|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 122, Issue 9 2611-2621, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
L Garcia-Alonso, RD Fetter and CS Goodman
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
Genetic analysis of the Laminin A (LamA) gene in Drosophila reveals that distinct classes of sensory axons have different requirements for extracellular matrix (ECM) containing laminin A versus epithelial cell surfaces. In the eye-antenna imaginal disc, the nerve from the three simple eyes (ocelli) to the brain is pioneered by a population of transient ocellar neurons whose axons extend on an ECM that covers and connects the disc epithelium and brain. Axons from neighboring mechanosensory (bristle) neurons extend under the ECM in direct contact with the surface of the disc cells, and pioneer a different axon pathway that enters the brain in a different location. In LamA mutants, the ocellar pioneer axons display striking pathfinding defects, while neighboring bristle axons appear normal; the ocellar pioneers usually extend in the proper direction, adhering to the epithelium and sometimes fasciculating with mechanosensory axons, but they invariably fail to reach the brain.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  Z. Huang, U. Yazdani, K. L. Thompson-Peer, A. L. Kolodkin, and J. R. Terman Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development Development, June 15, 2007; 134(12): 2337 - 2347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Vadivelu, R. Kurzbauer, B. Dieplinger, M. Zweyer, R. Schafer, A. Wernig, I. Vietor, and L. A. Huber Muscle Regeneration and Myogenic Differentiation Defects in Mice Lacking TIS7 Mol. Cell. Biol., April 15, 2004; 24(8): 3514 - 3525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-c. Huang, D. H. Hall, E. M. Hedgecock, G. Kao, V. Karantza, B. E. Vogel, H. Hutter, A. D. Chisholm, P. D. Yurchenco, and W. G. Wadsworth Laminin {alpha} subunits and their role in C. elegans development Development, July 15, 2003; 130(14): 3343 - 3358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Stevens and J. R. Jacobs Integrins Regulate Responsiveness to Slit Repellent Signals J. Neurosci., June 1, 2002; 22(11): 4448 - 4455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bonner and T. P. O'Connor The Permissive Cue Laminin Is Essential for Growth Cone Turning In Vivo J. Neurosci., December 15, 2001; 21(24): 9782 - 9791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. W. Dobie, C. D. Kennedy, V. M. Velasco, T. L. McGrath, J. Weko, R. W. Patterson, and G. H. Karpen Identification of Chromosome Inheritance Modifiers in Drosophila melanogaster Genetics, April 1, 2001; 157(4): 1623 - 1637. [Abstract] [Full Text]
|
|
|
|
|
|
D. Montell The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development Development, January 6, 1999; 126(14): 3035 - 3046. [Abstract] [PDF]
|
|
|
|
 |
|
 J. H. Miner, B. L. Patton, S. I. Lentz, D. J. Gilbert, W. D. Snider, N. A. Jenkins, N. G. Copeland, and J. R. Sanes The Laminin {alpha} Chains: Expression, Developmental Transitions, and Chromosomal Locations of {alpha}1-5, Identification of Heterotrimeric Laminins 8-11, and Cloning of a Novel {alpha}3 Isoform J. Cell Biol., May 5, 1997; 137(3): 685 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Gellon, K. Harding, N McGinnis, M. Martin, and W McGinnis A genetic screen for modifiers of Deformed homeotic function identifies novel genes required for head development Development, January 9, 1997; 124(17): 3321 - 3331. [Abstract] [PDF]
|
|
