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Development, Vol 122, Issue 6 1919-1929, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
A Schuchardt, V D'Agati, V Pachnis and F Costantini
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, NY 10032, USA.
The c-ret gene encodes a receptor tyrosine kinase that is expressed in the Wolffian duct and ureteric bud of the developing excretory system. Newborn mice homozygous for a mutation in c-ret displayed renal agenesis or severe hypodysplasia, suggesting a critical role for this gene in metanephric kidney development. To investigate the embryological basis of these defects, we characterized the early development of the excretory system in mutant homozygotes, and observed a range of defects in the formation, growth and branching of the ureteric bud, which account for the spectrum of renal defects seen at birth. Co-culture of isolated ureteric buds and metanephric mesenchyme show that the primary defect is intrinsic to the ureteric bud. While the mutant bud failed to respond to induction by wild-type mesenchyme, mutant mesenchyme was competent to induce the growth and branching of the wild-type bud. Furthermore, the mutant metanephric mesenchyme displayed a normal capacity to differentiate into nephric tubules when co-cultured with embryonic spinal cord. These findings suggest a model in which c-ret encodes the receptor for a (yet to be identified) factor produced by the metanephric mesenchyme, which mediates the inductive effects of this tissue upon the ureteric bud. This factor appears to stimulate the initial evagination of the ureteric bud from the Wolffian duct, as well as its subsequent growth and branching.
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 U Muller and A. Brandli Cell adhesion molecules and extracellular-matrix constituents in kidney development and disease J. Cell Sci., January 11, 1999; 112(22): 3855 - 3867. [Abstract] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
A. Moore, L McInnes, J Kreidberg, N. Hastie, and A Schedl YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis Development, January 5, 1999; 126(9): 1845 - 1857. [Abstract] [PDF]
|
|
|
|
|
|
S Srinivas, Z Wu, C. Chen, V D'Agati, and F Costantini Dominant effects of RET receptor misexpression and ligand-independent RET signaling on ureteric bud development Development, January 4, 1999; 126(7): 1375 - 1386. [Abstract] [PDF]
|
|
|
|
|
|
C Mendelsohn, E Batourina, S Fung, T Gilbert, and J Dodd Stromal cells mediate retinoid-dependent functions essential for renal development Development, January 3, 1999; 126(6): 1139 - 1148. [Abstract] [PDF]
|
|
|
|
|
|
E. Moreau, J. Vilar, M. Lelievre-Pegorier, C. Merlet-Benichou, and T. Gilbert Regulation of c-ret expression by retinoic acid in rat metanephros: implication in nephron mass control Am J Physiol Renal Physiol, December 1, 1998; 275(6): F938 - F945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Bullock, J. M. Fletcher, R. S.P. Beddington, and V. A. Wilson Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase Genes & Dev., June 15, 1998; 12(12): 1894 - 1906. [Abstract] [Full Text]
|
|
|
|
|
|
P Lindahl, M Hellstrom, M Kalen, L Karlsson, M Pekny, M Pekna, P Soriano, and C Betsholtz Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli Development, January 9, 1998; 125(17): 3313 - 3322. [Abstract] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
K Sainio, P Suvanto, J Davies, J Wartiovaara, K Wartiovaara, M Saarma, U Arumae, X Meng, M Lindahl, V Pachnis, et al. Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium Development, January 10, 1997; 124(20): 4077 - 4087. [Abstract] [PDF]
|
|
|
|
|
|
N Miyamoto, M Yoshida, S Kuratani, I Matsuo, and S Aizawa Defects of urogenital development in mice lacking Emx2 Development, January 5, 1997; 124(9): 1653 - 1664. [Abstract] [PDF]
|
|
|
|
|
|
M. Hahn and J. M. Bishop Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons PNAS, January 30, 2001; 98(3): 1053 - 1058. [Abstract] [Full Text] [PDF]
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