spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gonczy, P.
Right arrow Articles by DiNardo, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gonczy, P.
Right arrow Articles by DiNardo, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 122, Issue 8 2437-2447, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

The germ line regulates somatic cyst cell proliferation and fate during Drosophila spermatogenesis

P Gonczy and S DiNardo
Rockefeller University, New York City, New York 10021-6399, USA.

Spermatogenesis relies on the function of germ-line stem cells, as a continuous supply of differentiated spermatids is produced throughout life. In Drosophila, there must also be somatic stem cells that produce the cyst cells that accompany germ cells throughout spermatogenesis. By lineage tracing, we demonstrate the existence of such somatic stem cells and confirm that of germ-line stem cells. The somatic stem cells likely correspond to the ultrastructurally described cyst progenitor cells. The stem cells for both the germ-line and cyst lineage are anchored around the hub of non-dividing somatic cells located at the testis tip. We then address whether germ cells regulate the behavior of somatic hub cells, cyst progenitors and their daughter cyst cells by analyzing cell proliferation and fate in testes in which the germ line has been genetically ablated. Daughter cyst cells, which normally withdraw from the cell cycle, continue to proliferate in the absence of germ cells. In addition, cells from the cyst lineage switch to the hub cell fate. Male-sterile alleles of chickadee and diaphanous, which are deficient in germ cells, exhibit similar cyst cell phenotypes. We conclude that signaling from germ cells regulates the proliferation and fate of cells in the somatic cyst lineage.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
M. G. Riparbelli, G. Colozza, and G. Callaini
Procentriole elongation and recruitment of pericentriolar material are downregulated in cyst cells as they enter quiescence
J. Cell Sci., October 15, 2009; 122(20): 3613 - 3618.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
E.L. Davies and M.T. Fuller
Regulation of Self-renewal and Differentiation in Adult Stem Cell Lineages: Lessons from the Drosophila Male Germ Line
Cold Spring Harb Symp Quant Biol, March 27, 2009; (2009) sqb.2008.73.063v1.
[Abstract] [PDF]

Home page
 GeneticsHome page
D. Drummond-Barbosa
Stem Cells, Their Niches and the Systemic Environment: An Aging Network
Genetics, December 1, 2008; 180(4): 1787 - 1797.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. Jung, M. Hollmann, and M. A. Schafer
The fatty acid elongase NOA is necessary for viability and has a somatic role in Drosophila sperm development
J. Cell Sci., August 15, 2007; 120(16): 2924 - 2934.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Z. Jin, E. M. Homola, P. Goldbach, Y. Choi, J. A. Brill, and S. D. Campbell
Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis
Development, September 15, 2005; 132(18): 4075 - 4085.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
C. Schulz, A. A. Kiger, S. I. Tazuke, Y. M. Yamashita, L. C. Pantalena-Filho, D. L. Jones, C. G. Wood, and M. T. Fuller
A Misexpression Screen Reveals Effects of bag-of-marbles and TGF{beta} Class Signaling on the Drosophila Male Germ-Line Stem Cell Lineage
Genetics, June 1, 2004; 167(2): 707 - 723.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Z. Wang and R. S. Mann
Requirement for two nearly identical TGIF-related homeobox genes in Drosophila spermatogenesis
Development, July 1, 2003; 130(13): 2853 - 2865.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. I. Tazuke, C. Schulz, L. Gilboa, M. Fogarty, A. P. Mahowald, A. Guichet, A. Ephrussi, C. G. Wood, R. Lehmann, and M. T. Fuller
A germline-specific gap junction protein required for survival of differentiating early germ cells
Development, March 7, 2003; 129(10): 2529 - 2539.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Schulz, C. G. Wood, D. L. Jones, S. I. Tazuke, and M. T. Fuller
Signaling from germ cells mediated by the rhomboid homolog stet organizes encapsulation by somatic support cells
Development, January 10, 2002; 129(19): 4523 - 4534.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A. A. Kiger, D. L. Jones, C. Schulz, M. B. Rogers, and M. T. Fuller
Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue
Science, December 21, 2001; 294(5551): 2542 - 2545.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
E. Bergeret, I. Pignot-Paintrand, A. Guichard, K. Raymond, M.-O. Fauvarque, M. Cazemajor, and R. Griffin-Shea
RotundRacGAP Functions with Ras during Spermatogenesis and Retinal Differentiation in Drosophila melanogaster
Mol. Cell. Biol., September 15, 2001; 21(18): 6280 - 6291.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Cox, A Chao, and H Lin
piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells
Development, January 2, 2000; 127(3): 503 - 514.
[Abstract] [PDF]

Home page
 JCBHome page
S. Gigliotti, G. Callaini, S. Andone, M. G. Riparbelli, R. Pernas-Alonso, G. Hoffmann, F. Graziani, and C. Malva
Nup154, a New Drosophila Gene Essential for Male and Female Gametogenesis Is Related to the Nup155 Vertebrate Nucleoporin Gene
J. Cell Biol., September 7, 1998; 142(5): 1195 - 1207.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
P Gonczy, E Matunis, and S DiNardo
bag-of-marbles and benign gonial cell neoplasm act in the germline to restrict proliferation during Drosophila spermatogenesis
Development, January 11, 1997; 124(21): 4361 - 4371.
[Abstract] [PDF]

Home page
 DevelopmentHome page
E Matunis, J Tran, P Gonczy, K Caldwell, and S DiNardo
punt and schnurri regulate a somatically derived signal that restricts proliferation of committed progenitors in the germline
Development, January 11, 1997; 124(21): 4383 - 4391.
[Abstract] [PDF]

Home page
 DevelopmentHome page
B Ohlstein and D McKearin
Ectopic expression of the Drosophila Bam protein eliminates oogenic germline stem cells
Development, January 9, 1997; 124(18): 3651 - 3662.
[Abstract] [PDF]

Home page
 DevelopmentHome page
S Staab, A Heller, and M Steinmann-Zwicky
Somatic sex-determining signals act on XX germ cells in Drosophila embryos
Development, January 12, 1996; 122(12): 4065 - 4071.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
T. Matsushita, I. Fujii-Taira, Y. Tanaka, K. J. Homma, and S. Natori
Male-specific IDGF, a Novel Gene Encoding a Membrane-bound Extracellular Signaling Molecule Expressed Exclusively in Testis of Drosophila melanogaster
J. Biol. Chem., November 17, 2000; 275(47): 36934 - 36941.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1996