Mutations affecting the development of the embryonic zebrafish brain

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JOURNAL ARTICLES

Mutations affecting the development of the embryonic zebrafish brain

AF Schier, SC Neuhauss, M Harvey, J Malicki, L Solnica-Krezel, DY Stainier, F Zwartkruis, S Abdelilah, DL Stemple, Z Rangini, H Yang and W Driever
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA.

In a large scale mutagenesis screen for embryonic mutants in zebrafish, we have identified 63 mutations in 24 loci affecting the morphogenesis of the zebrafish brain. The expression of marker genes and the integrity of the axonal scaffold have been studied to investigate abnormalities in regionalization, neurogenesis and axonogenesis in the brain. Mutants can be broadly classified into two groups, one affecting regionalization along the anterior-posterior or dorsal-ventral axis, and the other affecting general features of brain morphology. The first group includes one locus that is required to generate the anlage of the midbrain-hindbrain boundary region at the beginning of somitogenesis. Four loci were identified that affect dorsal-ventral patterning of the brain, including the previously described cyclops locus. Mutant embryos of this class show a reduction of ventral neuroectodermal structures and variable fusion of the eyes. The second group includes a large class of mutations affecting the formation of brain ventricles. Analysis of this class reveals the requirement of a functional cardiovascular system for ventricle enlargement during embryogenesis. Mutations in one locus lead to the formation of supernumerary primary neurons, a phenotype reminiscent of neurogenic mutants in Drosophila. Other mutant phenotypes described here range from abnormalities in the fasciculation and outgrowth of axons to defects in the diameter of the neural tube. The identified loci establish the genetic foundation for a further analysis of the development of the zebrafish embryonic brain.

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				J. Shin, J. Poling, H.-C. Park, and B. Appel Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish Development, May 15, 2007; 134(10): 1911 - 1920. [Abstract] [Full Text] [PDF]

				S. J. England, G. B. Blanchard, L. Mahadevan, and R. J. Adams A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia Development, December 1, 2006; 133(23): 4613 - 4617. [Abstract] [Full Text] [PDF]

				G. Reim and M. Brand Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4 Development, July 15, 2006; 133(14): 2757 - 2770. [Abstract] [Full Text] [PDF]

				R. Brooker, K. Hozumi, and J. Lewis Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear Development, April 1, 2006; 133(7): 1277 - 1286. [Abstract] [Full Text] [PDF]

				C. E. Burns, D. Traver, E. Mayhall, J. L. Shepard, and L. I. Zon Hematopoietic stem cell fate is established by the Notch-Runx pathway Genes & Dev., October 1, 2005; 19(19): 2331 - 2342. [Abstract] [Full Text] [PDF]

				B.-K. Koo, H.-S. Lim, R. Song, M.-J. Yoon, K.-J. Yoon, J.-S. Moon, Y.-W. Kim, M.-c. Kwon, K.-W. Yoo, M.-P. Kong, et al. Mind bomb 1 is essential for generating functional Notch ligands to activate Notch Development, August 1, 2005; 132(15): 3459 - 3470. [Abstract] [Full Text] [PDF]

				H.-C. Park, J. Boyce, J. Shin, and B. Appel Oligodendrocyte Specification in Zebrafish Requires Notch-Regulated Cyclin-Dependent Kinase Inhibitor Function J. Neurosci., July 20, 2005; 25(29): 6836 - 6844. [Abstract] [Full Text] [PDF]

				W. Wang and G. Struhl Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila Development, June 15, 2005; 132(12): 2883 - 2894. [Abstract] [Full Text] [PDF]

				E. C. Lai, F. Roegiers, X. Qin, Y. N. Jan, and G. M. Rubin The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta Development, May 15, 2005; 132(10): 2319 - 2332. [Abstract] [Full Text] [PDF]

				L. A. Lowery and H. Sive Initial formation of zebrafish brain ventricles occurs independently of circulation and requires the nagie oko and snakehead/atp1a1a.1 gene products Development, May 1, 2005; 132(9): 2057 - 2067. [Abstract] [Full Text] [PDF]

				A. Filippi, N. Tiso, G. Deflorian, E. Zecchin, M. Bortolussi, and F. Argenton The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord PNAS, March 22, 2005; 102(12): 4377 - 4382. [Abstract] [Full Text] [PDF]

				Y.-K. Bae, T. Shimizu, and M. Hibi Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm Development, March 15, 2005; 132(6): 1375 - 1385. [Abstract] [Full Text] [PDF]

