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Development, Vol 122, Issue 9 2729-2737, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development

DJ Phippard, SJ Weber-Hall, PT Sharpe, MS Naylor, H Jayatalake, R Maas, I Woo, D Roberts-Clark, PH Francis-West, YH Liu, R Maxson, RE Hill and TC Dale
Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK.

Expression of the Msx-1 and Msx-2 homeobox genes have been shown to be coordinately regulated with the Bmp-2 and Bmp-4 ligands in a variety of developing tissues. Here we report that transcripts from all four genes are developmentally regulated during both foetal and postnatal mammary gland development. The location and time-course of the Bmp and Msx expression point to a role for Msx and Bmp gene products in the control of epithelial-mesenchymal interactions. Expression of Msx-2, but not Msx-1, Bmp-2 or Bmp-4 was decreased following ovariectomy, while expression of the human Msx-2 homologue was regulated by 17beta-oestradiol in the MCF-7 breast cancer cell line. The regulation of Msx-2 expression by oestrogen raises the possibility that hormonal regulation of mammary development is mediated through the control of epithelial-mesenchymal interactions.


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© The Company of Biologists Ltd 1996