Genes & Dev., July 1, 1999; 13(13): 1704 - 1716. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Jun, R. V. Wallen, A. Goriely, B. Kalionis, and C. Desplan Lune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition PNAS, November 10, 1998; 95(23): 13720 - 13725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Horner, S. Quintin, M. E. Domeier, J. Kimble, M. Labouesse, and S. E. Mango pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans Genes & Dev., July 1, 1998; 12(13): 1947 - 1952. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. J. ANDREW Regulation and Formation of the Drosophila Salivary Glands Ann. N.Y. Acad. Sci., April 15, 1998; 842(1): 55 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Jones, Y. Kuo, Y. Sun, and S. Beckendorf The Drosophila Pax gene eye gone is required for embryonic salivary duct development Development, January 11, 1998; 125(21): 4163 - 4174. [Abstract] [PDF]
|
|
|
|
|
|
K. Stark, G. Yee, C. Roote, E. Williams, S Zusman, and R. Hynes A novel alpha integrin subunit associates with betaPS and functions in tissue morphogenesis and movement during Drosophila development Development, January 11, 1997; 124(22): 4583 - 4594. [Abstract] [PDF]
|
|
|
|
|
|
T Ohshiro and K Saigo Transcriptional regulation of breathless FGF receptor gene by binding of TRACHEALESS/dARNT heterodimers to three central midline elements in Drosophila developing trachea Development, January 10, 1997; 124(20): 3975 - 3986. [Abstract] [PDF]
|
|
|
|
|
|
B Schnepp, G Grumbling, T Donaldson, and A Simcox Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes & Dev., September 15, 1996; 10(18): 2302 - 2313. [Abstract] [PDF]
|
|
