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Development, Vol 122, Issue 7 2251-2259, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
H Uyttendaele, G Marazzi, G Wu, Q Yan, D Sassoon and J Kitajewski
Department of Pathology in the Center of Reproductive Sciences, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
The int-3 oncogene was identified as a frequent target in Mouse Mammary Tumor Virus (MMTV)-induced mammary carcinomas and encodes the intracellular domain of a novel mouse Notch gene. To investigate the role of the int-3 proto-oncogene in mouse development and carcinogenesis, we isolated cDNA clones corresponding to the entire coding potential of the int-3 proto-oncogene. We propose to name this gene Notch4 and reserve the int-3 nomenclature for references to the oncogenic form. The deduced amino acid sequence of Notch4 contains conserved motifs found in Notch proteins; however Notch4 has fewer epidermal growth factor (EGF)-like repeats and a shorter intracellular domain than other mouse Notch homologues. Comparison of the coding potential of the int-3 gene to that of Notch4 suggests that loss of the extracellular domain of Notch4 leads to constitutive activation of this murine Notch protein. In situ hybridization revealed that Notch4 transcripts are primarily restricted to endothelial cells in embryonic and adult life. Truncated Notch4 transcripts were detected in post-meiotic male germ cells. The distinct Notch4 protein features and its restricted expression pattern suggests a specific role for Notch4 during development of vertebrate endothelium.
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W. Wang, A. H. Campos, C. Z. Prince, Y. Mou, and M. J. Pollman Coordinate Notch3-Hairy-related Transcription Factor Pathway Regulation in Response to Arterial Injury. MEDIATOR ROLE OF PLATELET-DERIVED GROWTH FACTOR AND ERK J. Biol. Chem., June 21, 2002; 277(26): 23165 - 23171. [Abstract] [Full Text] [PDF] |
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S. Tsai, J. Fero, and S. Bartelmez Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact Blood, August 1, 2000; 96(3): 950 - 957. [Abstract] [Full Text] [PDF] |
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S. Jeffries and A. J. Capobianco Neoplastic Transformation by Notch Requires Nuclear Localization Mol. Cell. Biol., June 1, 2000; 20(11): 3928 - 3941. [Abstract] [Full Text] |
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J. R. Shutter, S. Scully, W. Fan, W. G. Richards, J. Kitajewski, G. A. Deblandre, C. R. Kintner, and K. L. Stark Dll4, a novel Notch ligand expressed in arterial endothelium Genes & Dev., June 1, 2000; 14(11): 1313 - 1318. [Abstract] [Full Text] |
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L. T. Krebs, Y. Xue, C. R. Norton, J. R. Shutter, M. Maguire, J. P. Sundberg, D. Gallahan, V. Closson, J. Kitajewski, R. Callahan, et al. Notch signaling is essential for vascular morphogenesis in mice Genes & Dev., June 1, 2000; 14(11): 1343 - 1352. [Abstract] [Full Text] |
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K. Ohishi, B. Varnum-Finney, D. Flowers, C. Anasetti, D. Myerson, and I. D. Bernstein Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1 Blood, May 1, 2000; 95(9): 2847 - 2854. [Abstract] [Full Text] [PDF] |
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K. Shimizu, S. Chiba, K. Kumano, N. Hosoya, T. Takahashi, Y. Kanda, Y. Hamada, Y. Yazaki, and H. Hirai Mouse Jagged1 Physically Interacts with Notch2 and Other Notch Receptors. ASSESSMENT BY QUANTITATIVE METHODS J. Biol. Chem., November 12, 1999; 274(46): 32961 - 32969. [Abstract] [Full Text] [PDF] |
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E. Tsifrina, N. M. Ananyeva, G. Hastings, and G. Liau Identification and Characterization of Three cDNAs That Encode Putative Novel Hyaluronan-Binding Proteins, Including an Endothelial Cell-Specific Hyaluronan Receptor Am. J. Pathol., November 1, 1999; 155(5): 1625 - 1633. [Abstract] [Full Text] [PDF] |
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M. P. Felli, M. Maroder, T. A. Mitsiadis, A. F. Campese, D. Bellavia, A. Vacca, R. S. Mann, L. Frati, U. Lendahl, A. Gulino, et al. Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development Int. Immunol., July 1, 1999; 11(7): 1017 - 1025. [Abstract] [Full Text] [PDF] |