				C. Crosnier, N. Vargesson, S. Gschmeissner, L. Ariza-McNaughton, A. Morrison, and J. Lewis Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine Development, March 1, 2005; 132(5): 1093 - 1104. [Abstract] [Full Text] [PDF]

				N. Daudet and J. Lewis Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation Development, February 1, 2005; 132(3): 541 - 551. [Abstract] [Full Text] [PDF]

				R. Catena, C. Tiveron, A. Ronchi, S. Porta, A. Ferri, L. Tatangelo, M. Cavallaro, R. Favaro, S. Ottolenghi, R. Reinbold, et al. Conserved POU Binding DNA Sites in the Sox2 Upstream Enhancer Regulate Gene Expression in Embryonic and Neural Stem Cells J. Biol. Chem., October 1, 2004; 279(40): 41846 - 41857. [Abstract] [Full Text] [PDF]

				G. Deflorian, N. Tiso, E. Ferretti, D. Meyer, F. Blasi, M. Bortolussi, and F. Argenton Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation Development, February 1, 2004; 131(3): 613 - 627. [Abstract] [Full Text] [PDF]

				P. S. Kunwar, S. Zimmerman, J. T. Bennett, Y. Chen, M. Whitman, and A. F. Schier Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction Development, December 1, 2003; 130(23): 5589 - 5599. [Abstract] [Full Text] [PDF]

				Y.-W. Liu, W. Gao, H.-L. Teh, J.-H. Tan, and W.-K. Chan Prox1 Is a Novel Coregulator of Ff1b and Is Involved in the Embryonic Development of the Zebra Fish Interrenal Primordium Mol. Cell. Biol., October 15, 2003; 23(20): 7243 - 7255. [Abstract] [Full Text] [PDF]

				B. Geldmacher-Voss, A. M. Reugels, S. Pauls, and J. A. Campos-Ortega A 90{degrees} rotation of the mitotic spindle changes the orientation of mitoses of zebrafish neuroepithelial cells Development, August 15, 2003; 130(16): 3767 - 3780. [Abstract] [Full Text] [PDF]

				J. Tian, C. Yam, G. Balasundaram, H. Wang, A. Gore, and K. Sampath A temperature-sensitive mutation in the nodal-related gene cyclops reveals that the floor plate is induced during gastrulation in zebrafish Development, July 15, 2003; 130(14): 3331 - 3342. [Abstract] [Full Text] [PDF]

				E. Cau and S. W. Wilson Ash1a and Neurogenin1 function downstream of Floating head to regulate epiphysial neurogenesis Development, June 1, 2003; 130(11): 2455 - 2466. [Abstract] [Full Text] [PDF]

				Y.-K. Bae, T. Shimizu, T. Yabe, C.-H. Kim, T. Hirata, H. Nojima, O. Muraoka, T. Hirano, and M. Hibi A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish Development, May 1, 2003; 130(9): 1853 - 1865. [Abstract] [Full Text] [PDF]

				S. Burgess, G. Reim, W. Chen, N. Hopkins, and M. Brand The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis Development, March 4, 2003; 129(4): 905 - 916. [Abstract] [Full Text] [PDF]

				G. Reim and M. Brand spiel-ohne-grenzen/pou2 mediates regional competence to respond to Fgf8 during zebrafish early neural development Development, March 4, 2003; 129(4): 917 - 933. [Abstract] [Full Text] [PDF]

				P. L. Pfeffer, B. Payer, G. Reim, M. P. di Magliano, and M. Busslinger The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by separate enhancers Development, March 3, 2003; 129(2): 307 - 318. [Abstract] [Full Text] [PDF]

				R. A. Cornell and J. S. Eisen Delta/Notch signaling promotes formation of zebrafish neural crest by repressing Neurogenin 1 function Development, January 6, 2002; 129(11): 2639 - 2648. [Abstract] [Full Text] [PDF]

				G. Hauptmann, H.-G. Belting, U. Wolke, K. Lunde, I. Soll, S. Abdelilah-Seyfried, V. Prince, and W. Driever spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation Development, January 4, 2002; 129(7): 1645 - 1655. [Abstract] [Full Text] [PDF]

				H.-G. Belting, G. Hauptmann, D. Meyer, S. Abdelilah-Seyfried, A. Chitnis, C. Eschbach, I. Soll, C. Thisse, B. Thisse, K. B. Artinger, et al. spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer Development, November 1, 2001; 128(21): 4165 - 4176. [Abstract] [Full Text] [PDF]

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