|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 123, Issue 1 369-389, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
RN Kelsh, M Brand, YJ Jiang, CP Heisenberg, S Lin, P Haffter, J Odenthal, MC Mullins, FJ van Eeden, M Furutani-Seiki, M Granato, M Hammerschmidt, DA Kane, RM Warga, D Beuchle, L Vogelsang and C Nusslein-Volhard
Max-Planck-Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany. kelsh@uoneuro.uoregon.edu
Neural crest development involves cell-fate specification, proliferation, patterned cell migration, survival and differentiation. Zebrafish neural crest derivatives include three distinct chromatophores, which are well-suited to genetic analysis of their development. As part of a large-scale mutagenesis screen for embryonic/early larval mutations, we have isolated 285 mutations affecting all aspects of zebrafish larval pigmentation. By complementation analysis, we define 94 genes. We show here that comparison of their phenotypes permits classification of these mutations according to the types of defects they cause, and these suggest which process of neural crest development is probably affected. Mutations in eight genes affect the number of chromatophores: these include strong candidates for genes necessary for the processes of pigment cell specification and proliferation. Mutations in five genes remove part of the wild-type pigment pattern, and suggest a role in larval pigment pattern formation. Mutations in five genes show ectopic chromatophores in distinct sites, and may have implications for chromatophore patterning and proliferation. 76 genes affect pigment or morphology of one or more chromatophore types: these mutations include strong candidates for genes important in various aspects of chromatophore differentiation and survival. In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development.
This article has been cited by other articles:
|
|
 |
|
  H. B. Schonthaler, V. C. Fleisch, O. Biehlmaier, Y. Makhankov, O. Rinner, R. Bahadori, R. Geisler, H. Schwarz, S. C. F. Neuhauss, and R. Dahm The zebrafish mutant lbk/vam6 resembles human multisystemic disorders caused by aberrant trafficking of endosomal vesicles Development, January 15, 2008; 135(2): 387 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yamaguchi, E. Yoshimoto, and S. Kondo Pattern regulation in the stripe of zebrafish suggests an underlying dynamic and autonomous mechanism PNAS, March 20, 2007; 104(12): 4790 - 4793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Svetic, G. E. Hollway, S. Elworthy, T. R. Chipperfield, C. Davison, R. J. Adams, J. S. Eisen, P. W. Ingham, P. D. Currie, and R. N. Kelsh Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants Development, March 1, 2007; 134(5): 1011 - 1022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Carney, K. A. Dutton, E. Greenhill, M. Delfino-Machin, P. Dufourcq, P. Blader, and R. N. Kelsh A direct role for Sox10 in specification of neural crest-derived sensory neurons Development, December 1, 2006; 133(23): 4619 - 4630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bahadori, O. Rinner, H. B. Schonthaler, O. Biehlmaier, Y. V. Makhankov, P. Rao, P. Jagadeeswaran, and S. C. F. Neuhauss The Zebrafish fade out Mutant: A Novel Genetic Model for Hermansky-Pudlak Syndrome. Invest. Ophthalmol. Vis. Sci., October 1, 2006; 47(10): 4523 - 4531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-T. Yang and S. L. Johnson Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes Development, September 15, 2006; 133(18): 3563 - 3573. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Cerda-Reverter, T. Haitina, H. B. Schioth, and R. E. Peter Gene Structure of the Goldfish Agouti-Signaling Protein: A Putative Role in the Dorsal-Ventral Pigment Pattern of Fish Endocrinology, March 1, 2005; 146(3): 1597 - 1610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lopez-Schier and A. J. Hudspeth Supernumerary neuromasts in the posterior lateral line of zebrafish lacking peripheral glia PNAS, February 1, 2005; 102(5): 1496 - 1501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Link, M. P. Gray, R. S. Smith, and S. W. M. John Intraocular Pressure in Zebrafish: Comparison of Inbred Strains and Identification of a Reduced Melanin Mutant with Raised IOP Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4415 - 4422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fukamachi, M. Sugimoto, H. Mitani, and A. Shima Somatolactin selectively regulates proliferation and morphogenesis of neural-crest derived pigment cells in medaka PNAS, July 20, 2004; 101(29): 10661 - 10666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Kay, T. Roeser, J. S. Mumm, L. Godinho, A. Mrejeru, R. O. L. Wong, and H. Baier Transient requirement for ganglion cells during assembly of retinal synaptic layers Development, March 15, 2004; 131(6): 1331 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Elworthy, J. A. Lister, T. J. Carney, D. W. Raible, and R. N. Kelsh Transcriptional regulation of mitfa accounts for the sox10 requirement in zebrafish melanophore development Development, June 15, 2003; 130(12): 2809 - 2818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Parichy and J. M. Turner Temporal and cellular requirements for Fms signaling during zebrafish adult pigment pattern development Development, March 1, 2003; 130(5): 817 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Rawls, M. R. Frieda, A. R. McAdow, J. P. Gross, C. M. Clayton, C. K. Heyen, and S. L. Johnson Coupled Mutagenesis Screens and Genetic Mapping in Zebrafish Genetics, March 1, 2003; 163(3): 997 - 1009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Dutton, A. Pauliny, S. S. Lopes, S. Elworthy, T. J. Carney, J. Rauch, R. Geisler, P. Haffter, and R. N. Kelsh Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates Development, November 1, 2001; 128(21): 4113 - 4125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Peterson, B. A. Link, J. E. Dowling, and S. L. Schreiber Small molecule developmental screens reveal the logic and timing of vertebrate development PNAS, November 21, 2000; 97(24): 12965 - 12969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cornell and J. Eisen Delta signaling mediates segregation of neural crest and spinal sensory neurons from zebrafish lateral neural plate Development, January 7, 2000; 127(13): 2873 - 2882. [Abstract] [PDF]
|
|
|
|
|
|
R. Kelsh and J. Eisen The zebrafish colourless gene regulates development of non-ectomesenchymal neural crest derivatives Development, January 2, 2000; 127(3): 515 - 525. [Abstract] [PDF]
|
|
|
|
 |
|
 S. C. F. Neuhauss, O. Biehlmaier, M. W. Seeliger, T. Das, K. Kohler, W. A. Harris, and H. Baier Genetic Disorders of Vision Revealed by a Behavioral Screen of 400 Essential Loci in Zebrafish J. Neurosci., October 1, 1999; 19(19): 8603 - 8615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Fishman Zebrafish genetics: The enigma of arrival PNAS, September 14, 1999; 96(19): 10554 - 10556. [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Southard-Smith, M. Angrist, J. S. Ellison, R. Agarwala, A. D. Baxevanis, A. Chakravarti, and W. J. Pavan The Sox10Dom Mouse: Modeling the Genetic Variation of Waardenburg-Shah (WS4) Syndrome Genome Res., March 1, 1999; 9(3): 215 - 225. [Abstract] [Full Text]
|
|
|
|
|
|
J. Lister, C. Robertson, T Lepage, S. Johnson, and D. Raible nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate Development, January 9, 1999; 126(17): 3757 - 3767. [Abstract] [PDF]
|
|
|
|
|
|
K. Artinger, A. Chitnis, M Mercola, and W Driever Zebrafish narrowminded suggests a genetic link between formation of neural crest and primary sensory neurons Development, January 9, 1999; 126(18): 3969 - 3979. [Abstract] [PDF]
|
|
|
|
|
|
D. Parichy, J. Rawls, S. Pratt, T. Whitfield, and S. Johnson Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development Development, January 8, 1999; 126(15): 3425 - 3436. [Abstract] [PDF]
|
|
|
|
|
|