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K. Penta, J. A. Varner, L. Liaw, C. Hidai, R. Schatzman, and T. Quertermous Del1 Induces Integrin Signaling and Angiogenesis by Ligation of alpha Vbeta 3 J. Biol. Chem., April 16, 1999; 274(16): 11101 - 11109. [Abstract] [Full Text] [PDF] |
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N. Carlesso, J. C. Aster, J. Sklar, and D. T. Scadden Notch1-Induced Delay of Human Hematopoietic Progenitor Cell Differentiation Is Associated With Altered Cell Cycle Kinetics Blood, February 1, 1999; 93(3): 838 - 848. [Abstract] [Full Text] [PDF] |
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S. Du Yan, Y. Shi, A. Zhu, J. Fu, H. Zhu, Y. Zhu, L. Gibson, E. Stern, K. Collison, F. Al-Mohanna, et al. Role of ERAB/L-3-Hydroxyacyl-coenzyme A Dehydrogenase Type II Activity in Abeta -induced Cytotoxicity J. Biol. Chem., January 22, 1999; 274(4): 2145 - 2156. [Abstract] [Full Text] [PDF] |
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T Ikeya and S Hayashi Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea Development, January 10, 1999; 126(20): 4455 - 4463. [Abstract] [PDF] |
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Y Hamada, Y Kadokawa, M Okabe, M Ikawa, J. Coleman, and Y Tsujimoto Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality Development, January 8, 1999; 126(15): 3415 - 3424. [Abstract] [PDF] |
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H. K. Kim and G. Siu The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression Mol. Cell. Biol., December 1, 1998; 18(12): 7166 - 7175. [Abstract] [Full Text] |
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S. Jarriault, O. Le Bail, E. Hirsinger, O. Pourquié, F. Logeat, C. F. Strong, C. Brou, N. G. Seidah, and A. Israël Delta-1 Activation of Notch-1 Signaling Results in HES-1 Transactivation Mol. Cell. Biol., December 1, 1998; 18(12): 7423 - 7431. [Abstract] [Full Text] |
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P. Jones, G. May, L. Healy, J. Brown, G. Hoyne, S. Delassus, and T. Enver Stromal Expression of Jagged 1 Promotes Colony Formation by Fetal Hematopoietic Progenitor Cells Blood, September 1, 1998; 92(5): 1505 - 1511. [Abstract] [Full Text] [PDF] |
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B. Herren, B. Levkau, E. W. Raines, and R. Ross Cleavage of beta -Catenin and Plakoglobin and Shedding of VE-Cadherin during Endothelial Apoptosis: Evidence for a Role for Caspases and Metalloproteinases Mol. Biol. Cell, June 1, 1998; 9(6): 1589 - 1601. [Abstract] [Full Text] |
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B. Varnum-Finney, L. E. Purton, M. Yu, C. Brashem-Stein, D. Flowers, S. Staats, K. A. Moore, I. Le Roux, R. Mann, G. Gray, et al. The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells Blood, June 1, 1998; 91(11): 4084 - 4091. [Abstract] [Full Text] [PDF] |
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A. Bigas, D. I. K. Martin, and L. A. Milner Notch1 and Notch2 Inhibit Myeloid Differentiation in Response to Different Cytokines Mol. Cell. Biol., April 1, 1998; 18(4): 2324 - 2333. [Abstract] [Full Text] |
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E. J. A. Hubbard, G. Wu, J. Kitajewski, and I. Greenwald sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins Genes & Dev., December 1, 1997; 11(23): 3182 - 3193. [Abstract] [Full Text] [PDF] |
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D. Sherwood and D. McClay Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation Development, January 9, 1997; 124(17): 3363 - 3374. [Abstract] [PDF] |
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S. Dunwoodie, D Henrique, S. Harrison, and R. Beddington Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo Development, January 8, 1997; 124(16): 3065 - 3076. [Abstract] [PDF] |
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J. de la Pompa, A Wakeham, K. Correia, E Samper, S Brown, R. Aguilera, T Nakano, T Honjo, T. Mak, J Rossant, et al. Conservation of the Notch signalling pathway in mammalian neurogenesis Development, January 3, 1997; 124(6): 1139 - 1148. [Abstract] [PDF] |
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