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Development, Vol 122, Issue 7 2153-2162, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
V. Wiersdorff, T. Lecuit, S. M. Cohen and M. Mlodzik
Decapentaplegic (Dpp), a member of the TGF-betta family of cytokines, has been implicated in many patterning processes in Drosophila, including the initial steps of pattern formation in the developing eye. We show that the Mothers against dpp (Mad) gene is required for dpp signaling during eye development. Clonal analysis demonstrates a cell-autonomous function for Mad and genetic interactions indicate that Mad is an essential component of the signal transduction pathway downstream of the Dpp receptors in responding cells. Mad-mediated dpp signaling is absolutely required for the initiation of the morphogenetic furrow in the eye, but has only a minor role in its subsequent propagation across the eye
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J Royet and R Finkelstein Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog Development, January 12, 1997; 124(23): 4793 - 4800. [Abstract] [PDF]
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