|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 123, Issue 1 439-450, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
T Trowe, S Klostermann, H Baier, M Granato, AD Crawford, B Grunewald, H Hoffmann, RO Karlstrom, SU Meyer, B Muller, S Richter, C Nusslein-Volhard and F Bonhoeffer
Abteilung Physikalische Biologie, Max-Planck-Institut fur Entwicklungsbiologie, Tubingen, Germany. trowe@mpib-tuebingen.mpg.de
Retinal ganglion cells connect to their target organ, the rectum, in a highly ordered fashion. We performed a large-scale screen for mutations affecting the retinotectal projection of the zebrafish, which resulted in the identification of 114 mutations. 44 of these mutations disturb either the order of RGC axons in the optic nerve and tract, the establishment of a topographic map on the tectum, or the formation of proper termination fields. Mutations in three genes, boxer, dackel and pinscher, disrupt the sorting of axons in the optic tract but do not affect mapping on the tectum. In these mutants, axons from the dorsal retina grow along both the ventral and the dorsal branch of the optic tract. Mutations in two genes, nevermind and who-cares, affect the dorsoventral patterning of the projection. In embryos homozygous for either of these mutations, axons from dorsal retinal ganglion cells terminate ventrally and dorsally in the tectum. In nevermind, the retinotopic order of axons along the optic nerve and tract is changed in a characteristic way as well, while it appears to be unaffected in who-cares. Two mutations in two complementation groups, gnarled and macho, affect the anteroposterior patterning of the projection. In these mutants, nasodorsal axons branch and terminate too soon in the anterior tectum. In 27 mutants belonging to six complementation groups, retinal axons do not form normal termination fields. Some implications for models concerning the formation of topographic projections are discussed.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Xiao, T. Roeser, W. Staub, and H. Baier A GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projection Development, July 1, 2005; 132(13): 2955 - 2967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D'Souza, M. Hendricks, S. Le Guyader, S. Subburaju, B. Grunewald, K. Scholich, and S. Jesuthasan Formation of the retinotectal projection requires Esrom, an ortholog of PAM (protein associated with Myc) Development, January 15, 2005; 132(2): 247 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Key and J. St John Axon Navigation in the Mammalian Primary Olfactory Pathway: Where to Next? Chem Senses, March 1, 2002; 27(3): 245 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ichijo and I. Kawabata Roles of the Telencephalic Cells and their Chondroitin Sulfate Proteoglycans in Delimiting an Anterior Border of the Retinal Pathway J. Neurosci., December 1, 2001; 21(23): 9304 - 9314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gnuegge, S. Schmid, and S. C. F. Neuhauss Analysis of the Activity-Deprived Zebrafish Mutant macho Reveals an Essential Requirement of Neuronal Activity for the Development of a Fine-Grained Visuotopic Map J. Neurosci., May 15, 2001; 21(10): 3542 - 3548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Li and J. E. Dowling Disruption of the Olfactoretinal Centrifugal Pathway May Relate to the Visual System Defect in night blindness b Mutant Zebrafish J. Neurosci., March 1, 2000; 20(5): 1883 - 1892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. F. Neuhauss, O. Biehlmaier, M. W. Seeliger, T. Das, K. Kohler, W. A. Harris, and H. Baier Genetic Disorders of Vision Revealed by a Behavioral Screen of 400 Essential Loci in Zebrafish J. Neurosci., October 1, 1999; 19(19): 8603 - 8615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Fishman Zebrafish genetics: The enigma of arrival PNAS, September 14, 1999; 96(19): 10554 - 10556. [Full Text] [PDF]
|
|
|
|
|
|
A Picker, C Brennan, F Reifers, J. Clarke, N Holder, and M Brand Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection Development, January 7, 1999; 126(13): 2967 - 2978. [Abstract] [PDF]
|
|
|
|
|
|
