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Development, Vol 122, Issue 7 2251-2259, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
H Uyttendaele, G Marazzi, G Wu, Q Yan, D Sassoon and J Kitajewski
Department of Pathology in the Center of Reproductive Sciences, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
The int-3 oncogene was identified as a frequent target in Mouse Mammary Tumor Virus (MMTV)-induced mammary carcinomas and encodes the intracellular domain of a novel mouse Notch gene. To investigate the role of the int-3 proto-oncogene in mouse development and carcinogenesis, we isolated cDNA clones corresponding to the entire coding potential of the int-3 proto-oncogene. We propose to name this gene Notch4 and reserve the int-3 nomenclature for references to the oncogenic form. The deduced amino acid sequence of Notch4 contains conserved motifs found in Notch proteins; however Notch4 has fewer epidermal growth factor (EGF)-like repeats and a shorter intracellular domain than other mouse Notch homologues. Comparison of the coding potential of the int-3 gene to that of Notch4 suggests that loss of the extracellular domain of Notch4 leads to constitutive activation of this murine Notch protein. In situ hybridization revealed that Notch4 transcripts are primarily restricted to endothelial cells in embryonic and adult life. Truncated Notch4 transcripts were detected in post-meiotic male germ cells. The distinct Notch4 protein features and its restricted expression pattern suggests a specific role for Notch4 during development of vertebrate endothelium.
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Z.-J. Liu, T. Shirakawa, Y. Li, A. Soma, M. Oka, G. P. Dotto, R. M. Fairman, O. C. Velazquez, and M. Herlyn Regulation of Notch1 and Dll4 by Vascular Endothelial Growth Factor in Arterial Endothelial Cells: Implications for Modulating Arteriogenesis and Angiogenesis Mol. Cell. Biol., January 1, 2003; 23(1): 14 - 25. [Abstract] [Full Text] |
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C. Talora, D. C. Sgroi, C. P. Crum, and G. P. Dotto Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation Genes & Dev., September 1, 2002; 16(17): 2252 - 2263. [Abstract] [Full Text] [PDF] |
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W. Wang, A. H. Campos, C. Z. Prince, Y. Mou, and M. J. Pollman Coordinate Notch3-Hairy-related Transcription Factor Pathway Regulation in Response to Arterial Injury. MEDIATOR ROLE OF PLATELET-DERIVED GROWTH FACTOR AND ERK J. Biol. Chem., June 21, 2002; 277(26): 23165 - 23171. [Abstract] [Full Text] [PDF] |
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V. Sriuranpong, M. W. Borges, C. L. Strock, E. K. Nakakura, D. N. Watkins, C. M. Blaumueller, B. D. Nelkin, and D. W. Ball Notch Signaling Induces Rapid Degradation of Achaete-Scute Homolog 1 Mol. Cell. Biol., May 1, 2002; 22(9): 3129 - 3139. [Abstract] [Full Text] [PDF] |
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K. G. Leong, X. Hu, L. Li, M. Noseda, B. Larrivee, C. Hull, L. Hood, F. Wong, and A. Karsan Activated Notch4 Inhibits Angiogenesis: Role of {beta}1-Integrin Activation Mol. Cell. Biol., April 15, 2002; 22(8): 2830 - 2841. [Abstract] [Full Text] [PDF] |
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S. Stier, T. Cheng, D. Dombkowski, N. Carlesso, and D. T. Scadden Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome Blood, April 1, 2002; 99(7): 2369 - 2378. [Abstract] [Full Text] [PDF] |
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S. J. Morrison, D. Qian, L. Jerabek, B. A. Thiel, I.-K. Park, P. S. Ford, M. J. Kiel, N. J. Schork, I. L. Weissman, and M. F. Clarke A Genetic Determinant That Specifically Regulates the Frequency of Hematopoietic Stem Cells J. Immunol., January 15, 2002; 168(2): 635 - 642. [Abstract] [Full Text] [PDF] |
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A. Stollewerk Recruitment of cell groups through Delta/Notch signalling during spider neurogenesis Development, January 12, 2002; 129(23): 5339 - 5348. [Abstract] [Full Text] [PDF] |
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S. L. Dunwoodie, M. Clements, D. B. Sparrow, X. Sa, R. A. Conlon, and R. S. P. Beddington Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm Development, January 4, 2002; 129(7): 1795 - 1806. [Abstract] [Full Text] [PDF] |
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X.-Q. Yan, U. Sarmiento, Y. Sun, G. Huang, J. Guo, T. Juan, G. Van, M.-Y. Qi, S. Scully, G. Senaldi, et al. A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer Blood, December 15, 2001; 98(13): 3793 - 3799. [Abstract] [Full Text] [PDF] |
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K. Kumano, S. Chiba, K. Shimizu, T. Yamagata, N. Hosoya, T. Saito, T. Takahashi, Y. Hamada, and H. Hirai Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression Blood, December 1, 2001; 98(12): 3283 - 3289. [Abstract] [Full Text] [PDF] |
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G. Wu, S. Lyapina, I. Das, J. Li, M. Gurney, A. Pauley, I. Chui, R. J. Deshaies, and J. Kitajewski SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation Mol. Cell. Biol., November 1, 2001; 21(21): 7403 - 7415. [Abstract] [Full Text] [PDF] |
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M. T. Saxena, E. H. Schroeter, J. S. Mumm, and R. Kopan Murine Notch Homologs (N1-4) Undergo Presenilin-dependent Proteolysis J. Biol. Chem., October 19, 2001; 276(43): 40268 - 40273. [Abstract] [Full Text] [PDF] |
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T. Mizutani, Y. Taniguchi, T. Aoki, N. Hashimoto, and T. Honjo Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members PNAS, July 13, 2001; (2001) 161269998. [Abstract] [Full Text] [PDF] |
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T. Gridley Notch signaling during vascular development PNAS, May 8, 2001; 98(10): 5377 - 5378. [Full Text] [PDF] |
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H. Uyttendaele, J. Ho, J. Rossant, and J. Kitajewski Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium PNAS, May 8, 2001; 98(10): 5643 - 5648. [Abstract] [Full Text] [PDF] |
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V. Sriuranpong, M. W. Borges, R. K. Ravi, D. R. Ar |