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Development, Vol 122, Issue 7 2251-2259, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

H Uyttendaele, G Marazzi, G Wu, Q Yan, D Sassoon and J Kitajewski
Department of Pathology in the Center of Reproductive Sciences, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.

The int-3 oncogene was identified as a frequent target in Mouse Mammary Tumor Virus (MMTV)-induced mammary carcinomas and encodes the intracellular domain of a novel mouse Notch gene. To investigate the role of the int-3 proto-oncogene in mouse development and carcinogenesis, we isolated cDNA clones corresponding to the entire coding potential of the int-3 proto-oncogene. We propose to name this gene Notch4 and reserve the int-3 nomenclature for references to the oncogenic form. The deduced amino acid sequence of Notch4 contains conserved motifs found in Notch proteins; however Notch4 has fewer epidermal growth factor (EGF)-like repeats and a shorter intracellular domain than other mouse Notch homologues. Comparison of the coding potential of the int-3 gene to that of Notch4 suggests that loss of the extracellular domain of Notch4 leads to constitutive activation of this murine Notch protein. In situ hybridization revealed that Notch4 transcripts are primarily restricted to endothelial cells in embryonic and adult life. Truncated Notch4 transcripts were detected in post-meiotic male germ cells. The distinct Notch4 protein features and its restricted expression pattern suggests a specific role for Notch4 during development of vertebrate endothelium.
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K. Shimizu, S. Chiba, N. Hosoya, K. Kumano, T. Saito, M. Kurokawa, Y. Kanda, Y. Hamada, and H. Hirai
Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2
Mol. Cell. Biol., September 15, 2000; 20(18): 6913 - 6922.
[Abstract] [Full Text]

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 Circ. Res.Home page
P. Carmeliet
Fibroblast Growth Factor-1 Stimulates Branching and Survival of Myocardial Arteries : A Goal for Therapeutic Angiogenesis?
Circ. Res., August 4, 2000; 87(3): 176 - 178.
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 BloodHome page
S. Tsai, J. Fero, and S. Bartelmez
Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact
Blood, August 1, 2000; 96(3): 950 - 957.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
S. Jeffries and A. J. Capobianco
Neoplastic Transformation by Notch Requires Nuclear Localization
Mol. Cell. Biol., June 1, 2000; 20(11): 3928 - 3941.
[Abstract] [Full Text]

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 Genes Dev.Home page
J. R. Shutter, S. Scully, W. Fan, W. G. Richards, J. Kitajewski, G. A. Deblandre, C. R. Kintner, and K. L. Stark
Dll4, a novel Notch ligand expressed in arterial endothelium
Genes & Dev., June 1, 2000; 14(11): 1313 - 1318.
[Abstract] [Full Text]

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 Genes Dev.Home page
L. T. Krebs, Y. Xue, C. R. Norton, J. R. Shutter, M. Maguire, J. P. Sundberg, D. Gallahan, V. Closson, J. Kitajewski, R. Callahan, et al.
Notch signaling is essential for vascular morphogenesis in mice
Genes & Dev., June 1, 2000; 14(11): 1343 - 1352.
[Abstract] [Full Text]

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 BloodHome page
K. Ohishi, B. Varnum-Finney, D. Flowers, C. Anasetti, D. Myerson, and I. D. Bernstein
Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1
Blood, May 1, 2000; 95(9): 2847 - 2854.
[Abstract] [Full Text] [PDF]

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 JEMHome page
F. Radtke, I. Ferrero, A. Wilson, R. Lees, M. Aguet, and H. R. MacDonald
Notch1 Deficiency Dissociates the Intrathymic Development of Dendritic Cells and T Cells
J. Exp. Med., April 3, 2000; 191(7): 1085 - 1094.
[Abstract] [Full Text] [PDF]

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 BloodHome page
W. Han, Q. Ye, and M. A. S. Moore
A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells
Blood, March 1, 2000; 95(5): 1616 - 1625.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
M. Rones, K. McLaughlin, M Raffin, and M Mercola
Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis
Development, January 9, 2000; 127(17): 3865 - 3876.
[Abstract] [PDF]

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 DevelopmentHome page
T Ito, N Udaka, T Yazawa, K Okudela, H Hayashi, T Sudo, F Guillemot, R Kageyama, and H Kitamura
Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium
Development, January 9, 2000; 127(18): 3913 - 3921.
[Abstract] [PDF]

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 DevelopmentHome page
A Zine, T. Van De Water, and F de Ribaupierre
Notch signaling regulates the pattern of auditory hair cell differentiation in mammals
Development, January 8, 2000; 127(15): 3373 - 3383.
[Abstract] [PDF]

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 Cancer Res.Home page
T. Veikkola, M. Karkkainen, L. Claesson-Welsh, and K. Alitalo
Regulation of Angiogenesis via Vascular Endothelial Growth Factor Receptors
Cancer Res., January 1, 2000; 60(2): 203 - 212.
[Full Text]