A. B. Ribera and C. Nusslein-Volhard Zebrafish Touch-Insensitive Mutants Reveal an Essential Role for the Developmental Regulation of Sodium Current J. Neurosci., November 15, 1998; 18(22): 9181 - 9191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chen, F. van Eeden, K. Warren, A Chin, C Nusslein-Volhard, P Haffter, and M. Fishman Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish Development, January 11, 1997; 124(21): 4373 - 4382. [Abstract] [PDF]
|
|
|
|
|
|
P Haffter, M Granato, M Brand, M. Mullins, M Hammerschmidt, D. Kane, J Odenthal, F. van Eeden, Y. Jiang, C. Heisenberg, et al. The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 1 - 36. [Abstract] [PDF]
|
|
|
|
|
|
M Brand, C. Heisenberg, R. Warga, F Pelegri, R. Karlstrom, D Beuchle, A Picker, Y. Jiang, M Furutani-Seiki, F. van Eeden, et al. Mutations affecting development of the midline and general body shape during zebrafish embryogenesis Development, January 12, 1996; 123(1): 129 - 142. [Abstract] [PDF]
|
|
|
|
|
|
C. Heisenberg, M Brand, Y. Jiang, R. Warga, D Beuchle, F. van Eeden, M Furutani-Seiki, M Granato, P Haffter, M Hammerschmidt, et al. Genes involved in forebrain development in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 191 - 203. [Abstract] [PDF]
|
|
|
|
|
|
Y. Jiang, M Brand, C. Heisenberg, D Beuchle, M Furutani-Seiki, R. Kelsh, R. Warga, M Granato, P Haffter, M Hammerschmidt, et al. Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 205 - 216. [Abstract] [PDF]
|
|
|
|
|
|
M Furutani-Seiki, Y. Jiang, M Brand, C. Heisenberg, C Houart, D Beuchle, F. van Eeden, M Granato, P Haffter, M Hammerschmidt, et al. Neural degeneration mutants in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 229 - 239. [Abstract] [PDF]
|
|
|
|
|
|
T. Whitfield, M Granato, F. van Eeden, U Schach, M Brand, M Furutani-Seiki, P Haffter, M Hammerschmidt, C. Heisenberg, Y. Jiang, et al. Mutations affecting development of the zebrafish inner ear and lateral line Development, January 12, 1996; 123(1): 241 - 254. [Abstract] [PDF]
|
|
|
|
|
|
F. van Eeden, M Granato, U Schach, M Brand, M Furutani-Seiki, P Haffter, M Hammerschmidt, C. Heisenberg, Y. Jiang, D. Kane, et al. Genetic analysis of fin formation in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 255 - 262. [Abstract] [PDF]
|
|
|
|
|
|
D. Ransom, P Haffter, J Odenthal, A Brownlie, E Vogelsang, R. Kelsh, M Brand, F. van Eeden, M Furutani-Seiki, M Granato, et al. Characterization of zebrafish mutants with defects in embryonic hematopoiesis Development, January 12, 1996; 123(1): 311 - 319. [Abstract] [PDF]
|
|
|
|
|
|
T. Schilling, T Piotrowski, H Grandel, M Brand, C. Heisenberg, Y. Jiang, D Beuchle, M Hammerschmidt, D. Kane, M. Mullins, et al. Jaw and branchial arch mutants in zebrafish I: branchial arches Development, January 12, 1996; 123(1): 329 - 344. [Abstract] [PDF]
|
|
|
|
|
|
J Odenthal, K Rossnagel, P Haffter, R. Kelsh, E Vogelsang, M Brand, F. van Eeden, M Furutani-Seiki, M Granato, M Hammerschmidt, et al. Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 391 - 398. [Abstract] [PDF]
|
|
|
|
|
|
M Granato, F. van Eeden, U Schach, T Trowe, M Brand, M Furutani-Seiki, P Haffter, M Hammerschmidt, C. Heisenberg, Y. Jiang, et al. Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva Development, January 12, 1996; 123(1): 399 - 413. [Abstract] [PDF]
|
|
|
|
|
|
H Baier, S Klostermann, T Trowe, R. Karlstrom, C Nusslein-Volhard, and F Bonhoeffer Genetic dissection of the retinotectal projection Development, January 12, 1996; 123(1): 415 - 425. [Abstract] [PDF]
|
|
|
|
|
|
T Trowe, S Klostermann, H Baier, M Granato, A. Crawford, B Grunewald, H Hoffmann, R. Karlstrom, S. Meyer, B Muller, et al. Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 439 - 450. [Abstract] [PDF]
|
|
|
|
 |
|
 I. Ziegler, T. McDonaldo, C. Hesslinger, I. Pelletier, and P. Boyle Development of the Pteridine Pathway in the Zebrafish, Danio rerio J. Biol. Chem., June 16, 2000; 275(25): 18926 - 18932. [Abstract] [Full Text] [PDF]
|
|