A. B. Ribera and C. Nusslein-Volhard Zebrafish Touch-Insensitive Mutants Reveal an Essential Role for the Developmental Regulation of Sodium Current J. Neurosci., November 15, 1998; 18(22): 9181 - 9191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ott, M. Bastmeyer, and C. A. O. Stuermer Neurolin, the Goldfish Homolog of DM-GRASP, Is Involved in Retinal Axon Pathfinding to the Optic Disk J. Neurosci., May 1, 1998; 18(9): 3363 - 3372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chen, F. van Eeden, K. Warren, A Chin, C Nusslein-Volhard, P Haffter, and M. Fishman Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish Development, January 11, 1997; 124(21): 4373 - 4382. [Abstract] [PDF]
|
|
|
|
|
|
R Macdonald, J Scholes, U Strahle, C Brennan, N Holder, M Brand, and S. Wilson The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain Development, January 6, 1997; 124(12): 2397 - 2408. [Abstract] [PDF]
|
|
|
|
 |
|
 W. Driever, L. Solnica-Krezel, S. Abdelilah, D. Meyer, and D. Stemple Genetic Analysis of Pattern Formation in the Zebrafish Neural Plate Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 523 - 534. [Abstract] [PDF]
|
|
|
|
|
|
P Haffter, M Granato, M Brand, M. Mullins, M Hammerschmidt, D. Kane, J Odenthal, F. van Eeden, Y. Jiang, C. Heisenberg, et al. The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 1 - 36. [Abstract] [PDF]
|
|
|
|
|
|
M Brand, C. Heisenberg, R. Warga, F Pelegri, R. Karlstrom, D Beuchle, A Picker, Y. Jiang, M Furutani-Seiki, F. van Eeden, et al. Mutations affecting development of the midline and general body shape during zebrafish embryogenesis Development, January 12, 1996; 123(1): 129 - 142. [Abstract] [PDF]
|
|
|
|
|
|
M Brand, C. Heisenberg, Y. Jiang, D Beuchle, K Lun, M Furutani-Seiki, M Granato, P Haffter, M Hammerschmidt, D. Kane, et al. Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain Development, January 12, 1996; 123(1): 179 - 190. [Abstract] [PDF]
|
|
|
|
|
|
C. Heisenberg, M Brand, Y. Jiang, R. Warga, D Beuchle, F. van Eeden, M Furutani-Seiki, M Granato, P Haffter, M Hammerschmidt, et al. Genes involved in forebrain development in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 191 - 203. [Abstract] [PDF]
|
|
|
|
|
|
M Furutani-Seiki, Y. Jiang, M Brand, C. Heisenberg, C Houart, D Beuchle, F. van Eeden, M Granato, P Haffter, M Hammerschmidt, et al. Neural degeneration mutants in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 229 - 239. [Abstract] [PDF]
|
|
|
|
|
|
T. Whitfield, M Granato, F. van Eeden, U Schach, M Brand, M Furutani-Seiki, P Haffter, M Hammerschmidt, C. Heisenberg, Y. Jiang, et al. Mutations affecting development of the zebrafish inner ear and lateral line Development, January 12, 1996; 123(1): 241 - 254. [Abstract] [PDF]
|
|
|
|
|
|
F. van Eeden, M Granato, U Schach, M Brand, M Furutani-Seiki, P Haffter, M Hammerschmidt, C. Heisenberg, Y. Jiang, D. Kane, et al. Genetic analysis of fin formation in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 255 - 262. [Abstract] [PDF]
|
|
|
|
|
|
T. Schilling, T Piotrowski, H Grandel, M Brand, C. Heisenberg, Y. Jiang, D Beuchle, M Hammerschmidt, D. Kane, M. Mullins, et al. Jaw and branchial arch mutants in zebrafish I: branchial arches Development, January 12, 1996; 123(1): 329 - 344. [Abstract] [PDF]
|
|
|
|
|
|
R. Kelsh, M Brand, Y. Jiang, C. Heisenberg, S Lin, P Haffter, J Odenthal, M. Mullins, F. van Eeden, M Furutani-Seiki, et al. Zebrafish pigmentation mutations and the processes of neural crest development Development, January 12, 1996; 123(1): 369 - 389. [Abstract] [PDF]
|
|
|
|
|
|
M Granato, F. van Eeden, U Schach, T Trowe, M Brand, M Furutani-Seiki, P Haffter, M Hammerschmidt, C. Heisenberg, Y. Jiang, et al. Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva Development, January 12, 1996; 123(1): 399 - 413. [Abstract] [PDF]
|
|
|
|
|
|
H Baier, S Klostermann, T Trowe, R. Karlstrom, C Nusslein-Volhard, and F Bonhoeffer Genetic dissection of the retinotectal projection Development, January 12, 1996; 123(1): 415 - 425. [Abstract] [PDF]
|
|
|
|
|
|
R. Karlstrom, T Trowe, S Klostermann, H Baier, M Brand, A. Crawford, B Grunewald, P Haffter, H Hoffmann, S. Meyer, et al. Zebrafish mutations affecting retinotectal axon pathfinding Development, January 12, 1996; 123(1): 427 - 438. [Abstract] [PDF]
|
|