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 J. Biol. Chem.Home page
K. Shimizu, S. Chiba, K. Kumano, N. Hosoya, T. Takahashi, Y. Kanda, Y. Hamada, Y. Yazaki, and H. Hirai
Mouse Jagged1 Physically Interacts with Notch2 and Other Notch Receptors. ASSESSMENT BY QUANTITATIVE METHODS
J. Biol. Chem., November 12, 1999; 274(46): 32961 - 32969.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
E. Tsifrina, N. M. Ananyeva, G. Hastings, and G. Liau
Identification and Characterization of Three cDNAs That Encode Putative Novel Hyaluronan-Binding Proteins, Including an Endothelial Cell-Specific Hyaluronan Receptor
Am. J. Pathol., November 1, 1999; 155(5): 1625 - 1633.
[Abstract] [Full Text] [PDF]

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 Int ImmunolHome page
M. P. Felli, M. Maroder, T. A. Mitsiadis, A. F. Campese, D. Bellavia, A. Vacca, R. S. Mann, L. Frati, U. Lendahl, A. Gulino, et al.
Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development
Int. Immunol., July 1, 1999; 11(7): 1017 - 1025.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
K. Penta, J. A. Varner, L. Liaw, C. Hidai, R. Schatzman, and T. Quertermous
Del1 Induces Integrin Signaling and Angiogenesis by Ligation of alpha Vbeta 3
J. Biol. Chem., April 16, 1999; 274(16): 11101 - 11109.
[Abstract] [Full Text] [PDF]

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 BloodHome page
N. Carlesso, J. C. Aster, J. Sklar, and D. T. Scadden
Notch1-Induced Delay of Human Hematopoietic Progenitor Cell Differentiation Is Associated With Altered Cell Cycle Kinetics
Blood, February 1, 1999; 93(3): 838 - 848.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
S. Du Yan, Y. Shi, A. Zhu, J. Fu, H. Zhu, Y. Zhu, L. Gibson, E. Stern, K. Collison, F. Al-Mohanna, et al.
Role of ERAB/L-3-Hydroxyacyl-coenzyme A Dehydrogenase Type II Activity in Abeta -induced Cytotoxicity
J. Biol. Chem., January 22, 1999; 274(4): 2145 - 2156.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
T Ikeya and S Hayashi
Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea
Development, January 10, 1999; 126(20): 4455 - 4463.
[Abstract] [PDF]

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 DevelopmentHome page
Y Hamada, Y Kadokawa, M Okabe, M Ikawa, J. Coleman, and Y Tsujimoto
Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality
Development, January 8, 1999; 126(15): 3415 - 3424.
[Abstract] [PDF]

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 Mol. Cell. Biol.Home page
H. K. Kim and G. Siu
The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression
Mol. Cell. Biol., December 1, 1998; 18(12): 7166 - 7175.
[Abstract] [Full Text]

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 Mol. Cell. Biol.Home page
S. Jarriault, O. Le Bail, E. Hirsinger, O. Pourquié, F. Logeat, C. F. Strong, C. Brou, N. G. Seidah, and A. Israël
Delta-1 Activation of Notch-1 Signaling Results in HES-1 Transactivation
Mol. Cell. Biol., December 1, 1998; 18(12): 7423 - 7431.
[Abstract] [Full Text]

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 BloodHome page
P. Jones, G. May, L. Healy, J. Brown, G. Hoyne, S. Delassus, and T. Enver
Stromal Expression of Jagged 1 Promotes Colony Formation by Fetal Hematopoietic Progenitor Cells
Blood, September 1, 1998; 92(5): 1505 - 1511.
[Abstract] [Full Text] [PDF]

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 Mol. Biol. CellHome page
B. Herren, B. Levkau, E. W. Raines, and R. Ross
Cleavage of beta -Catenin and Plakoglobin and Shedding of VE-Cadherin during Endothelial Apoptosis: Evidence for a Role for Caspases and Metalloproteinases
Mol. Biol. Cell, June 1, 1998; 9(6): 1589 - 1601.
[Abstract] [Full Text]

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 BloodHome page
B. Varnum-Finney, L. E. Purton, M. Yu, C. Brashem-Stein, D. Flowers, S. Staats, K. A. Moore, I. Le Roux, R. Mann, G. Gray, et al.
The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells
Blood, June 1, 1998; 91(11): 4084 - 4091.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
A. Bigas, D. I. K. Martin, and L. A. Milner
Notch1 and Notch2 Inhibit Myeloid Differentiation in Response to Different Cytokines
Mol. Cell. Biol., April 1, 1998; 18(4): 2324 - 2333.
[Abstract] [Full Text]

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 Genes Dev.Home page
E. J. A. Hubbard, G. Wu, J. Kitajewski, and I. Greenwald
sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins
Genes & Dev., December 1, 1997; 11(23): 3182 - 3193.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
D. Sherwood and D. McClay
Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation
Development, January 9, 1997; 124(17): 3363 - 3374.
[Abstract] [PDF]

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 DevelopmentHome page
S. Dunwoodie, D Henrique, S. Harrison, and R. Beddington
Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo
Development, January 8, 1997; 124(16): 3065 - 3076.
[Abstract] [PDF]

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 DevelopmentHome page
J. de la Pompa, A Wakeham, K. Correia, E Samper, S Brown, R. Aguilera, T Nakano, T Honjo, T. Mak, J Rossant, et al.
Conservation of the Notch signalling pathway in mammalian neurogenesis
Development, January 3, 1997; 124(6): 1139 - 1148.
[Abstract] [PDF]


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