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Development, Vol 123, Issue 1 37-46, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
W Driever, L Solnica-Krezel, AF Schier, SC Neuhauss, J Malicki, DL Stemple, DY Stainier, F Zwartkruis, S Abdelilah, Z Rangini, J Belak and C Boggs
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA. Driever@Helix.MGH.Harvard.EDU
Systematic genome-wide mutagenesis screens for embryonic phenotypes have been instrumental in the understanding of invertebrate and plant development. Here, we report the results from the first application of such a large-scale genetic screening to vertebrate development. Male zebrafish were mutagenized with N-ethyl N-nitrosourea to induce mutations in spermatogonial cells at an average specific locus rate of one in 651 mutagenized genomes. Mutations were transmitted to the F1 generation, and 2205 F2 families were raised. F3 embryos from sibling crosses within the F2 families were screened for developmental abnormalities. A total of 2337 mutagenized genomes were analyzed, and 2383 mutations resulting in abnormal embryonic and early larval phenotypes were identified. The phenotypes of 695 mutants indicated involvement of the identified loci in specific aspects of embryogenesis. These mutations were maintained for further characterization and were classified into categories according to their phenotypes. The analyses and genetic complementation of mutations from several categories are reported in separate manuscripts. Mutations affecting pigmentation, motility, muscle and body shape have not been extensively analyzed and are listed here. A total of 331 mutations were tested for allelism within their respective categories. This defined 220 genetic loci with on average 1.5 alleles per locus. For about two-thirds of all loci only one allele was isolated. Therefore it is not possible to give a reliable estimate on the degree of saturation reached in our screen; however, the number of genes that can mutate to visible embryonic and early larval phenotypes in zebrafish is expected to be several-fold larger than the one for which we have observed mutant alleles during the screen. This screen demonstrates that mutations affecting a variety of developmental processes can be efficiently recovered from zebrafish.
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P. Blader and U. Strahle Zebrafish developmental genetics and central nervous system development Hum. Mol. Genet., April 1, 2000; 9(6): 945 - 951. [Abstract] [Full Text] [PDF] |
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P. D. Kelly, F. Chu, I. G. Woods, P. Ngo-Hazelett, T. Cardozo, H. Huang, F. Kimm, L. Liao, Y.-L. Yan, Y. Zhou, et al. Genetic Linkage Mapping of Zebrafish Genes and ESTs Genome Res., April 1, 2000; 10(4): 558 - 567. [Abstract] [Full Text] |
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W. S. Talbot and N. Hopkins Zebrafish mutations and functional analysis of the vertebrate genome Genes & Dev., April 1, 2000; 14(7): 755 - 762. [Full Text] |
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A. C. LEKVEN, K. A. HELDE, C. J. THORPE, R. ROOKE, and R. T. MOON Reverse genetics in zebrafish Physiol Genomics, March 14, 2000; 2(2): 37 - 48. [Abstract] [Full Text] [PDF] |
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M. Halloran, M Sato-Maeda, J. Warren, F Su, Z Lele, P. Krone, J. Kuwada, and W Shoji Laser-induced gene expression in specific cells of transgenic zebrafish Development, January 5, 2000; 127(9): 1953 - 1960. [Abstract] [PDF] |
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R. Kelsh and J. Eisen The zebrafish colourless gene regulates development of non-ectomesenchymal neural crest derivatives Development, January 2, 2000; 127(3): 515 - 525. [Abstract] [PDF] |
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S.-i. Higashijima, Y. Hotta, and H. Okamoto Visualization of Cranial Motor Neurons in Live Transgenic Zebrafish Expressing Green Fluorescent Protein Under the Control of the Islet-1 Promoter/Enhancer J. Neurosci., January 1, 2000; 20(1): 206 - 218. [Abstract] [Full Text] [PDF] |
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M. Ohtsuka, S. Makino, K. Yoda, H. Wada, K. Naruse, H. Mitani, A. Shima, K. Ozato, M. Kimura, and H. Inoko Construction of a Linkage Map of the Medaka (Oryzias latipes) and Mapping of the Da Mutant Locus Defective in Dorsoventral Patterning Genome Res., December 1, 1999; 9(12): 1277 - 1287. [Abstract] [Full Text] |
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A. Amsterdam, S. Burgess, G. Golling, W. Chen, Z. Sun, K. Townsend, S. Farrington, M. Haldi, and N. Hopkins A large-scale insertional mutagenesis screen in zebrafish Genes & Dev., October 15, 1999; 13(20): 2713 - 2724. [Abstract] [Full Text] |
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K. Hatta and H. Korn Tonic inhibition alternates in paired neurons that set direction of fish escape reaction PNAS, October 12, 1999; 96(21): 12090 - 12095. [Abstract] [Full Text] [PDF] |
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S. C. F. Neuhauss, O. Biehlmaier, M. W. Seeliger, T. Das, K. Kohler, W. A. Harris, and H. Baier Genetic Disorders of Vision Revealed by a Behavioral Screen of 400 Essential Loci in Zebrafish J. Neurosci., October 1, 1999; 19(19): 8603 - 8615. [Abstract] [Full Text] [PDF] |
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J. Cerdà, S. Reidenbach, S. Prätzel, and W. W. Franke Cadherin-Catenin Complexes During Zebrafish Oogenesis: Heterotypic Junctions Between Oocytes and Follicle Cells Biol Reprod, September 1, 1999; 61(3): 692 - 704. [Abstract] [Full Text] |
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N. A. Hukriede, L. Joly, M. Tsang, J. Miles, P. Tellis, J. A. Epstein, W. B. Barbazuk, F. N. Li, B. Paw, J. H. Postlethwait, et al. Radiation hybrid mapping of the zebrafish genome PNAS, August 17, 1999; 96(17): 9745 - 9750. [Abstract] [Full Text] [PDF] |
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M. A. Gates, L. Kim, E. S. Egan, T. Cardozo, H. I. Sirotkin, S. T. Dougan, D. Lashkari, R. Abagyan, A. F. Schier, and W. S. Talbot A Genetic Linkage Map for Zebrafish: Comparative Analysis and Localization of Genes and Expressed Sequences Genome Res., April 1, 1999; 9(4): 334 - 347. [Abstract] [Full Text] |
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K. Artinger, A. Chitnis, M Mercola, and W Driever Zebrafish narrowminded suggests a genetic link between formation of neural crest and primary sensory neurons Development, January 9, 1999; 126(18): 3969 - 3979. [Abstract] [PDF] |
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J Malicki and W Driever oko meduzy mutations affect neuronal patterning in the zebrafish retina and reveal cell-cell interactions of the retinal neuroepithelial sheet Development, January 3, 1999; 126(6): 1235 - 1246. [Abstract] [PDF] |
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